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Gene Expression Literature Summary
Symbol
Name
ID
Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
MGI:97384

199 matching records from 199 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1 E6.5 E7.5 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19.5 E P
Immunohistochemistry (section) 1 1 10 4 23 5 23 4 26 2 14 2 16 6 6 4 7 1 19 3 47
In situ RNA (section) 1 1 8 1 11 1 8 1 15 3 9 2 8 1 11 1 3 2 12 1 28
Immunohistochemistry (whole mount) 1 1 1 1 1
In situ RNA (whole mount) 1 1 1
In situ reporter (knock in) 1 3 2 1 1 5
Northern blot 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 3
Western blot 2 3 2 1 2 4 2 1 2 1 16
RT-PCR 1 1 1 2 3 2 2 2 5 3 1 1 2 3 2 2 18
cDNA clones 1 1 2 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Ntrk2  neurotrophic tyrosine kinase, receptor, type 2   (Synonyms: C030027L06Rik, Tkrb, trkB)
Results  Reference
6J:184160 Abdo H, Li L, Lallemend F, Bachy I, Xu XJ, Rice FL, Ernfors P, Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch. Eur J Neurosci. 2011 Nov;34(10):1529-41
1J:206954 Achuta VS, Rezov V, Uutela M, Louhivuori V, Louhivuori L, Castren ML, Tissue plasminogen activator contributes to alterations of neuronal migration and activity-dependent responses in fragile X mice. J Neurosci. 2014 Jan 29;34(5):1916-23
1J:160730 Alavian KN, Sgado P, Alberi L, Subramaniam S, Simon HH, Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev. 2009;4:11
2J:212682 Anastasia A, Deinhardt K, Wang S, Martin L, Nichol D, Irmady K, Trinh J, Parada L, Rafii S, Hempstead BL, Kermani P, Trkb signaling in pericytes is required for cardiac microvessel stabilization. PLoS One. 2014;9(1):e87406
1J:119656 Andrieu D, Meziane H, Marly F, Angelats C, Fernandez PA, Muscatelli F, Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell death. BMC Dev Biol. 2006;6:56
5J:267338 Angelim MKSC, Maia LMSS, Mouffle C, Ginhoux F, Low D, Amancio-Dos-Santos A, Makhoul J, Le Corronc H, Mangin JM, Legendre P, Embryonic macrophages and microglia ablation alter the development of dorsal root ganglion sensory neurons in mouse embryos. Glia. 2018 Nov;66(11):2470-2486
5J:31113 Armanini MP, McMahon SB, Sutherland J, Shelton DL, Phillips HS, Truncated and catalytic isoforms of trkB are co-expressed in neurons of rat and mouse CNS. Eur J Neurosci. 1995 Jun 1;7(6):1403-9
5J:178481 Bachy I, Franck MC, Li L, Abdo H, Pattyn A, Ernfors P, The transcription factor Cux2 marks development of an A-delta sublineage of TrkA sensory neurons. Dev Biol. 2011 Dec 1;360(1):77-86
4*J:201549 Bando T, Morikawa Y, Hisaoka T, Komori T, Miyajima A, Senba E, Dynamic expression pattern of leucine-rich repeat neuronal protein 4 in the mouse dorsal root ganglia during development. Neurosci Lett. 2013 Aug 26;548:73-8
3J:288459 Bartesaghi L, Wang Y, Fontanet P, Wanderoy S, Berger F, Wu H, Akkuratova N, Boucanova F, Medard JJ, Petitpre C, Landy MA, Zhang MD, Harrer P, Stendel C, Stucka R, Dusl M, Kastriti ME, Croci L, Lai HC, Consalez GG, Pattyn A, Ernfors P, Senderek J, Adameyko I, Lallemend F, Hadjab S, Chrast R, PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis. Cell Rep. 2019 Mar 26;26(13):3484-3492.e4
3J:168326 Baydyuk M, Russell T, Liao GY, Zang K, An JJ, Reichardt LF, Xu B, TrkB receptor controls striatal formation by regulating the number of newborn striatal neurons. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1669-74
1*J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1J:183366 Belluoccio D, Etich J, Rosenbaum S, Frie C, Grskovic I, Stermann J, Ehlen H, Vogel S, Zaucke F, von der Mark K, Bateman JF, Brachvogel B, Sorting of growth plate chondrocytes allows the isolation and characterization of cells of a defined differentiation status. J Bone Miner Res. 2010 Jun;25(6):1267-81
1J:81473 Beltran PJ, Bixby JL, Masters BA, Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neurons. J Comp Neurol. 2003 Feb 17;456(4):384-95
1J:142362 Ben-Zvi A, Manor O, Schachner M, Yaron A, Tessier-Lavigne M, Behar O, The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development. J Neurosci. 2008 Nov 19;28(47):12427-32
1J:309445 Bernal Sierra YA, Haseleu J, Kozlenkov A, Begay V, Lewin GR, Genetic Tracing of Cav3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System. Front Mol Neurosci. 2017;10:70
1J:353444 Bessa P, Newman AG, Yan K, Schaub T, Dannenberg R, Lajko D, Eilenberger J, Brunet T, Textoris-Taube K, Kemmler E, Deng P, Banerjee P, Ravindran E, Preissner R, Rosario M, Tarabykin V, Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring. Nat Commun. 2024 Aug 16;15(1):7059
1*J:245526 Bibollet-Bahena O, Okafuji T, Hokamp K, Tear G, Mitchell KJ, A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. PLoS One. 2017;12(5):e0177977
3J:65040 Botchkareva NV, Botchkarev VA, Albers KM, Metz M, Paus R, Distinct roles for nerve growth factor and brain-derived neurotrophic factor in controlling the rate of hair follicle morphogenesis. J Invest Dermatol. 2000 Feb;114(2):314-20
1J:58865 Botchkareva NV, Botchkarev VA, Chen LH, Lindner G, Paus R, A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis. Dev Biol. 1999 Dec 1;216(1):135-53
1J:230425 Bouilloux F, Thireau J, Venteo S, Farah C, Karam S, Dauvilliers Y, Valmier J, Copeland NG, Jenkins NA, Richard S, Marmigere F, Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death. Elife. 2016;5:e11627
3J:157721 Bourane S, Garces A, Venteo S, Pattyn A, Hubert T, Fichard A, Puech S, Boukhaddaoui H, Baudet C, Takahashi S, Valmier J, Carroll P, Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling. Neuron. 2009 Dec 24;64(6):857-70
1J:164699 Breuskin I, Bodson M, Thelen N, Thiry M, Borgs L, Nguyen L, Stolt C, Wegner M, Lefebvre PP, Malgrange B, Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10. J Neurochem. 2010 Sep;114(6):1827-39
1J:149223 Buchmann-Moller S, Miescher I, John N, Krishnan J, Deng CX, Sommer L, Multiple lineage-specific roles of Smad4 during neural crest development. Dev Biol. 2009 Jun 15;330(2):329-38
1*J:203073 Cesca F, Yabe A, Spencer-Dene B, Scholz-Starke J, Medrihan L, Maden CH, Gerhardt H, Orriss IR, Baldelli P, Al-Qatari M, Koltzenburg M, Adams RH, Benfenati F, Schiavo G, Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems. Cell Death Differ. 2012 Feb;19(2):194-208
1*J:254788 Chen Z, Donnelly CR, Dominguez B, Harada Y, Lin W, Halim AS, Bengoechea TG, Pierchala BA, Lee KF, p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. Cell Rep. 2017 Oct 17;21(3):707-720
1J:70560 Chen Z, Rebelo S, White F, Malmberg AB, Baba H, Lima D, Woolf CJ, Basbaum AI, Anderson DJ, The paired homeodomain protein drg11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron. 2001 Jul 19;31(1):59-73
10*J:83933 Cheng A, Wang S, Cai J, Rao MS, Mattson MP, Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol. 2003 Jun 15;258(2):319-33
5J:268047 Cheng I, Jin L, Rose LC, Deppmann CD, Temporally restricted death and the role of p75NTR as a survival receptor in the developing sensory nervous system. Dev Neurobiol. 2018 Jul;78(7):701-717
3J:72304 Coppola V, Kucera J, Palko ME, Martinez-De Velasco J, Lyons WE, Fritzsch B, Tessarollo L, Dissection of NT3 functions in vivo by gene replacement strategy. Development. 2001 Nov;128(21):4315-27
1J:243001 Cordon-Barris L, Pascual-Guiral S, Yang S, Gimenez-Llort L, Lope-Piedrafita S, Niemeyer C, Claro E, Lizcano JM, Bayascas JR, Mutation of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) substrate-docking site in the developing brain causes microcephaly with abnormal brain morphogenesis independently of Akt, leading to impaired cognition and disruptive behaviors. Mol Cell Biol. 2016 Sep 19;
1J:169302 da Silva S, Hasegawa H, Scott A, Zhou X, Wagner AK, Han BX, Wang F, Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-{beta} signaling. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3395-400
5*J:282348 Dasgupta K, Chung JU, Asam K, Jeong J, Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling. Dev Biol. 2019 Nov 15;455(2):434-448
6J:172162 de Melo J, Zhou QP, Zhang Q, Zhang S, Fonseca M, Wigle JT, Eisenstat DD, Dlx2 homeobox gene transcriptional regulation of Trkb neurotrophin receptor expression during mouse retinal development. Nucleic Acids Res. 2008 Feb;36(3):872-84
5J:353354 Desiderio S, Schwaller F, Tartour K, Padmanabhan K, Lewin GR, Carroll P, Marmigere F, Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2. Elife. 2024 Feb 22;12
8J:283226 Desiderio S, Vermeiren S, Van Campenhout C, Kricha S, Malki E, Richts S, Fletcher EV, Vanwelden T, Schmidt BZ, Henningfeld KA, Pieler T, Woods CG, Nagy V, Verfaillie C, Bellefroid EJ, Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA. Cell Rep. 2019 Mar 26;26(13):3522-3536.e5
3J:260552 Donnelly CR, Shah AA, Mistretta CM, Bradley RM, Pierchala BA, Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E516-E525
4J:64681 Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kraemer R, Hahn R, Wang S, Ibanez CF, Rafii S, Hempstead BL, Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development. 2000 Nov;127(21):4531-40
3*J:296604 Durbeej M, Soderstrom S, Ebendal T, Birchmeier C, Ekblom P, Differential expression of neurotrophin receptors during renal development. Development. 1993 Dec;119(4):977-89
8J:160718 Dykes IM, Lanier J, Eng SR, Turner EE, Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation. Neural Dev. 2010;5:3
1J:174563 Dykes IM, Tempest L, Lee SI, Turner EE, Brn3a and Islet1 act epistatically to regulate the gene expression program of sensory differentiation. J Neurosci. 2011 Jul 6;31(27):9789-99
1J:207799 Fado R, Moubarak RS, Minano-Molina AJ, Barneda-Zahonero B, Valero J, Saura CA, Moran J, Comella JX, Rodriguez-Alvarez J, X-linked inhibitor of apoptosis protein negatively regulates neuronal differentiation through interaction with cRAF and Trk. Sci Rep. 2013;3:2397
5J:35563 Fagan AM, Zhang H, Landis S, Smeyne RJ, Silos-Santiago I, Barbacid M, TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo. J Neurosci. 1996 1;16(19):6208-18
3J:70840 Farinas I, Jones KR, Tessarollo L, Vigers AJ, Huang E, Kirstein M, de Caprona DC, Coppola V, Backus C, Reichardt LF, Fritzsch B, Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. J Neurosci. 2001 Aug 15;21(16):6170-80
5*J:49434 Farinas I, Wilkinson GA, Backus C, Reichardt LF, Patapoutian A, Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo. Neuron. 1998 Aug;21(2):325-34
2J:299733 Faure L, Wang Y, Kastriti ME, Fontanet P, Cheung KKY, Petitpre C, Wu H, Sun LL, Runge K, Croci L, Landy MA, Lai HC, Consalez GG, de Chevigny A, Lallemend F, Adameyko I, Hadjab S, Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates. Nat Commun. 2020 Aug 21;11(1):4175
1J:209845 Fei D, Krimm RF, Taste neurons consist of both a large TrkB-receptor-dependent and a small TrkB-receptor-independent subpopulation. PLoS One. 2013;8(12):e83460
1J:333967 Filova I, Pysanenko K, Tavakoli M, Vochyanova S, Dvorakova M, Bohuslavova R, Smolik O, Fabriciova V, Hrabalova P, Benesova S, Valihrach L, Cerny J, Yamoah EN, Syka J, Fritzsch B, Pavlinkova G, ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2207433119
2*J:315751 Fuschini G, Cotrufo T, Ros O, Muhaisen A, Andres R, Comella JX, Soriano E, Syntaxin-1/TI-VAMP SNAREs interact with Trk receptors and are required for neurotrophin-dependent outgrowth. Oncotarget. 2018 Nov 13;9(89):35922-35940
1J:164668 Gascon E, Gaillard S, Malapert P, Liu Y, Rodat-Despoix L, Samokhvalov IM, Delmas P, Helmbacher F, Maina F, Moqrich A, Hepatocyte growth factor-Met signaling is required for Runx1 extinction and peptidergic differentiation in primary nociceptive neurons. J Neurosci. 2010 Sep 15;30(37):12414-23
3J:196589 Gatto G, Dudanova I, Suetterlin P, Davies AM, Drescher U, Bixby JL, Klein R, Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling. J Neurosci. 2013 Mar 20;33(12):5399-410
1J:266784 Gay MH, Valenta T, Herr P, Paratore-Hari L, Basler K, Sommer L, Distinct adhesion-independent functions of beta-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biol. 2015 Apr 11;13:24
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1J:253121 Gresset A, Coulpier F, Gerschenfeld G, Jourdon A, Matesic G, Richard L, Vallat JM, Charnay P, Topilko P, Boundary Caps Give Rise to Neurogenic Stem Cells and Terminal Glia in the Skin. Stem Cell Reports. 2015 Aug 11;5(2):278-90
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1J:253913 Guimaraes-Camboa N, Cattaneo P, Sun Y, Moore-Morris T, Gu Y, Dalton ND, Rockenstein E, Masliah E, Peterson KL, Stallcup WB, Chen J, Evans SM, Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017 Mar 2;20(3):345-359.e5
4J:345844 Guo Y, Xiang P, Sun X, Liu W, Zhou J, Yin B, Hou L, Qiang B, Li H, Shu P, Peng X, Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32
1J:204192 Hadjab S, Franck MC, Wang Y, Sterzenbach U, Sharma A, Ernfors P, Lallemend F, A local source of FGF initiates development of the unmyelinated lineage of sensory neurons. J Neurosci. 2013 Nov 6;33(45):17656-66
3J:315755 Hancock ML, Nowakowski DW, Role LW, Talmage DA, Flanagan JG, Type III neuregulin 1 regulates pathfinding of sensory axons in the developing spinal cord and periphery. Development. 2011 Nov;138(22):4887-98
1J:167838 Harlow DE, Yang H, Williams T, Barlow LA, Epibranchial placode-derived neurons produce BDNF required for early sensory neuron development. Dev Dyn. 2011 Feb;240(2):309-23
1J:208752 Hasegawa H, Wang F, Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice. J Comp Neurol. 2008 Dec 1;511(4):543-56
1J:100886 Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle DR, Arber S, A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol. 2005 May;3(5):e159
4J:83661 Holm PC, Rodriguez FJ, Kresse A, Canals JM, Silos-Santiago I, Arenas E, Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons. Development. 2003 Aug;130(15):3535-45
2*J:143398 Homma S, Shimada T, Hikake T, Yaginuma H, Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo. Gene Expr Patterns. 2009 Jan;9(1):1-26
1J:342152 Honda A, Nozumi M, Ito Y, Natsume R, Kawasaki A, Nakatsu F, Abe M, Uchino H, Matsushita N, Ikeda K, Arita M, Sakimura K, Igarashi M, Very-long-chain fatty acids are crucial to neuronal polarity by providing sphingolipids to lipid rafts. Cell Rep. 2023 Oct 31;42(10):113195
1J:161851 Honma Y, Kawano M, Kohsaka S, Ogawa M, Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret. Development. 2010 Jul;137(14):2319-28
5J:162252 Horiguchi S, Horiguchi K, Nojyo Y, Iino S, Downregulation of msh-like 2 (msx2) and neurotrophic tyrosine kinase receptor type 2 (ntrk2) in the developmental gut of KIT mutant mice. Biochem Biophys Res Commun. 2010 Jun 4;396(3):774-9
1J:184447 Hu J, Huang T, Li T, Guo Z, Cheng L, c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections. J Neurosci. 2012 Apr 18;32(16):5362-73
2J:187349 Hu XL, Cheng X, Cai L, Tan GH, Xu L, Feng XY, Lu TJ, Xiong H, Fei J, Xiong ZQ, Conditional deletion of NRSF in forebrain neurons accelerates epileptogenesis in the kindling model. Cereb Cortex. 2011 Sep;21(9):2158-65
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1J:95688 Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, Jan LY, Jan YN, Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 2005 Jan 1;19(1):138-51
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6*J:54178 Huang EJ, Wilkinson GA, Farinas I, Backus C, Zang K, Wong SL, Reichardt LF, Expression of Trk receptors in the developing mouse trigeminal ganglion: in vivo evidence for NT-3 activation of TrkA and TrkB in addition to TrkC. Development. 1999 May;126(10):2191-203
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4J:165547 Huang T, Krimm RF, Developmental expression of Bdnf, Ntf4/5, and TrkB in the mouse peripheral taste system. Dev Dyn. 2010 Oct;239(10):2637-46
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1J:140017 Komori T, Gyobu H, Ueno H, Kitamura T, Senba E, Morikawa Y, Expression of kin of irregular chiasm-like 3/mKirre in proprioceptive neurons of the dorsal root ganglia and its interaction with nephrin in muscle spindles. J Comp Neurol. 2008 Nov 1;511(1):92-108
3J:91006 Koponen E, Voikar V, Riekki R, Saarelainen T, Rauramaa T, Rauvala H, Taira T, Castren E, Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning. Mol Cell Neurosci. 2004 May;26(1):166-81
1*J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1J:342051 Koutsioumpa C, Santiago C, Jacobs K, Lehnert BP, Barrera V, Hutchinson JN, Schmelyun D, Lehoczky JA, Paul DL, Ginty DD, Skin-type-dependent development of murine mechanosensory neurons. Dev Cell. 2023 Oct 23;58(20):2032-2047.e6
3J:106980 Kramer I, Sigrist M, de Nooij JC, Taniuchi I, Jessell TM, Arber S, A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification. Neuron. 2006 Feb 2;49(3):379-93
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory