Symbol Name ID |
Pax5
paired box 5 MGI:97489 |
Age | E1.5 | E2 | E7.5 | E8 | E8.5 | E9.5 | E10.5 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15.5 | E16.5 | E17 | E17.5 | E18.5 | E | P |
Immunohistochemistry (section) | 1 | 1 | 3 | 2 | 2 | 1 | 1 | 1 | |||||||||||||
In situ RNA (section) | 2 | 1 | 6 | 3 | 1 | 4 | 1 | 2 | 4 | 1 | 1 | 2 | 5 | ||||||||
In situ RNA (whole mount) | 1 | 5 | 3 | 7 | 8 | 1 | 2 | ||||||||||||||
In situ reporter (knock in) | 2 | 1 | 1 | 2 | |||||||||||||||||
Western blot | 1 | 1 | |||||||||||||||||||
RT-PCR | 1 | 1 | 2 | 2 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 2 | |||||||||
RNase protection | 2 | 1 | 2 | 3 | 2 | 1 | 2 | 1 | 2 | 2 |
Pax5 paired box 5 (Synonyms: EBB-1, Pax-5) | |
Results | Reference |
13 | J:2251 Adams B, Dorfler P, Aguzzi A, Kozmik Z, Urbanek P, Maurer-Fogy I, Busslinger M, Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. Genes Dev. 1992 Sep;6(9):1589-607 |
1 | J:333368 Aldea D, Kokalari B, Atsuta Y, Dingwall HL, Zheng Y, Nace A, Cotsarelis G, Kamberov YG, Differential modularity of the mammalian Engrailed 1 enhancer network directs sweat gland development. PLoS Genet. 2023 Feb;19(2):e1010614 |
1 | J:227638 Alvarez S, Diaz M, Flach J, Rodriguez-Acebes S, Lopez-Contreras AJ, Martinez D, Canamero M, Fernandez-Capetillo O, Isern J, Passegue E, Mendez J, Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality. Nat Commun. 2015;6:8548 |
9* | J:3679 Asano M, Gruss P, Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development. Mech Dev. 1992 Nov;39(1-2):29-39 |
1* | J:67011 Bain G, Maandag EC, Izon DJ, Amsen D, Kruisbeek AM, Weintraub BC, Krop I, Schlissel MS, Feeney AJ, van Roon M, et al., E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell. 1994 Dec 2;79(5):885-92 |
1 | J:182611 Bard-Chapeau EA, Jeyakani J, Kok CH, Muller J, Chua BQ, Gunaratne J, Batagov A, Jenjaroenpun P, Kuznetsov VA, Wei CL, D'Andrea RJ, Bourque G, Jenkins NA, Copeland NG, Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2168-73 |
2* | J:63683 Bouchard M, Pfeffer P, Busslinger M, Functional equivalence of the transcription factors pax2 and pax5 in mouse development. Development. 2000 Sep;127(17):3703-13 |
1* | J:120667 Bouzin C, Clotman F, Renauld JC, Lemaigre FP, Rousseau GG, The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver. J Immunol. 2003 Aug 1;171(3):1297-303 |
1* | J:93240 Brenner O, Levanon D, Negreanu V, Golubkov O, Fainaru O, Woolf E, Groner Y, Loss of Runx3 function in leukocytes is associated with spontaneously developed colitis and gastric mucosal hyperplasia. Proc Natl Acad Sci U S A. 2004 Dec 9;101(45):16016-21 |
2* | J:108393 Chung AC, Xu X, Niederreither KA, Cooney AJ, Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer. Dev Biol. 2006 May 1;293(1):13-24 |
3* | J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92 |
1* | J:35491 Danielian PS, McMahon AP, Engrailed-1 as a target of the Wnt-1 signalling pathway in vertebrate midbrain development. Nature. 1996 Sep 26;383(6598):332-4 |
1 | J:319391 Decourtye L, McCallum-Loudeac JA, Zellhuber-McMillan S, Young E, Sircombe KJ, Wilson MJ, Characterization of a novel Lbx1 mouse loss of function strain. Differentiation. 2021 Dec 9;123:30-41 |
1* | J:74716 DeKoter RP, Lee HJ, Singh H, PU.1 Regulates Expression of the Interleukin-7 Receptor in Lymphoid Progenitors. Immunity. 2002 Feb;16(2):297-309 |
1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
1 | J:305174 Dong X, Kwan KM, Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis. Mol Brain. 2020 Jul 23;13(1):104 |
3* | J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257 |
1* | J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004; |
1* | J:177585 Hesse K, Vaupel K, Kurt S, Buettner R, Kirfel J, Moser M, AP-2delta is a crucial transcriptional regulator of the posterior midbrain. PLoS One. 2011;6(8):e23483 |
1 | J:317377 Hinoi E, Nakatani E, Yamamoto T, Iezaki T, Takahata Y, Fujita H, Ishiura R, Takamori M, Yoneda Y, The transcription factor paired box-5 promotes osteoblastogenesis through direct induction of Osterix and Osteocalcin. J Bone Miner Res. 2012 Dec;27(12):2526-34 |
3 | J:71074 Hirata H, Tomita K, Bessho Y, Kageyama R, Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. EMBO J. 2001 Aug 15;20(16):4454-66 |
1* | J:98483 Hjerling-Leffler J, Marmigere F, Heglind M, Cederberg A, Koltzenburg M, Enerback S, Ernfors P, The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes. Development. 2005 Jun;132(11):2623-32 |
1 | J:300883 Hornblad A, Bastide S, Langenfeld K, Langa F, Spitz F, Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy. Nat Commun. 2021 Jan 19;12(1):439 |
2* | J:87698 Ikawa T, Masuda K, Lu M, Minato N, Katsura Y, Kawamoto H, Identification of the earliest prethymic T-cell progenitors in murine fetal blood. Blood. 2004 Jan 15;103(2):530-7 |
1 | J:112633 Jukkola T, Lahti L, Naserke T, Wurst W, Partanen J, FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region. Dev Biol. 2006 Sep 1;297(1):141-57 |
3* | J:66592 Liu A, Joyner AL, EN and GBX2 play essential roles downstream of FGF8 in patterning the mouse mid/hindbrain region. Development. 2001 Jan;128(2):181-91 |
1* | J:58078 Liu A, Losos K, Joyner AL, FGF8 can activate Gbx2 and transform regions of the rostral mouse brain into a hindbrain fate. Development. 1999 Nov;126(21):4827-38 |
1 | J:287326 Malik N, Dunn KM, Cassels J, Hay J, Estell C, Sansom OJ, Michie AM, mTORC1 activity is essential for erythropoiesis and B cell lineage commitment. Sci Rep. 2019 Nov 15;9(1):16917 |
3 | J:169135 Mao Y, Mulvaney J, Zakaria S, Yu T, Morgan KM, Allen S, Basson MA, Francis-West P, Irvine KD, Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development. 2011 Mar;138(5):947-57 |
1 | J:279141 Masuda K, Kubagawa H, Ikawa T, Chen CC, Kakugawa K, Hattori M, Kageyama R, Cooper MD, Minato N, Katsura Y, Kawamoto H, Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors. EMBO J. 2005 Dec 7;24(23):4052-60 |
2 | J:30339 Millen KJ, Hui CC, Joyner AL, A role for En-2 and other murine homologues of Drosophila segment polarity genes in regulating positional information in the developing cerebellum. Development. 1995 Dec;121(12):3935-45 |
3 | J:305279 Morello F, Borshagovski D, Survila M, Tikker L, Sadik-Ogli S, Kirjavainen A, Estartus N, Knaapi L, Lahti L, Toronen P, Mazutis L, Delogu A, Salminen M, Achim K, Partanen J, Molecular Fingerprint and Developmental Regulation of the Tegmental GABAergic and Glutamatergic Neurons Derived from the Anterior Hindbrain. Cell Rep. 2020 Oct 13;33(2):108268 |
1* | J:54106 Nutt SL, Vambrie S, Steinlein P, Kozmik Z, Rolink A, Weith A, Busslinger M, Independent regulation of the two Pax5 alleles during B-cell development. Nat Genet. 1999 Apr;21(4):390-5 |
1 | J:296045 Patmore DM, Jassim A, Nathan E, Gilbertson RJ, Tahan D, Hoffmann N, Tong Y, Smith KS, Kanneganti TD, Suzuki H, Taylor MD, Northcott P, Gilbertson RJ, DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma. Dev Cell. 2020 Aug 24;54(4):455-470.e5 |
3* | J:60092 Pfeffer PL, Bouchard M, Busslinger M, Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary. Development. 2000 Mar;127(5):1017-28 |
2 | J:117030 Pillai A, Mansouri A, Behringer R, Westphal H, Goulding M, Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord. Development. 2007 Jan;134(2):357-66 |
4* | J:336866 Puelles L, Hidalgo-Sanchez M, The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer. Int J Mol Sci. 2023 Jun 5;24(11) |
3* | J:27755 Rowitch DH, McMahon AP, Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1. Mech Dev. 1995 Jul;52(1):3-8 |
2* | J:45075 Schwarz M, Alvarez-Bolado G, Urbanek P, Busslinger M, Gruss P, Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: evidence from targeted mutations. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14518-23 |
1 | J:39856 Scott EW, Fisher RC, Olson MC, Kehrli EW, Simon MC, Singh H, PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Immunity. 1997 Apr;6(4):437-47 |
1 | J:243893 Solanki A, Lau CI, Saldana JI, Ross S, Crompton T, The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh. J Exp Med. 2017 Jul 03;214(7):2041-2058 |
2 | J:17132 Stoykova A, Gruss P, Roles of Pax-genes in developing and adult brain as suggested by expression patterns. J Neurosci. 1994 Mar;14(3 Pt 2):1395-412 |
3* | J:70745 Suda Y, Hossain ZM, Kobayashi C, Hatano O, Yoshida M, Matsuo I, Aizawa S, Emx2 directs the development of diencephalon in cooperation with Otx2. Development. 2001 Jul;128(13):2433-50 |
2* | J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208 |
5* | J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23 |
1* | J:36834 Torres M, Gomez-Pardo E, Gruss P, Pax2 contributes to inner ear patterning and optic nerve trajectory. Development. 1996 Nov;122(11):3381-91 |
1* | J:34768 Tremblay P, Pituello F, Gruss P, Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic mice. Development. 1996 Aug;122(8):2555-67 |
1* | J:40910 Urbanek P, Fetka I, Meisler MH, Busslinger M, Cooperation of Pax2 and Pax5 in midbrain and cerebellum development. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5703-8 |
5* | J:21935 Urbanek P, Wang ZQ, Fetka I, Wagner EF, Busslinger M, Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP [see comments]. Cell. 1994 Dec 2;79(5):901-12 |
1 | J:44764 Wehr R, Mansouri A, de Maeyer T, Gruss P, Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body. Development. 1997 Nov;124(22):4447-56 |
1* | J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130 |
1 | J:61429 Xu J, Liu Z, Ornitz DM, Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Development. 2000 May;127(9):1833-43 |
1 | J:326661 Xu P, He H, Gao Q, Zhou Y, Wu Z, Zhang X, Sun L, Hu G, Guan Q, You Z, Zhang X, Zheng W, Xiong M, Chen Y, Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson's disease model. J Clin Invest. 2022 Jul 15;132(14):e156768 |
1 | J:72984 Ye W, Bouchard M, Stone D, Liu X, Vella F, Lee J, Nakamura H, Ang SL, Busslinger M, Rosenthal A, Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8. Nat Neurosci. 2001 Dec;4(12):1175-81 |
3* | J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48 |
1* | J:325429 Zhou HM, Conway SJ, Pax3 Hypomorphs Reveal Hidden Pax7 Functional Genetic Compensation in Utero. J Dev Biol. 2022 May 17;10(2) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/02/2024 MGI 6.24 |
![]() |
|