Gene Expression Literature Summary

• Symbol: Scn5a
• Name: sodium channel, voltage-gated, type V, alpha
• ID: MGI:98251

37 matching records from 37 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15	E15.5	E16.5	E17.5	E18.5	E19.5	E	P
Immunohistochemistry (section)	1	1		1	2	2	2			1	1	1		1	7
In situ RNA (section)				1		1	5		1		1	2			3
Western blot															5
RT-PCR		2	4	3	4	3	3	1	1	1	3	1	1		19

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Scn5a  sodium channel, voltage-gated, type V, alpha   (Synonyms: mH1, Nav1.5, Nav1.5c, SkM2)
Results	Reference
1	J:171828 Aanhaanen WT, Boukens BJ, Sizarov A, Wakker V, de Gier-de Vries C, van Ginneken AC, Moorman AF, Coronel R, Christoffels VM, Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice. J Clin Invest. 2011 Feb 1;121(2):534-44
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2	J:280846 Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Borggrefe M, Schimpf R, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kaab S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bezieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Le Marec H, Wilde AA, Probst V, Schott JJ, Dina C, Redon R, Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nat Genet. 2013 Sep;45(9):1044-9
3	J:213278 Boukens BJ, Sylva M, de Gier-de Vries C, Remme CA, Bezzina CR, Christoffels VM, Coronel R, Reduced sodium channel function unmasks residual embryonic slow conduction in the adult right ventricular outflow tract. Circ Res. 2013 Jul 5;113(2):137-41
1	J:161206 Chen F, De Diego C, Chang MG, McHarg JL, John S, Klitzner TS, Weiss JN, Atrioventricular conduction and arrhythmias at the initiation of beating in embryonic mouse hearts. Dev Dyn. 2010 Jul;239(7):1941-9
2	J:172665 Chinchilla A, Daimi H, Lozano-Velasco E, Dominguez JN, Caballero R, Delpon E, Tamargo J, Cinca J, Hove-Madsen L, Aranega AE, Franco D, PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis. Circ Cardiovasc Genet. 2011 Jun;4(3):269-79
8	J:211437 de la Rosa AJ, Dominguez JN, Sedmera D, Sankova B, Hove-Madsen L, Franco D, Aranega AE, Functional suppression of Kcnq1 leads to early sodium channel remodelling and cardiac conduction system dysmorphogenesis. Cardiovasc Res. 2013 Jun 1;98(3):504-14
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
13	J:161910 Dominguez JN, de la Rosa A, Navarro F, Franco D, Aranega AE, Tissue distribution and subcellular localization of the cardiac sodium channel during mouse heart development. Cardiovasc Res. 2008 Apr 1;78(1):45-52
1*	J:98707 Ferguson DA, Chiang JT, Richardson JA, Graff J, eXPRESSION: An in silico tool to predict patterns of gene expression. Gene Expr Patterns. 2005 Jun;5(5):619-28
2	J:231297 Furtado MB, Wilmanns JC, Chandran A, Tonta M, Biben C, Eichenlaub M, Coleman HA, Berger S, Bouveret R, Singh R, Harvey RP, Ramialison M, Pearson JT, Parkington HC, Rosenthal NA, Costa MW, A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels. Differentiation. 2016 Jan-Mar;91(1-3):29-41
1	J:189007 Gaborit N, Sakuma R, Wylie JN, Kim KH, Zhang SS, Hui CC, Bruneau BG, Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology. Development. 2012 Nov;139(21):4007-19
1	J:299975 Gharibeh L, Yamak A, Whitcomb J, Lu A, Joyal M, Komati H, Liang W, Fiset C, Nemer M, GATA6 is a regulator of sinus node development and heart rhythm. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2007322118
1	J:252755 Gillers BS, Chiplunkar A, Aly H, Valenta T, Basler K, Christoffels VM, Efimov IR, Boukens BJ, Rentschler S, Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties. Circ Res. 2015 Jan 30;116(3):398-406
1	J:355142 Gomez-Del Arco P, Isern J, Jimenez-Carretero D, Lopez-Maderuelo D, Pineiro-Sabaris R, El Abdellaoui-Soussi F, Torroja C, Vera-Pedrosa ML, Grima-Terren M, Benguria A, Simon-Chica A, Queiro-Palou A, Dopazo A, Sanchez-Cabo F, Jalife J, de la Pompa JL, Filgueiras-Rama D, Munoz-Canoves P, Redondo JM, The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and ventricular conduction system development. Nat Commun. 2024 Oct 4;15(1):8602
2	J:250657 Greulich F, Trowe MO, Leffler A, Stoetzer C, Farin HF, Kispert A, Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature. J Mol Cell Cardiol. 2016 Aug;97:140-9
2*	J:186617 Hao MM, Lomax AE, McKeown SJ, Reid CA, Young HM, Bornstein JC, Early development of electrical excitability in the mouse enteric nervous system. J Neurosci. 2012 Aug 8;32(32):10949-60
2*	J:119550 Harrell MD, Harbi S, Hoffman JF, Zavadil J, Coetzee WA, Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Physiol Genomics. 2007 Feb 12;28(3):273-83
2*	J:109097 Haufe V, Camacho JA, Dumaine R, Gunther B, Bollensdorff C, von Banchet GS, Benndorf K, Zimmer T, Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart. J Physiol. 2005 May 1;564(Pt 3):683-96
2	J:121230 Hoogaars WM, Engel A, Brons JF, Verkerk AO, de Lange FJ, Wong LY, Bakker ML, Clout DE, Wakker V, Barnett P, Ravesloot JH, Moorman AF, Verheijck EE, Christoffels VM, Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev. 2007 May 1;21(9):1098-112
2	J:263568 Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH, LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Cardiovasc Res. 2015 Oct 1;108(1):197-208
1	J:347631 Li C, Zhang Y, Shen J, Bao H, Zhao Y, Li D, Li S, Liu Y, Yang J, Zhou Z, Gao K, Zhao L, Pei Y, Lu Y, Pan Z, Cai B, Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes. Adv Sci (Weinh). 2024 Mar;11(11):e2305992
2	J:293668 Li H, Li D, Wang Y, Huang Z, Xu J, Yang T, Wang L, Tang Q, Cai CL, Huang H, Zhang Y, Chen Y, Nkx2-5 defines a subpopulation of pacemaker cells and is essential for the physiological function of the sinoatrial node in mice. Development. 2019 Jul 25;146(14):dev178145
3	J:281596 Man JCK, Mohan RA, Boogaard MVD, Hilvering CRE, Jenkins C, Wakker V, Bianchi V, Laat W, Barnett P, Boukens BJ, Christoffels VM, An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo. Nat Commun. 2019 Oct 30;10(1):4943
1	J:237617 Menendez-Montes I, Escobar B, Palacios B, Gomez MJ, Izquierdo-Garcia JL, Flores L, Jimenez-Borreguero LJ, Aragones J, Ruiz-Cabello J, Torres M, Martin-Puig S, Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation. Dev Cell. 2016 Dec 19;39(6):724-739
2	J:273025 Moreau JLM, Kesteven S, Martin EMMA, Lau KS, Yam MX, O'Reilly VC, Del Monte-Nieto G, Baldini A, Feneley MP, Moon AM, Harvey RP, Sparrow DB, Chapman G, Dunwoodie SL, Gene-environment interaction impacts on heart development and embryo survival. Development. 2019 Feb 20;146(4):dev172957
1*	J:293579 Moumne O, Chowdhurry R, Doll C, Pereira N, Hashimi M, Grindrod T, Dollar JJ, Riva A, Kasahara H, Mechanism Sharing Between Genetic and Gestational Hypoxia-Induced Cardiac Anomalies. Front Cardiovasc Med. 2018;5:100
1	J:268565 Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, Miura E, Mazaki E, Ernst SJ, Cao D, Ohtani H, Itohara S, Yanagawa Y, Montal M, Yuzaki M, Inoue Y, Hensch TK, Noebels JL, Yamakawa K, Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice. Commun Biol. 2018;1
4	J:152116 Remme CA, Verkerk AO, Hoogaars WM, Aanhaanen WT, Scicluna BP, Annink C, van den Hoff MJ, Wilde AA, van Veen TA, Veldkamp MW, de Bakker JM, Christoffels VM, Bezzina CR, The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium. Basic Res Cardiol. 2009 Sep;104(5):511-22
1	J:314288 Samal E, Evangelista M, Galang G, Srivastava D, Zhao Y, Vedantham V, Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System. Front Physiol. 2019;10:235
1*	J:276621 Semmler J, Kormann J, Srinivasan SP, Koster A, Salzer D, Reppel M, Hescheler J, Plomann M, Nguemo F, Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart. Pharmacol Res. 2018 Feb;128:200-210
1	J:289625 Shawer H, Aiyelaagbe E, Clowes C, Lean SC, Lu Y, Kadler KE, Kerby A, Dilworth MR, Hentges KE, Heazell AEP, A missense mutation of ErbB2 produces a novel mouse model of stillbirth associated with a cardiac abnormality but lacking abnormalities of placental structure. PLoS One. 2020;15(6):e0233007
3	J:239700 Shekhar A, Lin X, Liu FY, Zhang J, Mo H, Bastarache L, Denny JC, Cox NJ, Delmar M, Roden DM, Fishman GI, Park DS, Transcription factor ETV1 is essential for rapid conduction in the heart. J Clin Invest. 2016 Dec 01;126(12):4444-4459
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
6	J:190769 van den Boogaard M, Wong LY, Tessadori F, Bakker ML, Dreizehnter LK, Wakker V, Bezzina CR, 't Hoen PA, Bakkers J, Barnett P, Christoffels VM, Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer. J Clin Invest. 2012 Jul 2;122(7):2519-30
1	J:293906 van Weerd JH, Mohan RA, van Duijvenboden K, Hooijkaas IB, Wakker V, Boukens BJ, Barnett P, Christoffels VM, Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction. Elife. 2020 Jul 16;9:e56697
1	J:251389 Zakariyah AF, Rajgara RF, Veinot JP, Skerjanc IS, Burgon PG, Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit. J Mol Cell Cardiol. 2017 Apr;105:89-98