Gene Expression Literature Summary

• Symbol: Scn2a
• Name: sodium channel, voltage-gated, type II, alpha
• ID: MGI:98248

11 matching records from 11 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E12.5	E13	E14.5	E15	E15.5	E16.5	E18	E18.5	P
Immunohistochemistry (section)									1
In situ RNA (section)			2		1		1		2
Northern blot				1					1
Western blot			1			1		1	3
RT-PCR	1	1	1	1		1		1	4

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Scn2a  sodium channel, voltage-gated, type II, alpha   (Synonyms: A230052E19Rik, Nav1.2, Scn2a1)
Results	Reference
1*	J:90115 Albrieux M, Platel JC, Dupuis A, Villaz M, Moody WJ, Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex. J Neurosci. 2004 Feb 18;24(7):1719-25
2	J:98945 Ballas N, Grunseich C, Lu DD, Speh JC, Mandel G, REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell. 2005 May 20;121(4):645-57
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2*	J:109097 Haufe V, Camacho JA, Dumaine R, Gunther B, Bollensdorff C, von Banchet GS, Benndorf K, Zimmer T, Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart. J Physiol. 2005 May 1;564(Pt 3):683-96
1	J:187349 Hu XL, Cheng X, Cai L, Tan GH, Xu L, Feng XY, Lu TJ, Xiong H, Fei J, Xiong ZQ, Conditional deletion of NRSF in forebrain neurons accelerates epileptogenesis in the kindling model. Cereb Cortex. 2011 Sep;21(9):2158-65
5	J:240247 Notwell JH, Heavner WE, Darbandi SF, Katzman S, McKenna WL, Ortiz-Londono CF, Tastad D, Eckler MJ, Rubenstein JL, McConnell SK, Chen B, Bejerano G, TBR1 regulates autism risk genes in the developing neocortex. Genome Res. 2016 Aug;26(8):1013-22
6	J:268565 Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, Miura E, Mazaki E, Ernst SJ, Cao D, Ohtani H, Itohara S, Yanagawa Y, Montal M, Yuzaki M, Inoue Y, Hensch TK, Noebels JL, Yamakawa K, Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice. Commun Biol. 2018;1
1	J:340358 Oh H, Lee S, Oh Y, Kim S, Kim YS, Yang Y, Choi W, Yoo YE, Cho H, Lee S, Yang E, Koh W, Won W, Kim R, Lee CJ, Kim H, Kang H, Kim JY, Ku T, Paik SB, Kim E, Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice. Nat Commun. 2023 Jun 15;14(1):3547
1*	J:328858 Poeta L, Padula A, Attianese B, Valentino M, Verrillo L, Filosa S, Shoubridge C, Barra A, Schwartz CE, Christensen J, van Bokhoven H, Helin K, Lioi MB, Collombat P, Gecz J, Altucci L, Di Schiavi E, Miano MG, Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders. Hum Mol Genet. 2019 Dec 15;28(24):4089-4102
2*	J:3447 Sashihara S, Yanagihara N, Kobayashi H, Izumi F, Tsuji S, Murai Y, Mita T, Overproduction of voltage-dependent Na+ channels in the developing brain of genetically seizure-susceptible E1 mice. Neuroscience. 1992;48(2):285-91
3	J:279152 Shin W, Kweon H, Kang R, Kim D, Kim K, Kang M, Kim SY, Hwang SN, Kim JY, Yang E, Kim H, Kim E, Scn2a Haploinsufficiency in Mice Suppresses Hippocampal Neuronal Excitability, Excitatory Synaptic Drive, and Long-Term Potentiation, and Spatial Learning and Memory. Front Mol Neurosci. 2019;12:145