Gene Expression Literature Summary

• Symbol: Sox7
• Name: SRY (sex determining region Y)-box 7
• ID: MGI:98369

54 matching records from 54 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E2.5	E3	E3.5	E4	E4.5	E5.5	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)					1	1	1	1			1		2		2		4		1		2	1	3		2		1			1	3
In situ RNA (section)											2		2		2		3		3		2	5	3		3				2		3
Immunohistochemistry (whole mount)							2						1		1		2						1								3
In situ RNA (whole mount)											2	1	4	1	3		1				2	1			2
In situ reporter (knock in)											1						3						2				2		1		2
Northern blot																															1
Western blot																	1
RT-PCR	2	1	2	1	2	1	2	1	1	1	1	1			3	1	1	1	4	1	3	2		1	3	1		1	1	1	9
cDNA clones													1										1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sox7  SRY (sex determining region Y)-box 7
Results	Reference
2	J:163855 Alder O, Lavial F, Helness A, Brookes E, Pinho S, Chandrashekran A, Arnaud P, Pombo A, O'Neill L, Azuara V, Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment. Development. 2010 Aug 1;137(15):2483-92
5	J:269508 Alonso-Martin S, Aurade F, Mademtzoglou D, Rochat A, Zammit PS, Relaix F, SOXF factors regulate murine satellite cell self-renewal and function through inhibition of beta-catenin activity. Elife. 2018 Jun 8;7:e26039
1*	J:296653 Armfield BA, Seifert AW, Zheng Z, Merton EM, Rock JR, Lopez MC, Baker HV, Cohn MJ, Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium. J Urol. 2016 Oct;196(4):1295-302
4	J:170416 Artus J, Piliszek A, Hadjantonakis AK, The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev Biol. 2011 Feb 15;350(2):393-404
4	J:355327 Blucher RO, Lim RS, Ritchie ME, Western PS, VEGF-dependent testicular vascularisation involves MEK1/2 signalling and the essential angiogenesis factors, SOX7 and SOX17. BMC Biol. 2024 Oct 1;22(1):222
6	J:219394 Boroviak T, Loos R, Bertone P, Smith A, Nichols J, The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
1	J:353339 Butts JC, Wu SR, Durham MA, Dhindsa RS, Revelli JP, Ljungberg MC, Saulnier O, McLaren ME, Taylor MD, Zoghbi HY, A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 Aug 19;59(16):2171-2188.e7
6	J:333725 Chiang IKN, Graus MS, Kirschnick N, Davidson T, Luu W, Harwood R, Jiang K, Li B, Wong YY, Moustaqil M, Lesieur E, Skoczylas R, Kouskoff V, Kazenwadel J, Arriola-Martinez L, Sierecki E, Gambin Y, Alitalo K, Kiefer F, Harvey NL, Francois M, The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner. EMBO J. 2023 Mar 1;42(5):e109032
3*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
1	J:198502 Clarke RL, Yzaguirre AD, Yashiro-Ohtani Y, Bondue A, Blanpain C, Pear WS, Speck NA, Keller G, The expression of Sox17 identifies and regulates haemogenic endothelium. Nat Cell Biol. 2013 May;15(5):502-10
1	J:206194 Corada M, Orsenigo F, Morini MF, Pitulescu ME, Bhat G, Nyqvist D, Breviario F, Conti V, Briot A, Iruela-Arispe ML, Adams RH, Dejana E, Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat Commun. 2013;4:2609
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
1	J:198640 Frum T, Halbisen MA, Wang C, Amiri H, Robson P, Ralston A, Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst. Dev Cell. 2013 Jun 24;25(6):610-22
4	J:155476 Gandillet A, Serrano AG, Pearson S, Lie-A-Ling M, Lacaud G, Kouskoff V, Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification. Blood. 2009 Nov 26;114(23):4813-22
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
3*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
2*	J:186535 Herriges JC, Yi L, Hines EA, Harvey JF, Xu G, Gray PA, Ma Q, Sun X, Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
6	J:306193 Hong N, Zhang E, Xie H, Jin L, Zhang Q, Lu Y, Chen AF, Yu Y, Zhou B, Chen S, Yu Y, Sun K, The transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling. Cell Death Dis. 2021 Apr 12;12(4):393
3	J:150354 Hosking B, Francois M, Wilhelm D, Orsenigo F, Caprini A, Svingen T, Tutt D, Davidson T, Browne C, Dejana E, Koopman P, Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice. Development. 2009 Jul;136(14):2385-91
6	J:265463 Igarashi H, Uemura M, Hiramatsu R, Hiramatsu R, Segami S, Pattarapanawan M, Hirate Y, Yoshimura Y, Hashimoto H, Higashiyama H, Sumitomo H, Kurohmaru M, Saijoh Y, Suemizu H, Kanai-Azuma M, Kanai Y, Sox17 is essential for proper formation of the marginal zone of extraembryonic endoderm adjacent to a developing mouse placental disk. Biol Reprod. 2018 Sep 1;99(3):578-589
2	J:254511 Inoue K, Hirose M, Inoue H, Hatanaka Y, Honda A, Hasegawa A, Mochida K, Ogura A, The Rodent-Specific MicroRNA Cluster within the Sfmbt2 Gene Is Imprinted and Essential for Placental Development. Cell Rep. 2017 May 2;19(5):949-956
3*	J:75946 Kanai-Azuma M, Kanai Y, Gad JM, Tajima Y, Taya C, Kurohmaru M, Sanai Y, Yonekawa H, Yazaki K, Tam PP, Hayashi Y, Depletion of definitive gut endoderm in Sox17-null mutant mice. Development. 2002 May;129(10):2367-79
5*	J:229536 Kawasaki K, Kawasaki M, Watanabe M, Idrus E, Nagai T, Oommen S, Maeda T, Hagiwara N, Que J, Sharpe PT, Ohazama A, Expression of Sox genes in tooth development. Int J Dev Biol. 2015;59(10-12):471-8
5	J:251608 Kim K, Kim IK, Yang JM, Lee E, Koh BI, Song S, Park J, Lee S, Choi C, Kim JW, Kubota Y, Koh GY, Kim I, SoxF Transcription Factors Are Positive Feedback Regulators of VEGF Signaling. Circ Res. 2016 Sep 16;119(7):839-52
1	J:222397 Kulinski TM, Casari MR, Guenzl PM, Wenzel D, Andergassen D, Hladik A, Datlinger P, Farlik M, Theussl HC, Penninger JM, Knapp S, Bock C, Barlow DP, Hudson QJ, Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Dev Biol. 2015 Jun 15;402(2):291-305
1	J:345473 Lee JG, Yon JM, Kim G, Lee SG, Kim CY, Cheong SA, Kim HY, Yu J, Kim K, Sung YH, Yoo HJ, Woo DC, Rho JK, Ha CH, Pack CG, Oh SH, Lim JS, Han YM, Hong EJ, Seong JK, Lee HW, Lee SW, Lee KU, Kim CJ, Nam SY, Cho YS, Baek IJ, PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
3*	J:237528 Lilly AJ, Costa G, Largeot A, Fadlullah MZ, Lie-A-Ling M, Lacaud G, Kouskoff V, Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac. Development. 2016 Dec 01;143(23):4341-4351
4*	J:242898 Lilly AJ, Mazan A, Scott DA, Lacaud G, Kouskoff V, SOX7 expression is critically required in FLK1-expressing cells for vasculogenesis and angiogenesis during mouse embryonic development. Mech Dev. 2017 Aug;146:31-41
3*	J:84446 Lioubinski O, Muller M, Wegner M, Sander M, Expression of Sox transcription factors in the developing mouse pancreas. Dev Dyn. 2003 Jul;227(3):402-8
1	J:326547 Lu P, Wang P, Wu B, Wang Y, Liu Y, Cheng W, Feng X, Yuan X, Atteya MM, Ferro H, Sugi Y, Rydquist G, Esmaily M, Butcher JT, Chang CP, Lenz J, Zheng D, Zhou B, A SOX17-PDGFB signaling axis regulates aortic root development. Nat Commun. 2022 Jul 13;13(1):4065
1	J:264943 Manganelli G, Fico A, Masullo U, Pizzolongo F, Cimmino A, Filosa S, Modulation of the pentose phosphate pathway induces endodermal differentiation in embryonic stem cells. PLoS One. 2012;7(1):e29321
4	J:113127 Matsui T, Kanai-Azuma M, Hara K, Matoba S, Hiramatsu R, Kawakami H, Kurohmaru M, Koopman P, Kanai Y, Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J Cell Sci. 2006 Sep 1;119(Pt 17):3513-26
1	J:91550 Murakami A, Shen H, Ishida S, Dickson C, SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. J Biol Chem. 2004 Jul 2;279(27):28564-73
3	J:191641 Oommen S, Francois M, Kawasaki M, Murrell M, Kawasaki K, Porntaveetus T, Ghafoor S, Young NJ, Okamatsu Y, McGrath J, Koopman P, Sharpe PT, Ohazama A, Cytoplasmic plaque formation in hemidesmosome development is dependent on SoxF transcription factor function. PLoS One. 2012;7(9):e43857
2	J:273632 Planells B, Gomez-Redondo I, Pericuesta E, Lonergan P, Gutierrez-Adan A, Differential isoform expression and alternative splicing in sex determination in mice. BMC Genomics. 2019 Mar 12;20(1):202
2	J:276877 Qu X, Harmelink C, Baldwin HS, Tie2 regulates endocardial sprouting and myocardial trabeculation. JCI Insight. 2019 May 21;5
1	J:148018 Sagai T, Amano T, Tamura M, Mizushina Y, Sumiyama K, Shiroishi T, A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings. Development. 2009 May;136(10):1665-74
2	J:123026 Sakamoto Y, Hara K, Kanai-Azuma M, Matsui T, Miura Y, Tsunekawa N, Kurohmaru M, Saijoh Y, Koopman P, Kanai Y, Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos. Biochem Biophys Res Commun. 2007 Aug 31;360(3):539-44
1*	J:268273 Simon CS, Zhang L, Wu T, Cai W, Saiz N, Nowotschin S, Cai CL, Hadjantonakis AK, A Gata4 nuclear GFP transcriptional reporter to study endoderm and cardiac development in the mouse. Biol Open. 2018 Dec 10;7(12):bio036517
1	J:36018 Stock DW, Buchanan AV, Zhao Z, Weiss KM, Numerous members of the Sox family of HMG box-containing genes are expressed in developing mouse teeth. Genomics. 1996 Oct 15;37(2):234-7
2	J:93592 Tam PP, Khoo PL, Wong N, Tsang TE, Behringer RR, Regionalization of cell fates and cell movement in the endoderm of the mouse gastrula and the impact of loss of Lhx1(Lim1) function. Dev Biol. 2004 Oct 1;274(1):171-87
3	J:55058 Taniguchi K, Hiraoka Y, Ogawa M, Sakai Y, Kido S, Aiso S, Isolation and characterization of a mouse SRY-related cDNA, mSox7. Biochim Biophys Acta. 1999 May 14;1445(2):225-31
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:328045 Trinh LT, Osipovich AB, Sampson L, Wong J, Wright CVE, Magnuson MA, Differential regulation of alternate promoter regions in Sox17 during endodermal and vascular endothelial development. iScience. 2022 Sep 16;25(9):104905
1	J:222450 Uribe V, Badia-Careaga C, Casanova JC, Dominguez JN, de la Pompa JL, Sanz-Ezquerro JJ, Arid3b is essential for second heart field cell deployment and heart patterning. Development. 2014 Nov;141(21):4168-81
3	J:241851 Villani R, Hodgson S, Legrand J, Greaney J, Wong HY, Pichol-Thievend C, Adolphe C, Wainwight B, Francois M, Khosrotehrani K, Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types. Development. 2017 May 15;144(10):1887-1895
5	J:187416 Wat MJ, Beck TF, Hernandez-Garcia A, Yu Z, Veenma D, Garcia M, Holder AM, Wat JJ, Chen Y, Mohila CA, Lally KP, Dickinson M, Tibboel D, de Klein A, Lee B, Scott DA, Mouse model reveals the role of SOX7 in the development of congenital diaphragmatic hernia associated with recurrent deletions of 8p23.1. Hum Mol Genet. 2012 Sep 15;21(18):4115-25
3*	J:235366 Watanabe M, Kawasaki K, Kawasaki M, Portaveetus T, Oommen S, Blackburn J, Nagai T, Kitamura A, Nishikawa A, Kodama Y, Takagi R, Maeda T, Sharpe PT, Ohazama A, Spatio-temporal expression of Sox genes in murine palatogenesis. Gene Expr Patterns. 2016 Jul;21(2):111-8
1	J:228855 Wicklow E, Blij S, Frum T, Hirate Y, Lang RA, Sasaki H, Ralston A, HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst. PLoS Genet. 2014 Oct;10(10):e1004618
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
1*	J:104307 Wilson ME, Yang KY, Kalousova A, Lau J, Kosaka Y, Lynn FC, Wang J, Mrejen C, Episkopou V, Clevers HC, German MS, The HMG Box Transcription Factor Sox4 Contributes to the Development of the Endocrine Pancreas. Diabetes. 2005 Dec;54(12):3402-9
1*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
3	J:264733 Zhou Y, Williams J, Smallwood PM, Nathans J, Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina. PLoS One. 2015;10(12):e0143650