Gene Expression Literature Summary
|
Symbol Name ID |
Pax2
paired box 2 MGI:97486 |
| Age | E1.5 | E2 | E2.5 | E3 | E3.5 | E4.5 | E6.5 | E7 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E19.5 | E | P |
| Immunohistochemistry (section) | 1 | 4 | 5 | 2 | 30 | 7 | 91 | 19 | 102 | 12 | 101 | 7 | 60 | 8 | 68 | 4 | 53 | 2 | 36 | 3 | 20 | 3 | 56 | 1 | 2 | 12 | 101 | ||||||||
| In situ RNA (section) | 1 | 4 | 13 | 4 | 35 | 6 | 56 | 7 | 40 | 7 | 38 | 4 | 24 | 4 | 29 | 2 | 15 | 1 | 11 | 1 | 7 | 13 | 1 | 2 | 14 | ||||||||||
| Immunohistochemistry (whole mount) | 1 | 3 | 3 | 5 | 3 | 12 | 7 | 13 | 1 | 10 | 2 | 5 | 1 | 3 | 3 | 3 | 1 | 2 | 2 | ||||||||||||||||
| In situ RNA (whole mount) | 1 | 1 | 5 | 18 | 22 | 15 | 53 | 5 | 34 | 5 | 23 | 1 | 16 | 10 | 1 | 3 | 1 | 1 | 1 | 5 | |||||||||||||||
| In situ reporter (knock in) | 1 | 3 | 4 | 2 | 4 | 1 | 1 | 1 | 1 | 3 | |||||||||||||||||||||||||
| Northern blot | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||||||||||||
| Western blot | 1 | 1 | 1 | 2 | 2 | 3 | 2 | 3 | 2 | 1 | 4 | 3 | |||||||||||||||||||||||
| RT-PCR | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 2 | 7 | 12 | 2 | 12 | 7 | 1 | 12 | 6 | 3 | 5 | 2 | 7 | 2 | 14 | ||||||||||||
| cDNA clones | 1 | 3 | 1 | ||||||||||||||||||||||||||||||||
| RNase protection | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||||||||||||||||||||||
| Nuclease S1 | 1 | 1 | 1 | 1 | 1 |
| Pax2 paired box 2 (Synonyms: Opdc, Pax-2) | |
| Results | Reference |
| 2* | J:89361 Acampora D, Annino A, Puelles E, Alfano I, Tuorto F, Simeone A, OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm. Gene Expr Patterns. 2003 Aug;3(4):497-501 |
| 1* | J:49817 Acampora D, Avantaggiato V, Tuorto F, Briata P, Corte G, Simeone A, Visceral endoderm-restricted translation of otx1 mediates recovery of otx2 requirements for specification of anterior neural plate and normal gastrulation. Development. 1998 Dec;125(24):5091-104 |
| 2 | J:43308 Acampora D, Avantaggiato V, Tuorto F, Simeone A, Genetic control of brain morphogenesis through Otx gene dosage requirement. Development. 1997 Sep;124(18):3639-50 |
| 1 | J:320348 Aditi, Downing SM, Schreiner PA, Kwak YD, Li Y, Shaw TI, Russell HR, McKinnon PJ, Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair. Neuron. 2021 Dec 15;109(24):3962-3979.e6 |
| 1 | J:69637 Alavizadeh A, Kiernan AE, Nolan P, Lo C, Steel KP, Bucan M, The wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects. Dev Biol. 2001 Jun 1;234(1):244-60 |
| 2* | J:159240 Alur RP, Vijayasarathy C, Brown JD, Mehtani M, Onojafe IF, Sergeev YV, Boobalan E, Jones M, Tang K, Liu H, Xia CH, Gong X, Brooks BP, Papillorenal syndrome-causing missense mutations in PAX2/Pax2 result in hypomorphic alleles in mouse and human. PLoS Genet. 2010;6(3):e1000870 |
| 2* | J:87221 Alvarez Y, Alonso MT, Vendrell V, Zelarayan LC, Chamero P, Theil T, Bosl MR, Kato S, Maconochie M, Riethmacher D, Schimmang T, Requirements for FGF3 and FGF10 during inner ear formation. Development. 2003 Dec;130(25):6329-38 |
| 2 | J:332930 Anderson MJ, Misaghian S, Sharma N, Perantoni AO, Lewandoski M, Fgf8 promotes survival of nephron progenitors by regulating BAX/BAK-mediated apoptosis. Differentiation. 2022 Dec 6;130:7-15 |
| 2 | J:187218 Andersson LS, Larhammar M, Memic F, Wootz H, Schwochow D, Rubin CJ, Patra K, Arnason T, Wellbring L, Hjalm G, Imsland F, Petersen JL, McCue ME, Mickelson JR, Cothran G, Ahituv N, Roepstorff L, Mikko S, Vallstedt A, Lindgren G, Andersson L, Kullander K, Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice. Nature. 2012 Aug 30;488(7413):642-6 |
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| 4* | J:3679 Asano M, Gruss P, Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development. Mech Dev. 1992 Nov;39(1-2):29-39 |
| 2* | J:32929 Avantaggiato V, Acampora D, Tuorto F, Simeone A, Retinoic acid induces stage-specific repatterning of the rostral central nervous system. Dev Biol. 1996 May 1;175(2):347-57 |
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| 4 | J:226938 Bagherie-Lachidan M, Reginensi A, Pan Q, Zaveri HP, Scott DA, Blencowe BJ, Helmbacher F, McNeill H, Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool. Development. 2015 Aug 1;142(15):2564-73 |
| 2 | J:352627 Baltar J, Miranda RM, Cabral M, Rebelo S, Grahammer F, Huber TB, Reguenga C, Monteiro FA, Neph1 is required for neurite branching and is negatively regulated by the PRRXL1 homeodomain factor in the developing spinal cord dorsal horn. Neural Dev. 2024 Jul 24;19(1):13 |
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| 4 | J:185582 Barak H, Huh SH, Chen S, Jeanpierre C, Martinovic J, Parisot M, Bole-Feysot C, Nitschke P, Salomon R, Antignac C, Ornitz DM, Kopan R, FGF9 and FGF20 Maintain the Stemness of Nephron Progenitors in Mice and Man. Dev Cell. 2012 Jun 12;22(6):1191-207 |
| 4* | J:74241 Barbieri AM, Broccoli V, Bovolenta P, Alfano G, Marchitiello A, Mocchetti C, Crippa L, Bulfone A, Marigo V, Ballabio A, Banfi S, Vax2 inactivation in mouse determines alteration of the eye dorsal-ventral axis, misrouting of the optic fibres and eye coloboma. Development. 2002 Feb;129(3):805-13 |
| 1* | J:73206 Bard JB, Gordon A, Sharp L, Sellers WI, Early nephron formation in the developing mouse kidney. J Anat. 2001 Oct;199(Pt 4):385-92 |
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| 3 | J:136177 Barrionuevo F, Naumann A, Bagheri-Fam S, Speth V, Taketo MM, Scherer G, Neubuser A, Sox9 is required for invagination of the otic placode in mice. Dev Biol. 2008 May 1;317(1):213-24 |
| 7 | J:158712 Bassett EA, Williams T, Zacharias AL, Gage PJ, Fuhrmann S, West-Mays JA, AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis. Hum Mol Genet. 2010 May 1;19(9):1791-804 |
| 3 | J:208419 Basta JM, Robbins L, Kiefer SM, Dorsett D, Rauchman M, Sall1 balances self-renewal and differentiation of renal progenitor cells. Development. 2014 Mar;141(5):1047-58 |
| 3 | J:184000 Baubet V, Xiang C, Molczan A, Roccograndi L, Melamed S, Dahmane N, Rp58 is essential for the growth and patterning of the cerebellum and for glutamatergic and GABAergic neuron development. Development. 2012 Jun;139(11):1903-9 |
| 4 | J:83532 Baumer N, Marquardt T, Stoykova A, Spieler D, Treichel D, Ashery-Padan R, Gruss P, Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6. Development. 2003 Jul;130(13):2903-15 |
| 2 | J:176604 Bell SM, Zhang L, Mendell A, Xu Y, Haitchi HM, Lessard JL, Whitsett JA, Kruppel-like factor 5 is required for formation and differentiation of the bladder urothelium. Dev Biol. 2011 Oct 1;358(1):79-90 |
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| 1* | J:321845 Bernhardt N, Memic F, Velica A, Tran MA, Vieillard J, Sayyab S, Chersa T, Andersson L, Whelan PJ, Boije H, Kullander K, Hop Mice Display Synchronous Hindlimb Locomotion and a Ventrally Fused Lumbar Spinal Cord Caused by a Point Mutation in Ttc26. eNeuro. 2022 Mar-Apr;9(2):ENEURO.0518-21.2022 |
| 5 | J:294509 Bertacchi M, Gruart A, Kaimakis P, Allet C, Serra L, Giacobini P, Delgado-Garcia JM, Bovolenta P, Studer M, Mouse Nr2f1 haploinsufficiency unveils new pathological mechanisms of a human optic atrophy syndrome. EMBO Mol Med. 2019 Aug;11(8):e10291 |
| 3 | J:58996 Bertuzzi S, Hindges R, Mui SH, O'Leary DD, Lemke G, The homeodomain protein vax1 is required for axon guidance and major tract formation in the developing forebrain. Genes Dev. 1999 Dec 1;13(23):3092-105 |
| 3 | J:84363 Bilovocky NA, Romito-DiGiacomo RR, Murcia CL, Maricich SM, Herrup K, Factors in the genetic background suppress the engrailed-1 cerebellar phenotype. J Neurosci. 2003 Jun 15;23(12):5105-12 |
| 5 | J:228880 Birol O, Ohyama T, Edlund RK, Drakou K, Georgiades P, Groves AK, The mouse Foxi3 transcription factor is necessary for the development of posterior placodes. Dev Biol. 2016 Jan 1;409(1):139-51 |
| 1 | J:137136 Blaess S, Stephen D, Joyner AL, Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling. Development. 2008 Jun;135(12):2093-103 |
| 2* | J:118802 Blak AA, Naserke T, Saarimaki-Vire J, Peltopuro P, Giraldo-Velasquez M, Vogt Weisenhorn DM, Prakash N, Sendtner M, Partanen J, Wurst W, Fgfr2 and Fgfr3 are not required for patterning and maintenance of the midbrain and anterior hindbrain. Dev Biol. 2007 Mar 1;303(1):231-43 |
| 1 | J:153960 Blank U, Brown A, Adams DC, Karolak MJ, Oxburgh L, BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism. Development. 2009 Nov;136(21):3557-66 |
| 1* | J:333828 Blommers M, Stanton-Turcotte D, Iulianella A, Retinal neuroblast migration and ganglion cell layer organization require the cytoskeletal-interacting protein Mllt11. Dev Dyn. 2023 Feb;252(2):305-319 |
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| 1 | J:213872 Borromeo MD, Meredith DM, Castro DS, Chang JC, Tung KC, Guillemot F, Johnson JE, A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord. Development. 2014 Jul;141(14):2803-12 |
| 2 | J:287985 Bosze B, Moon MS, Kageyama R, Brown NL, Simultaneous Requirements for Hes1 in Retinal Neurogenesis and Optic Cup-Stalk Boundary Maintenance. J Neurosci. 2020 Feb 12;40(7):1501-1513 |
| 1 | J:341148 Bosze B, Suarez-Navarro J, Cajias I, Brzezinski Iv JA, Brown NL, Notch pathway mutants do not equivalently perturb mouse embryonic retinal development. PLoS Genet. 2023 Sep;19(9):e1010928 |
| 9 | J:303632 Bosze B, Suarez-Navarro J, Soofi A, Lauderdale JD, Dressler GR, Brown NL, Multiple roles for Pax2 in the embryonic mouse eye. Dev Biol. 2021 Apr;472:18-29 |
| 1 | J:174353 Boualia SK, Gaitan Y, Murawski I, Nadon R, Gupta IR, Bouchard M, Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for pax2 and emx2. PLoS One. 2011;6(6):e21529 |
| 1 | J:202352 Boualia SK, Gaitan Y, Tremblay M, Sharma R, Cardin J, Kania A, Bouchard M, A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis. Dev Biol. 2013 Oct 15;382(2):555-66 |
| 2 | J:163537 Bouchard M, de Caprona D, Busslinger M, Xu P, Fritzsch B, Pax2 and Pax8 cooperate in mouse inner ear morphogenesis and innervation. BMC Dev Biol. 2010 Aug 20;10(1):89 |
| 2* | J:98482 Bouchard M, Grote D, Craven SE, Sun Q, Steinlein P, Busslinger M, Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region. Development. 2005 Jun;132(11):2633-43 |
| 5* | J:63683 Bouchard M, Pfeffer P, Busslinger M, Functional equivalence of the transcription factors pax2 and pax5 in mouse development. Development. 2000 Sep;127(17):3703-13 |
| 1 | J:80208 Bouchard M, Souabni A, Mandler M, Neubuser A, Busslinger M, Nephric lineage specification by Pax2 and Pax8. Genes Dev. 2002 Nov 15;16(22):2958-70 |
| 1* | J:271281 Bowles J, Feng CW, Ineson J, Miles K, Spiller CM, Harley VR, Sinclair AH, Koopman P, Retinoic Acid Antagonizes Testis Development in Mice. Cell Rep. 2018 Jul 31;24(5):1330-1341 |
| 1* | J:123322 Boyle S, Shioda T, Perantoni AO, de Caestecker M, Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis. Dev Dyn. 2007 Aug;236(8):2321-30 |
| 1 | J:150080 Braunstein EM, Monks DC, Aggarwal VS, Arnold JS, Morrow BE, Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis. BMC Dev Biol. 2009;9:31 |
| 3* | J:136068 Bridgewater D, Cox B, Cain J, Lau A, Athaide V, Gill PS, Kuure S, Sainio K, Rosenblum ND, Canonical WNT/beta-catenin signaling is required for ureteric branching. Dev Biol. 2008 May 1;317(1):83-94 |
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| 1 | J:308269 Brodie-Kommit J, Clark BS, Shi Q, Shiau F, Kim DW, Langel J, Sheely C, Ruzycki PA, Fries M, Javed A, Cayouette M, Schmidt T, Badea T, Glaser T, Zhao H, Singer J, Blackshaw S, Hattar S, Atoh7-independent specification of retinal ganglion cell identity. Sci Adv. 2021 Mar;7(11) |
| 4 | J:141954 Brohl D, Strehle M, Wende H, Hori K, Bormuth I, Nave KA, Muller T, Birchmeier C, A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord. Dev Biol. 2008 Aug 7;322(2):381-393 |
| 1* | J:72723 Brophy PD, Ostrom L, Lang KM, Dressler GR, Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development. 2001 Dec;128(23):4747-56 |
| 1 | J:180898 Brown AS, Epstein DJ, Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development. Development. 2011 Sep;138(18):3967-76 |
| 2* | J:286303 Buckley DM, Burroughs-Garcia J, Kriks S, Lewandoski M, Waters ST, Gbx1 and Gbx2 Are Essential for Normal Patterning and Development of Interneurons and Motor Neurons in the Embryonic Spinal Cord. J Dev Biol. 2020 Apr 1;8(2) |
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| 1* | J:89168 Bulfone A, Caccioppoli C, Pardini C, Faedo A, Martinez S, Banfi S, Pcp4l1, a novel gene encoding a Pcp4-like polypeptide, is expressed in specific domains of the developing brain. Gene Expr Patterns. 2004 May;4(3):297-301 |
| 1 | J:89364 Bulgakov OV, Eggenschwiler JT, Hong DH, Anderson KV, Li T, FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. Development. 2004 May;131(9):2149-59 |
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| 1* | J:154967 Bulut OP, Dipp S, El-Dahr S, Ontogeny of bradykinin B1 receptors in the mouse kidney. Pediatr Res. 2009 Nov;66(5):519-23 |
| 1* | J:196346 Burgold T, Voituron N, Caganova M, Tripathi PP, Menuet C, Tusi BK, Spreafico F, Bevengut M, Gestreau C, Buontempo S, Simeone A, Kruidenier L, Natoli G, Casola S, Hilaire G, Testa G, The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival. Cell Rep. 2012 Nov 29;2(5):1244-58 |
| 3 | J:249800 Burnett JB, Lupu FI, Eggenschwiler JT, Proper ciliary assembly is critical for restricting Hedgehog signaling during early eye development in mice. Dev Biol. 2017 Oct 1;430(1):32-40 |
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| 3 | J:214343 Cai Z, Grobe K, Zhang X, Role of heparan sulfate proteoglycans in optic disc and stalk morphogenesis. Dev Dyn. 2014 Oct;243(10):1310-6 |
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| 2 | J:154102 Cain JE, Islam E, Haxho F, Chen L, Bridgewater D, Nieuwenhuis E, Hui CC, Rosenblum ND, GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells. PLoS One. 2009;4(10):e7313 |
| 1 | J:107067 Capela A, Temple S, LeX is expressed by principle progenitor cells in the embryonic nervous system, is secreted into their environment and binds Wnt-1. Dev Biol. 2006 Mar 15;291(2):300-13 |
| 6 | J:198381 Carbe C, Garg A, Cai Z, Li H, Powers A, Zhang X, An allelic series at the paired box gene 6 (Pax6) locus reveals the functional specificity of Pax genes. J Biol Chem. 2013 Apr 26;288(17):12130-41 |
| 1 | J:238024 Carmona R, Canete A, Cano E, Ariza L, Rojas A, Munoz-Chapuli R, Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice. Elife. 2016 Sep 19;5:e16009 |
| 1 | J:220323 Carpenter AC, Smith AN, Wagner H, Cohen-Tayar Y, Rao S, Wallace V, Ashery-Padan R, Lang RA, Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse. Development. 2015 Mar 1;142(5):972-82 |
| 3 | J:100575 Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP, Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell. 2005 Aug;9(2):283-92 |
| 3 | J:114389 Cartry J, Nichane M, Ribes V, Colas A, Riou JF, Pieler T, Dolle P, Bellefroid EJ, Umbhauer M, Retinoic acid signalling is required for specification of pronephric cell fate. Dev Biol. 2006 Nov 1;299(1):35-51 |
| 1 | J:245759 Casoni F, Croci L, Bosone C, D'Ambrosio R, Badaloni A, Gaudesi D, Barili V, Sarna JR, Tessarollo L, Cremona O, Hawkes R, Warming S, Consalez GG, Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors. Development. 2017 Oct 15;144(20):3686-3697 |
| 4 | J:138769 Caubit X, Lye CM, Martin E, Core N, Long DA, Vola C, Jenkins D, Garratt AN, Skaer H, Woolf AS, Fasano L, Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development. 2008 Oct;135(19):3301-10 |
| 1* | J:89365 Cecconi F, Roth KA, Dolgov O, Munarriz E, Anokhin K, Gruss P, Salminen M, Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth. Development. 2004 May;131(9):2125-35 |
| 1 | J:46989 Celli G, LaRochelle WJ, Mackem S, Sharp R, Merlino G, Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning. EMBO J. 1998 Mar 16;17(6):1642-55 |
| 2 | J:292639 Cen C, Chen M, Zhou J, Zhang L, Duo S, Jiang L, Hou X, Gao F, Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development. Biol Reprod. 2020 Jun 23;103(1):60-69 |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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