Gene Expression Literature Summary

• Symbol: Prkcg
• Name: protein kinase C, gamma
• ID: MGI:97597

61 matching records from 61 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E1.5	E2	E2.5	E3	E3.5	E4	E6.5	E9	E9.5	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	P
Immunohistochemistry (section)								1	1	2	1							1	1	1			1	1			1	38
In situ RNA (section)																		1										2
Immunohistochemistry (whole mount)	2	1	2	2	1	1	1
Western blot	1	1	1			1				1	2	1	1	2	2	3	1	3		2		2	2	1		1		7
RT-PCR	2	1	1			1					1			1				1	1	1	1				1	1		5
cDNA clones																			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Prkcg  protein kinase C, gamma   (Synonyms: Pkcc, PKCgamma, Prkcc)
Results	Reference
1*	J:63629 Baas D, Bumsted KM, Martinez JA, Vaccarino FM, Wikler KC, Barnstable CJ, The subcellular localization of OTX2 is cell-type specific and developmentally regulated in the mouse retina. Brain Res Mol Brain Res. 2000 May 31;78(1-2):26-37
6	J:74087 Balasubramanian G, Amann JF, Reddy CS, Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development. J Craniofac Genet Dev Biol. 2000 Jan-Mar;20(1):26-34
4	J:26903 Bareggi R, Grill V, Zweyer M, Narducci P, Martelli AM, Distribution of the extended family of protein kinase C isoenzymes in fetal organs of mice: an immunohistochemical study. Cell Tissue Res. 1995 Jun;280(3):617-25
1*	J:20022 Bareggi R, Neri LM, Grill V, Cocco L, Martelli AM, An immunohistochemical study of protein kinase C distribution in fetal mouse vertebral column. Anat Embryol (Berl). 1994 Jul;190(1):47-54
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
3*	J:36065 Blackshear PJ, Lai WS, Tuttle JS, Stumpo DJ, Kennington E, Nairn AC, Sulik KK, Developmental expression of MARCKS and protein kinase C in mice in relation to the exencephaly resulting from MARCKS deficiency. Brain Res Dev Brain Res. 1996 Oct 23;96(1-2):62-75
1	J:70746 Brown NL, Patel S, Brzezinski J, Glaser T, Math5 is required for retinal ganglion cell and optic nerve formation. Development. 2001 Jul;128(13):2497-508
1	J:156665 Brzezinski JA 4th, Lamba DA, Reh TA, Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development. 2010 Feb;137(4):619-29
1	J:204690 Brzezinski JA 4th, Uoon Park K, Reh TA, Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence. Dev Biol. 2013 Dec 15;384(2):194-204
1	J:106971 Chen CL, Broom DC, Liu Y, de Nooij JC, Li Z, Cen C, Samad OA, Jessell TM, Woolf CJ, Ma Q, Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron. 2006 Feb 2;49(3):365-77
1	J:70560 Chen Z, Rebelo S, White F, Malmberg AB, Baba H, Lima D, Woolf CJ, Basbaum AI, Anderson DJ, The paired homeodomain protein drg11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron. 2001 Jul 19;31(1):59-73
1	J:248927 Clements R, Turk R, Campbell KP, Wright KM, Dystroglycan Maintains Inner Limiting Membrane Integrity to Coordinate Retinal Development. J Neurosci. 2017 Aug 30;37(35):8559-8574
12*	J:87315 Cogram P, Hynes A, Dunlevy LP, Greene ND, Copp AJ, Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol. Hum Mol Genet. 2004 Jan 1;13(1):7-14
1	J:172162 de Melo J, Zhou QP, Zhang Q, Zhang S, Fonseca M, Wigle JT, Eisenstat DD, Dlx2 homeobox gene transcriptional regulation of Trkb neurotrophin receptor expression during mouse retinal development. Nucleic Acids Res. 2008 Feb;36(3):872-84
5	J:101323 Dehghani H, Hahnel AC, Expression profile of protein kinase C isozymes in preimplantation mouse development. Reproduction. 2005 Oct;130(4):441-51
1*	J:244060 Depienne C, Bouteiller D, Meneret A, Billot S, Groppa S, Klebe S, Charbonnier-Beaupel F, Corvol JC, Saraiva JP, Brueggemann N, Bhatia K, Cincotta M, Brochard V, Flamand-Roze C, Carpentier W, Meunier S, Marie Y, Gaussen M, Stevanin G, Wehrle R, Vidailhet M, Klein C, Dusart I, Brice A, Roze E, RAD51 haploinsufficiency causes congenital mirror movements in humans. Am J Hum Genet. 2012 Feb 10;90(2):301-7
1	J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
1	J:192580 Diaz-Alonso J, Aguado T, Wu CS, Palazuelos J, Hofmann C, Garcez P, Guillemot F, Lu HC, Lutz B, Guzman M, Galve-Roperh I, The CB(1) cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis. J Neurosci. 2012 Nov 21;32(47):16651-65
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1	J:259795 Green RM, Fish JL, Young NM, Smith FJ, Roberts B, Dolan K, Choi I, Leach CL, Gordon P, Cheverud JM, Roseman CC, Williams TJ, Marcucio RS, Hallgrimsson B, Developmental nonlinearity drives phenotypic robustness. Nat Commun. 2017 Dec 6;8(1):1970
1	J:134668 Holstege JC, de Graaff W, Hossaini M, Cano SC, Jaarsma D, van den Akker E, Deschamps J, Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6338-43
1	J:348700 Hu L, Liu XY, Zhao L, Hu ZB, Li ZX, Liu WT, Song NN, Hu YQ, Jiang LP, Zhang L, Tao YC, Zhang Q, Chen JY, Lang B, Wang YB, Yue L, Ding YQ, Ventricular Netrin-1 deficiency leads to defective pyramidal decussation and mirror movement in mice. Cell Death Dis. 2024 May 17;15(5):343
1	J:280126 Iida A, Shinoe T, Baba Y, Mano H, Watanabe S, Dicer plays essential roles for retinal development by regulation of survival and differentiation. Invest Ophthalmol Vis Sci. 2011 May 6;52(6):3008-17
1	J:144066 Joshi PS, Molyneaux BJ, Feng L, Xie X, Macklis JD, Gan L, Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex. Neuron. 2008 Oct 23;60(2):258-72
1	J:338359 Kaur N, Han W, Li Z, Madrigal MP, Shim S, Pochareddy S, Gulden FO, Li M, Xu X, Xing X, Takeo Y, Li Z, Lu K, Imamura Kawasawa Y, Ballester-Lurbe B, Moreno-Bravo JA, Chedotal A, Terrado J, Perez-Roger I, Koleske AJ, Sestan N, Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold. Neuron. 2020 Sep 23;107(6):1197-1211.e9
1	J:314906 Khang R, Jo A, Kang H, Kim H, Kwag E, Lee JY, Koo O, Park J, Kim HK, Jo DG, Hwang I, Ahn JY, Lee Y, Choi JY, Lee YS, Shin JH, Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Sci Rep. 2021 Nov 23;11(1):22745
3	J:187604 Kimura TE, Merritt AJ, Lock FR, Eckert JJ, Fleming TP, Garrod DR, Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration. Dev Biol. 2012 Sep 15;369(2):286-97
1*	J:152410 Komai T, Iwanari H, Mochizuki Y, Hamakubo T, Shinkai Y, Expression of the mouse PR domain protein Prdm8 in the developing central nervous system. Gene Expr Patterns. 2009 Oct;9(7):503-14
7*	J:83700 Koyama N, Kashimata M, Sakashita H, Sakagami H, Gresik EW, EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland. Dev Dyn. 2003 Jun;227(2):216-26
1	J:270927 Kridsada K, Niu J, Haldipur P, Wang Z, Ding L, Li JJ, Lindgren AG, Herrera E, Thomas GM, Chizhikov VV, Millen KJ, Luo W, Roof Plate-Derived Radial Glial-like Cells Support Developmental Growth of Rapidly Adapting Mechanoreceptor Ascending Axons. Cell Rep. 2018 Jun 5;23(10):2928-2941
1	J:235635 Leone DP, Heavner WE, Ferenczi EA, Dobreva G, Huguenard JR, Grosschedl R, McConnell SK, Satb2 Regulates the Differentiation of Both Callosal and Subcerebral Projection Neurons in the Developing Cerebral Cortex. Cereb Cortex. 2015 Oct;25(10):3406-19
1	J:241102 Leone DP, Panagiotakos G, Heavner WE, Joshi P, Zhao Y, Westphal H, McConnell SK, Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation. Cereb Cortex. 2017 Feb 01;27(2):1686-1699
1	J:109564 Li MZ, Wang JS, Jiang DJ, Xiang CX, Wang FY, Zhang KH, Williams PR, Chen ZF, Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening. Dev Biol. 2006 Apr 15;292(2):555-64
1	J:169062 Lopez-Juarez A, Morales-Lazaro S, Sanchez-Sanchez R, Sunkara M, Lomeli H, Velasco I, Morris AJ, Escalante-Alcalde D, Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. Glia. 2011 Apr;59(4):577-89
1	J:210221 Mandai K, Reimert DV, Ginty DD, Linx mediates interaxonal interactions and formation of the internal capsule. Neuron. 2014 Jul 2;83(1):93-103
1	J:145002 Medina CF, Mazerolle C, Wang Y, Berube NG, Coupland S, Gibbons RJ, Wallace VA, Picketts DJ, Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome. Hum Mol Genet. 2009 Mar 1;18(5):966-77
1*	J:332746 Navas-Perez E, Vicente-Garcia C, Mirra S, Burguera D, Fernandez-Castillo N, Ferran JL, Lopez-Mayorga M, Alaiz-Noya M, Suarez-Pereira I, Anton-Galindo E, Ulloa F, Herrera-Ubeda C, Cusco P, Falcon-Moya R, Rodriguez-Moreno A, D'Aniello S, Cormand B, Marfany G, Soriano E, Carrion AM, Carvajal JJ, Garcia-Fernandez J, Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions. Genome Biol. 2020 Oct 26;21(1):267
14*	J:63657 Pauken CM, Capco DG, The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development. Dev Biol. 2000 Jul 15;223(2):411-21
3	J:178898 Pinzon-Guzman C, Zhang SS, Barnstable CJ, Specific protein kinase C isoforms are required for rod photoreceptor differentiation. J Neurosci. 2011 Dec 14;31(50):18606-17
1	J:304285 Pourchet O, Morel MP, Welniarz Q, Sarrazin N, Marti F, Heck N, Gallea C, Doulazmi M, Roig Puiggros S, Moreno-Bravo JA, Vidailhet M, Trembleau A, Faure P, Chedotal A, Roze E, Dusart I, Loss of floor plate Netrin-1 impairs midline crossing of corticospinal axons and leads to mirror movements. Cell Rep. 2021 Jan 19;34(3):108654
1	J:212261 Qu Y, Huang Y, Feng J, Alvarez-Bolado G, Grove EA, Yang Y, Tissir F, Zhou L, Goffinet AM, Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2996-3004
1	J:158273 Ross SE, Mardinly AR, McCord AE, Zurawski J, Cohen S, Jung C, Hu L, Mok SI, Shah A, Savner EM, Tolias C, Corfas R, Chen S, Inquimbert P, Xu Y, McInnes RR, Rice FL, Corfas G, Ma Q, Woolf CJ, Greenberg ME, Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 2010 Mar 25;65(6):886-98
1	J:182304 Ross SE, McCord AE, Jung C, Atan D, Mok SI, Hemberg M, Kim TK, Salogiannis J, Hu L, Cohen S, Lin Y, Harrar D, McInnes RR, Greenberg ME, Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. Neuron. 2012 Jan 26;73(2):292-303
3*	J:138696 Sato A, Sekine Y, Saruta C, Nishibe H, Morita N, Sato Y, Sadakata T, Shinoda Y, Kojima T, Furuichi T, Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum. Neural Netw. 2008 Oct;21(8):1056-69
1	J:125324 Sato S, Inoue T, Terada K, Matsuo I, Aizawa S, Tano Y, Fujikado T, Furukawa T, Dkk3-Cre BAC transgenic mouse line: a tool for highly efficient gene deletion in retinal progenitor cells. Genesis. 2007 Aug;45(8):502-7
1	J:138693 Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, Furukawa T, Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. Nat Neurosci. 2008 Aug;11(8):923-31
1	J:213580 Schrode N, Saiz N, Di Talia S, Hadjantonakis AK, GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. Dev Cell. 2014 May 27;29(4):454-67
1	J:186632 Shim S, Kwan KY, Li M, Lefebvre V, Sestan N, Cis-regulatory control of corticospinal system development and evolution. Nature. 2012 Jun 7;486(7401):74-9
1*	J:249375 Smiley S, Nickerson PE, Comanita L, Daftarian N, El-Sehemy A, Tsai EL, Matan-Lithwick S, Yan K, Thurig S, Touahri Y, Dixit R, Aavani T, De Repentingy Y, Baker A, Tsilfidis C, Biernaskie J, Sauve Y, Schuurmans C, Kothary R, Mears AJ, Wallace VA, Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line. Sci Rep. 2016 Mar 11;6:22867
1	J:169133 Stafford DA, Brunet LJ, Khokha MK, Economides AN, Harland RM, Cooperative activity of noggin and gremlin 1 in axial skeleton development. Development. 2011 Mar;138(5):1005-14
1	J:221589 Szabo NE, da Silva RV, Sotocinal SG, Zeilhofer HU, Mogil JS, Kania A, Hoxb8 intersection defines a role for Lmx1b in excitatory dorsal horn neuron development, spinofugal connectivity, and nociception. J Neurosci. 2015 Apr 1;35(13):5233-46
1	J:151993 Tao H, Suzuki M, Kiyonari H, Abe T, Sasaoka T, Ueno N, Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14426-31
1	J:117333 Tu X, Joeng KS, Nakayama KI, Nakayama K, Rajagopal J, Carroll TJ, McMahon AP, Long F, Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell. 2007 Jan;12(1):113-27
1	J:282827 Tulloch AJ, Teo S, Carvajal BV, Tessier-Lavigne M, Jaworski A, Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3(Cre) mouse. J Comp Neurol. 2019 Dec 15;527(18):2948-2972
1	J:197621 Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M, Yamashita T, Layer V cortical neurons require microglial support for survival during postnatal development. Nat Neurosci. 2013 May;16(5):543-51
2	J:174064 Vesterlund L, Tohonen V, Hovatta O, Kere J, Co-localization of neural cell adhesion molecule and fibroblast growth factor receptor 2 in early embryo development. Int J Dev Biol. 2011;55(3):313-9
1	J:310861 Wang L, Lam JS, Zhao H, Wang J, Chan SO, Localization of protein kinase C isoforms in the optic pathway of mouse embryos and their role in axon routing at the optic chiasm. Brain Res. 2014 Aug 5;1575:22-32
1	J:230714 Xing L, Larsen RS, Bjorklund GR, Li X, Wu Y, Philpot BD, Snider WD, Newbern JM, Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex. Elife. 2016;5:e11123
1	J:201733 Xu Y, Lopes C, Wende H, Guo Z, Cheng L, Birchmeier C, Ma Q, Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities. J Neurosci. 2013 Sep 11;33(37):14738-48
1	J:144660 Yoshida Y, Han B, Mendelsohn M, Jessell TM, PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Neuron. 2006 Dec 7;52(5):775-88
3*	J:36988 Zappelli F, Willems D, Osada S, Ohno S, Wetsel WC, Molinaro M, Cossu G, Bouche M, The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis. Dev Biol. 1996 Nov 25;180(1):156-64