Symbol Name ID |
Otx2
orthodenticle homeobox 2 MGI:97451 |
Age | E1.5 | E2 | E2.5 | E3 | E3.5 | E4 | E4.5 | E5 | E5.5 | E6 | E6.5 | E7 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E19.5 | E | P |
Immunohistochemistry (section) | 2 | 3 | 2 | 8 | 6 | 13 | 6 | 9 | 5 | 3 | 12 | 2 | 24 | 4 | 26 | 5 | 42 | 5 | 30 | 3 | 36 | 2 | 17 | 4 | 18 | 5 | 10 | 3 | 16 | 1 | 1 | 9 | 50 | ||||||
In situ RNA (section) | 2 | 4 | 18 | 5 | 15 | 8 | 7 | 3 | 19 | 9 | 51 | 2 | 28 | 4 | 52 | 1 | 15 | 4 | 26 | 4 | 18 | 3 | 8 | 1 | 5 | 2 | 16 | 6 | 20 | ||||||||||
Immunohistochemistry (whole mount) | 1 | 3 | 2 | 2 | 1 | 1 | 1 | 1 | 2 | 3 | 1 | 2 | 1 | 1 | 1 | ||||||||||||||||||||||||
In situ RNA (whole mount) | 2 | 5 | 3 | 23 | 16 | 74 | 42 | 79 | 22 | 74 | 3 | 29 | 1 | 10 | 5 | 1 | 1 | 2 | 4 | 11 | |||||||||||||||||||
In situ reporter (knock in) | 1 | 1 | 1 | 2 | 8 | 1 | 6 | 4 | 5 | 1 | 4 | 1 | 4 | 2 | 1 | 1 | 1 | 2 | 1 | 3 | |||||||||||||||||||
Northern blot | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||||||||||||||
Western blot | 4 | 1 | 4 | 1 | 2 | 1 | 1 | 1 | 5 | ||||||||||||||||||||||||||||||
RT-PCR | 2 | 2 | 2 | 2 | 3 | 2 | 9 | 2 | 7 | 4 | 9 | 3 | 6 | 1 | 8 | 1 | 5 | 10 | 6 | 1 | 9 | 3 | 3 | 2 | 1 | 1 | 1 | 2 | 16 | ||||||||||
cDNA clones | 1 | 2 | 1 | 1 | 2 | ||||||||||||||||||||||||||||||||||
RNase protection | 1 | 1 | 5 |
Otx2 orthodenticle homeobox 2 (Synonyms: E130306E05Rik) | |
Results | Reference |
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8* | J:89361 Acampora D, Annino A, Puelles E, Alfano I, Tuorto F, Simeone A, OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm. Gene Expr Patterns. 2003 Aug;3(4):497-501 |
3* | J:52989 Acampora D, Avantaggiato V, Tuorto F, Barone P, Perera M, Choo D, Wu D, Corte G, Simeone A, Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes. Development. 1999 Apr;126(7):1417-26 |
3 | J:47899 Acampora D, Avantaggiato V, Tuorto F, Barone P, Reichert H, Finkelstein R, Simeone A, Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development. Development. 1998 May;125(9):1691-702 |
11* | J:49817 Acampora D, Avantaggiato V, Tuorto F, Briata P, Corte G, Simeone A, Visceral endoderm-restricted translation of otx1 mediates recovery of otx2 requirements for specification of anterior neural plate and normal gastrulation. Development. 1998 Dec;125(24):5091-104 |
4 | J:43308 Acampora D, Avantaggiato V, Tuorto F, Simeone A, Genetic control of brain morphogenesis through Otx gene dosage requirement. Development. 1997 Sep;124(18):3639-50 |
7* | J:72726 Acampora D, Boyl PP, Signore M, Martinez-Barbera JP, Ilengo C, Puelles E, Annino A, Reichert H, Corte G, Simeone A, OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation. Development. 2001 Dec;128(23):4801-13 |
16* | J:153562 Acampora D, Di Giovannantonio LG, Di Salvio M, Mancuso P, Simeone A, Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev. 2009 Oct;126(10):882-97 |
7 | J:191079 Acampora D, Di Giovannantonio LG, Simeone A, Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition. Development. 2013 Jan 1;140(1):43-55 |
13* | J:29276 Acampora D, Mazan S, Lallemand Y, Avantaggiato V, Maury M, Simeone A, Brulet P, Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 1995 Oct;121(10):3279-90 |
2 | J:56557 Acampora D, Merlo GR, Paleari L, Zerega B, Postiglione MP, Mantero S, Bober E, Barbieri O, Simeone A, Levi G, Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Development. 1999 Sep;126(17):3795-809 |
10 | J:238298 Acampora D, Omodei D, Petrosino G, Garofalo A, Savarese M, Nigro V, Di Giovannantonio LG, Mercadante V, Simeone A, Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast. Cell Rep. 2016 Jun 21;15(12):2651-64 |
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