Gene Expression Literature Summary

• Symbol: Sp1
• Name: trans-acting transcription factor 1
• ID: MGI:98372

39 matching records from 39 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4.5	E7.5	E8.5	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)											1	1		2	1	1	1		1	1	1		1	2		4
In situ RNA (section)												1			1		2	2		1				1		2
Immunohistochemistry (whole mount)	1	1			1		2
In situ RNA (whole mount)							1		1			2		1						2
Northern blot																								1
Western blot	1	1			1		1					1	1	2	1		1	1		1	3				2	2
RT-PCR	2	2	2	3	3	2	3	1		1	2	1		1						1	1	2		1	1	5
cDNA clones																										1
RNase protection															1		2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sp1  trans-acting transcription factor 1   (Synonyms: 1110003E12Rik, Sp1-1)
Results	Reference
2	J:67892 Andrews GK, Lee DK, Ravindra R, Lichtlen P, Sirito M, Sawadogo M, Schaffner W, The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development. EMBO J. 2001 Mar 1;20(5):1114-22
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1*	J:229171 Beketaev I, Zhang Y, Weng KC, Rhee S, Yu W, Liu Y, Mager J, Wang J, cis-regulatory control of Mesp1 expression by YY1 and SP1 during mouse embryogenesis. Dev Dyn. 2016 Mar;245(3):379-87
5*	J:198584 Carver BJ, Plosa EJ, Stinnett AM, Blackwell TS, Prince LS, Interactions between NF-kappaB and SP3 connect inflammatory signaling with reduced FGF-10 expression. J Biol Chem. 2013 May 24;288(21):15318-25
3	J:210983 Chang AC, Garside VC, Fournier M, Smrz J, Vrljicak P, Umlandt P, Fuller M, Robertson G, Zhao Y, Tam A, Jones SJ, Marra MA, Hoodless PA, Karsan A, A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion. Dev Dyn. 2014 Jul;243(7):894-905
2	J:231798 Chen CY, Chan CH, Chen CM, Tsai YS, Tsai TY, Wu Lee YH, You LR, Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 July 15;25(14):2905-2922
1*	J:57857 Donohoe ME, Zhang X, McGinnis L, Biggers J, Li E, Shi Y, Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol. 1999 Oct;19(10):7237-44
6*	J:149868 Ema M, Mori D, Niwa H, Hasegawa Y, Yamanaka Y, Hitoshi S, Mimura J, Kawabe Y, Hosoya T, Morita M, Shimosato D, Uchida K, Suzuki N, Yanagisawa J, Sogawa K, Rossant J, Yamamoto M, Takahashi S, Fujii-Kuriyama Y, Kruppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell. 2008 Nov 6;3(5):555-67
4*	J:56023 Ferretti E, Schulz H, Talarico D, Blasi F, Berthelsen J, The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse. Mech Dev. 1999 May;83(1-2):53-64
1*	J:152838 Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, Stiles CD, A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci. 2009 Sep 9;29(36):11399-408
2*	J:77894 Gollner H, Bouwman P, Mangold M, Karis A, Braun H, Rohner I, Del Rey A, Besedovsky HO, Meinhardt A, van den Broek M, Cutforth T, Grosveld F, Philipsen S, Suske G, Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene. Genes Cells. 2001 Aug;6(8):689-97
3*	J:208871 Gong L, Ji WK, Hu XH, Hu WF, Tang XC, Huang ZX, Li L, Liu M, Xiang SH, Wu E, Woodward Z, Liu YZ, Nguyen QD, Li DW, Sumoylation differentially regulates Sp1 to control cell differentiation. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5574-9
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:48216 Gunes C, Heuchel R, Georgiev O, Muller KH, Lichtlen P, Bluthmann H, Marino S, Aguzzi A, Schaffner W, Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1. EMBO J. 1998 May 15;17(10):2846-54
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1	J:330390 Gura MA, Relovska S, Abt KM, Seymour KA, Wu T, Kaya H, Turner JMA, Fazzio TG, Freiman RN, TAF4b transcription networks regulating early oocyte differentiation. Development. 2022 Feb 1;149(3):dev200074
2*	J:88676 Hammer F, Compagnone NA, Vigne JL, Bair SR, Mellon SH, Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system. Endocrinology. 2004 Feb;145(2):901-12
2	J:96358 Isono K, Mizutani-Koseki Y, Komori T, Schmidt-Zachmann MS, Koseki H, Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1. Genes Dev. 2005 Mar 1;19(5):536-41
3*	J:306453 Kajioka D, Suzuki K, Matsushita S, Hino S, Sato T, Takada S, Isono K, Takeo T, Kajimoto M, Nakagata N, Nakao M, Suyama M, DeFalco T, Miyagawa S, Yamada G, Sexual fate of murine external genitalia development: Conserved transcriptional competency for male-biased genes in both sexes. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2024067118
2	J:169234 Kim JD, Kim H, Ekram MB, Yu S, Faulk C, Kim J, Rex1/Zfp42 as an epigenetic regulator for genomic imprinting. Hum Mol Genet. 2011 Apr 1;20(7):1353-62
1*	J:212420 Kolesnikoff N, Attema JL, Roslan S, Bert AG, Schwarz QP, Gregory PA, Goodall GJ, Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition. J Biol Chem. 2014 Apr 18;289(16):11194-205
1	J:123073 Kruger I, Vollmer M, Simmons DG, Elsasser HP, Philipsen S, Suske G, Sp1/Sp3 compound heterozygous mice are not viable: Impaired erythropoiesis and severe placental defects. Dev Dyn. 2007 Aug;236(8):2235-44
2*	J:226028 Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H, Vokes SA, Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103
1	J:40354 Marin M, Karis A, Visser P, Grosveld F, Philipsen S, Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell. 1997 May 16;89(4):619-28
2*	J:15697 Mitchell PJ, Timmons PM, Hebert JM, Rigby PW, Tjian R, Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes Dev. 1991 Jan;5(1):105-19
12*	J:103362 Nakamura H, Ueda J, Sugar J, Yue BY, Developmentally regulated expression of Sp1 in the mouse cornea. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4092-6
1	J:350494 Perrin S, Protic S, Bretegnier V, Laurendeau I, de Lageneste OD, Panara N, Ruckebusch O, Luka M, Masson C, Maillard T, Coulpier F, Pannier S, Wicart P, Hadj-Rabia S, Radomska KJ, Zarhrate M, Menager M, Vidaud D, Topilko P, Parfait B, Colnot C, MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells. Sci Transl Med. 2024 Jun 26;16(753):eadj1597
1*	J:332092 Rigkou A, Magyar A, Speer JM, Roussa E, TGF-beta2 Regulates Transcription of the K(+)/Cl(-) Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons. Cells. 2022 Nov 30;11(23)
1*	J:40975 Sack MN, Disch DL, Rockman HA, Kelly DP, A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6438-43
1	J:129766 Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Makela TP, Schneider MD, Menage-a-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Cell Metab. 2007 Feb;5(2):129-42
2*	J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
13*	J:38660 Worrad DM, Schultz RM, Regulation of gene expression in the preimplantation mouse embryo: temporal and spatial patterns of expression of the transcription factor Sp1. Mol Reprod Dev. 1997 Mar;46(3):268-77
1*	J:140053 Xie Z, Zhang H, Tsai W, Zhang Y, Du Y, Zhong J, Szpirer C, Zhu M, Cao X, Barton MC, Grusby MJ, Zhang WJ, Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10859-64
1*	J:102143 Yoshikawa T, Piao Y, Zhong J, Matoba R, Carter MG, Wang Y, Goldberg I, Ko MS, High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Gene Expr Patterns. 2006 Jan;6(2):213-24
1	J:136961 Zhang Y, Andl T, Yang SH, Teta M, Liu F, Seykora JT, Tobias JW, Piccolo S, Schmidt-Ullrich R, Nagy A, Taketo MM, Dlugosz AA, Millar SE, Activation of {beta}-catenin signaling programs embryonic epidermis to hair follicle fate. Development. 2008 Jun;135(12):2161-72
1*	J:324720 Zhao Q, Yan S, Lu J, Parker DJ, Wu H, Sun Q, Crossman DK, Liu S, Wang Q, Sesaki H, Mitra K, Liu K, Jiao K, Drp1 regulates transcription of ribosomal protein genes in embryonic hearts. J Cell Sci. 2022 Feb 15;135(4):jcs258956