Gene Expression Literature Summary

• Symbol: Pik3r1
• Name: phosphoinositide-3-kinase regulatory subunit 1
• ID: MGI:97583

40 matching records from 40 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1.5	E2	E4	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)						1						1		2	1	1		1
In situ RNA (section)								2				1		3		5	1				1	1		1	5
Immunohistochemistry (whole mount)	1			1																				1
In situ RNA (whole mount)																1
Northern blot											1								1						1
Western blot				1	2		1	2	1	1	1	1	1	2	1	3	1	2	1	3		3		1	14
RT-PCR		1	1													1		1	1	1		1	1		4
cDNA clones					1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pik3r1  phosphoinositide-3-kinase regulatory subunit 1   (Synonyms: p50alpha, p55alpha, p85alpha, PI3K)
Results	Reference
8*	J:196196 Awuah PK, Nejak-Bowen KN, Monga SP, Role and Regulation of PDGFRalpha Signaling in Liver Development and Regeneration. Am J Pathol. 2013 May;182(5):1648-58
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
3*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
1	J:277122 Buenaventura DF, Corseri A, Emerson MM, Identification of Genes With Enriched Expression in Early Developing Mouse Cone Photoreceptors. Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):2787-2799
1	J:334838 Chang JH, Chou CH, Wu JC, Liao KM, Luo WJ, Hsu WL, Chen XR, Yu SL, Pan SH, Yang PC, Su KY, LCRMP-1 is required for spermatogenesis and stabilises spermatid F-actin organization via the PI3K-Akt pathway. Commun Biol. 2023 Apr 10;6(1):389
1	J:341966 Chen X, Song QL, Wang JY, Ji R, Cao ML, Guo DY, Zhang Y, Yang J, FKBP5 regulates trophoblast-macrophage crosstalk in recurrent spontaneous abortion through PI3K/AKT and NF-kappaB signaling pathways. Free Radic Biol Med. 2023 Oct 10;209(Pt 1):55-69
4*	J:131397 Cho KW, Cho SW, Lee JM, Lee MJ, Gang HS, Jung HS, Expression of phosphorylated forms of ERK, MEK, PTEN and PI3K in mouse oral development. Gene Expr Patterns. 2008 Apr;8(4):284-290
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:129381 Eickholt BJ, Ahmed AI, Davies M, Papakonstanti EA, Pearce W, Starkey ML, Bilancio A, Need AC, Smith AJ, Hall SM, Hamers FP, Giese KP, Bradbury EJ, Vanhaesebroeck B, Control of Axonal Growth and Regeneration of Sensory Neurons by the p110delta PI 3-Kinase. PLoS One. 2007;2(9):e869
2	J:109024 Foukas LC, Claret M, Pearce W, Okkenhaug K, Meek S, Peskett E, Sancho S, Smith AJ, Withers DJ, Vanhaesebroeck B, Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature. 2006 May 18;441(7091):366-70
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:279329 Huisman C, Cho H, Brock O, Lim SJ, Youn SM, Park Y, Kim S, Lee SK, Delogu A, Lee JW, Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators. Nat Commun. 2019 Aug 16;10(1):3696
2	J:301083 Huisman C, Kim YA, Jeon S, Shin B, Choi J, Lim SJ, Youn SM, Park Y, K C M, Kim S, Lee SK, Lee S, Lee JW, The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus. Nat Commun. 2021 Jan 11;12(1):256
1*	J:171508 Ikegami D, Akiyama H, Suzuki A, Nakamura T, Nakano T, Yoshikawa H, Tsumaki N, Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011 Apr;138(8):1507-19
1	J:181994 Kamileri I, Karakasilioti I, Sideri A, Kosteas T, Tatarakis A, Talianidis I, Garinis GA, Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
7*	J:83700 Koyama N, Kashimata M, Sakashita H, Sakagami H, Gresik EW, EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland. Dev Dyn. 2003 Jun;227(2):216-26
2	J:51720 Laviola L, Giorgino F, Chow JC, Baquero JA, Hansen H, Ooi J, Zhu J, Riedel H, Smith RJ, The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts. J Clin Invest. 1997 Mar 1;99(5):830-7
1	J:246200 Lof-Ohlin ZM, Nyeng P, Bechard ME, Hess K, Bankaitis E, Greiner TU, Ameri J, Wright CV, Semb H, EGFR signalling controls cellular fate and pancreatic organogenesis by regulating apicobasal polarity. Nat Cell Biol. 2017 Nov;19(11):1313-1325
3	J:317070 Luo L, Jiang W, Liu H, Bu J, Tang P, Du C, Xu Z, Luo H, Liu B, Xiao B, Zhou Z, Liu F, De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liver. J Mol Endocrinol. 2018 May;60(4):285-297
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:227021 Mallika C, Guo Q, Li JY, Gbx2 is essential for maintaining thalamic neuron identity and repressing habenular characters in the developing thalamus. Dev Biol. 2015 Nov 1;407(1):26-39
6	J:152818 Melnick M, Phair RD, Lapidot SA, Jaskoll T, Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol. 2009;9:32
1	J:152699 Mouta-Bellum C, Kirov A, Miceli-Libby L, Mancini ML, Petrova TV, Liaw L, Prudovsky I, Thorpe PE, Miura N, Cantley LC, Alitalo K, Fruman DA, Vary CP, Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Dev Dyn. 2009 Aug 24;238(10):2670-2679
1	J:141066 Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z, Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science. 2008 Nov 7;322(5903):963-6
2	J:233610 Peng Y, Lu Z, Li G, Piechowicz M, Anderson M, Uddin Y, Wu J, Qiu S, The autism-associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the forebrain. Mol Psychiatry. 2016 Jul;21(7):925-35
3	J:77800 Pimentel B, Rodriguez-Borlado L, Hernandez C, Carrera AC, A Role for phosphoinositide 3-kinase in the control of cell division and survival during retinal development. Dev Biol. 2002 Jul 15;247(2):295-306
3*	J:36742 Pons S, Asano T, Glasheen E, Miralpeix M, Zhang Y, Fisher TL, Myers MG Jr, Sun XJ, White MF, The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol. 1995 Aug;15(8):4453-65
1	J:311917 Qiu X, Wei R, Li Y, Zhu Q, Xiong C, Chen Y, Zhang Y, Lu K, He F, Zhang L, NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner. Oncotarget. 2016 May 24;7(21):31440-53
4	J:100565 Riley JK, Carayannopoulos MO, Wyman AH, Chi M, Ratajczak CK, Moley KH, The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo. Dev Biol. 2005 Aug 15;284(2):377-86
3	J:251785 Sheen MR, Warner SL, Fields JL, Conejo-Garcia JR, Fiering S, Myristoylated p110alpha Causes Embryonic Death Due to Developmental and Vascular Defects. Open Life Sci. 2015 Oct;10(1):461-478
1	J:164696 Tan Y, You H, Coffey FJ, Wiest DL, Testa JR, Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development. Genesis. 2010 Sep;48(9):531-9
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2	J:345099 Wang X, Zhang Y, Yu J, Ma Y, Xu Y, Shi J, Qi Z, Liu X, Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development. BMC Genomics. 2024 Feb 3;25(1):139
1	J:281388 Xu J, Huang Z, Wang W, Tan X, Li H, Zhang Y, Tian W, Hu T, Chen YP, FGF8 Signaling Alters the Osteogenic Cell Fate in the Hard Palate. J Dent Res. 2018 May;97(5):589-596
1	J:102264 Yamashita H, Shao J, Qiao L, Pagliassotti M, Friedman JE, Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice. Pediatr Res. 2003 Mar;53(3):411-8
5	J:180006 Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, Yamamoto T, NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. EMBO J. 2011 Nov 30;30(23):4739-54
1	J:239252 Zhang T, Yao Y, Wang J, Li Y, He P, Pasupuleti V, Hu Z, Jia X, Song Q, Tian XL, Hu C, Chen Q, Wang QK, Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin. Hum Mol Genet. 2016 Dec 1;25(23):5094-5110
1	J:300786 Zhang Z, Ye M, Li Q, You Y, Yu H, Ma Y, Mei L, Sun X, Wang L, Yue W, Li R, Li J, Zhang D, The Schizophrenia Susceptibility Gene OPCML Regulates Spine Maturation and Cognitive Behaviors through Eph-Cofilin Signaling. Cell Rep. 2019 Oct 1;29(1):49-61.e7