Gene Expression Literature Summary

• Symbol: Ren1
• Name: renin 1 structural
• ID: MGI:97898

45 matching records from 45 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)										1	1	1	3	1	3	3	3	2	4	2	7	1	13
In situ RNA (section)				1			2				1	1	1			1	2		1		1		7
In situ RNA (whole mount)											2
In situ reporter (knock in)														1		1							1
Northern blot											1				1								2
Western blot							1						2								1		3
RT-PCR	2	1	2	1	3	2	4	2	4	2	2	3	7	1	1	2	4	1	1	2	5		14
cDNA clones									1		1
RNase protection																							1
Primer Extension																							1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ren1  renin 1 structural   (Synonyms: Ren, Ren-1, Ren1c, Ren1d, Ren-A, Rn-1, Rnr)
Results	Reference
2	J:98922 Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM, Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Development. 2005 Jul;132(13):3045-54
7*	J:93500 Bouma GJ, Hart GT, Washburn LL, Recknagel AK, Eicher EM, Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development. Gene Expr Patterns. 2004 Nov;5(1):141-9
1*	J:183829 Correa SM, Washburn LL, Kahlon RS, Musson MC, Bouma GJ, Eicher EM, Albrecht KH, Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway. PLoS Genet. 2012 Apr;8(4):e1002569
8*	J:218046 Cuffe JS, Walton SL, Steane SE, Singh RR, Simmons DG, Moritz KM, The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. Placenta. 2014 Nov;35(11):953-61
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2*	J:65386 El-Dahr SS, Harrison-Bernard LM, Dipp S, Yosipiv IV, Meleg-Smith S, Bradykinin B2 null mice are prone to renal dysplasia: gene-environment interactions in kidney development. Physiol Genomics. 2000 Sep 8;3(3):121-31
2*	J:336175 Fuchs MAA, Schrankl J, Leupold C, Wagner C, Kurtz A, Broeker KA, Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice. Am J Physiol Renal Physiol. 2022 Mar 1;322(3):F295-F307
7	J:78461 Fuchs S, Germain S, Philippe J, Corvol P, Pinet F, Expression of renin in large arteries outside the kidney revealed by human renin promoter/LacZ transgenic mouse. Am J Pathol. 2002 Aug;161(2):717-25
4	J:243840 Gerl K, Steppan D, Fuchs M, Wagner C, Willam C, Kurtz A, Kurt B, Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development. Am J Pathol. 2017 Jul;187(7):1496-1511
1	J:334094 Gu X, Heinrich A, Li SY, DeFalco T, Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions. Nat Commun. 2023 Mar 15;14(1):1439
4*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
4	J:333395 Gunawardhana KL, Hong L, Rugira T, Uebbing S, Kucharczak J, Mehta S, Karunamuni DR, Cabera-Mendoza B, Gandotra N, Scharfe C, Polimanti R, Noonan JP, Mani A, A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension. J Clin Invest. 2023 Feb 15;133(4)
7	J:308884 Julien E, Biasch K, El Omar R, Freund JN, Gachet C, Lanza F, Tavian M, Renin-angiotensin system is involved in embryonic emergence of hematopoietic stem/progenitor cells. Stem Cells. 2021 May;39(5):636-649
2*	J:175301 Kitazawa T, Sato T, Nishiyama K, Asai R, Arima Y, Uchijima Y, Kurihara Y, Kurihara H, Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney. Gene Expr Patterns. 2011 Oct;11(7):371-7
3	J:152122 Kurtz L, Janssen-Bienhold U, Kurtz A, Wagner C, Connexin expression in renin-producing cells. J Am Soc Nephrol. 2009 Mar;20(3):506-12
2	J:227300 Lin EE, Pentz ES, Sequeira-Lopez ML, Gomez RA, Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling. Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R576-84
1	J:50064 Lindahl P, Hellstrom M, Kalen M, Karlsson L, Pekny M, Pekna M, Soriano P, Betsholtz C, Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli. Development. 1998 Sep;125(17):3313-22
4*	J:241798 Lo HF, Tsai CY, Chen CP, Wang LJ, Lee YS, Chen CY, Liang CT, Cheong ML, Chen H, Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion. J Pathol. 2017 Feb;241(3):324-336
4	J:153990 Machura K, Steppan D, Neubauer B, Alenina N, Coffman TM, Facemire CS, Hilgers KF, Eckardt KU, Wagner C, Kurtz A, Developmental renin expression in mice with a defective renin-angiotensin system. Am J Physiol Renal Physiol. 2009 Nov;297(5):F1371-80
1	J:327589 Madhavan SM, Konieczkowski M, Bruggeman LA, DeWalt M, Nguyen JK, O'Toole JF, Sedor JR, Essential role of Wtip in mouse development and maintenance of the glomerular filtration barrier. Am J Physiol Renal Physiol. 2022 Sep 1;323(3):F272-F287
2*	J:81347 Menke DB, Page DC, Sexually dimorphic gene expression in the developing mouse gonad. Gene Expr Patterns. 2002 Dec;2(3-4):359-67
2	J:321844 Mochida Y, Ochiai K, Nagase T, Nonomura K, Akimoto Y, Fukuhara H, Sakai T, Matsumura G, Yamaguchi Y, Nagase M, Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells. Sci Rep. 2022 Mar 10;12(1):4197
1	J:154029 Munger SC, Aylor DL, Syed HA, Magwene PM, Threadgill DW, Capel B, Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. Genes Dev. 2009 Nov 1;23(21):2521-36
1	J:92201 Natoli TA, Alberta JA, Bortvin A, Taglienti ME, Menke DB, Loring J, Jaenisch R, Page DC, Housman DE, Kreidberg JA, Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. Dev Biol. 2004 Apr 15;268(2):429-40
8	J:173799 Neubauer B, Machura K, Schnermann J, Wagner C, Renin expression in large renal vessels during fetal development depends on functional {beta}1/{beta}2-adrenergic receptors. Am J Physiol Renal Physiol. 2011 Jul;301(1):F71-7
6	J:72077 Pentz ES, Lopez ML, Kim HS, Carretero O, Smithies O, Gomez RA, Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1d. Physiol Genomics. 2001 Jun 6;6(1):45-55
14	J:67267 Perera EM, Martin H, Seeherunvong T, Kos L, Hughes IA, Hawkins JR, Berkovitz GD, Tescalcin, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, Col9a3, and renin are expressed in the mouse testis during the early stages of gonadal differentiation. Endocrinology. 2001 Jan;142(1):455-63
1	J:273075 Phua YL, Chu JY, Marrone AK, Bodnar AJ, Sims-Lucas S, Ho J, Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival. Physiol Rep. 2015 Oct;3(10)
2*	J:308609 Sararols P, Stevant I, Neirijnck Y, Rebourcet D, Darbey A, Curley MK, Kuhne F, Dermitzakis E, Smith LB, Nef S, Specific Transcriptomic Signatures and Dual Regulation of Steroidogenesis Between Fetal and Adult Mouse Leydig Cells. Front Cell Dev Biol. 2021;9:695546
11	J:127938 Sauter A, Machura K, Neubauer B, Kurtz A, Wagner C, Development of renin expression in the mouse kidney. Kidney Int. 2008 Jan;73(1):43-51
1	J:137729 Schuhmacher AJ, Guerra C, Sauzeau V, Canamero M, Bustelo XR, Barbacid M, A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. J Clin Invest. 2008 Jun;118(6):2169-79
5	J:70875 Sequeira Lopez ML, Pentz ES, Robert B, Abrahamson DR, Gomez RA, Embryonic origin and lineage of juxtaglomerular cells. Am J Physiol Renal Physiol. 2001 Aug;281(2):F345-56
3	J:227281 Sequeira-Lopez ML, Nagalakshmi VK, Li M, Sigmund CD, Gomez RA, Vascular versus tubular renin: role in kidney development. Am J Physiol Regul Integr Comp Physiol. 2015 Sep 15;309(6):R650-7
5*	J:160194 Shaw L, Johnson PA, Kimber SJ, Gene expression profiling of the developing mouse kidney and embryo. In Vitro Cell Dev Biol Anim. 2010 Feb;46(2):155-65
2*	J:36423 Sigmund CD, Jones CA, Mullins JJ, Kim U, Gross KW, Expression of murine renin genes in subcutaneous connective tissue. Proc Natl Acad Sci U S A. 1990 Oct;87(20):7993-7
3	J:263733 Song R, Lopez MLSS, Yosypiv IV, Foxd1 is an upstream regulator of the renin-angiotensin system during metanephric kidney development. Pediatr Res. 2017 Nov;82(5):855-862
1	J:164624 Takabatake Y, Sugiyama T, Kohara H, Matsusaka T, Kurihara H, Koni PA, Nagasawa Y, Hamano T, Matsui I, Kawada N, Imai E, Nagasawa T, Rakugi H, Isaka Y, The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature. J Am Soc Nephrol. 2009 Aug;20(8):1714-23
1*	J:106710 Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C, Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J. 2006 Mar 8;25(5):1160-74
1	J:320196 Tanigawa S, Tanaka E, Miike K, Ohmori T, Inoue D, Cai CL, Taguchi A, Kobayashi A, Nishinakamura R, Generation of the organotypic kidney structure by integrating pluripotent stem cell-derived renal stroma. Nat Commun. 2022 Feb 1;13(1):611
1	J:330616 Wang F, Ngo J, Li Y, Liu H, Chen CH, Saifudeen Z, Sequeira-Lopez MLS, El-Dahr SS, Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia. Epigenetics. 2021 Nov;16(11):1235-1250
1	J:317791 Wilkinson LJ, Neal CS, Singh RR, Sparrow DB, Kurniawan ND, Ju A, Grieve SM, Dunwoodie SL, Moritz KM, Little MH, Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric beta-catenin signaling. Kidney Int. 2015 May;87(5):975-83
5	J:74016 Xia Y, Wen H, Prashner HR, Chen R, Inagami T, Catanzaro DF, Kellems RE, Pregnancy-induced changes in renin gene expression in mice. Biol Reprod. 2002 Jan;66(1):135-43
3*	J:169129 Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD, Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension. 2009 Dec;54(6):1240-7
1	J:320691 Yadav VK, Berger JM, Singh P, Nagarajan P, Karsenty G, Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse. J Clin Invest. 2022 Feb 15;132(4):e153752
1	J:275548 Yosypiv IV, Sequeira-Lopez MLS, Song R, De Goes Martini A, Stromal prorenin receptor is critical for normal kidney development. Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R640-R650