Gene Expression Literature Summary

• Symbol: Shc1
• Name: src homology 2 domain-containing transforming protein C1
• ID: MGI:98296

16 matching records from 16 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E9	E9.5	E10	E10.5	E11.5	E12	E12.5	E13.5	E14.5	E15.5	E16	E16.5	E18.5	E	P
Immunohistochemistry (section)											1		1	1		1			1	1		1
In situ RNA (section)										1		1			1	1						1
Immunohistochemistry (whole mount)	1	1	1	1	1	1	1															1
In situ RNA (whole mount)								1		1
Northern blot								1						1			1					1
Western blot	1	1			1		1	1	1	1				1		1	1			1		4
RT-PCR	1	1			1		1								1	1					1	1
cDNA clones																		2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Shc1  src homology 2 domain-containing transforming protein C1   (Synonyms: p66, p66shc, ShcA)
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:39401 Blaikie P, Immanuel D, Wu J, Li N, Yajnik V, Margolis B, A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. J Biol Chem. 1994 Dec 23;269(51):32031-4
1	J:183920 Chen J, Lai F, Niswander L, The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 2012 Apr 15;26(8):803-15
14*	J:321237 Edwards NA, Watson AJ, Betts DH, P66Shc, a key regulator of metabolism and mitochondrial ROS production, is dysregulated by mouse embryo culture. Mol Hum Reprod. 2016 Sep;22(9):634-47
2	J:185833 Fernandes R, Tsuda C, Perumalsamy AL, Naranian T, Chong J, Acton BM, Tong ZB, Nelson LM, Jurisicova A, NLRP5 mediates mitochondrial function in mouse oocytes and embryos. Biol Reprod. 2012;86(5):138, 1-10
4*	J:166965 Hawley SP, Wills MK, Rabalski AJ, Bendall AJ, Jones N, Expression patterns of ShcD and Shc family adaptor proteins during mouse embryonic development. Dev Dyn. 2011 Jan;240(1):221-31
1	J:104361 Jiang ST, Chiou YY, Wang E, Lin HK, Lin YT, Chi YC, Wang CK, Tang MJ, Li H, Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of pkd1. Am J Pathol. 2006 Jan;168(1):205-20
1	J:91006 Koponen E, Voikar V, Riekki R, Saarelainen T, Rauramaa T, Rauvala H, Taira T, Castren E, Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning. Mol Cell Neurosci. 2004 May;26(1):166-81
1	J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
7	J:62182 Lai KM, Pawson T, The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev. 2000 May 1;14(9):1132-45
4	J:111058 McFarland KN, Wilkes SR, Koss SE, Ravichandran KS, Mandell JW, Neural-specific inactivation of ShcA results in increased embryonic neural progenitor apoptosis and microencephaly. J Neurosci. 2006 Jul 26;26(30):7885-97
7*	J:98227 Miyamoto Y, Chen L, Sato M, Sokabe M, Nabeshima T, Pawson T, Sakai R, Mori N, Hippocampal synaptic modulation by the phosphotyrosine adapter protein ShcC/N-Shc via interaction with the NMDA receptor. J Neurosci. 2005 Feb 16;25(7):1826-35
3	J:217881 Mlih M, Host L, Martin S, Niederhoffer N, Monassier L, Terrand J, Messaddeq N, Radke M, Gotthardt M, Bruban V, Kober F, Bernard M, Canet-Soulas E, Abt-Jijon F, Boucher P, Matz RL, The Src Homology and Collagen A (ShcA) Adaptor Protein Is Required for the Spatial Organization of the Costamere/Z-disk Network during Heart Development. J Biol Chem. 2015 Jan 23;290(4):2419-30
1	J:43710 Okada S, Kao AW, Ceresa BP, Blaikie P, Margolis B, Pessin JE, The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway. J Biol Chem. 1997 Oct 31;272(44):28042-9
2*	J:66508 Sakai R, Henderson JT, O'Bryan JP, Elia AJ, Saxton TM, Pawson T, The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons. Neuron. 2000 Dec;28(3):819-33
1	J:121631 Xie L, Chen H, Overbeek PA, Reneker LW, Elevated insulin signaling disrupts the growth and differentiation pattern of the mouse lens. Mol Vis. 2007;13:397-407