Symbol Name ID |
Pfn1
profilin 1 MGI:97549 |
Age | E2.5 | E3.5 | E10 | E10.5 | E11.5 | E12.5 | E13 | E13.5 | E14.5 | E15 | E15.5 | E17 | E18.5 | E20 | P |
Immunohistochemistry (section) | 1 | 1 | |||||||||||||
In situ RNA (section) | 1 | ||||||||||||||
In situ reporter (knock in) | 1 | 1 | 1 | 1 | 1 | ||||||||||
Northern blot | 1 | ||||||||||||||
Western blot | 2 | 1 | 1 | 1 | 3 | 1 | 3 | 1 | 2 | 1 | 2 | 5 | |||
RT-PCR | 2 |
Pfn1 profilin 1 (Synonyms: actin binding protein, Pfn) | |
Results | Reference |
1* | J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034 |
2* | J:282177 Brettle M, Stefen H, Djordjevic A, Fok SYY, Chan JW, van Hummel A, van der Hoven J, Przybyla M, Volkerling A, Ke YD, Delerue F, Ittner LM, Fath T, Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice. Front Mol Neurosci. 2019;12:231 |
7 | J:310888 Di Domenico M, Jokwitz M, Witke W, Pilo Boyl P, Specificity and Redundancy of Profilin 1 and 2 Function in Brain Development and Neuronal Structure. Cells. 2021 Sep 3;10(9) |
1* | J:276652 Fang Q, Zhang Y, Da P, Shao B, Pan H, He Z, Cheng C, Li D, Guo J, Wu X, Guan M, Liao M, Zhang Y, Sha S, Zhou Z, Wang J, Wang T, Su K, Chai R, Chen F, Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Sci Rep. 2019 Mar 4;9(1):3357 |
1 | J:233564 Gurniak CB, Chevessier F, Jokwitz M, Jonsson F, Perlas E, Richter H, Matern G, Boyl PP, Chaponnier C, Furst D, Schroder R, Witke W, Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance. Eur J Cell Biol. 2014 May-Jun;93(5-6):252-66 |
6* | J:209786 Gurniak CB, Witke W, HuGE, a novel GFP-actin-expressing mouse line for studying cytoskeletal dynamics. Eur J Cell Biol. 2007 Jan;86(1):3-12 |
3 | J:181033 Kullmann JA, Neumeyer A, Gurniak CB, Friauf E, Witke W, Rust MB, Profilin1 is required for glial cell adhesion and radial migration of cerebellar granule neurons. EMBO Rep. 2011 Jan;13(1):75-82 |
1 | J:309992 Vasilopoulou E, Kolatsi-Joannou M, Lindenmeyer MT, White KE, Robson MG, Cohen CD, Sebire NJ, Riley PR, Winyard PJ, Long DA, Loss of endogenous thymosin beta4 accelerates glomerular disease. Kidney Int. 2016 Nov;90(5):1056-1070 |
6* | J:24346 Witke W, Sharpe AH, Hartwig JH, Azuma T, Stossel TP, Kwiatkowski DJ, Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell. 1995 Apr 7;81(1):41-51 |
6* | J:77643 Witke W, Sutherland JD, Sharpe A, Arai M, Kwiatkowski DJ, Profilin I is essential for cell survival and cell division in early mouse development. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3832-6 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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