Gene Expression Literature Summary

• Symbol: Pcp2
• Name: Purkinje cell protein 2 (L7)
• ID: MGI:97508

16 matching records from 16 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E11.5	E13	E13.5	E14.5	E15	E15.5	E17.5	E18	E18.5	P
Immunohistochemistry (section)										6
In situ RNA (section)	2		1			2	1		3	6
In situ reporter (knock in)										1
Northern blot										1
Western blot										1
RT-PCR		1		1	1			1		3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pcp2  Purkinje cell protein 2 (L7)   (Synonyms: L7, Pcp-2)
Results	Reference
8	J:46505 Baader SL, Sanlioglu S, Berrebi AS, Parker-Thornburg J, Oberdick J, Ectopic overexpression of engrailed-2 in cerebellar Purkinje cells causes restricted cell loss and retarded external germinal layer development at lobule junctions. J Neurosci. 1998 Mar 1;18(5):1763-73
1*	J:30900 Banfi S, Servadio A, Chung M, Capozzoli F, Duvick LA, Elde R, Zoghbi HY, Orr HT, Cloning and developmental expression analysis of the murine homolog of the spinocerebellar ataxia type 1 gene (Sca1). Hum Mol Genet. 1996 Jan;5(1):33-40
1	J:110638 Catalano SM, Messersmith EK, Goodman CS, Shatz CJ, Chedotal A, Many major CNS axon projections develop normally in the absence of semaphorin III. Mol Cell Neurosci. 1998 Jul;11(4):173-82
1*	J:143073 Fujieda H, Bremner R, Mears AJ, Sasaki H, Retinoic acid receptor-related orphan receptor alpha regulates a subset of cone genes during mouse retinal development. J Neurochem. 2009 Jan;108(1):91-101
1	J:306113 Kojic M, Gawda T, Gaik M, Begg A, Salerno-Kochan A, Kurniawan ND, Jones A, Drozdzyk K, Koscielniak A, Chramiec-Glabik A, Hediyeh-Zadeh S, Kasherman M, Shim WJ, Sinniah E, Genovesi LA, Abrahamsen RK, Fenger CD, Madsen CG, Cohen JS, Fatemi A, Stark Z, Lunke S, Lee J, Hansen JK, Boxill MF, Keren B, Marey I, Saenz MS, Brown K, Alexander SA, Mureev S, Batzilla A, Davis MJ, Piper M, Boden M, Burne THJ, Palpant NJ, Moller RS, Glatt S, Wainwright BJ, Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype. Nat Commun. 2021 May 11;12(1):2678
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:208769 Nakatani T, Minaki Y, Kumai M, Nitta C, Ono Y, The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells. Dev Biol. 2014 Apr 1;388(1):68-80
1*	J:98285 Saito H, Tsumura H, Otake S, Nishida A, Furukawa T, Suzuki N, L7/Pcp-2-specific expression of Cre recombinase using knock-in approach. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1216-21
1*	J:16438 Sasaki H, Hogan BL, HNF-3 beta as a regulator of floor plate development. Cell. 1994 Jan 14;76(1):103-15
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:116593 Wang T, Parris J, Li L, Morgan JI, The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype. Mol Cell Neurosci. 2006 Oct;33(2):200-13
1	J:316423 Whittaker DE, Oleari R, Gregory LC, Le Quesne-Stabej P, Williams HJ, Torpiano JG, Formosa N, Cachia MJ, Field D, Lettieri A, Ocaka LA, Paganoni AJ, Rajabali SH, Riegman KL, De Martini LB, Chaya T, Robinson IC, Furukawa T, Cariboni A, Basson MA, Dattani MT, A recessive PRDM13 mutation results in congenital hypogonadotropic hypogonadism and cerebellar hypoplasia. J Clin Invest. 2021 Dec 15;131(24):e141587
1	J:242933 Whittaker DE, Riegman KL, Kasah S, Mohan C, Yu T, Sala BP, Hebaishi H, Caruso A, Marques AC, Michetti C, Smachetti ME, Shah A, Sabbioni M, Kulhanci O, Tee WW, Reinberg D, Scattoni ML, Volk H, McGonnell I, Wardle FC, Fernandes C, Basson MA, The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression. J Clin Invest. 2017 Mar 01;127(3):874-887
3*	J:71938 Wu Y, Cutting GR, Developmentally regulated expression of GABA receptor rho1 and rho2 subunits, L7 and cone-rod homeobox (CRX) genes in mouse retina. Brain Res. 2001 Aug 31;912(1):1-8
1	J:173529 Yu T, Yaguchi Y, Echevarria D, Martinez S, Basson MA, Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum. Development. 2011 Jul;138(14):2957-68
1	J:290155 Zhuang P, Zhang H, Welchko RM, Thompson RC, Xu S, Turner DL, Combined microRNA and mRNA detection in mammalian retinas by in situ hybridization chain reaction. Sci Rep. 2020 Jan 15;10(1):351