Symbol Name ID |
Otx1
orthodenticle homeobox 1 MGI:97450 |
Age | E1.5 | E2 | E2.5 | E3 | E3.5 | E4.5 | E5.5 | E6.5 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E | P |
Immunohistochemistry (section) | 2 | 1 | 1 | 1 | 2 | 3 | 2 | 3 | 2 | 8 | |||||||||||||||||||||||
In situ RNA (section) | 1 | 1 | 1 | 2 | 2 | 5 | 5 | 20 | 3 | 10 | 4 | 18 | 1 | 10 | 4 | 9 | 1 | 15 | 3 | 7 | 1 | 1 | 2 | 8 | 3 | 17 | |||||||
In situ RNA (whole mount) | 6 | 6 | 2 | 8 | 2 | 14 | 1 | 4 | 2 | 1 | |||||||||||||||||||||||
In situ reporter (knock in) | 1 | ||||||||||||||||||||||||||||||||
Northern blot | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||||||||||
Western blot | 1 | 1 | 3 | 1 | 1 | 1 | 1 | ||||||||||||||||||||||||||
RT-PCR | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 1 | 4 | 2 | 1 | 4 | 1 | 1 | 2 | 1 | 2 | ||||||||||||||
cDNA clones | 1 | ||||||||||||||||||||||||||||||||
RNase protection | 2 |
Otx1 orthodenticle homeobox 1 (Synonyms: A730044F23Rik, jv) | |
Results | Reference |
1 | J:142510 Abraira VE, Del Rio T, Tucker AF, Slonimsky J, Keirnes HL, Goodrich LV, Cross-repressive interactions between Lrig3 and netrin 1 shape the architecture of the inner ear. Development. 2008 Dec;135(24):4091-9 |
3* | J:52989 Acampora D, Avantaggiato V, Tuorto F, Barone P, Perera M, Choo D, Wu D, Corte G, Simeone A, Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes. Development. 1999 Apr;126(7):1417-26 |
1 | J:47899 Acampora D, Avantaggiato V, Tuorto F, Barone P, Reichert H, Finkelstein R, Simeone A, Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development. Development. 1998 May;125(9):1691-702 |
3* | J:49817 Acampora D, Avantaggiato V, Tuorto F, Briata P, Corte G, Simeone A, Visceral endoderm-restricted translation of otx1 mediates recovery of otx2 requirements for specification of anterior neural plate and normal gastrulation. Development. 1998 Dec;125(24):5091-104 |
1* | J:29276 Acampora D, Mazan S, Lallemand Y, Avantaggiato V, Maury M, Simeone A, Brulet P, Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 1995 Oct;121(10):3279-90 |
4 | J:53300 Acampora D, Simeone A, The TINS Lecture. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis. Trends Neurosci. 1999 Mar;22(3):116-22 |
1 | J:254591 Alldredge A, Fuhrmann S, Loss of Axin2 Causes Ocular Defects During Mouse Eye Development. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5253-5262 |
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1 | J:180898 Brown AS, Epstein DJ, Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development. Development. 2011 Sep;138(18):3967-76 |
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1* | J:130649 Fossat N, Le Greneur C, Beby F, Vincent S, Godement P, Chatelain G, Lamonerie T, A new GFP-tagged line reveals unexpected Otx2 protein localization in retinal photoreceptors. BMC Dev Biol. 2007;7:122 |
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1 | J:180774 Grimsley-Myers CM, Sipe CW, Wu DK, Lu X, Redundant functions of Rac GTPases in inner ear morphogenesis. Dev Biol. 2012 Feb 15;362(2):172-86 |
1* | J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004; |
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1 | J:87404 Hanashima C, Li SC, Shen L, Lai E, Fishell G, Foxg1 suppresses early cortical cell fate. Science. 2004 Jan 2;303(5654):56-9 |
1 | J:217375 Heavner WE, Andoniadou CL, Pevny LH, Establishment of the neurogenic boundary of the mouse retina requires cooperation of SOX2 and WNT signaling. Neural Dev. 2014;9:27 |
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1* | J:73652 Hitoshi S, Tropepe V, Ekker M, van der Kooy D, Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain. Development. 2002 Jan;129(1):233-44 |
1* | J:98483 Hjerling-Leffler J, Marmigere F, Heglind M, Cederberg A, Koltzenburg M, Enerback S, Ernfors P, The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes. Development. 2005 Jun;132(11):2623-32 |
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1 | J:117489 Horn Z, Papachristou P, Shariatmadari M, Peyronnet J, Eriksson B, Ringstedt T, Wnt7a overexpression delays beta-tubulin III expression in transgenic mouse embryos. Brain Res. 2007 Jan 26;1130(1):67-72 |
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1 | J:82307 Hulander M, Kiernan AE, Blomqvist SR, Carlsson P, Samuelsson EJ, Johansson BR, Steel KP, Enerback S, Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice. Development. 2003 May;130(9):2013-25 |
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2* | J:153730 Hwang CH, Simeone A, Lai E, Wu DK, Foxg1 is required for proper separation and formation of sensory cristae during inner ear development. Dev Dyn. 2009 Nov;238(11):2725-34 |
1* | J:157698 Ideguchi M, Palmer TD, Recht LD, Weimann JM, Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets. J Neurosci. 2010 Jan 20;30(3):894-904 |
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1* | J:73067 Li JY, Joyner AL, Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression. Development. 2001 Dec;128(24):4979-91 |
1 | J:314167 Lim S, Kim YJ, Park S, Choi JH, Sung YH, Nishimori K, Kozmik Z, Lee HW, Kim JW, mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Muller glia. Elife. 2021 Oct 22;10:e70079 |
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