Symbol Name ID |
Pax9
paired box 9 MGI:97493 |
Age | E7 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18.5 | E19.5 | E | P |
Immunohistochemistry (section) | 1 | 1 | 1 | 1 | 5 | 1 | 8 | 1 | 4 | 1 | 1 | 1 | 2 | 1 | 2 | 3 | ||||||||
In situ RNA (section) | 2 | 14 | 2 | 12 | 2 | 15 | 2 | 18 | 3 | 37 | 2 | 16 | 4 | 4 | 3 | 2 | 1 | 6 | 5 | |||||
Immunohistochemistry (whole mount) | 1 | 1 | 1 | 1 | ||||||||||||||||||||
In situ RNA (whole mount) | 3 | 4 | 25 | 3 | 26 | 2 | 37 | 1 | 20 | 9 | 2 | 2 | 5 | 1 | 1 | 1 | ||||||||
In situ reporter (knock in) | 1 | 2 | 2 | 4 | 1 | 3 | 1 | 2 | 3 | 1 | 2 | 1 | 1 | |||||||||||
Northern blot | 1 | 1 | 1 | 1 | 1 | 2 | ||||||||||||||||||
Western blot | 1 | |||||||||||||||||||||||
RT-PCR | 1 | 4 | 2 | 3 | 4 | 3 | 2 | 1 | 2 | 1 | 1 | 3 | ||||||||||||
cDNA clones | 1 | 1 | 1 | 1 | 1 | |||||||||||||||||||
RNase protection | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Pax9 paired box 9 (Synonyms: Pax-9) | |
Results | Reference |
2* | J:92174 Aberg T, Wang XP, Kim JH, Yamashiro T, Bei M, Rice R, Ryoo HM, Thesleff I, Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol. 2004 Jun 1;270(1):76-93 |
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1 | J:95764 Alappat SR, Zhang Z, Suzuki K, Zhang X, Liu H, Jiang R, Yamada G, Chen Y, The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice. Dev Biol. 2005 Jan 1;277(1):102-13 |
1* | J:208345 Almaidhan A, Cesario J, Landin Malt A, Zhao Y, Sharma N, Choi V, Jeong J, Neural crest-specific deletion of Ldb1 leads to cleft secondary palate with impaired palatal shelf elevation. BMC Dev Biol. 2014;14:3 |
1* | J:320682 Amano T, Sagai T, Seki R, Shiroishi T, Two Types of Etiological Mutation in the Limb-Specific Enhancer of Shh. G3 (Bethesda). 2017 Sep 7;7(9):2991-2998 |
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1 | J:119316 Baffi MO, Moran MA, Serra R, Tgfbr2 regulates the maintenance of boundaries in the axial skeleton. Dev Biol. 2006 Aug 15;296(2):363-74 |
2 | J:152830 Balic A, Adams D, Mina M, Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process. Dev Dyn. 2009 Sep 23;238(10):2599-2613 |
1 | J:284675 Bar C, Cohen I, Zhao D, Pothula V, Litskevitch A, Koseki H, Zheng D, Ezhkova E, Polycomb Repressive Complex 1 Controls Maintenance of Fungiform Papillae by Repressing Sonic Hedgehog Expression. Cell Rep. 2019 Jul 2;28(1):257-266.e5 |
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1 | J:171190 Bensoussan-Trigano V, Lallemand Y, Saint Cloment C, Robert B, Msx1 and Msx2 in limb mesenchyme modulate digit number and identity. Dev Dyn. 2011 May;240(5):1190-202 |
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1* | J:80726 Biben C, Wang CC, Harvey RP, NK-2 class homeobox genes and pharyngeal/oral patterning: Nkx2-3 is required for salivary gland and tooth morphogenesis. Int J Dev Biol. 2002;46(4):415-22 |
2* | J:278801 Bloomquist RF, Fowler TE, An Z, Yu TY, Abdilleh K, Fraser GJ, Sharpe PT, Streelman JT, Developmental plasticity of epithelial stem cells in tooth and taste bud renewal. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17858-17866 |
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1* | J:116770 Britanova O, Depew MJ, Schwark M, Thomas BL, Miletich I, Sharpe P, Tarabykin V, Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development. Am J Hum Genet. 2006 Oct;79(4):668-78 |
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1 | J:148411 Cameron DA, Pennimpede T, Petkovich M, Tulp3 is a critical repressor of mouse hedgehog signaling. Dev Dyn. 2009 May;238(5):1140-9 |
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1 | J:103334 Cui YZ, Peng YF, Tian Q, Expression of man, a formin homology domain-containing gene in the mouse limb. Sheng Li Xue Bao. 2005 Aug 25;57(4):433-438 |
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1* | J:264204 Deimling SJ, Lau K, Hui CC, Hopyan S, Genetic interaction between Gli3 and Ezh2 during limb pattern formation. Mech Dev. 2018 Jun;151:30-36 |
1 | J:132122 Delgado I, Dominguez-Frutos E, Schimmang T, Ros MA, The incomplete inactivation of Fgf8 in the limb ectoderm affects the morphogenesis of the anterior autopod through BMP-mediated cell death. Dev Dyn. 2008 Mar;237(3):649-58 |
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1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
4* | J:207523 Edlund RK, Ohyama T, Kantarci H, Riley BB, Groves AK, Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol. 2014 Jun 1;390(1):1-13 |
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1* | J:73527 Ferguson CA, Tucker AS, Heikinheimo K, Nomura M, Oh P, Li E, Sharpe PT, The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development. Development. 2001 Nov;128(22):4605-13 |
1 | J:166947 Fujimori S, Novak H, Weissenbock M, Jussila M, Goncalves A, Zeller R, Galloway J, Thesleff I, Hartmann C, Wnt/beta-catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4. Dev Biol. 2010 Dec 1;348(1):97-106 |
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1* | J:55575 Furumoto TA, Miura N, Akasaka T, Mizutani-Koseki Y, Sudo H, Fukuda K , Maekawa M , Yuasa S , Fu Y , Moriya H , Taniguchi M , Imai K , Dahl E , Balling R , Pavlova M , Gossler A , Koseki H, Notochord-dependent expression of MFH1 and PAX1 cooperates to maintain the proliferation of sclerotome cells during the vertebral column development. Dev Biol. 1999 Jun 1;210(1):15-29 |
3* | J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257 |
1* | J:79899 Grotewold L, Ruther U, The Fused toes (Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly. Dev Biol. 2002 Nov 1;251(1):129-41 |
1* | J:161785 Gu WX, Kania A, Identification of genes controlled by LMX1B in E13.5 mouse limbs. Dev Dyn. 2010 Aug;239(8):2246-55 |
2* | J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004; |
3 | J:84737 Hamachi T, Sasaki Y, Hidaka K, Nakata M, Association between palatal morphogenesis and Pax9 expression pattern in CL/Fr embryos with clefting during palatal development. Arch Oral Biol. 2003 Aug;48(8):581-7 |
2 | J:279006 Hasten E, Morrow BE, Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndrome. PLoS Genet. 2019 Aug;15(8):e1008301 |
1 | J:233374 Hayashi S, Akiyama R, Wong J, Tahara N, Kawakami H, Kawakami Y, Gata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb Development. PLoS Genet. 2016 Jun;12(6):e1006138 |
1* | J:149502 Hill P, Gotz K, Ruther U, A SHH-independent regulation of Gli3 is a significant determinant of anteroposterior patterning of the limb bud. Dev Biol. 2009 Apr 15;328(2):506-16 |
1 | J:125087 Hill P, Wang B, Ruther U, The molecular basis of Pallister Hall associated polydactyly. Hum Mol Genet. 2007 Sep 1;16(17):2089-96 |
1* | J:228853 Hoffmann AD, Yang XH, Burnicka-Turek O, Bosman JD, Ren X, Steimle JD, Vokes SA, McMahon AP, Kalinichenko VV, Moskowitz IP, Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation. PLoS Genet. 2014 Oct;10(10):e1004604 |
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1 | J:93588 Hu T, Yamagishi H, Maeda J, McAnally J, Yamagishi C, Srivastava D, Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development. 2004 Nov;131(21):5491-502 |
1* | J:171052 Itou J, Taniguchi N, Oishi I, Kawakami H, Lotz M, Kawakami Y, HMGB factors are required for posterior digit development through integrating signaling pathway activities. Dev Dyn. 2011 May;240(5):1151-62 |
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3 | J:74539 Jaskoll T, Zhou YM, Chai Y, Makarenkova HP, Collinson JM, West JD, Hajihosseini MK, Lee J, Melnick M, Embryonic Submandibular Gland Morphogenesis: Stage-Specific Protein Localization of FGFs, BMPs, Pax6 and Pax9 in Normal Mice and Abnormal SMG Phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) Mice. Cells Tissues Organs. 2002;170(2-3):83-98 |
1 | J:232412 Jeon S, Seong RH, Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway. PLoS Genet. 2016 Mar;12(3):e1005915 |
1 | J:89445 Jeong J, Mao J, Tenzen T, Kottmann AH, McMahon AP, Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 2004 Apr 15;18(8):937-51 |
1* | J:296444 Jia S, Zhou J, D'Souza RN, Pax9's dual roles in modulating Wnt signaling during murine palatogenesis. Dev Dyn. 2020 Oct;249(10):1274-1284 |
3 | J:245767 Jia S, Zhou J, Fanelli C, Wee Y, Bonds J, Schneider P, Mues G, D'Souza RN, Small-molecule Wnt agonists correct cleft palates in Pax9 mutant mice in utero. Development. 2017 Oct 15;144(20):3819-3828 |
1 | J:327415 Jing J, Feng J, Yuan Y, Guo T, Lei J, Pei F, Ho TV, Chai Y, Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat Commun. 2022 Aug 16;13(1):4803 |
4* | J:94541 Jonker L, Kist R, Aw A, Wappler I, Peters H, Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium. Mech Dev. 2004 Nov;121(11):1313-22 |
1 | J:321816 Kano S, Higashihori N, Thiha P, Takechi M, Iseki S, Moriyama K, The role of the histone methyltransferase SET domain bifurcated 1 during palatal development. Biochem Biophys Res Commun. 2022 Apr 2;598:74-80 |
1 | J:93443 Keller C, Hansen MS, Coffin CM, Capecchi MR, Pax3:Fkhr interferes with embryonic Pax3 and Pax7 function: implications for alveolar rhabdomyosarcoma cell of origin. Genes Dev. 2004 Dec 1;18(21):2608-13 |
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1 | J:127453 Kettunen P, Spencer-Dene B, Furmanek T, Kvinnsland IH, Dickson C, Thesleff I, Luukko K, Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. Mech Dev. 2007 Nov-Dec;124(11-12):868-83 |
1* | J:260416 Kibe K, Nakatomi M, Kataoka S, Toyono T, Seta Y, Hey1 and Hey2 are differently expressed during mouse tooth development. Gene Expr Patterns. 2018 Jan;27:99-105 |
1 | J:282804 Kim HT, Yin W, Nakamichi Y, Panza P, Grohmann B, Buettner C, Guenther S, Ruppert C, Kobayashi Y, Guenther A, Stainier DYR, WNT/RYK signaling restricts goblet cell differentiation during lung development and repair. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25697-25706 |
2 | J:125026 Kist R, Greally E, Peters H, Derivation of a mouse model for conditional inactivation of Pax9. Genesis. 2007 Jul;45(7):460-4 |
6 | J:228858 Kist R, Watson M, Crosier M, Robinson M, Fuchs J, Reichelt J, Peters H, The formation of endoderm-derived taste sensory organs requires a Pax9-dependent expansion of embryonic taste bud progenitor cells. PLoS Genet. 2014 Oct;10(10):e1004709 |
3 | J:104121 Kist R, Watson M, Wang X, Cairns P, Miles C, Reid DJ, Peters H, Reduction of Pax9 gene dosage in an allelic series of mouse mutants causes hypodontia and oligodontia. Hum Mol Genet. 2005 Dec 1;14(23):3605-17 |
1 | J:128941 Ko SO, Chung IH, Xu X, Oka S, Zhao H, Cho ES, Deng C, Chai Y, Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol. 2007 Dec 1;312(1):435-47 |
1 | J:205405 Kozhemyakina E, Ionescu A, Lassar AB, GATA6 is a crucial regulator of Shh in the limb bud. PLoS Genet. 2014 Jan;10(1):e1004072 |
1 | J:356521 Krawchuk D, Kania A, Identification of genes controlled by LMX1B in the developing mouse limb bud. Dev Dyn. 2008 Apr;237(4):1183-92 |
2 | J:187871 Krebs LT, Bradley CK, Norton CR, Xu J, Oram KF, Starling C, Deftos ML, Bevan MJ, Gridley T, The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice. Genesis. 2012 Apr;50(4):366-74 |
1* | J:87042 Krebs O, Schreiner CM, Scott WJ Jr, Bell SM, Robbins DJ, Goetz JA, Alt H, Hawes N, Wolf E, Favor J, Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud. Development. 2003 Dec;130(24):6037-47 |
3 | J:235727 Kuta A, Mao Y, Martin T, Ferreira de Sousa C, Whiting D, Zakaria S, Crespo-Enriquez I, Evans P, Balczerski B, Mankoo B, Irvine KD, Francis-West PH, Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae. Development. 2016 Jul 1;143(13):2367-75 |
1 | J:187316 Kyrylkova K, Kyryachenko S, Biehs B, Klein O, Kioussi C, Leid M, BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PLoS One. 2012;7(5):e37670 |
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1 | J:147277 Lan Y, Jiang R, Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development. 2009 Apr;136(8):1387-96 |
4 | J:94755 Lan Y, Ovitt CE, Cho ES, Maltby KM, Wang Q, Jiang R, Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis. Development. 2004 Jul;131(13):3207-16 |
1 | J:175841 Lana-Elola E, Tylzanowski P, Takatalo M, Alakurtti K, Veistinen L, Mitsiadis TA, Graf D, Rice R, Luyten FP, Rice DP, Noggin null allele mice exhibit a microform of holoprosencephaly. Hum Mol Genet. 2011 Oct 15;20(20):4005-15 |
1 | J:107400 Laurikkala J, Mikkola ML, James M, Tummers M, Mills AA, Thesleff I, p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development. 2006 Apr;133(8):1553-63 |
2* | J:62022 Leitges M, Neidhardt L, Haenig B, Herrmann BG, Kispert A, The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column. Development. 2000 Jun;127(11):2259-67 |
1* | J:317083 Letelier J, Naranjo S, Sospedra-Arrufat I, Martinez-Morales JR, Lopez-Rios J, Shubin N, Gomez-Skarmeta JL, The Shh/Gli3 gene regulatory network precedes the origin of paired fins and reveals the deep homology between distal fins and digits. Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):e2100575118 |
2* | J:226028 Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H, Vokes SA, Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103 |
1 | J:240835 Li CY, Hu J, Lu H, Lan J, Du W, Galicia N, Klein OD, alphaE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development. Nat Commun. 2016 Jul 13;7:12133 |
2* | J:213418 Li D, Sakuma R, Vakili NA, Mo R, Puviindran V, Deimling S, Zhang X, Hopyan S, Hui CC, Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling. Dev Cell. 2014 Apr 28;29(2):233-40 |
1 | J:235489 Li J, Wang Q, Cui Y, Yang X, Li Y, Zhang X, Qiu M, Zhang Z, Zhang Z, Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/Gremlin. PLoS One. 2015;10(5):e0128006 |
1 | J:168033 Li L, Lin M, Wang Y, Cserjesi P, Chen Z, Chen Y, BmprIa is required in mesenchymal tissue and has limited redundant function with BmprIb in tooth and palate development. Dev Biol. 2011 Jan 15;349(2):451-61 |
2 | J:234990 Li S, Morley M, Lu M, Zhou S, Stewart K, French CA, Tucker HO, Fisher SE, Morrisey EE, Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development. Dev Biol. 2016 Aug 15;416(2):338-46 |
1 | J:142133 Li Y, Gordon J, Manley NR, Litingtung Y, Chiang C, Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis. Dev Biol. 2008 Oct 1;322(1):145-55 |
1 | J:120878 Lin D, Huang Y, He F, Gu S, Zhang G, Chen Y, Zhang Y, Expression survey of genes critical for tooth development in the human embryonic tooth germ. Dev Dyn. 2007 May;236(5):1307-12 |
1 | J:130228 Liu F, Chu EY, Watt B, Zhang Y, Gallant NM, Andl T, Yang SH, Lu MM, Piccolo S, Schmidt-Ullrich R, Taketo MM, Morrisey EE, Atit R, Dlugosz AA, Millar SE, Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol. 2008 Jan 1;313(1):210-24 |
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