Gene Expression Literature Summary

• Symbol: Sparc
• Name: secreted acidic cysteine rich glycoprotein
• ID: MGI:98373

60 matching records from 60 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7.5	E8	E8.5	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)	1			1		1	1	1	1	3	1	1	1		4	1	2		2		7
In situ RNA (section)		2		1	1		2		3	7	9		6	2	4	1	4		7		7
Immunohistochemistry (whole mount)				1
In situ RNA (whole mount)			1	1	1	1	2		2	2	2
Northern blot		1		1	1	1	2		2	1	2	1	1		2		1		1	2	3
Western blot																					3
RT-PCR							3		3	2	1		1	1	1	1	3	1	2		5
cDNA clones		1					1				1										1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Sparc  secreted acidic cysteine rich glycoprotein   (Synonyms: BM-40, osteonectin)
Results	Reference
1	J:204445 Andersen DC, Laborda J, Baladron V, Kassem M, Sheikh SP, Jensen CH, Dual role of delta-like 1 homolog (DLK1) in skeletal muscle development and adult muscle regeneration. Development. 2013 Sep;140(18):3743-53
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
4	J:145493 Chakraborty S, Cheek J, Sakthivel B, Aronow BJ, Yutzey KE, Shared gene expression profiles in developing heart valves and osteoblast progenitor cells. Physiol Genomics. 2008 Sep 17;35(1):75-85
1*	J:316663 Cheng P, Andersen P, Hassel D, Kaynak BL, Limphong P, Juergensen L, Kwon C, Srivastava D, Fibronectin mediates mesendodermal cell fate decisions. Development. 2013 Jun;140(12):2587-96
1	J:357459 Combes AN, Phipson B, Lawlor KT,Dorison A, Patrick R, Zappia L, Harvey RP, Oshlack A, Little MH, Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk. Development. 2019;146(12):dev178673
4*	J:263439 Deans MR, Peterson JM, Wong GW, Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1. PLoS One. 2010 Sep 15;5(9):e12765
2	J:197462 Dillman AA, Hauser DN, Gibbs JR, Nalls MA, McCoy MK, Rudenko IN, Galter D, Cookson MR, mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex. Nat Neurosci. 2013 Apr;16(4):499-506
1	J:115635 Elling U, Klasen C, Eisenberger T, Anlag K, Treier M, Murine inner cell mass-derived lineages depend on Sall4 function. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16319-24
1	J:73345 Gaikwad JS, Cavender A, D'Souza RN, Identification of tooth-specific downstream targets of Runx2. Gene. 2001 Nov 14;279(1):91-7
2	J:306309 Genestine M, Ambriz D, Crabtree GW, Dummer P, Molotkova A, Quintero M, Mela A, Biswas S, Feng H, Zhang C, Canoll P, Hargus G, Agalliu D, Gogos JA, Au E, Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons. Elife. 2021 Apr 27;10:e56063
2	J:47014 Gilmour DT, Lyon GJ, Carlton MB, Sanes JR, Cunningham JM, Anderson JR, Hogan BL, Evans MJ, Colledge WH, Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J. 1998 Apr 1;17(7):1860-70
4*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2*	J:19171 Holland PW, Harper SJ, McVey JH, Hogan BL, In vivo expression of mRNA for the Ca++-binding protein SPARC (osteonectin) revealed by in situ hybridization. J Cell Biol. 1987 Jul;105(1):473-82
5*	J:24183 Howe CC, Overton GC, Sawicki J, Solter D, Stein P, Strickland S, Expression of SPARC/osteonectin transcript in murine embryos and gonads. Differentiation. 1988;37(1):20-5
2	J:36211 Iruela-Arispe ML, Vernon RB, Wu H, Jaenisch R, Sage EH, Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function. Dev Dyn. 1996 Oct;207(2):171-83
1	J:55594 Iseki S, Wilkie AO, Morriss-Kay GM, Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault. Development. 1999 Dec;126(24):5611-20
3*	J:307832 Kaji DA, Montero AM, Patel R, Huang AH, Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch. Nat Commun. 2021 Jul 9;12(1):4208
2	J:111223 Kitano Y, Kurihara H, Kurihara Y, Maemura K, Ryo Y, Yazaki Y, Harii K, Gene expression of bone matrix proteins and endothelin receptors in endothelin-1-deficient mice revealed by in situ hybridization. J Bone Miner Res. 1998 Feb;13(2):237-44
1	J:50869 Ko MSH, Threat TA, Wang X, Horton JH, Cui Y, Pryor E, Paris J , Wells-Smith J , Kitchen JR , Rowe LB , Eppig J , Satoh T , Brant L , Fujiwara H , Yotsumoto S , Nakashima H, Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
1*	J:40783 Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K , Shimizu Y , Bronson RT , Gao YH , Inada M , Sato M , Okamoto R , Kitamura Y , Yoshiki S , Kishimoto T, Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 1997 May 30;89(5):755-64
1*	J:50915 Kupprion C, Motamed K, Sage EH, SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells. J Biol Chem. 1998 Nov 6;273(45):29635-40
1	J:169836 Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, Nair KS, Cosma MI, Smith RS, Hodges E, Alfadhli SM, Al-Hajeri A, Shamseldin HE, Behbehani A, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, John SW, Maas RL, Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011 Mar 25;331(6024):1571-6
2*	J:17050 Lane TF, Sage EH, The biology of SPARC, a protein that modulates cell-matrix interactions. FASEB J. 1994 Feb;8(2):163-73
2*	J:321499 Lee DR, Rhodes C, Mitra A, Zhang Y, Maric D, Dale RK, Petros TJ, Transcriptional heterogeneity of ventricular zone cells in the ganglionic eminences of the mouse forebrain. Elife. 2022 Feb 17;11:e71864
2	J:352716 Li C, Zhang M, Du Y, Liu S, Li D, Zhang S, Ji F, Zhang J, Jiao J, Compromised cell competition exhausts neural stem cells pool. Cell Prolif. 2024 Jul 15;:e13710
6*	J:321931 Liu J, Wu X, Lu Q, Molecular divergence of mammalian astrocyte progenitor cells at early gliogenesis. Development. 2022 Mar 1;149(5):dev199985
3	J:300509 Liu Y, Zhou X, Hu N, Wang C, Zhao L, P311 regulates distal lung development via its interaction with several binding proteins. Mech Dev. 2020 Sep;163:103633
2	J:187341 Lloyd-Burton S, Roskams AJ, SPARC-like 1 (SC1) is a diversely expressed and developmentally regulated matricellular protein that does not compensate for the absence of SPARC in the CNS. J Comp Neurol. 2012 Aug 15;520(12):2575-90
1	J:244530 Maeda K, Enomoto A, Hara A, Asai N, Kobayashi T, Horinouchi A, Maruyama S, Ishikawa Y, Nishiyama T, Kiyoi H, Kato T, Ando K, Weng L, Mii S, Asai M, Mizutani Y, Watanabe O, Hirooka Y, Goto H, Takahashi M, Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells. Sci Rep. 2016 Feb 29;6:22288
7	J:8425 Mason IJ, Murphy D, Munke M, Francke U, Elliott RW, Hogan BL, Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11. EMBO J. 1986 Aug;5(8):1831-7
4	J:8388 Mason IJ, Taylor A, Williams JG, Sage H, Hogan BL, Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000. EMBO J. 1986 Jul;5(7):1465-72
2	J:274409 Masuda T, Sankowski R, Staszewski O, Bottcher C, Amann L, Sagar, Scheiwe C, Nessler S, Kunz P, van Loo G, Coenen VA, Reinacher PC, Michel A, Sure U, Gold R, Grun D, Priller J, Stadelmann C, Prinz M, Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution. Nature. 2019 Feb;566(7744):388-392
1	J:261809 Mayer C, Hafemeister C, Bandler RC, Machold R, Batista Brito R, Jaglin X, Allaway K, Butler A, Fishell G, Satija R, Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462
1*	J:205051 Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Sestan N, Gage FH, Lein ES, Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
1	J:91550 Murakami A, Shen H, Ishida S, Dickson C, SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. J Biol Chem. 2004 Jul 2;279(27):28564-73
1*	J:74344 Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B, The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002 Jan 11;108(1):17-29
1*	J:321553 Neupane S, Berardinelli SJ, Cameron DC, Grady RC, Komatsu DE, Percival CJ, Takeuchi M, Ito A, Liu TW, Nairn AV, Moremen KW, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development. Matrix Biol. 2022 Feb 12;
3*	J:74179 Nikaido T, Yokoya S, Mori T, Hagino S, Iseki K, Zhang Y, Takeuchi M, Takaki H, Kikuchi S, Wanaka A, Expression of the novel transcription factor OASIS, which belongs to the CREB/ATF family, in mouse embryo with special reference to bone development. Histochem Cell Biol. 2001 Aug;116(2):141-8
11*	J:9026 Nomura S, Wills AJ, Edwards DR, Heath JK, Hogan BL, Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. J Cell Biol. 1988 Feb;106(2):441-50
1	J:118794 Oka K, Oka S, Sasaki T, Ito Y, Bringas P Jr, Nonaka K, Chai Y, The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev Biol. 2007 Mar 1;303(1):391-404
1*	J:221086 Patra D, DeLassus E, Liang G, Sandell LJ, Cartilage-specific ablation of site-1 protease in mice results in the endoplasmic reticulum entrapment of type IIb procollagen and down-regulation of cholesterol and lipid homeostasis. PLoS One. 2014;9(8):e105674
2*	J:340391 Pina JO, Raju R, Roth DM, Winchester EW, Chattaraj P, Kidwai F, Faucz FR, Iben J, Mitra A, Campbell K, Fridell G, Esnault C, Cotney JL, Dale RK, D'Souza RN, Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis. Nat Commun. 2023 Sep 14;14(1):5687
1	J:343286 Queen R, Crosier M, Eley L, Kerwin J, Turner JE, Yu J, Alqahtani A, Dhanaseelan T, Overman L, Soetjoadi H, Baldock R, Coxhead J, Boczonadi V, Laude A, Cockell SJ, Kane MA, Lisgo S, Henderson DJ, Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves. PLoS Genet. 2023 Nov;19(11):e1010777
1*	J:50239 Ringuette M, Rogers I, Varmuza S, Rush S, Brown IR, Expression of SC1 is associated with the migration of myotomes along the dermomyotome during somitogenesis in early mouse embryos. Dev Genes Evol. 1998 Sep;208(7):403-6
1	J:105169 Sasaki T, Ito Y, Bringas P Jr, Chou S, Urata MM, Slavkin H, Chai Y, TGF{beta}-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development. Development. 2006 Jan;133(2):371-81
4*	J:306243 Shur I, Socher R, Benayahu D, In vivo association of CReMM/CHD9 with promoters in osteogenic cells. J Cell Physiol. 2006 May;207(2):374-8
1*	J:40645 Soderling JA, Reed MJ, Corsa A, Sage EH, Cloning and expression of murine SC1, a gene product homologous to SPARC. J Histochem Cytochem. 1997 Jun;45(6):823-35
2*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
6*	J:67747 Thut CJ, Rountree RB, Hwa M, Kingsley DM, A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol. 2001 Mar 1;231(1):63-76
2	J:175540 Tsau C, Ito M, Gromova A, Hoffman MP, Meech R, Makarenkova HP, Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodeling. Development. 2011 Aug;138(15):3307-17
6*	J:134286 Vincent AJ, Lau PW, Roskams AJ, SPARC is expressed by macroglia and microglia in the developing and mature nervous system. Dev Dyn. 2008 May;237(5):1449-62
1	J:158773 Wang Y, Sun M, Uhlhorn VL, Zhou X, Peter I, Martinez-Abadias N, Hill CA, Percival CJ, Richtsmeier JT, Huso DL, Jabs EW, Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice. BMC Dev Biol. 2010;10:22
2	J:101174 Wang Y, Xiao R, Yang F, Karim BO, Iacovelli AJ, Cai J, Lerner CP, Richtsmeier JT, Leszl JM, Hill CA, Yu K, Ornitz DM, Elisseeff J, Huso DL, Jabs EW, Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse. Development. 2005 Aug;132(15):3537-48
1	J:190491 Wang Y, Zhou X, Oberoi K, Phelps R, Couwenhoven R, Sun M, Rezza A, Holmes G, Percival CJ, Friedenthal J, Krejci P, Richtsmeier JT, Huso DL, Rendl M, Jabs EW, p38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare-Stevenson mice. J Clin Invest. 2012 Jun 1;122(6):2153-64
4*	J:65653 Wertz K, Herrmann BG, Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
9	J:109014 Wilson MJ, Bowles J, Koopman P, The matricellular protein SPARC is internalized in Sertoli, Leydig, and germ cells during testis differentiation. Mol Reprod Dev. 2006 May;73(5):531-9
4	J:164319 Xu Y, Zhang H, Yang H, Zhao X, Lovas S, Lundberg YW, Expression, functional, and structural analysis of proteins critical for otoconia development. Dev Dyn. 2010 Oct;239(10):2659-73
1*	J:356741 Zhang S, Mo X, Jin Y, Niu Z, Yao M, Zhang Y, Li L, Hu G, Ning W, Single-cell transcriptome analysis reveals cellular heterogeneity and highlights Fstl1-regulated alveolar myofibroblasts in mouse lung at birth. Genomics. 2023 Sep;115(5):110677