Gene Expression Literature Summary

• Symbol: Pkd1
• Name: polycystin 1, transient receptor potential channel interacting
• ID: MGI:97603

55 matching records from 55 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E2.5	E3.5	E6.5	E8	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)	1	1			1		1		1	1	2	2	1	1	3		4	1			1	1				4
In situ RNA (section)			1	2		2	1		4	1	2		3	1	2		3	1	4		1	1	3		1	8
Immunohistochemistry (whole mount)					1
In situ RNA (whole mount)					1
In situ reporter (knock in)						1	1		1	1			1		1		1		2				1		1	5
Northern blot							1	1			2			1			1	1	1	1		1		1	1	1
Western blot							1		1	1	5		1		6		2		3		1	1	4			8
RT-PCR		1					1		3		4		2	1	8	1	5	1	4	2	5	2	6	1	1	16
cDNA clones																			1		1	1				2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pkd1  polycystin 1, transient receptor potential channel interacting   (Synonyms: PC-1, PC1, polycystin-1)
Results	Reference
3*	J:161879 Asai Y, Holt JR, Geleoc GS, A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea. J Assoc Res Otolaryngol. 2010 Mar;11(1):27-37
1*	J:76062 Bhunia AK, Piontek K, Boletta A, Liu L, Qian F, Xu PN, Germino FJ, Germino GG, PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell. 2002 Apr 19;109(2):157-68
5*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
10*	J:72238 Boulter C, Mulroy S, Webb S, Fleming S, Brindle K, Sandford R, Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12174-9
1*	J:137337 Cadieux C, Harada R, Paquet M, Cote O, Trudel M, Nepveu A, Bouchard M, Polycystic kidneys caused by sustained expression of Cux1 isoform p75. J Biol Chem. 2008 May 16;283(20):13817-24
2	J:317220 Cebotaru V, Cebotaru L, Kim H, Chiaravalli M, Boletta A, Qian F, Guggino WB, Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway. J Biol Chem. 2014 Mar 7;289(10):6404-6414
2	J:94419 Chauvet V, Tian X, Husson H, Grimm DH, Wang T, Hieseberger T, Igarashi P, Bennett AM, Ibraghimov-Beskrovnaya O, Somlo S, Caplan MJ, Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J Clin Invest. 2004 Nov;114(10):1433-43
7	J:95109 Corey DP, Garcia-Anoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Geleoc GS, Gray PA, Hoffman MP, Rehm HL, Tamasauskas D, Zhang DS, TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature. 2004 Dec 9;432(7018):723-30
1	J:220324 De Vas MG, Kopp JL, Heliot C, Sander M, Cereghini S, Haumaitre C, Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors. Development. 2015 Mar 1;142(5):871-82
1	J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
2*	J:169812 Foggensteiner L, Bevan AP, Thomas R, Coleman N, Boulter C, Bradley J, Ibraghimov-Beskrovnaya O, Klinger K, Sandford R, Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene. J Am Soc Nephrol. 2000 May;11(5):814-27
2	J:125113 Garcia-Gonzalez MA, Menezes LF, Piontek KB, Kaimori J, Huso DL, Watnick T, Onuchic LF, Guay-Woodford LM, Germino GG, Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway. Hum Mol Genet. 2007 Aug 15;16(16):1940-50
9	J:165114 Garcia-Gonzalez MA, Outeda P, Zhou Q, Zhou F, Menezes LF, Qian F, Huso DL, Germino GG, Piontek KB, Watnick T, Pkd1 and Pkd2 are required for normal placental development. PLoS One. 2010;5(9)
25*	J:40260 Geng L, Segal Y, Pavlova A, Barros EJ, Lohning C, Lu W, Nigam SK , Frischauf AM , Reeders ST , Zhou J, Distribution and developmentally regulated expression of murine polycystin. Am J Physiol. 1997 Apr;272(4 Pt 2):F451-9
9	J:44584 Griffin MD, O'Sullivan DA, Torres VE, Grande JP, Kanwar YS, Kumar R, Expression of polycystin in mouse metanephros and extra-metanephric tissues. Kidney Int. 1997 Nov;52(5):1196-205
19*	J:54093 Guillaume R, D'Agati V, Daoust M, Trudel M, Murine Pkd1 is a developmentally regulated gene from morula to adulthood: role in tissue condensation and patterning. Dev Dyn. 1999 Apr;214(4):337-48
10*	J:62085 Guillaume R, Trudel M, Distinct and common developmental expression patterns of the murine pkd2 and pkd1 genes. Mech Dev. 2000 May;93(1-2):179-83
1*	J:119488 Hossain Z, Ali SM, Ko HL, Xu J, Ng CP, Guo K, Qi Z, Ponniah S, Hong W, Hunziker W, Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1631-6
3*	J:102103 Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T, A neurogenomics approach to gene expression analysis in the developing brain. Brain Res Mol Brain Res. 2004 Dec 20;132(2):116-27
2	J:104361 Jiang ST, Chiou YY, Wang E, Lin HK, Lin YT, Chi YC, Wang CK, Tang MJ, Li H, Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of pkd1. Am J Pathol. 2006 Jan;168(1):205-20
1	J:103305 Karcher C, Fischer A, Schweickert A, Bitzer E, Horie S, Witzgall R, Blum M, Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia. Differentiation. 2005 Oct;73(8):425-32
2*	J:68331 Kim K, Drummond I, Ibraghimov-Beskrovnaya O, Klinger K, Arnaout MA, Polycystin 1 is required for the structural integrity of blood vessels. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1731-6
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
3	J:224268 Kurbegovic A, Kim H, Xu H, Yu S, Cruanes J, Maser RL, Boletta A, Trudel M, Qian F, Novel functional complexity of polycystin-1 by GPS cleavage in vivo: role in polycystic kidney disease. Mol Cell Biol. 2014 Sep;34(17):3341-53
3	J:148796 Lechner SG, Frenzel H, Wang R, Lewin GR, Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development. EMBO J. 2009 May 20;28(10):1479-91
1*	J:110462 LopezJimenez ND, Cavenagh MM, Sainz E, Cruz-Ithier MA, Battey JF, Sullivan SL, Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells. J Neurochem. 2006 Jul;98(1):68-77
1*	J:43193 Lu W, Peissel B, Babakhanlou H, Pavlova A, Geng L, Fan X, Larson C, Brent G, Zhou J, Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat Genet. 1997 Oct;17(2):179-81
6*	J:72627 Lu W, Shen X, Pavlova A, Lakkis M, Ward CJ, Pritchard L, Harris PC, Genest DR, Perez-Atayde AR, Zhou J, Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects. Hum Mol Genet. 2001 Oct 1;10(21):2385-96
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
3	J:132020 Makita R, Uchijima Y, Nishiyama K, Amano T, Chen Q, Takeuchi T, Mitani A, Nagase T, Yatomi Y, Aburatani H, Nakagawa O, Small EV, Cobo-Stark P, Igarashi P, Murakami M, Tominaga J, Sato T, Asano T, Kurihara Y, Kurihara H, Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am J Physiol Renal Physiol. 2008 Mar;294(3):F542-53
1*	J:77927 Muto S, Aiba A, Saito Y, Nakao K, Nakamura K, Tomita K, Kitamura T, Kurabayashi M, Nagai R, Higashihara E, Harris PC, Katsuki M, Horie S, Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant. Hum Mol Genet. 2002 Jul 15;11(15):1731-42
2	J:235788 Nagy II, Xu Q, Naillat F, Ali N, Miinalainen I, Samoylenko A, Vainio SJ, Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis. BMC Dev Biol. 2016 Aug 31;16(1):30
2	J:347984 Naillat F, Deshar G, Hankkila A, Rak-Raszewska A, Sharma A, Prunskaite-Hyyrylainen R, Railo A, Shan J, Vainio SJ, Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167180
1	J:104377 Nakaya MA, Biris K, Tsukiyama T, Jaime S, Rawls JA, Yamaguchi TP, Wnt3alinks left-right determination with segmentation and anteroposterior axis elongation. Development. 2005 Dec;132(24):5425-36
1	J:81443 Nauli SM, Alenghat FJ, Luo Y, Williams E, Vassilev P, Li X, Elia AE, Lu W, Brown EM, Quinn SJ, Ingber DE, Zhou J, Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet. 2003 Feb;33(2):129-37
1*	J:148449 Nauli SM, Kawanabe Y, Kaminski JJ, Pearce WJ, Ingber DE, Zhou J, Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation. 2008 Mar 4;117(9):1161-71
4	J:306107 Niborski LL, Paces-Fessy M, Ricci P, Bourgeois A, Magalhaes P, Kuzma-Kuzniarska M, Lesaulnier C, Reczko M, Declercq E, Zurbig P, Doucet A, Umbhauer M, Cereghini S, Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model. Dis Model Mech. 2021 May 1;14(5):dmm047498
3*	J:204460 Nie X, Arend LJ, Pkd1 is required for male reproductive tract development. Mech Dev. 2013 Nov-Dec;130(11-12):567-76
1	J:214978 Nie X, Arend LJ, Novel roles of Pkd2 in male reproductive system development. Differentiation. 2014 Mar-Apr;87(3-4):161-71
2	J:104891 Osafune K, Takasato M, Kispert A, Asashima M, Nishinakamura R, Identification of multipotent progenitors in the embryonic mouse kidney by a novel colony-forming assay. Development. 2006 Jan;133(1):151-61
2	J:266901 Parnell SC, Magenheimer BS, Maser RL, Pavlov TS, Havens MA, Hastings ML, Jackson SF, Ward CJ, Peterson KR, Staruschenko A, Calvet JP, A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD. Hum Mol Genet. 2018 Oct 1;27(19):3313-3324
1	J:313370 Pena-Jimenez D, Fontenete S, Megias D, Fustero-Torre C, Grana-Castro O, Castellana D, Loewe R, Perez-Moreno M, Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo. EMBO J. 2019 Oct 1;38(19):e101688
5	J:125042 Pierreux CE, Poll AV, Kemp CR, Clotman F, Maestro MA, Cordi S, Ferrer J, Leyns L, Rousseau GG, Lemaigre FP, The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology. 2006 Feb;130(2):532-41
2	J:103719 Piontek KB, Huso DL, Grinberg A, Liu L, Bedja D, Zhao H, Gabrielson K, Qian F, Mei C, Westphal H, Germino GG, A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol. 2004 Dec;15(12):3035-43
5	J:255143 Rasouly HM, Kumar S, Chan S, Pisarek-Horowitz A, Sharma R, Xi QJ, Nishizaki Y, Higashi Y, Salant DJ, Maas RL, Lu W, Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease. Kidney Int. 2016 Dec;90(6):1262-1273
6	J:176236 Steigelman KA, Lelli A, Wu X, Gao J, Lin S, Piontek K, Wodarczyk C, Boletta A, Kim H, Qian F, Germino G, Geleoc GS, Holt JR, Zuo J, Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells. J Neurosci. 2011 Aug 24;31(34):12241-50
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2	J:158678 Tran U, Zakin L, Schweickert A, Agrawal R, Doger R, Blum M, De Robertis EM, Wessely O, The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity. Development. 2010 Apr;137(7):1107-16
3	J:153606 Wodarczyk C, Rowe I, Chiaravalli M, Pema M, Qian F, Boletta A, A novel mouse model reveals that polycystin-1 deficiency in ependyma and choroid plexus results in dysfunctional cilia and hydrocephalus. PLoS One. 2009;4(9):e7137
2*	J:164014 Woodward OM, Li Y, Yu S, Greenwell P, Wodarczyk C, Boletta A, Guggino WB, Qian F, Identification of a polycystin-1 cleavage product, P100, that regulates store operated ca entry through interactions with STIM1. PLoS One. 2010;5(8)
1	J:158762 Xia S, Li X, Johnson T, Seidel C, Wallace DP, Li R, Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development. 2010 Apr;137(7):1075-84
1*	J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
1*	J:164472 Yi T, Tan K, Cho SG, Wang Y, Luo J, Zhang W, Li D, Liu M, Regulation of embryonic kidney branching morphogenesis and glomerular development by KISS1 receptor (Gpr54) through NFAT2- and Sp1-mediated Bmp7 expression. J Biol Chem. 2010 Jun 4;285(23):17811-20
7	J:127628 Yu S, Hackmann K, Gao J, He X, Piontek K, Garcia Gonzalez MA, Menezes LF, Xu H, Germino GG, Zuo J, Qian F, Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18688-93