Gene Expression Literature Summary

• Symbol: Pappa
• Name: pregnancy-associated plasma protein A
• ID: MGI:97479

11 matching records from 11 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E18.5	E	P
In situ RNA (section)				2	2		2	1		3
In situ RNA (whole mount)	1	1	1	1	1	1	1
RT-PCR					1			1	1	4

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pappa  pregnancy-associated plasma protein A   (Synonyms: 8430414N03Rik, IGFBP-4ase, PAG1, PAPP-A)
Results	Reference
2	J:360072 Basu S, Mautner L, Whiting K, Hasenpusch-Theil K, Borkowska M, Theil T, Identification of Pappa and Sall3 as Gli3 direct target genes acting downstream of cilia signaling in corticogenesis. Cereb Cortex. 2024 Dec 3;34(12)
3	J:322321 Catela C, Chen Y, Weng Y, Wen K, Kratsios P, Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity. Elife. 2022 Mar 22;11:e70766
8*	J:88578 Conover CA, Bale LK, Overgaard MT, Johnstone EW, Laursen UH, Fuchtbauer EM, Oxvig C, van Deursen J, Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development. Development. 2004 Mar;131(5):1187-94
2*	J:174887 Conover CA, Boldt HB, Bale LK, Clifton KB, Grell JA, Mader JR, Mason EJ, Powell DR, Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice. Endocrinology. 2011 Jul;152(7):2837-44
1*	J:182578 Kay JN, Chu MW, Sanes JR, MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. Nature. 2012 Mar 22;483(7390):465-9
1*	J:321365 Knoedler JR, Inoue S, Bayless DW, Yang T, Tantry A, Davis CH, Leung NY, Parthasarathy S, Wang G, Alvarado M, Rizvi AH, Fenno LE, Ramakrishnan C, Deisseroth K, Shah NM, A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior. Cell. 2022 Feb 17;185(4):654-671.e22
1	J:311909 Machado CB, Kanning KC, Kreis P, Stevenson D, Crossley M, Nowak M, Iacovino M, Kyba M, Chambers D, Blanc E, Lieberam I, Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons. Development. 2014 Feb;141(4):784-94
2	J:76120 Soe R, Overgaard MT, Thomsen AR, Laursen LS, Olsen IM, Sottrup-Jensen L, Haaning J, Giudice LC, Conover CA, Oxvig C, Expression of recombinant murine pregnancy-associated plasma protein-A (PAPP-A) and a novel variant (PAPP-Ai) with differential proteolytic activity. Eur J Biochem. 2002 Apr;269(8):2247-56
1	J:332242 Vieira JR, Shah B, Dupraz S, Paredes I, Himmels P, Schermann G, Adler H, Motta A, Gartner L, Navarro-Aragall A, Ioannou E, Dyukova E, Bonnavion R, Fischer A, Bonanomi D, Bradke F, Ruhrberg C, Ruiz de Almodovar C, Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development. Neuron. 2022 Dec 21;110(24):4074-4089.e6
2	J:163277 Wagner PK, Christians JK, Altered placental expression of PAPPA2 does not affect birth weight in mice. Reprod Biol Endocrinol. 2010;8:90
1	J:157468 Zagoraiou L, Akay T, Martin JF, Brownstone RM, Jessell TM, Miles GB, A cluster of cholinergic premotor interneurons modulates mouse locomotor activity. Neuron. 2009 Dec 10;64(5):645-62