Gene Expression Literature Summary

• Symbol: Pde6b
• Name: phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
• ID: MGI:97525

17 matching records from 17 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E18.5	P
Immunohistochemistry (section)								2
In situ RNA (section)						1		1
In situ reporter (knock in)								1
Western blot								1
RT-PCR	1	1	1	3	2	2	1	12

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pde6b  phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide   (Synonyms: nmf137, Pdeb, r, rd, rd1, rd10)
Results	Reference
7*	J:70841 Bibb LC, Holt JK, Tarttelin EE, Hodges MD, Gregory-Evans K, Rutherford A, Lucas RJ, Sowden JC, Gregory-Evans CY, Temporal and spatial expression patterns of the CRX transcription factor and its downstream targets. Critical differences during human and mouse eye development. Hum Mol Genet. 2001 Jul 15;10(15):1571-9
1	J:278101 Brightman DS, Grant RL, Ruzycki PA, Suzuki R, Hennig AK, Chen S, MLL1 is essential for retinal neurogenesis and horizontal inner neuron integrity. Sci Rep. 2018 Aug 9;8(1):11902
1*	J:114905 Cheng H, Aleman TS, Cideciyan AV, Khanna R, Jacobson SG, Swaroop A, In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development. Hum Mol Genet. 2006 Sep 1;15(17):2588-602
1*	J:107820 Corbo JC, Cepko CL, A Hybrid Photoreceptor Expressing Both Rod and Cone Genes in a Mouse Model of Enhanced S-Cone Syndrome. PLoS Genet. 2005 Aug 5;1(2):e11
1	J:153683 Jia L, Oh EC, Ng L, Srinivas M, Brooks M, Swaroop A, Forrest D, Retinoid-related orphan nuclear receptor RORbeta is an early-acting factor in rod photoreceptor development. Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17534-9
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:266268 Kowalchuk AM, Maurer KA, Shoja-Taheri F, Brown NL, Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis. Dev Biol. 2018 Oct 15;442(2):220-235
1	J:329268 Langouet M, Jolicoeur C, Javed A, Mattar P, Gearhart MD, Daiger SP, Bertelsen M, Tranebjaerg L, Rendtorff ND, Gronskov K, Jespersgaard C, Chen R, Sun Z, Li H, Alirezaie N, Majewski J, Bardwell VJ, Sui R, Koenekoop RK, Cayouette M, Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with early-onset retinal degeneration. Sci Adv. 2022 Sep 9;8(36):eabh2868
1	J:301112 Maddala R, Gao J, Mathias RT, Lewis TR, Arshavsky VY, Levine A, Backer JM, Bresnick AR, Rao PV, Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract. Sci Rep. 2021 Jan 26;11(1):2203
3	J:87739 Rutherford AD, Dhomen N, Smith HK, Sowden JC, Delayed expression of the Crx gene and photoreceptor development in the Chx10-deficient retina. Invest Ophthalmol Vis Sci. 2004 Feb;45(2):375-84
1	J:346629 Schmidt H, Peters S, Frank K, Wen L, Feil R, Rathjen FG, Dorsal root ganglion axon bifurcation tolerates increased cyclic GMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3. Eur J Neurosci. 2016 Dec;44(12):2991-3000
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
5	J:270322 Wada K, Saito J, Yamaguchi M, Seki Y, Furugori M, Takahashi G, Nishito Y, Matsuda H, Shitara H, Kikkawa Y, Pde6b(rd1) mutation modifies cataractogenesis in Foxe3(rct) mice. Biochem Biophys Res Commun. 2018 Jan 29;496(1):231-237
1	J:274446 Wei W, Liu B, Jiang H, Jin K, Xiang M, Requirement of the Mowat-Wilson Syndrome Gene Zeb2 in the Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development. Mol Neurobiol. 2019 Mar;56(3):1719-1736
1*	J:274764 Wu KC, Chen XJ, Jin GH, Wang XY, Yang DD, Li YP, Xiang L, Zhang BW, Zhou GH, Zhang CJ, Jin ZB, Deletion of miR-182 Leads to Retinal Dysfunction in Mice. Invest Ophthalmol Vis Sci. 2019 Mar 1;60(4):1265-1274
1	J:286615 Yan X, Atorf J, Ramos D, Thiele F, Weber S, Dalke C, Sun M, Puk O, Michel D, Fuchs H, Klaften M, Przemeck GKH, Sabrautzki S, Favor J, Ruberte J, Kremers J, de Angelis MH, Graw J, Mutation in Bmpr1b Leads to Optic Disc Coloboma and Ventral Retinal Gliosis in Mice. Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):44
1*	J:225638 Yoshida S, Mears AJ, Friedman JS, Carter T, He S, Oh E, Jing Y, Farjo R, Fleury G, Barlow C, Hero AO, Swaroop A, Expression profiling of the developing and mature Nrl-/- mouse retina: identification of retinal disease candidates and transcriptional regulatory targets of Nrl. Hum Mol Genet. 2004 Jul 15;13(14):1487-503