Gene Expression Literature Summary

• Symbol: Sim2
• Name: single-minded family bHLH transcription factor 2
• ID: MGI:98307

36 matching records from 36 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18.5	E19	E	P
In situ RNA (section)				2	1	2	1	7	3	9	2	8		4		7		2	3			2		1	5
In situ RNA (whole mount)		2	2	3	1	7		9	1	2		1	1	1				2
Northern blot										2															3
RT-PCR	1			1		1		3	1	3		4		1	1	1	1	2	2	1	1	2	1		6
cDNA clones										3											1				1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sim2  single-minded family bHLH transcription factor 2   (Synonyms: bHLHe15)
Results	Reference
2	J:248734 Bolt CC, Negi S, Guimaraes-Camboa N, Zhang H, Troy JM, Lu X, Kispert A, Evans SM, Stubbs L, Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate. PLoS One. 2016;11(4):e0154413
1*	J:142800 Brunskill EW, Aronow BJ, Georgas K, Rumballe B, Valerius MT, Aronow J, Kaimal V, Jegga AG, Yu J, Grimmond S, McMahon AP, Patterson LT, Little MH, Potter SS, Atlas of gene expression in the developing kidney at microanatomic resolution. (Erratum: Dev Cell 2009; 16:482). Dev Cell. 2008 Nov;15(5):781-91
3*	J:119269 Caqueret A, Boucher F, Michaud JL, Laminar organization of the early developing anterior hypothalamus. Dev Biol. 2006 Oct 1;298(1):95-106
6*	J:143023 Coumailleau P, Duprez D, Sim1 and Sim2 expression during chick and mouse limb development. Int J Dev Biol. 2009;53(1):149-57
3*	J:35345 Ema M, Morita M, Ikawa S, Tanaka M, Matsuda Y, Gotoh O, Saijoh Y, Fujii H, Hamada H, Kikuchi Y, Fujii-Kuriyama Y, Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis. Mol Cell Biol. 1996 Oct;16(10):5865-75
10*	J:30907 Ema M, Suzuki M, Morita M, Hirose K, Sogawa K, Matsuda Y, Gotoh O, Saijoh Y, Fujii H, Hamada H, Fujii-Kuriyama Y, cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development, and chromosome localization. Biochem Biophys Res Commun. 1996 Jan 17;218(2):588-94
4	J:64678 Epstein DJ, Martinu L, Michaud JL, Losos KM, Fan C, Joyner AL, Members of the bHLH-PAS family regulate shh transcription in forebrain regions of the mouse CNS. Development. 2000 Nov;127(21):4701-9
12*	J:31897 Fan CM, Kuwana E, Bulfone A, Fletcher CF, Copeland NG, Jenkins NA, Crews S, Martinez S, Puelles L, Rubenstein JL, Tessier-Lavigne M, Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome. Mol Cell Neurosci. 1996 Jan;7(1):1-16
3*	J:80501 Gitton Y, Dahmane N, Baik S, Ruiz I Altaba A, Neidhardt L, Scholze M, Herrmann BG, Kahlem P, Benkahla A, Schrinner S, Yildirimman R, Herwig R, Lehrach H, Yaspo ML, A gene expression map of human chromosome 21 orthologues in the mouse. Nature. 2002 Dec 5;420(6915):586-90
6	J:76787 Goshu E, Jin H, Fasnacht R, Sepenski M, Michaud JL, Fan CM, Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants. Mol Cell Biol. 2002 Jun;22(12):4147-57
4	J:89548 Goshu E, Jin H, Lovejoy J, Marion JF, Michaud JL, Fan CM, Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus. Mol Endocrinol. 2004 May;18(5):1251-62
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
2*	J:41401 Grindley JC, Hargett LK, Hill RE, Ross A, Hogan BL, Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon. Mech Dev. 1997 Jun;64(1-2):111-26
1*	J:161785 Gu WX, Kania A, Identification of genes controlled by LMX1B in E13.5 mouse limbs. Dev Dyn. 2010 Aug;239(8):2246-55
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
5	J:184003 Havis E, Coumailleau P, Bonnet A, Bismuth K, Bonnin MA, Johnson R, Fan CM, Relaix F, Shi DL, Duprez D, Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis. Development. 2012 Jun;139(11):1910-20
2	J:187966 Jeong J, Cesario J, Zhao Y, Burns L, Westphal H, Rubenstein JL, Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate. Dev Dyn. 2012 Nov;241(11):1757-69
3	J:213620 Kong P, Racedo SE, Macchiarulo S, Hu Z, Carpenter C, Guo T, Wang T, Zheng D, Morrow BE, Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication. Hum Mol Genet. 2014 Aug 15;23(16):4215-31
10*	J:134028 Levesque BM, Zhou S, Shan L, Johnston P, Kong Y, Degan S, Sunday ME, NPAS1 regulates branching morphogenesis in embryonic lung. Am J Respir Cell Mol Biol. 2007 Apr;36(4):427-34
5	J:104419 Marion JF, Yang C, Caqueret A, Boucher F, Michaud JL, Sim1 and Sim2 are required for the correct targeting of mammillary body axons. Development. 2005 Dec;132(24):5527-37
1*	J:36064 Mastick GS, Fan CM, Tessier-Lavigne M, Serbedzija GN, McMahon AP, Easter SS Jr, Early deletion of neuromeres in Wnt-1-/- mutant mice: evaluation by morphological and molecular markers. J Comp Neurol. 1996 Oct 14;374(2):246-58
6*	J:33928 Moffett P, Dayo M, Reece M, McCormick MK, Pelletier J, Characterization of msim, a murine homologue of the Drosophila sim transcription factor. Genomics. 1996 Jul 1;35(1):144-55
5*	J:80366 Ooe N, Saito K, Mikami N, Nakatuka I, Kaneko H, Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression. Mol Cell Biol. 2004 Jan;24(2):608-16
7*	J:80502 Reymond A, Marigo V, Yaylaoglu MB, Leoni A, Ucla C, Scamuffa N, Caccioppoli C, Dermitzakis ET, Lyle R, Banfi S, Eichele G, Antonarakis SE, Ballabio A, Human chromosome 21 gene expression atlas in the mouse. Nature. 2002 Dec 5;420(6915):582-6
3*	J:160194 Shaw L, Johnson PA, Kimber SJ, Gene expression profiling of the developing mouse kidney and embryo. In Vitro Cell Dev Biol Anim. 2010 Feb;46(2):155-65
2	J:239547 Sivakamasundari V, Kraus P, Sun W, Hu X, Lim SL, Prabhakar S, Lufkin T, A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development. Biol Open. 2017 Feb 15;6(2):187-199
1	J:182258 Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I, Loots GG, Global gene expression analysis of murine limb development. PLoS One. 2011;6(12):e28358
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1*	J:293200 Vanyai HK, Garnham A, May RE, McRae HM, Collin C, Wilcox S, Smyth GK, Thomas T, Voss AK, MOZ directs the distal-less homeobox gene expression program during craniofacial development. Development. 2019 Jul 24;146(14):dev175042
3*	J:62599 Vialard F, Toyama K, Vernoux S, Carlson EJ, Epstein CJ, Sinet PM, Rahmani Z, Overexpression of mSim2 gene in the zona limitans of the diencephalon of segmental trisomy 16 Ts1Cje fetuses, a mouse model for trisomy 21: a novel whole-mount based RNA hybridization study. Brain Res Dev Brain Res. 2000 May 11;121(1):73-8
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
3	J:65759 Wang W, Lufkin T, The murine otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus. Dev Biol. 2000 Nov 15;227(2):432-49
1	J:287549 Xu J, Liu H, Lan Y, Park JS, Jiang R, Genome-wide Identification of Foxf2 Target Genes in Palate Development. J Dent Res. 2020 Apr;99(4):463-471
1	J:326661 Xu P, He H, Gao Q, Zhou Y, Wu Z, Zhang X, Sun L, Hu G, Guan Q, You Z, Zhang X, Zheng W, Xiong M, Chen Y, Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson's disease model. J Clin Invest. 2022 Jul 15;132(14):e156768
6*	J:33820 Yamaki A, Noda S, Kudoh J, Shindoh N, Maeda H, Minoshima S, Kawasaki K, Shimizu Y, Shimizu N, The mammalian single-minded (SIM) gene: mouse cDNA structure and diencephalic expression indicate a candidate gene for Down syndrome. Genomics. 1996 Jul 1;35(1):136-43
2*	J:344941 Yan F, Suzuki A, Iwaya C, Pei G, Chen X, Yoshioka H, Yu M, Simon LM, Iwata J, Zhao Z, Single-cell multiomics decodes regulatory programs for mouse secondary palate development. Nat Commun. 2024 Jan 27;15(1):821