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Gene Expression Literature Summary
Symbol
Name
ID 		T
brachyury, T-box transcription factor T
MGI:98472

639 matching records from 639 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E1.5 E2 E2.5 E3 E3.5 E4 E4.5 E5 E5.5 E6 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14.5 E15 E15.5 E16.5 E17.5 E18.5 E P
Immunohistochemistry (section) 4 2 18 18 46 17 29 7 14 11 2 4 1 1 2 2 9 2
In situ RNA (section) 1 1 21 9 45 15 26 4 13 1 10 1 5 3 3 3 1 4 1
Immunohistochemistry (whole mount) 10 13 24 12 17 5 13 5 2 2 1 1 1 4
In situ RNA (whole mount) 1 1 1 5 8 73 54 189 53 148 17 87 4 31 2 10 1 5 5 2 2 17
In situ reporter (knock in) 2 2 1 3 1
Northern blot 1 1 2 3 1 1 1 1 1 1 3
Western blot 3 1 4 1 1 1 1 3 1 1 1 1
RT-PCR 3 2 2 1 4 3 3 5 1 20 8 34 5 25 3 20 1 11 1 6 6 5 4 1 2 1 1 7 7
cDNA clones 1 2 1 1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
T  brachyury, T-box transcription factor T   (Synonyms: Bra, T1, Tbxt)
Results  Reference
4*J:91405 Abdelkhalek HB, Beckers A, Schuster-Gossler K, Pavlova MN, Burkhardt H, Lickert H, Rossant J, Reinhardt R, Schalkwyk LC, Muller I, Herrmann BG, Ceolin M, Rivera-Pomar R, Gossler A, The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev. 2004 Jul 15;18(14):1725-36
1J:314668 Abrams SR, Reiter JF, Ciliary Hedgehog signaling regulates cell survival to build the facial midline. Elife. 2021 Oct 21;10:e68558
2J:67399 Abu-Abed S, Dolle P, Metzger D, Beckett B, Chambon P, Petkovich M, The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev. 2001 Jan 15;15(2):226-40
1*J:81583 Abu-Abed S, Dolle P, Metzger D, Wood C, MacLean G, Chambon P, Petkovich M, Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1. Development. 2003 Apr;130(7):1449-59
1*J:49817 Acampora D, Avantaggiato V, Tuorto F, Briata P, Corte G, Simeone A, Visceral endoderm-restricted translation of otx1 mediates recovery of otx2 requirements for specification of anterior neural plate and normal gastrulation. Development. 1998 Dec;125(24):5091-104
2*J:153562 Acampora D, Di Giovannantonio LG, Di Salvio M, Mancuso P, Simeone A, Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev. 2009 Oct;126(10):882-97
2J:191079 Acampora D, Di Giovannantonio LG, Simeone A, Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition. Development. 2013 Jan 1;140(1):43-55
2*J:29276 Acampora D, Mazan S, Lallemand Y, Avantaggiato V, Maury M, Simeone A, Brulet P, Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 1995 Oct;121(10):3279-90
2J:238298 Acampora D, Omodei D, Petrosino G, Garofalo A, Savarese M, Nigro V, Di Giovannantonio LG, Mercadante V, Simeone A, Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast. Cell Rep. 2016 Jun 21;15(12):2651-64
2*J:254332 Acharya D, Hainer SJ, Yoon Y, Wang F, Bach I, Rivera-Perez JA, Fazzio TG, KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency. Cell Rep. 2017 Apr 25;19(4):671-679
1J:86265 Adhikary S, Peukert K, Karsunky H, Beuger V, Lutz W, Elsasser HP, Moroy T, Eilers M, Miz1 is required for early embryonic development during gastrulation. Mol Cell Biol. 2003 Nov;23(21):7648-57
4*J:272567 Aires R, de Lemos L, Novoa A, Jurberg AD, Mascrez B, Duboule D, Mallo M, Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes. Dev Cell. 2019 Feb 11;48(3):383-395.e8
7*J:236309 Aires R, Jurberg AD, Leal F, Novoa A, Cohn MJ, Mallo M, Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity. Dev Cell. 2016 Aug 8;38(3):262-74
4J:311976 Ajima R, Sakakibara Y, Sakurai-Yamatani N, Muraoka M, Saga Y, Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice. Development. 2021 Oct 15;148(20):dev194613
1J:146589 Akamatsu W, DeVeale B, Okano H, Cooney AJ, van der Kooy D, Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage. J Neurosci. 2009 Feb 18;29(7):2113-24
2J:340418 Amadei G, Handford CE, Qiu C, De Jonghe J, Greenfeld H, Tran M, Martin BK, Chen DY, Aguilera-Castrejon A, Hanna JH, Elowitz MB, Hollfelder F, Shendure J, Glover DM, Zernicka-Goetz M, Embryo model completes gastrulation to neurulation and organogenesis. Nature. 2022 Oct;610(7930):143-153
1*J:78010 Amieux PS, Howe DG, Knickerbocker H, Lee DC, Su T, Laszlo GS, Idzerda RL, McKnight GS, Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J Biol Chem. 2002 Jul 26;277(30):27294-304
9J:239303 Amin S, Neijts R, Simmini S, van Rooijen C, Tan SC, Kester L, van Oudenaarden A, Creyghton MP, Deschamps J, Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche. Cell Rep. 2016 Dec 20;17(12):3165-3177
1*J:155226 Andersson ER, Bryjova L, Biris K, Yamaguchi TP, Arenas E, Bryja V, Genetic interaction between Lrp6 and Wnt5a during mouse development. Dev Dyn. 2009 Sep 30;239(1):237-245
2J:127541 Andersson O, Bertolino P, Ibanez CF, Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol. 2007 Nov 15;311(2):500-11
4*J:108723 Andersson O, Reissmann E, Jornvall H, Ibanez CF, Synergistic interaction between Gdf1 and Nodal during anterior axis development. Dev Biol. 2006 May 15;293(2):370-81
5J:220460 Andre P, Song H, Kim W, Kispert A, Yang Y, Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27
2*J:30828 Ang SL, Jin O, Rhinn M, Daigle N, Stevenson L, Rossant J, A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development. 1996 Jan;122(1):243-52
3*J:19895 Ang SL, Rossant J, HNF-3 beta is essential for node and notochord formation in mouse development. Cell. 1994 Aug 26;78(4):561-74
1J:145732 Aoto K, Shikata Y, Imai H, Matsumaru D, Tokunaga T, Shioda S, Yamada G, Motoyama J, Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis. Dev Biol. 2009 Mar 1;327(1):106-20
1*J:184591 Aoyama M, Sun-Wada GH, Yamamoto A, Yamamoto M, Hamada H, Wada Y, Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway. Dev Cell. 2012 Jun 12;22(6):1163-75
3*J:290235 Archambault D, Cheong A, Iverson E, Tremblay KD, Mager J, Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development. Dev Biol. 2020 Jul 3;465(1):1-10
1J:131055 Arnold SJ, Hofmann UK, Bikoff EK, Robertson EJ, Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development. 2008 Feb;135(3):501-11
4*J:50876 Arsenian S, Weinhold B, Oelgeschlager M, Ruther U, Nordheim A, Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J. 1998 Nov 2;17(21):6289-99
3J:290418 Ashokkumar D, Zhang Q, Much C, Bledau AS, Naumann R, Alexopoulou D, Dahl A, Goveas N, Fu J, Anastassiadis K, Stewart AF, Kranz A, MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation. Development. 2020 Jun 17;147(12):dev186999
1J:88851 Aulehla A, Wehrle C, Brand-Saberi B, Kemler R, Gossler A, Kanzler B, Herrmann BG, Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell. 2003 Mar;4(3):395-406
1J:76369 Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T, Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Development. 2002 Jun;129(11):2733-47
3J:314663 Bang J, Han M, Yoo TJ, Qiao L, Jung J, Na J, Carlson BA, Gladyshev VN, Hatfield DL, Kim JH, Kim LK, Lee BJ, Identification of Signaling Pathways for Early Embryonic Lethality and Developmental Retardation in Sephs1(-/-) Mice. Int J Mol Sci. 2021 Oct 28;22(21)
4*J:110714 Barrionuevo F, Taketo MM, Scherer G, Kispert A, Sox9 is required for notochord maintenance in mice. Dev Biol. 2006 Jul 1;295(1):128-40
1J:173672 Barrott JJ, Cash GM, Smith AP, Barrow JR, Murtaugh LC, Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12752-7
2J:130205 Barrow JR, Howell WD, Rule M, Hayashi S, Thomas KR, Capecchi MR, McMahon AP, Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol. 2007 Dec 1;312(1):312-20
1J:253960 Basilicata MF, Frank M, Solter D, Brabletz T, Stemmler MP, Inappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation. Sci Rep. 2016 May 24;6:26562
1J:158671 Baur F, Nau K, Sadic D, Allweiss L, Elsasser HP, Gillemans N, de Wit T, Kruger I, Vollmer M, Philipsen S, Suske G, Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts. PLoS One. 2010;5(3):e9587
1J:208632 Bazzi H, Anderson KV, Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1491-500
1J:251816 Bazzi H, Soroka E, Alcorn HL, Anderson KV, STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10928-E10936
1J:81247 Beck S, Le Good JA, Guzman M, Ben Haim N, Roy K, Beermann F, Constam DB, Extraembryonic proteases regulate Nodal signalling during gastrulation. Nat Cell Biol. 2002 Dec;4(12):981-5
6J:257034 Beisaw A, Tsaytler P, Koch F, Schmitz SU, Melissari MT, Senft AD, Wittler L, Pennimpede T, Macura K, Herrmann BG, Grote P, BRACHYURY directs histone acetylation to target loci during mesoderm development. EMBO Rep. 2018 Jan;19(1):118-134
1*J:49955 Belaoussoff M, Farrington SM, Baron MH, Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo. Development. 1998 Dec;125(24):5009-18
3*J:329966 Bell CJ, Gupta N, Tremblay KD, Mager J, Borcs6 is required for endo-lysosomal degradation during early development. Mol Reprod Dev. 2022 Aug;89(8):337-350
2J:112799 Ben-Haim N, Lu C, Guzman-Ayala M, Pescatore L, Mesnard D, Bischofberger M, Naef F, Robertson EJ, Constam DB, The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. Dev Cell. 2006 Sep;11(3):313-23
2J:234992 Benz BA, Nandadasa S, Takeuchi M, Grady RC, Takeuchi H, LoPilato RK, Kakuda S, Somerville RP, Apte SS, Haltiwanger RS, Holdener BC, Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion. Dev Biol. 2016 Aug 1;416(1):111-22
1J:61931 Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, Noda T, Miyazono K, BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol. 2000 May 1;221(1):249-58
1J:153091 Berman SD, West JC, Danielian PS, Caron AM, Stone JR, Lees JA, Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14932-6
1*J:264256 Bernardo AS, Jouneau A, Marks H, Kensche P, Kobolak J, Freude K, Hall V, Feher A, Polgar Z, Sartori C, Bock I, Louet C, Faial T, Kerstens HHD, Bouissou C, Parsonage G, Mashayekhi K, Smith JC, Lazzari G, Hyttel P, Stunnenberg HG, Huynen M, Pedersen RA, Dinnyes A, Mammalian embryo comparison identifies novel pluripotency genes associated with the naive or primed state. Biol Open. 2018 Aug 17;7(8):bio033282
1*J:86391 Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ, Dicer is essential for mouse development. Nat Genet. 2003 Nov;35(3):215-7
1J:221596 Bertero A, Madrigal P, Galli A, Hubner NC, Moreno I, Burks D, Brown S, Pedersen RA, Gaffney D, Mendjan S, Pauklin S, Vallier L, Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark. Genes Dev. 2015 Apr 1;29(7):702-17
1J:254597 Bhargava S, Cox B, Polydorou C, Gresakova V, Korinek V, Strnad H, Sedlacek R, Epp TA, Chawengsaksophak K, The epigenetic modifier Fam208a is required to maintain epiblast cell fitness. Sci Rep. 2017 Aug 24;7(1):9322
1J:175338 Bhattaram P, Penzo-Mendez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A, Depamphilis ML, Wegner M, Lefebvre V, Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun. 2010;1:9
1*J:46377 Biben C, Stanley E, Fabri L, Kotecha S, Rhinn M, Drinkwater C, Lah M, Wang CC, Nash A, Hilton D, Ang SL, Mohun T, Harvey RP, Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev Biol. 1998 Feb 15;194(2):135-51
1*J:198636 Biechele S, Cockburn K, Lanner F, Cox BJ, Rossant J, Porcn-dependent Wnt signaling is not required prior to mouse gastrulation. Development. 2013 Jul;140(14):2961-71
2*J:173623 Biechele S, Cox BJ, Rossant J, Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos. Dev Biol. 2011 Jul 15;355(2):275-85
1*J:125766 Biris KK, Dunty WC Jr, Yamaguchi TP, Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed during somitogenesis. Dev Dyn. 2007 Nov;236(11):3167-72
1*J:83956 Bladt F, Aippersbach E, Gelkop S, Strasser GA, Nash P, Tafuri A, Gertler FB, Pawson T, The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol. 2003 Jul;23(13):4586-97
3J:183946 Bloomekatz J, Grego-Bessa J, Migeotte I, Anderson KV, Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo. Dev Biol. 2012 Apr 15;364(2):192-201
1J:111395 Boehmelt G, Wakeham A, Elia A, Sasaki T, Plyte S, Potter J, Yang Y, Tsang E, Ruland J, Iscove NN, Dennis JW, Mak TW, Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells. EMBO J. 2000 Oct 2;19(19):5092-104
4J:93195 Bogani D, Warr N, Elms P, Davies J, Tymowska-Lalanne Z, Goldsworthy M, Cox RD, Keays DA, Flint J, Wilson V, Nolan P, Arkell R, New semidominant mutations that affect mouse development. Genesis. 2004 Oct;40(2):109
3*J:90291 Bohnsack BL, Lai L, Dolle P, Hirschi KK, Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation. Genes Dev. 2004 Jun 1;18(11):1345-58
4J:106770 Bohnsack BL, Lai L, Northrop JL, Justice MJ, Hirschi KK, Visceral endoderm function is regulated by quaking and required for vascular development. Genesis. 2006 Feb;44(2):93-104
10*J:18978 Bollag RJ, Siegfried Z, Cebra-Thomas JA, Garvey N, Davison EM, Silver LM, An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus. Nat Genet. 1994 Jul;7(3):383-9
4J:110914 Bommireddy R, Ormsby I, Yin M, Boivin GP, Babcock GF, Doetschman T, TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes. J Immunol. 2003 Apr 1;170(7):3645-52
2*J:124356 Bondareva AA, Capecchi MR, Iverson SV, Li Y, Lopez NI, Lucas O, Merrill GF, Prigge JR, Siders AM, Wakamiya M, Wallin SL, Schmidt EE, Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome. Free Radic Biol Med. 2007 Sep 15;43(6):911-23
6J:219394 Boroviak T, Loos R, Bertone P, Smith A, Nichols J, The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
2*J:35540 Bouillet P, Oulad-Abdelghani M, Ward SJ, Bronner S, Chambon P, Dolle P, A new mouse member of the Wnt gene family, mWnt-8, is expressed during early embryogenesis and is ectopically induced by retinoic acid. Mech Dev. 1996 Aug;58(1-2):141-52
4J:190545 Boulet AM, Capecchi MR, Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. Dev Biol. 2012 Nov 15;371(2):235-45
1J:70006 Brennan J, Lu CC, Norris DP, Rodriguez TA, Beddington RS, Robertson EJ, Nodal signalling in the epiblast patterns the early mouse embryo. Nature. 2001 Jun 21;411(6840):965-9
2J:55991 Brown D, Wagner D, Li X, Richardson JA, Olson EN, Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis. Development. 1999 Oct;126(19):4317-29
1*J:181635 Bruggeman BJ, Maier JA, Mohiuddin YS, Powers R, Lo Y, Guimaraes-Camboa N, Evans SM, Harfe BD, Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: Implications for evolution of the vertebrate disc. Dev Dyn. 2012 Apr;241(4):675-83
1J:163977 Bryja V, Andersson ER, Schambony A, Esner M, Bryjova L, Biris KK, Hall AC, Kraft B, Cajanek L, Yamaguchi TP, Buckingham M, Arenas E, The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol Biol Cell. 2009 Feb;20(3):924-36
1*J:302463 Buers I, Pennekamp P, Nitschke Y, Lowe C, Skryabin BV, Rutsch F, Lmbrd1 expression is essential for the initiation of gastrulation. J Cell Mol Med. 2016 Aug;20(8):1523-33
1*J:48519 Burdsal CA, Flannery ML, Pedersen RA, FGF-2 alters the fate of mouse epiblast from ectoderm to mesoderm in vitro. Dev Biol. 1998 Jun 15;198(2):231-44
1J:204475 Burtscher I, Barkey W, Lickert H, Foxa2-venus fusion reporter mouse line allows live-cell analysis of endoderm-derived organ formation. Genesis. 2013 Aug;51(8):596-604
5J:146275 Burtscher I, Lickert H, Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo. Development. 2009 Mar;136(6):1029-38
9J:124082 Cambray N, Wilson V, Two distinct sources for a population of maturing axial progenitors. Development. 2007 Aug;134(15):2829-40
1*J:62628 Cammas F, Mark M, Dolle P, Dierich A, Chambon P, Losson R, Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development. Development. 2000 Jul;127(13):2955-63
3J:324925 Campbell GP, Farkas DR, Chapman DL, Ectopic expression of T in the paraxial mesoderm disrupts somite maturation in the mouse. Dev Biol. 2022 May;485:37-49
1*J:139570 Capellini TD, Zewdu R, Di Giacomo G, Asciutti S, Kugler JE, Di Gregorio A, Selleri L, Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome. Dev Biol. 2008 Sep 15;321(2):500-14
1*J:165230 Carayannopoulos LN, Barks JL, Yokoyama WM, Riley JK, Murine trophoblast cells induce NK cell interferon-gamma production through KLRK1. Biol Reprod. 2010 Sep;83(3):404-14
1J:72861 Carver EA, Jiang R, Lan Y, Oram KF, Gridley T, The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol Cell Biol. 2001 Dec;21(23):8184-8
1J:342647 Chakraborty S, Kopitchinski N, Zuo Z, Eraso A, Awasthi P, Chari R, Mitra A, Tobias IC, Moorthy SD, Dale RK, Mitchell JA, Petros TJ, Rocha PP, Enhancer-promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness. Nat Genet. 2023 Feb;55(2):280-290
1J:236315 Chalamalasetty RB, Ajima R, Garriock RJ, Kennedy MW, Tessarollo L, Yamaguchi TP, A new gain-of-function mouse line to study the role of Wnt3a in development and disease. Genesis. 2016 Sep;54(9):497-502
3J:217598 Chalamalasetty RB, Garriock RJ, Dunty WC Jr, Kennedy MW, Jailwala P, Si H, Yamaguchi TP, Mesogenin 1 is a master regulator of paraxial presomitic mesoderm differentiation. Development. 2014 Nov;141(22):4285-97
4J:81651 Chao HH, Mentzer SE, Schimenti JC, You Y, Overlapping deletions define novel embryonic lethal loci in the mouse t complex. Genesis. 2003 Feb;35(2):133-42
1*J:37336 Chapman DL, Agulnik I, Hancock S, Silver LM, Papaioannou VE, Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation. Dev Biol. 1996 Dec 15;180(2):534-42
1*J:80954 Chapman DL, Papaioannou VE, Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature. 1998 Feb 12;391(6668):695-7
3J:139339 Chawengsaksophak K, de Graaff W, Rossant J, Deschamps J, Beck F, Cdx2 is essential for axial elongation in mouse development. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7641-5
4J:112232 Chazaud C, Rossant J, Disruption of early proximodistal patterning and AVE formation in Apc mutants. Development. 2006 Sep;133(17):3379-87
2J:104371 Chen C, Ware SM, Sato A, Houston-Hawkins DE, Habas R, Matzuk MM, Shen MM, Brown CW, The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo. Development. 2006 Jan;133(2):319-29
3J:277240 Chen CY, Yu IS, Pai CH, Lin CY, Lin SR, Chen YT, Lin SW, Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells. PLoS One. 2019;14(7):e0219221
1J:110693 Chen HJ, Lin CM, Lin CS, Perez-Olle R, Leung CL, Liem RK, The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 2006 Jul 15;20(14):1933-45
1J:347865 Chen KQ, Kawakami H, Anderson A, Corcoran D, Soni A, Nishinakamura R, Kawakami Y, Sall genes regulate hindlimb initiation in mouse embryos. Genetics. 2024 Feb 22;
2J:355696 Chen S, Hayoun-Neeman D, Nagar M, Pinyan S, Hadad L, Yaacobov L, Alon L, Shachar LE, Swissa T, Kryukov O, Gershoni-Yahalom O, Rosental B, Cohen S, Lichtenstein RG, Terminal alpha1,2-fucosylation of glycosphingolipids by FUT1 is a key regulator in early cell-fate decisions. EMBO Rep. 2024 Oct;25(10):4433-4464
2J:127458 Chen SH, Wu PS, Chou CH, Yan YT, Liu H, Weng SY, Yang-Yen HF, A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner. Mol Biol Cell. 2007 Jul;18(7):2525-32
2J:327432 Chen T, Alcorn H, Devbhandari S, Remus D, Lacy E, Huangfu D, Anderson KV, A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation. Biol Open. 2022 Aug 15;11(8):bio059307
2J:81582 Chen W, Liang Y, Deng W, Shimizu K, Ashique AM, Li E, Li YP, The zinc-finger protein CNBP is required for forebrain formation in the mouse. Development. 2003 Apr;130(7):1367-79
1J:21129 Chen WS, Manova K, Weinstein DC, Duncan SA, Plump AS, Prezioso VR, Bachvarova RF, Darnell JE Jr, Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 1994 Oct 15;8(20):2466-77
1J:24349 Chen ZF, Behringer RR, twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev. 1995 Mar 15;9(6):686-99
1J:337001 Cheng C, Cong Q, Liu Y, Hu Y, Liang G, Dioneda KMM, Yang Y, Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with FoxA2 and Shh expression. Sci Adv. 2023 Jun 16;9(24):eadf6927
2*J:290315 Cheong A, Archambault D, Degani R, Iverson E, Tremblay KD, Mager J, Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Development. 2020 May 26;147(10):dev188714
7*J:278736 Cheong A, Degani R, Tremblay KD, Mager J, A null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia. Hum Mol Genet. 2019 Aug 15;28(16):2775-2784
3J:35802 Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA, Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 1996 Oct 3;383(6599):407-13
1J:213158 Cho A, Tang Y, Davila J, Deng S, Chen L, Miller E, Wernig M, Graef IA, Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. Neuron. 2014 Apr 2;82(1):109-24
3J:163654 Cho MS, Chan IL, Flores ER, DeltaNp63 transcriptionally regulates brachyury, a gene with diverse roles in limb development, tumorigenesis and metastasis. Cell Cycle. 2010 Jun 15;9(12):2434-2441
1J:173333 Choi KS, Harfe BD, Hedgehog signaling is required for formation of the notochord sheath and patterning of nuclei pulposi within the intervertebral discs. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9484-9
3J:92066 Chu GC, Dunn NR, Anderson DC, Oxburgh L, Robertson EJ, Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development. 2004 Aug;131(15):3501-12
4J:67377 Chung AC, Katz D, Pereira FA, Jackson KJ, DeMayo FJ, Cooney AJ, O'Malley BW, Loss of orphan receptor germ cell nuclear factor function results in ectopic development of the tail bud and a novel posterior truncation. Mol Cell Biol. 2001 Jan;21(2):663-77
1J:70485 Ciruna B, Rossant J, FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell. 2001;1(1):37-49
2*J:33755 Clements D, Taylor HC, Herrmann BG, Stott D, Distinct regulatory control of the Brachyury gene in axial and non-axial mesoderm suggests separation of mesoderm lineages early in mouse gastrulation. Mech Dev. 1996 May;56(1-2):139-49
3*J:19211 Conlon FL, Lyons KM, Takaesu N, Barth KS, Kispert A, Herrmann B, Robertson EJ, A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development. 1994 Jul;120(7):1919-28
8*J:23131 Conlon FL, Wright CV, Robertson EJ, Effects of the TWis mutation on notochord formation and mesodermal patterning. Mech Dev. 1995 Feb;49(3):201-9
2*J:25248 Conlon RA, Reaume AG, Rossant J, Notch1 is required for the coordinate segmentation of somites. Development. 1995 May;121(5):1533-45
5J:148823 Corrigan PM, Dobbin E, Freeburn RW, Wheadon H, Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells Dev. 2009 Jun;18(5):759-72
2*J:226614 Costello I, Nowotschin S, Sun X, Mould AW, Hadjantonakis AK, Bikoff EK, Robertson EJ, Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015 Oct 15;29(20):2108-22
2*J:185600 Cota CD, Garcia-Garcia MJ, The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis. Dev Dyn. 2012 Aug;241(8):1249-59
1J:105812 Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B, HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006 Mar 1;20(5):557-70
3J:186907 D'Andrea D, Liguori GL, Le Good JA, Lonardo E, Andersson O, Constam DB, Persico MG, Minchiotti G, Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction. J Cell Biol. 2008 Feb 11;180(3):597-605
7J:239417 Dai HQ, Wang BA, Yang L, Chen JJ, Zhu GC, Sun ML, Ge H, Wang R, Chapman DL, Tang F, Sun X, Xu GL, TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature. 2016 Oct 27;538(7626):528-532
1*J:180827 David R, Jarsch VB, Schwarz F, Nathan P, Gegg M, Lickert H, Franz WM, Induction of MesP1 by Brachyury(T) generates the common multipotent cardiovascular stem cell. Cardiovasc Res. 2011 Oct 1;92(1):115-22
1*J:56091 Davidson BP, Kinder SJ, Steiner K, Schoenwolf GC, Tam PP, Impact of node ablation on the morphogenesis of the body axis and the lateral asymmetry of the mouse embryo during early organogenesis. Dev Biol. 1999 Jul 1;211(1):11-26
4J:269325 De Castro SCP, Gustavsson P, Marshall AR, Gordon WM, Galea G, Nikolopoulou E, Savery D, Rolo A, Stanier P, Andersen B, Copp AJ, Greene NDE, Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice. Hum Mol Genet. 2018 Dec 15;27(24):4218-4230
3J:22118 Deng CX, Wynshaw-Boris A, Shen MM, Daugherty C, Ornitz DM, Leder P, Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev. 1994 Dec 15;8(24):3045-57
3J:353553 Despin-Guitard E, Rosa VS, Plunder S, Mathiah N, Van Schoor K, Nehme E, Merino-Aceituno S, Egea J, Shahbazi MN, Theveneau E, Migeotte I, Non-apical mitoses contribute to cell delamination during mouse gastrulation. Nat Commun. 2024 Aug 28;15(1):7364
1*J:89944 DeYoung RA, Baker JC, Cado D, Winoto A, The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis. J Biol Chem. 2003 Nov 21;278(47):47104-9
1J:124681 Di-Gregorio A, Sancho M, Stuckey DW, Crompton LA, Godwin J, Mishina Y, Rodriguez TA, BMP signalling inhibits premature neural differentiation in the mouse embryo. Development. 2007 Sep;134(18):3359-69
7J:294824 Dias A, Lozovska A, Wymeersch FJ, Novoa A, Binagui-Casas A, Sobral D, Martins GG, Wilson V, Mallo M, A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation. Elife. 2020 Jun 29;9:e56615
4*J:16484 Dietrich S, Schubert FR, Gruss P, Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite. Mech Dev. 1993 Dec;44(2-3):189-207
1J:59749 Dietrich S, Schubert FR, Gruss P, Lumsden A, The role of the notochord for epaxial myotome formation in the mouse. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):601-16
1*J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2J:50343 Ding J, Yang L, Yan YT, Chen A, Desai N, Wynshaw-Boris A, Shen MM, Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo [see comments]. Nature. 1998 Oct 15;395(6703):702-7
3J:98382 Donnison M, Beaton A, Davey HW, Broadhurst R, L'huillier P, Pfeffer PL, Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning. Development. 2005 May;132(10):2299-308
5J:146503 Downs KM, Inman KE, Jin DX, Enders AC, The Allantoic Core Domain: New insights into development of the murine allantois and its relation to the primitive streak. Dev Dyn. 2009 Mar;238(3):532-53
1J:329267 Drozd AM, Mariani L, Guo X, Goitea V, Menezes NA, Ferretti E, Progesterone Receptor Modulates Extraembryonic Mesoderm and Cardiac Progenitor Specification during Mouse Gastrulation. Int J Mol Sci. 2022 Sep 7;23(18)
3*J:165751 Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
1*J:49657 Dufort D, Schwartz L, Harpal K, Rossant J, The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development. 1998 Aug;125(16):3015-25
1J:89189 Dunn NR, Vincent SD, Oxburgh L, Robertson EJ, Bikoff EK, Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo. Development. 2004 Apr;131(8):1717-28
1*J:129202 Dunty WC Jr, Biris KK, Chalamalasetty RB, Taketo MM, Lewandoski M, Yamaguchi TP, Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation. Development. 2008 Jan;135(1):85-94
1*J:286213 Dunty WC Jr, Kennedy MW, Chalamalasetty RB, Campbell K, Yamaguchi TP, Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/beta-catenin pathway in neuromesodermal stem cells. PLoS One. 2014;9(1):e87018
1*J:27183 Duyao MP, Auerbach AB, Ryan A, Persichetti F, Barnes GT, McNeil SM, Ge P, Vonsattel JP, Gusella JF, Joyner AL, MacDonald ME, Inactivation of the mouse Huntington's disease gene homolog Hdh. Science. 1995 Jul 21;269(5222):407-10
1*J:227640 Economou C, Tsakiridis A, Wymeersch FJ, Gordon-Keylock S, Dewhurst RE, Fisher D, Medvinsky A, Smith AJ, Wilson V, Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation. BMC Dev Biol. 2015;15:35
4J:142039 Egea J, Erlacher C, Montanez E, Burtscher I, Yamagishi S, Hess M, Hampel F, Sanchez R, Rodriguez-Manzaneque MT, Bosl MR, Fassler R, Lickert H, Klein R, Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Genes Dev. 2008 Dec 1;22(23):3349-3362
2J:238166 Eliades A, Wareing S, Marinopoulou E, Fadlullah MZ, Patel R, Grabarek JB, Plusa B, Lacaud G, Kouskoff V, The Hemogenic Competence of Endothelial Progenitors Is Restricted by Runx1 Silencing during Embryonic Development. Cell Rep. 2016 Jun 07;15(10):2185-99
2J:198627 Engert S, Burtscher I, Liao WP, Dulev S, Schotta G, Lickert H, Wnt/beta-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse. Development. 2013 Aug;140(15):3128-38
2J:68833 Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D, Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature. 2001 Apr 12;410(6830):825-30
3J:84753 Escalante-Alcalde D, Hernandez L, Le Stunff H, Maeda R, Lee HS, Jr-Gang-Cheng, Sciorra VA, Daar I, Spiegel S, Morris AJ, Stewart CL, The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning. Development. 2003 Oct;130(19):4623-37
5J:224201 Evans AL, Faial T, Gilchrist MJ, Down T, Vallier L, Pedersen RA, Wardle FC, Smith JC, Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells. PLoS One. 2012;7(3):e33346
1*J:76233 Faisst AM, Alvarez-Bolado G, Treichel D, Gruss P, Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos. Mech Dev. 2002 Apr;113(1):15-28
2J:154368 Farkas DR, Chapman DL, Kinked tail mutation results in notochord defects in heterozygotes and distal visceral endoderm defects in homozygotes. Dev Dyn. 2009 Oct 29;238(12):3237-3247
1*J:39447 Farmer SC, Sun CW, Winnier GE, Hogan BL, Townes TM, The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. Genes Dev. 1997 Mar 15;11(6):786-98
3J:213659 Fausett SR, Brunet LJ, Klingensmith J, BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis. Dev Biol. 2014 Jul 1;391(1):111-24
5*J:23134 Faust C, Schumacher A, Holdener B, Magnuson T, The eed mutation disrupts anterior mesoderm production in mice. Development. 1995 Feb;121(2):273-85
4J:165811 Fernandez-Diaz LC, Laurent A, Girasoli S, Turco M, Longobardi E, Iotti G, Jenkins NA, Fiorenza MT, Copeland NG, Blasi F, The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells. Development. 2010 Oct;137(20):3393-403
1J:222248 Fossat N, Ip CK, Jones VJ, Studdert JB, Khoo PL, Lewis SL, Power M, Tourle K, Loebel DA, Kwan KM, Behringer RR, Tam PP, Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo. Development. 2015 Jun 1;142(11):2069-79
1J:243623 Freyer L, Hsu CW, Nowotschin S, Pauli A, Ishida J, Kuba K, Fukamizu A, Schier AF, Hoodless PA, Dickinson ME, Hadjantonakis AK, Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives. Cell Rep. 2017 Aug 29;20(9):2116-2130
3J:226600 Freyer L, Schroter C, Saiz N, Schrode N, Nowotschin S, Martinez-Arias A, Hadjantonakis AK, A loss-of-function and H2B-Venus transcriptional reporter allele for Gata6 in mice. BMC Dev Biol. 2015;15:38
2*J:45340 Friedrich GA, Hildebrand JD, Soriano P, The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse. Dev Biol. 1997 Dec 15;192(2):364-74
2J:154679 Fu J, Jiang M, Mirando AJ, Yu HM, Hsu W, Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18598-603
1*J:30097 Fuchtbauer EM, Expression of M-twist during postimplantation development of the mouse. Dev Dyn. 1995 Nov;204(3):316-22
2*J:131814 Fukusumi Y, Naruse C, Asano M, Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo. Dev Dyn. 2008 Mar;237(3):618-29
1*J:29978 Furuta Y, Ilic D, Kanazawa S, Takeda N, Yamamoto T, Aizawa S, Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene. 1995 Nov 16;11(10):1989-95
1*J:316421 Fuselier KTB, Salbaum JM, Kappen C, Broad spectrum of CRISPR-induced edits in an embryonic lethal gene. Sci Rep. 2021 Dec 9;11(1):23732
2J:183346 Futterer A, Raya A, Llorente M, Izpisua-Belmonte JC, de la Pompa JL, Klatt P, Martinez-A C, Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development. Cell Death Differ. 2012 Jan;19(1):132-43
4J:133091 Galceran J, Hsu SC, Grosschedl R, Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8668-73
1J:94049 Galceran J, Sustmann C, Hsu SC, Folberth S, Grosschedl R, LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev. 2004 Nov 15;18(22):2718-23
4J:155476 Gandillet A, Serrano AG, Pearson S, Lie-A-Ling M, Lacaud G, Kouskoff V, Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification. Blood. 2009 Nov 26;114(23):4813-22
1*J:134633 Gao X, Tate P, Hu P, Tjian R, Skarnes WC, Wang Z, ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6656-61
2J:98216 Garcia-Garcia MJ, Eggenschwiler JT, Caspary T, Alcorn HL, Wyler MR, Huangfu D, Rakeman AS, Lee JD, Feinberg EH, Timmer JR, Anderson KV, Inaugural Article: Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5913-9
4J:139139 Garcia-Garcia MJ, Shibata M, Anderson KV, Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development. 2008 Sep;135(18):3053-62
1*J:115836 Garrick D, Sharpe JA, Arkell R, Dobbie L, Smith AJ, Wood WG, Higgs DR, Gibbons RJ, Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues. PLoS Genet. 2006 Apr;2(4):e58
3*J:221408 Garriock RJ, Chalamalasetty RB, Kennedy MW, Canizales LC, Lewandoski M, Yamaguchi TP, Lineage tracing of neuromesodermal progenitors reveals novel Wnt-dependent roles in trunk progenitor cell maintenance and differentiation. Development. 2015 May 1;142(9):1628-38
1J:291490 Garriock RJ, Chalamalasetty RB, Zhu J, Kennedy MW, Kumar A, Mackem S, Yamaguchi TP, A dorsal-ventral gradient of Wnt3a/beta-catenin signals controls mouse hindgut extension and colon formation. Development. 2020 Apr 12;147(8):dev185108
2J:328993 Genuth NR, Shi Z, Kunimoto K, Hung V, Xu AF, Kerr CH, Tiu GC, Oses-Prieto JA, Salomon-Shulman REA, Axelrod JD, Burlingame AL, Loh KM, Barna M, A stem cell roadmap of ribosome heterogeneity reveals a function for RPL10A in mesoderm production. Nat Commun. 2022 Sep 19;13(1):5491
4J:36210 Georges-Labouesse EN, George EL, Rayburn H, Hynes RO, Mesodermal development in mouse embryos mutant for fibronectin. Dev Dyn. 1996 Oct;207(2):145-56
2J:106548 Georgiades P, Rossant J, Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development. Development. 2006 Mar;133(6):1059-68
2J:219587 Geula S, Moshitch-Moshkovitz S, Dominissini D, Mansour AA, Kol N, Salmon-Divon M, Hershkovitz V, Peer E, Mor N, Manor YS, Ben-Haim MS, Eyal E, Yunger S, Pinto Y, Jaitin DA, Viukov S, Rais Y, Krupalnik V, Chomsky E, Zerbib M, Maza I, Rechavi Y, Massarwa R, Hanna S, Amit I, Levanon EY, Amariglio N, Stern-Ginossar N, Novershtern N, Rechavi G, Hanna JH, Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science. 2015 Feb 27;347(6225):1002-6
1J:176262 Giros A, Grgur K, Gossler A, Costell M, alpha5beta1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice. PLoS One. 2011;6(7):e22002
2J:107403 Glaser S, Schaft J, Lubitz S, Vintersten K, van der Hoeven F, Tufteland KR, Aasland R, Anastassiadis K, Ang SL, Stewart AF, Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development. Development. 2006 Apr;133(8):1423-32
2*J:44409 Gofflot F, Hall M, Morriss-Kay GM, Genetic patterning of the developing mouse tail at the time of posterior neuropore closure. Dev Dyn. 1997 Dec;210(4):431-45
2J:51455 Gofflot F, Hall M, Morriss-Kay GM, Genetic patterning of the posterior neuropore region of curly tail mouse embryos: deficiency of Wnt5a expression. Int J Dev Biol. 1998 Jul;42(5):637-44
1J:329965 Gogolou A, Souilhol C, Granata I, Wymeersch FJ, Manipur I, Wind M, Frith TJR, Guarini M, Bertero A, Bock C, Halbritter F, Takasato M, Guarracino MR, Tsakiridis A, Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor. Elife. 2022 Sep 26;11:e74263
1*J:44237 Goh KL, Yang JT, Hynes RO, Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos. Development. 1997 Nov;124(21):4309-19
2J:107619 Goldin SN, Papaioannou VE, Unusual misregulation of RNA splicing caused by insertion of a transposable element into the T (Brachyury) locus. BMC Genomics. 2003 Apr 17;4(1):14
2J:142592 Goller T, Vauti F, Ramasamy S, Arnold HH, Transcriptional regulator BPTF/FAC1 is essential for trophoblast differentiation during early mouse development. Mol Cell Biol. 2008 Nov;28(22):6819-27
1J:310310 Gordeeva O, Gordeev A, Khaydukov S, Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells. Oncotarget. 2019 May 14;10(35):3248-3266
1J:143572 Gorivodsky M, Mukhopadhyay M, Wilsch-Braeuninger M, Phillips M, Teufel A, Kim C, Malik N, Huttner W, Westphal H, Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain. Dev Biol. 2009 Jan 1;325(1):24-32
2J:98883 Gotoh N, Manova K, Tanaka S, Murohashi M, Hadari Y, Lee A, Hamada Y, Hiroe T, Ito M, Kurihara T, Nakazato H, Shibuya M, Lax I, Lacy E, Schlessinger J, The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development. Mol Cell Biol. 2005 May;25(10):4105-16
2*J:50519 Gotz J, Probst A, Ehler E, Hemmings B, Kues W, Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha. Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12370-5
1*J:76264 Gratsch TE, O'Shea KS, Noggin and chordin have distinct activities in promoting lineage commitment of mouse embryonic stem (ES) cells. Dev Biol. 2002 May 1;245(1):83-94
3*J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
8J:337476 Gredler ML, Zallen JA, Multicellular rosettes link mesenchymal-epithelial transition to radial intercalation in the mouse axial mesoderm. Dev Cell. 2023 Jun 5;58(11):933-950.e5
3*J:47700 Greene ND, Gerrelli D, Van Straaten HW, Copp AJ, Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects. Mech Dev. 1998 Apr;73(1):59-72
1J:230653 Grego-Bessa J, Bloomekatz J, Castel P, Omelchenko T, Baselga J, Anderson KV, The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium. Elife. 2016;5:e12034
2J:90119 Gregorieff A, Grosschedl R, Clevers H, Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos. EMBO J. 2004 Apr 21;23(8):1825-33
1J:184036 Gu P, Qi X, Zhou Y, Wang Y, Gao X, Generation of Ppp2Ca and Ppp2Cb conditional null alleles in mouse. Genesis. 2012 May;50(5):429-36
1*J:46637 Gu Z, Nomura M, Simpson BB, Lei H, Feijen A, van den Eijnden-van Raaij J , Donahoe PK , Li E, The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse. Genes Dev. 1998 Mar 15;12(6):844-57
2J:54394 Gu Z, Reynolds EM, Song J, Lei H, Feijen A, Yu L, He W, MacLaughlin DT , van den Eijnden-van Raaij J , Donahoe PK , Li E, The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development. 1999 Jun;126(11):2551-61
1*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
3J:135128 Guo Q, Li JY, Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation. Development. 2007 Jun;134(12):2251-60
10J:301045 Guo SS, Au TYK, Wynn S, Aszodi A, Chan D, Fassler R, Cheah KSE, beta1 Integrin regulates convergent extension in mouse notogenesis, ensures notochord integrity and the morphogenesis of vertebrae and intervertebral discs. Development. 2020 Nov 18;147(22):dev192724
1*J:217689 Guzman-Ayala M, Sachs M, Koh FM, Onodera C, Bulut-Karslioglu A, Lin CJ, Wong P, Nitta R, Song JS, Ramalho-Santos M, Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast. Development. 2015 Jan 1;142(1):118-27
1*J:258756 Gyuris A, Donovan DJ, Seymour KA, Lovasco LA, Smilowitz NR, Halperin AL, Klysik JE, Freiman RN, The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis. Biochim Biophys Acta. 2009 May;1789(5):413-21
1*J:29881 Haegel H, Larue L, Ohsugi M, Fedorov L, Herrenknecht K, Kemler R, Lack of beta-catenin affects mouse development at gastrulation. Development. 1995 Nov;121(11):3529-37
1*J:33880 Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmair A, Billia F, Firpo E, Hui CC, Roberts J, Rossant J, Mak TW, The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell. 1996 Jun 28;85(7):1009-23
1*J:217681 Halstead AM, Wright CV, Disrupting Foxh1-Groucho interaction reveals robustness of nodal-based embryonic patterning. Mech Dev. 2015 May;136:155-65
1J:79668 Hamamoto T, Beppu H, Okada H, Kawabata M, Kitamura T, Miyazono K, Kato M, Compound disruption of smad2 accelerates malignant progression of intestinal tumors in apc knockout mice. Cancer Res. 2002 Oct 15;62(20):5955-61
2J:166677 Han DW, Tapia N, Joo JY, Greber B, Arauzo-Bravo MJ, Bernemann C, Ko K, Wu G, Stehling M, Do JT, Scholer HR, Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages. Cell. 2010 Nov 12;143(4):617-27
1J:79491 Hanna LA, Foreman RK, Tarasenko IA, Kessler DS, Labosky PA, Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev. 2002 Oct 15;16(20):2650-61
1*J:306370 Harland LTG, Simon CS, Senft AD, Costello I, Greder L, Imaz-Rosshandler I, Gottgens B, Marioni JC, Bikoff EK, Porcher C, de Bruijn MFTR, Robertson EJ, The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors. Nat Cell Biol. 2021 Jan;23(1):61-74
2J:181536 Harrelson Z, Kaestner KH, Evans SM, Foxa2 mediates critical functions of prechordal plate in patterning and morphogenesis and is cell autonomously required for early ventral endoderm morphogenesis. Biol Open. 2012;1:173-181
1J:242068 Harrison SE, Sozen B, Christodoulou N, Kyprianou C, Zernicka-Goetz M, Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro. Science. 2017 Apr 14;356(6334)
8J:77443 Hart AH, Hartley L, Sourris K, Stadler ES, Li R, Stanley EG, Tam PP, Elefanty AG, Robb L, Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo. Development. 2002 Aug;129(15):3597-608
4J:334609 Hatakeyama Y, Saito N, Mii Y, Takada R, Shinozuka T, Takemoto T, Naoki H, Takada S, Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis. Nat Commun. 2023 Apr 6;14(1):1924
2J:317804 Hauswirth GM, Garside VC, Wong LSF, Bildsoe H, Manent J, Chang YC, Nefzger CM, Firas J, Chen J, Rossello FJ, Polo JM, McGlinn E, Breaking constraint of mammalian axial formulae. Nat Commun. 2022 Jan 11;13(1):243
10*J:238590 Hayashi K, Ikari T, Sugiyama G, Sugiura T, Ohyama Y, Kumamaru W, Shirasuna K, Mori Y, Involvement of the T-box transcription factor Brachyury in early-stage embryonic mouse salivary gland. Biochem Biophys Res Commun. 2016 Sep 02;477(4):814-9
2*J:79513 Hayashi K, Kobayashi T, Umino T, Goitsuka R, Matsui Y, Kitamura D, SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast. Mech Dev. 2002 Oct;118(1-2):99
2*J:310902 Hayashi S, Suzuki H, Takemoto T, The nephric mesenchyme lineage of intermediate mesoderm is derived from Tbx6-expressing derivatives of neuro-mesodermal progenitors via BMP-dependent Osr1 function. Dev Biol. 2021 Oct;478:155-162
1*J:348275 He XD, Phillips S, Hioki K, Majhi PD, Babbitt C, Tremblay KD, Pobezinsky LA, Mager J, TATA-binding associated factors have distinct roles during early mammalian development. Dev Biol. 2024 Jul;511:53-62
1*J:224211 Henrique D, Abranches E, Verrier L, Storey KG, Neuromesodermal progenitors and the making of the spinal cord. Development. 2015 Sep 1;142(17):2864-75
3*J:30820 Hermesz E, Mackem S, Mahon KA, Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo. Development. 1996 Jan;122(1):41-52
7J:279070 Hernandez-Martinez R, Ramkumar N, Anderson KV, p120-catenin regulates WNT signaling and EMT in the mouse embryo. Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16872-16881
5*J:1975 Herrmann BG, Expression pattern of the Brachyury gene in whole-mount TWis/TWis mutant embryos. Development. 1991 Nov;113(3):913-7
1J:21263 Herrmann BG, Labeit S, Poustka A, King TR, Lehrach H, Cloning of the T gene required in mesoderm formation in the mouse [see comments]. Nature. 1990 Feb 15;343(6259):617-22
1J:170392 Herzog M, Wendling O, Guillou F, Chambon P, Mark M, Losson R, Cammas F, TIF1beta association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis. Dev Biol. 2011 Feb 15;350(2):548-58
1*J:73507 Heyer J, Escalante-Alcalde D, Lia M, Boettinger E, Edelmann W, Stewart CL, Kucherlapati R, Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12595-600
2*J:155247 Hierholzer A, Kemler R, beta-catenin-mediated signaling and cell adhesion in postgastrulation mouse embryos. Dev Dyn. 2009 Aug 24;239(1):191-199
2*J:77905 Hildebrand JD, Soriano P, Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol Cell Biol. 2002 Aug;22(15):5296-307
2J:142596 Hirano M, Hashimoto S, Yonemura S, Sabe H, Aizawa S, EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J Cell Biol. 2008 Sep 22;182(6):1217-30
2J:95386 Hiratsuka S, Kataoka Y, Nakao K, Nakamura K, Morikawa S, Tanaka S, Katsuki M, Maru Y, Shibuya M, Vascular endothelial growth factor A (VEGF-A) is involved in guidance of VEGF receptor-positive cells to the anterior portion of early embryos. Mol Cell Biol. 2005 Jan;25(1):355-63
4J:195125 Hoffman JA, Wu CI, Merrill BJ, Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification. Development. 2013 Apr;140(8):1665-75
3J:69602 Hohenstein P, Kielman MF, Breukel C, Bennett LM, Wiseman R, Krimpenfort P, Cornelisse C, van Ommen GJ, Devilee P, Fodde R, A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage. Oncogene. 2001 May 3;20(20):2544-50
3*J:18126 Holdener BC, Faust C, Rosenthal NS, Magnuson T, msd is required for mesoderm induction in mice. Development. 1994 May;120(5):1335-46
2J:69594 Hoodless PA, Pye M, Chazaud C, Labbe E, Attisano L, Rossant J, Wrana JL, FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 2001 May 15;15(10):1257-71
1*J:119664 Houde C, Dickinson RJ, Houtzager VM, Cullum R, Montpetit R, Metzler M, Simpson EM, Roy S, Hayden MR, Hoodless PA, Nicholson DW, Hippi is essential for node cilia assembly and Sonic hedgehog signaling. Dev Biol. 2006 Dec 15;300(2):523-33
1*J:238567 Houtmeyers R, Tchouate Gainkam O, Glanville-Jones HA, Van den Bosch B, Chappell A, Barratt KS, Souopgui J, Tejpar S, Arkell RM, Zic2 mutation causes holoprosencephaly via disruption of NODAL signalling. Hum Mol Genet. 2016 Sep 15;25(18):3946-3959
2J:82316 Hsieh JC, Lee L, Zhang L, Wefer S, Brown K, DeRossi C, Wines ME, Rosenquist T, Holdener BC, Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell. 2003 Feb 7;112(3):355-67
1*J:281114 Hu J, Li S, Sun X, Fang Z, Wang L, Xiao F, Shao M, Ge L, Tang F, Gu J, Yu H, Guo Y, Guo X, Liao B, Jin Y, Stk40 deletion elevates c-JUN protein level and impairs mesoderm differentiation. J Biol Chem. 2019 Jun 21;294(25):9959-9972
3J:254969 Huang X, Balmer S, Yang F, Fidalgo M, Li D, Guallar D, Hadjantonakis AK, Wang J, Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling. Elife. 2017 Nov 23;6:e33333
1J:86437 Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV, Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature. 2003 Nov 6;426(6962):83-7
1J:60391 Huelsken J, Vogel R, Brinkmann V, Erdmann B, Birchmeier C, Birchmeier W, Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol. 2000 Feb 7;148(3):567-78
1*J:59131 Hurlin PJ, Steingrimsson E, Copeland NG, Jenkins NA, Eisenman RN, Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif. EMBO J. 1999 Dec 15;18(24):7019-28
2J:57589 Ikeda W, Nakanishi H, Miyoshi J, Mandai K, Ishizaki H, Tanaka M, Togawa A, Takahashi K, Nishioka H, Yoshida H, Mizoguchi A, Nishikawa S, Takai Y, Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis. J Cell Biol. 1999 Sep 6;146(5):1117-32
2*J:194054 Imuta Y, Kiyonari H, Jang CW, Behringer RR, Sasaki H, Generation of knock-in mice that express nuclear enhanced green fluorescent protein and tamoxifen-inducible Cre recombinase in the notochord from Foxa2 and T loci. Genesis. 2013 Mar;51(3):210-8
11*J:112218 Inman KE, Downs KM, Localization of Brachyury (T) in embryonic and extraembryonic tissues during mouse gastrulation. Gene Expr Patterns. 2006 Dec;6(8):783-93
4*J:119027 Inman KE, Downs KM, Brachyury is required for elongation and vasculogenesis in the murine allantois. Development. 2006 Aug;133(15):2947-59
4*J:122556 Inoue T, Ota M, Mikoshiba K, Aruga J, Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo. Dev Biol. 2007 Jun 15;306(2):669-84
4J:80667 Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM, Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1. Science. 2002 Dec 6;298(5600):1996-9
1*J:47940 Ishijima J, Yasui H, Morishima M, Shiroishi T, Dominant lethality of the mouse skeletal mutation tail-short (Ts) is determined by the Ts allele from mating partners. Genomics. 1998 May 1;49(3):341-50
3*J:81402 Ishikawa TO, Tamai Y, Li Q, Oshima M, Taketo MM, Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo. Dev Biol. 2003 Jan 15;253(2):230-46
1J:119566 Ishimura A, Ng JK, Taira M, Young SG, Osada S, Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling. Development. 2006 Oct;133(19):3919-28
3J:52208 Iulianella A, Beckett B, Petkovich M, Lohnes D, A molecular basis for retinoic acid-induced axial truncation. Dev Biol. 1999 JAN 1;205(1):33-48
2*J:306255 Ivanovitch K, Soro-Barrio P, Chakravarty P, Jones RA, Bell DM, Mousavy Gharavy SN, Stamataki D, Delile J, Smith JC, Briscoe J, Ventricular, atrial, and outflow tract heart progenitors arise from spatially and molecularly distinct regions of the primitive streak. PLoS Biol. 2021 May;19(5):e3001200
2J:189004 Iwafuchi-Doi M, Matsuda K, Murakami K, Niwa H, Tesar PJ, Aruga J, Matsuo I, Kondoh H, Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development. 2012 Nov;139(21):3926-37
1*J:225909 Jang CW, Shibata Y, Starmer J, Yee D, Magnuson T, Histone H3.3 maintains genome integrity during mammalian development. Genes Dev. 2015 Jul 1;29(13):1377-92
2*J:274134 Javali A, Misra A, Leonavicius K, Acharyya D, Vyas B, Sambasivan R, Co-expression of Tbx6 and Sox2 identifies a novel transient neuromesoderm progenitor cell state. Development. 2017 Dec 15;144(24):4522-4529
1*J:77516 Jiang P, Song J, Gu G, Slonimsky E, Li E, Rosenthal N, Targeted deletion of the MLC1f/3f downstream enhancer results in precocious MLC expression and mesoderm ablation. Dev Biol. 2002 Mar 15;243(2):281-93
2*J:200708 Jin JZ, Ding J, Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation. Dev Biol. 2013 Sep 1;381(1):170-8
1J:299860 Jin L, Chen Y, Crossman DK, Datta A, Vu T, Mobley JA, Basu MK, Scarduzio M, Wang H, Chang C, Datta PK, STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells. Nat Commun. 2020 Nov 23;11(1):5941
1J:216160 Jurberg AD, Aires R, Novoa A, Rowland JE, Mallo M, Compartment-dependent activities of Wnt3a/beta-catenin signaling during vertebrate axial extension. Dev Biol. 2014 Oct 15;394(2):253-63
3J:198634 Jurberg AD, Aires R, Varela-Lasheras I, Novoa A, Mallo M, Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos. Dev Cell. 2013 Jun 10;25(5):451-62
1*J:79831 Kawakami T, Kawcak T, Li YJ, Zhang W, Hu Y, Chuang PT, Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling. Development. 2002 Dec;129(24):5753-65
1J:187732 Kawamura N, Sun-Wada GH, Aoyama M, Harada A, Takasuga S, Sasaki T, Wada Y, Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos. Nat Commun. 2012 Sep 18;3:1071
1*J:295945 Kawamura N, Takaoka K, Hamada H, Hadjantonakis AK, Sun-Wada GH, Wada Y, Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism. Cell Rep. 2020 Jun 9;31(10):107733
4J:91055 Kelly OG, Pinson KI, Skarnes WC, The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development. 2004 Jun;131(12):2803-15
1J:94395 Kemler R, Hierholzer A, Kanzler B, Kuppig S, Hansen K, Taketo MM, de Vries WN, Knowles BB, Solter D, Stabilization of {beta}-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development. 2004 Dec;131(23):5817-5824
3J:341678 Kemmler CL, Smolikova J, Moran HR, Mannion BJ, Knapp D, Lim F, Czarkwiani A, Hermosilla Aguayo V, Rapp V, Fitch OE, Botschi S, Selleri L, Farley E, Braasch I, Yun M, Visel A, Osterwalder M, Mosimann C, Kozmik Z, Burger A, Conserved enhancers control notochord expression of vertebrate Brachyury. Nat Commun. 2023 Oct 18;14(1):6594
3*J:164475 Kennedy KA, Ostrakhovitch EA, Sandiford SD, Dayarathna T, Xie X, Waese EY, Chang WY, Feng Q, Skerjanc IS, Stanford WL, Li SS, Mammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cells. J Biol Chem. 2010 Jun 4;285(23):17974-85
1J:232050 Kennedy MW, Chalamalasetty RB, Thomas S, Garriock RJ, Jailwala P, Yamaguchi TP, Sp5 and Sp8 recruit beta-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3545-50
3*J:347581 Khatif H, Bazzi H, Generation and characterization of a Dkk4-Cre knock-in mouse line. Genesis. 2024 Feb;62(1):e23532
5J:329565 Kim J, Muraoka M, Okada H, Toyoda A, Ajima R, Saga Y, The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing. PLoS Genet. 2022 Oct;18(10):e1009967
3J:327957 Kim YS, Fan R, Lith SC, Dicke AK, Drexler HCA, Kremer L, Kuempel-Rink N, Hekking L, Stehling M, Bedzhov I, Rap1 controls epiblast morphogenesis in sync with the pluripotency states transition. Dev Cell. 2022 Aug 22;57(16):1937-1956.e8
1J:283312 Kim YY, Moon JS, Kwon MC, Shin J, Im SK, Kim HA, Han JK, Kong YY, Meteorin regulates mesendoderm development by enhancing nodal expression. PLoS One. 2014;9(2):e88811
2*J:70278 Kimura C, Shen MM, Takeda N, Aizawa S, Matsuo I, Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast. Dev Biol. 2001 Jul 1;235(1):12-32
1*J:64866 Kimura C, Yoshinaga K, Tian E, Suzuki M, Aizawa S, Matsuo I, Visceral endoderm mediates forebrain development by suppressing posteriorizing signals. Dev Biol. 2000 Sep 15;225(2):304-21
8*J:56361 Kimura N, Nakashima K, Ueno M, Kiyama H, Taga T, A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain. Brain Res Dev Brain Res. 1999 Jun 2;115(2):183-93
1J:324183 Kimura-Yoshida C, Mochida K, Kanno SI, Matsuo I, USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components. Commun Biol. 2022 Apr 19;5(1):378
1J:103272 Kimura-Yoshida C, Nakano H, Okamura D, Nakao K, Yonemura S, Belo JA, Aizawa S, Matsui Y, Matsuo I, Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm. Dev Cell. 2005 Nov;9(5):639-50
1J:120359 Kimura-Yoshida C, Tian E, Nakano H, Amazaki S, Shimokawa K, Rossant J, Aizawa S, Matsuo I, Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5919-24
1*J:74124 Kinder SJ, Tsang TE, Ang SL, Behringer RR, Tam PP, Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int J Dev Biol. 2001;45(1 Spec No):347-55
3*J:58082 Kinder SJ, Tsang TE, Quinlan GA, Hadjantonakis AK, Nagy A, Tam PP, The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo. Development. 1999 Nov;126(21):4691-701
18*J:16412 Kispert A, Herrmann BG, Immunohistochemical analysis of the Brachyury protein in wild-type and mutant mouse embryos. Dev Biol. 1994 Jan;161(1):179-93
4J:62984 Kitajima S, Takagi A, Inoue T, Saga Y, MesP1 and MesP2 are essential for the development of cardiac mesoderm. Development. 2000 Aug;127(15):3215-26
3J:167830 Koike S, Yutoh Y, Keino-Masu K, Noji S, Masu M, Ohuchi H, Autotaxin is required for the cranial neural tube closure and establishment of the midbrain-hindbrain boundary during mouse development. Dev Dyn. 2011 Feb;240(2):413-21
1J:210110 Komatsu Y, Kishigami S, Mishina Y, In situ hybridization methods for mouse whole mounts and tissue sections with and without additional beta-galactosidase staining. Methods Mol Biol. 2014;1092:1-15
1*J:117234 Komatsu Y, Scott G, Nagy A, Kaartinen V, Mishina Y, BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis. Dev Dyn. 2007 Feb;236(2):512-7
1*J:46145 Kos L, Chiang C, Mahon KA, Mediolateral patterning of somites: multiple axial signals, including Sonic hedgehog, regulate Nkx-3.1 expression. Mech Dev. 1998 Jan;70(1-2):25-34
2*J:16332 Koseki H, Wallin J, Wilting J, Mizutani Y, Kispert A, Ebensperger C, Herrmann BG, Christ B, Balling R, A role for Pax-1 as a mediator of notochordal signals during the dorsoventral specification of vertebrae. Development. 1993 Nov;119(3):649-60
1J:223226 Krawchuk D, Anani S, Honma-Yamanaka N, Polito S, Shafik M, Yamanaka Y, Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo. J Cell Sci. 2015 Mar 1;128(5):1011-22
2J:173571 Krol AJ, Roellig D, Dequeant ML, Tassy O, Glynn E, Hattem G, Mushegian A, Oates AC, Pourquie O, Evolutionary plasticity of segmentation clock networks. Development. 2011 Jul;138(13):2783-92
4J:170405 Kueh AJ, Dixon MP, Voss AK, Thomas T, HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development. Mol Cell Biol. 2011 Feb;31(4):845-60
1*J:210984 Kumar A, Lualdi M, Loncarek J, Cho YW, Lee JE, Ge K, Kuehn MR, Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development. Dev Dyn. 2014 Jul;243(7):937-47
1J:221169 Kumar A, Lualdi M, Lyozin GT, Sharma P, Loncarek J, Fu XY, Kuehn MR, Nodal signaling from the visceral endoderm is required to maintain Nodal gene expression in the epiblast and drive DVE/AVE migration. Dev Biol. 2015 Apr 1;400(1):1-9
1J:97950 Kurahashi H, Taniguchi M, Meno C, Taniguchi Y, Takeda S, Horie M, Otani H, Toda T, Basement membrane fragility underlies embryonic lethality in fukutin-null mice. Neurobiol Dis. 2005 Jun-Jul;19(1-2):208-17
4J:234323 Kurian L, Aguirre A, Sancho-Martinez I, Benner C, Hishida T, Nguyen TB, Reddy P, Nivet E, Krause MN, Nelles DA, Esteban CR, Campistol JM, Yeo GW, Belmonte JCI, Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development. Circulation. 2015 Apr 7;131(14):1278-1290
1*J:91012 Kurokawa D, Takasaki N, Kiyonari H, Nakayama R, Kimura-Yoshida C, Matsuo I, Aizawa S, Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm. Development. 2004 Jul;131(14):3307-17
3J:294100 Kyprianou C, Christodoulou N, Hamilton RS, Nahaboo W, Boomgaard DS, Amadei G, Migeotte I, Zernicka-Goetz M, Basement membrane remodelling regulates mouse embryogenesis. Nature. 2020 Jun;582(7811):253-258
3J:116646 Labelle-Dumais C, Jacob-Wagner M, Pare JF, Belanger L, Dufort D, Nuclear receptor NR5A2 is required for proper primitive streak morphogenesis. Dev Dyn. 2006 Dec;235(12):3359-69
1*J:76941 Lagger G, O'Carroll D, Rembold M, Khier H, Tischler J, Weitzer G, Schuettengruber B, Hauser C, Brunmeir R, Jenuwein T, Seiser C, Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J. 2002 Jun 3;21(11):2672-81
2J:147414 Landry J, Sharov AA, Piao Y, Sharova LV, Xiao H, Southon E, Matta J, Tessarollo L, Zhang YE, Ko MS, Kuehn MR, Yamaguchi TP, Wu C, Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. PLoS Genet. 2008 Oct;4(10):e1000241
4J:244157 Lange L, Marks M, Liu J, Wittler L, Bauer H, Piehl S, Blass G, Timmermann B, Herrmann BG, Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a. Biol Open. 2017 Jun 15;6(6):752-764
3J:236825 Langer D, Martianov I, Alpern D, Rhinn M, Keime C, Dolle P, Mengus G, Davidson I, Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation. Nat Commun. 2016 Mar 30;7:11063
1J:217820 Larabee SM, Coia H, Jones S, Cheung E, Gallicano GI, miRNA-17 Members that Target Bmpr2 Influence Signaling Mechanisms Important for Embryonic Stem Cell Differentiation In Vitro and Gastrulation in Embryos. Stem Cells Dev. 2015 Feb 1;24(3):354-71
3*J:36233 Larue L, Antos C, Butz S, Huber O, Delmas V, Dominis M, Kemler R, A role for cadherins in tissue formation. Development. 1996 Oct;122(10):3185-94
2*J:50931 Lee CG, da Costa Soares V, Newberger C, Manova K, Lacy E, Hurwitz J, RNA helicase A is essential for normal gastrulation. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13709-13
1J:155850 Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS, Choi K, ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2008 May 8;2(5):497-507
2*J:258200 Lee GH, Fujita M, Takaoka K, Murakami Y, Fujihara Y, Kanzawa N, Murakami KI, Kajikawa E, Takada Y, Saito K, Ikawa M, Hamada H, Maeda Y, Kinoshita T, A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO. J Cell Biol. 2016 Dec 5;215(5):705-718
1*J:122548 Lee JD, Silva-Gagliardi NF, Tepass U, McGlade CJ, Anderson KV, The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo. Development. 2007 Jun;134(11):2007-16
1*J:163739 Leung AW, Wong SY, Chan D, Tam PP, Cheah KS, Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain. Dev Dyn. 2010 Sep;239(9):2319-29
1*J:293790 Lewis EMA, Sankar S, Tong C, Patterson ES, Waller LE, Gontarz P, Zhang B, Ornitz DM, Kroll KL, Geminin is required for Hox gene regulation to pattern the developing limb. Dev Biol. 2020 Aug 1;464(1):11-23
1J:134688 Lewis SL, Khoo PL, De Young RA, Steiner K, Wilcock C, Mukhopadhyay M, Westphal H, Jamieson RV, Robb L, Tam PP, Dkk1 and Wnt3 interact to control head morphogenesis in the mouse. Development. 2008 May;135(10):1791-801
1*J:329046 Li B, Brusman L, Dahlka J, Niswander LA, TMEM132A ensures mouse caudal neural tube closure and regulates integrin-based mesodermal migration. Development. 2022 Sep 1;149(17):dev200442
1J:164717 Li C, Li YP, Fu XY, Deng CX, Anterior Visceral Endoderm SMAD4 Signaling Specifies Anterior Embryonic Patterning and Head Induction in Mice. Int J Biol Sci. 2010;6(6):569-83
1J:290444 Li J, Wang C, Feng G, Zhang L, Chen G, Sun H, Wang J, Zhang Y, Zhou Q, Li W, Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing. Cell Prolif. 2020 Jan;53(1):e12724
6*J:204971 Li L, Liu C, Biechele S, Zhu Q, Song L, Lanner F, Jing N, Rossant J, Location of transient ectodermal progenitor potential in mouse development. Development. 2013 Nov;140(22):4533-43
1J:354214 Li M, Jin H, Zhao Y, Zhu G, Liu Y, Long H, Shen X, PHD2 safeguards modest mesendoderm development. Commun Biol. 2024 Sep 7;7(1):1100
1J:335823 Li Q, Lu J, Yin X, Chang Y, Wang C, Yan M, Feng L, Cheng Y, Gao Y, Xu B, Zhang Y, Wang Y, Cui G, Xu L, Sun Y, Zeng R, Li Y, Jing N, Xu GL, Wu L, Tang F, Li J, Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation. Nat Commun. 2023 May 22;14(1):2922
1J:99494 Li W, Ferkowicz MJ, Johnson SA, Shelley WC, Yoder MC, Endothelial cells in the early murine yolk sac give rise to CD41-expressing hematopoietic cells. Stem Cells Dev. 2005 Feb;14(1):44-54
3J:239071 Li X, Yue X, Pastor WA, Lin L, Georges R, Chavez L, Evans SM, Rao A, Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):E8267-E8276
3J:118341 Li Y, Litingtung Y, Ten Dijke P, Chiang C, Aberrant Bmp signaling and notochord delamination in the pathogenesis of esophageal atresia. Dev Dyn. 2007 Mar;236(3):746-54
2J:348281 Li-Bao L, Diaz-Diaz C, Raiola M, Sierra R, Temino S, Moya FJ, Rodriguez-Perales S, Santos E, Giovinazzo G, Bleckwehl T, Rada-Iglesias A, Spitz F, Torres M, Regulation of Myc transcription by an enhancer cluster dedicated to pluripotency and early embryonic expression. Nat Commun. 2024 May 10;15(1):3931
5J:136396 Liao X, Collins MD, All-trans retinoic acid-induced ectopic limb and caudal structures: murine strain sensitivities and pathogenesis. Dev Dyn. 2008 Jun;237(6):1553-64
3*J:98484 Lickert H, Cox B, Wehrle C, Taketo MM, Kemler R, Rossant J, Dissecting Wnt/{beta}-catenin signaling during gastrulation using RNA interference in mouse embryos. Development. 2005 Jun;132(11):2599-609
1J:108981 Lickert H, Kutsch S, Kanzler B, Tamai Y, Taketo MM, Kemler R, Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm. Dev Cell. 2002 Aug;3(2):171-81
1J:168622 Lighthouse JK, Zhang L, Hsieh JC, Rosenquist T, Holdener BC, MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. Dev Dyn. 2011 Mar;240(3):577-88
2J:132584 Liguori GL, Borges AC, D'Andrea D, Liguoro A, Goncalves L, Salgueiro AM, Persico MG, Belo JA, Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo. Dev Biol. 2008 Mar 15;315(2):280-9
2*J:64021 Lin X, Wei G, Shi Z, Dryer L, Esko JD, Wells DE, Matzuk MM, Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice. Dev Biol. 2000 Aug 15;224(2):299-311
2J:81581 Liu C, Nakamura E, Knezevic V, Hunter S, Thompson K, Mackem S, A role for the mesenchymal T-box gene Brachyury in AER formation during limb development. Development. 2003 Apr;130(7):1327-37
1J:56511 Liu P, Wakamiya M, Shea MJ, Albrecht U, Behringer RR, Bradley A, Requirement for Wnt3 in vertebrate axis formation. Nat Genet. 1999 Aug;22(4):361-5
4J:207378 Lolas M, Valenzuela PD, Tjian R, Liu Z, Charting Brachyury-mediated developmental pathways during early mouse embryogenesis. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4478-83
3J:264113 Lopez-Escobar B, Caro-Vega JM, Vijayraghavan DS, Plageman TF, Sanchez-Alcazar JA, Moreno RC, Savery D, Marquez-Rivas J, Davidson LA, Ybot-Gonzalez P, The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate. Development. 2018 May 8;145(9):dev157487
1*J:129208 Lou DY, Dominguez I, Toselli P, Landesman-Bollag E, O'Brien C, Seldin DC, The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development. Mol Cell Biol. 2008 Jan;28(1):131-9
5*J:73506 Lowe LA, Yamada S, Kuehn MR, Genetic dissection of nodal function in patterning the mouse embryo. Development. 2001 May;128(10):1831-43
2J:176115 Lu H, Huang YY, Mehrotra S, Droz-Rosario R, Liu J, Bhaumik M, White E, Shen Z, Essential Roles of BCCIP in Mouse Embryonic Development and Structural Stability of Chromosomes. PLoS Genet. 2011 Sep;7(9):e1002291
2J:40594 Ludwig T, Chapman DL, Papaioannou VE, Efstratiadis A, Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 1997 May 15;11(10):1226-41
1*J:277316 Lukacs M, Roberts T, Chatuverdi P, Stottmann RW, Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival. Elife. 2019 Jun 24;8:e45248
2J:178623 Madabhushi M, Lacy E, Anterior visceral endoderm directs ventral morphogenesis and placement of head and heart via BMP2 expression. Dev Cell. 2011 Nov 15;21(5):907-19
2*J:279207 Mager J, A Catalog of Early Lethal KOMP Phenotypes. MGI Direct Data Submission. 2019-2024;
1J:194042 Mahaffey JP, Grego-Bessa J, Liem KF Jr, Anderson KV, Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development. 2013 Mar;140(6):1262-71
1*J:66591 Mahlapuu M, Ormestad M, Enerback S, Carlsson P, The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm. Development. 2001 Jan;128(2):155-66
1J:195910 Maier JA, Lo Y, Harfe BD, Foxa1 and Foxa2 are required for formation of the intervertebral discs. PLoS One. 2013;8(1):e55528
1J:152173 Maisonneuve C, Guilleret I, Vick P, Weber T, Andre P, Beyer T, Blum M, Constam DB, Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow. Development. 2009 Sep;136(17):3019-30
2J:50810 Manova K, Tomihara-Newberger C, Wang S, Godelman A, Kalantry S, Witty-Blease K, De Leon V, Chen WS, Lacy E, Bachvarova RF, Apoptosis in mouse embryos: elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice. Dev Dyn. 1998 Nov;213(3):293-308
2J:310041 Mariani L, Guo X, Menezes NA, Drozd AM, Cakal SD, Wang Q, Ferretti E, A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm. Nat Commun. 2021 Aug 26;12(1):5136
1*J:154534 Martinez G, Wijesinghe M, Turner K, Abud HE, Taketo MM, Noda T, Robinson ML, de Iongh RU, Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4794-806
4J:270575 Mastromina I, Verrier L, Silva JC, Storey KG, Dale JK, Myc activity is required for maintenance of the neuromesodermal progenitor signalling network and for segmentation clock gene oscillations in mouse. Development. 2018 Jul 30;145(14):dev161091
1J:29682 Matsuo I, Kuratani S, Kimura C, Takeda N, Aizawa S, Mouse Otx2 functions in the formation and patterning of rostral head. Genes Dev. 1995 Nov 1;9(21):2646-58
1J:122005 Mavrakis KJ, Andrew RL, Lee KL, Petropoulou C, Dixon JE, Navaratnam N, Norris DP, Episkopou V, Arkadia Enhances Nodal/TGF-beta Signaling by Coupling Phospho-Smad2/3 Activity and Turnover. PLoS Biol. 2007 Mar 6;5(3):e67
1J:40596 McClatchey AI, Saotome I, Ramesh V, Gusella JF, Jacks T, The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes Dev. 1997 May 15;11(10):1253-65
2J:187360 McKean DM, Niswander L, Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly. Biol Open. 2012;1(9):874-883
2*J:47724 McMahon JA, Takada S, Zimmerman LB, Fan CM, Harland RM, McMahon AP, Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 1998 May 15;12(10):1438-52
2*J:45709 Melloy PG, Ewart JL, Cohen MF, Desmond ME, Kuehn MR, Lo CW, No turning, a mouse mutation causing left-right and axial patterning defects. Dev Biol. 1998 Jan 1;193(1):77-89
2J:57907 Meno C, Gritsman K, Ohishi S, Ohfuji Y, Heckscher E, Mochida K, Shimono A, Kondoh H, Talbot WS, Robertson EJ, Schier AF, Hamada H, Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol Cell. 1999 Sep;4(3):287-98
2*J:90402 Merrill BJ, Pasolli HA, Polak L, Rendl M, Garcia-Garcia MJ, Anderson KV, Fuchs E, Tcf3: a transcriptional regulator of axis induction in the early embryo. Development. 2004 Jan;131(2):263-74
1J:176435 Mesnard D, Donnison M, Fuerer C, Pfeffer PL, Constam DB, The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities. Genes Dev. 2011 Sep 1;25(17):1871-80
2J:173526 Migeotte I, Grego-Bessa J, Anderson KV, Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo. Development. 2011 Jul;138(14):3011-20
2J:166095 Migeotte I, Omelchenko T, Hall A, Anderson KV, Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse. PLoS Biol. 2010;8(8):e1000442
1J:91048 Miner JH, Li C, Mudd JL, Go G, Sutherland AE, Compositional and structural requirements for laminin and basement membranes during mouse embryo implantation and gastrulation. Development. 2004 May;131(10):2247-56
1*J:236404 Minocha S, Bessonnard S, Sung TL, Moret C, Constam DB, Herr W, Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification. Dev Biol. 2016 Oct 1;418(1):75-88
2*J:57670 Mishina Y, Crombie R, Bradley A, Behringer RR, Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. Dev Biol. 1999 Sep 15;213(2):314-26
1J:30426 Mishina Y, Suzuki A, Ueno N, Behringer RR, Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev. 1995 Dec 15;9(24):3027-37
6*J:130526 Mitiku N, Baker JC, Genomic analysis of gastrulation and organogenesis in the mouse. Dev Cell. 2007 Dec;13(6):897-907
4J:144355 Mitrecic D, Cunko VF, Gajovic S, Semi-thin sections of epoxy resin-embedded mouse embryos in morphological analysis of whole mount in situ RNA hybridization. J Microsc. 2008 Dec;232(3):504-7
1J:119568 Miura S, Davis S, Klingensmith J, Mishina Y, BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. Development. 2006 Oct;133(19):3767-75
1*J:86144 Miura S, Mishina Y, Whole-embryo culture of E5.5 mouse embryos: development to the gastrulation stage. Genesis. 2003 Sep;37(1):38-43
2J:177114 Miura S, Mishina Y, Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of smads and TAK1 in early mouse embryo. Dev Dyn. 2011 Nov;240(11):2474-81
3J:159998 Miura S, Singh AP, Mishina Y, Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo. Dev Biol. 2010 May 1;341(1):246-54
1J:272622 Mochizuki K, Tando Y, Sekinaka T, Otsuka K, Hayashi Y, Kobayashi H, Kamio A, Ito-Matsuoka Y, Takehara A, Kono T, Osumi N, Matsui Y, SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling. Development. 2018 Dec 3;145(23):dev164160
4J:202591 Mohn D, Chen SW, Dias DC, Weinstein DC, Dyer MA, Sahr K, Ducker CE, Zahradka E, Keller G, Zaret KS, Gudas LJ, Baron MH, Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos. Dev Dyn. 2003 Mar;226(3):446-59
2J:40145 Molkentin JD, Lin Q, Duncan SA, Olson EN, Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 1997 APR 15;11(8):1061-1072
2*J:65873 Monkley SJ, Zhou XH, Kinston SJ, Giblett SM, Hemmings L, Brown JE, Pritchard CA, Critchley DR, Fassler R, Disruption of the talin gene arrests mouse development at the gastrulation stage. Dev Dyn. 2000 Dec;219(4):560-74
7J:258132 Morgani SM, Metzger JJ, Nichols J, Siggia ED, Hadjantonakis AK, Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning. Elife. 2018 Feb 7;7:e32839
6*J:264612 Morgani SM, Saiz N, Garg V, Raina D, Simon CS, Kang M, Arias AM, Nichols J, Schroter C, Hadjantonakis AK, A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice. Dev Biol. 2018 Sep 1;441(1):104-126
4J:308051 Morgani SM, Su J, Nichols J, Massague J, Hadjantonakis AK, The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos. Elife. 2021 Apr 30;10:e64811
1J:121791 Morita S, Horii T, Kimura M, Goto Y, Ochiya T, Hatada I, One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation. Genomics. 2007 Jun;89(6):687-696
1*J:87222 Morkel M, Huelsken J, Wakamiya M, Ding J, van de Wetering M, Clevers H, Taketo MM, Behringer RR, Shen MM, Birchmeier W, Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development. 2003 Dec;130(25):6283-94
2J:163858 Morsut L, Yan KP, Enzo E, Aragona M, Soligo SM, Wendling O, Mark M, Khetchoumian K, Bressan G, Chambon P, Dupont S, Losson R, Piccolo S, Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Development. 2010 Aug 1;137(15):2571-8
2J:140559 Mu W, Wang W, Schimenti JC, An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development. Mol Cell Biol. 2008 Oct;28(20):6439-51
1J:71787 Mukhopadhyay M, Shtrom S, Rodriguez-Esteban C, Chen L, Tsukui T, Gomer L, Dorward DW, Glinka A, Grinberg A, Huang SP, Niehrs C, Belmonte JC, Westphal H, Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell. 2001 Sep;1(3):423-34
2J:81152 Mukhopadhyay M, Teufel A, Yamashita T, Agulnick AD, Chen L, Downs KM, Schindler A, Grinberg A, Huang SP, Dorward D, Westphal H, Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development. 2003 Feb;130(3):495-505
1J:264114 Mulas C, Chia G, Jones KA, Hodgson AC, Stirparo GG, Nichols J, Oct4 regulates the embryonic axis and coordinates exit from pluripotency and germ layer specification in the mouse embryo. Development. 2018 Jun 18;145(12):dev159103
1*J:62025 Murcia NS, Richards WG, Yoder BK, Mucenski ML, Dunlap JR, Woychik RP, The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Development. 2000 Jun;127(11):2347-55
1J:111702 Murray SA, Gridley T, Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10300-4
1J:285408 Mzoughi S, Di Tullio F, Low DHP, Motofeanu CM, Ong SLM, Wollmann H, Wun CM, Kruszka P, Muenke M, Hildebrandt F, Dunn NR, Messerschmidt DM, Guccione E, PRDM15 loss of function links NOTCH and WNT/PCP signaling to patterning defects in holoprosencephaly. Sci Adv. 2020 Jan;6(2):eaax9852
2*J:64982 Nacke S, Schafer R, M, De Angelis H, Mundlos S, Mouse mutant 'rib-vertebrae' (rv): A defect in somite polarity. Dev Dyn. 2000 Oct;219(2):192-200
1J:356554 Nahaboo W, Eski SE, Despin-Guitard E, Vermeersch M, Versaevel M, Saykali B, Monteyne D, Gabriele S, Magin TM, Schwarz N, Leube RE, Zwijsen A, Perez-Morga D, Singh SP, Migeotte I, Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo. EMBO J. 2022 Apr 4;41(7):e108747
5J:170831 Naiche LA, Holder N, Lewandoski M, FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis. Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4018-23
1J:83256 Naiche LA, Papaioannou VE, Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois. Development. 2003 Jun;130(12):2681-93
2*J:328290 Nakagawa T, Jorg DJ, Watanabe H, Mizuno S, Han S, Ikeda T, Omatsu Y, Nishimura K, Fujita M, Takahashi S, Kondoh G, Simons BD, Yoshida S, Nagasawa T, A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis. Cell Rep. 2021 Oct 19;37(3):109875
2*J:195277 Nakamura H, Cook RN, Justice MJ, Mouse Tenm4 is required for mesoderm induction. BMC Dev Biol. 2013;13:9
1J:29515 Namciu S, Lyons GE, Micales BK, Heyman HC, Colmenares C, Stavnezer E, Enhanced expression of mouse c-ski accompanies terminal skeletal muscle differentiation in vivo and in vitro. Dev Dyn. 1995 Nov;204(3):291-300
1J:306231 Nandadasa S, O'Donnell A, Murao A, Yamaguchi Y, Midura RJ, Olson L, Apte SS, The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1(+) hematoendothelial progenitors. Matrix Biol. 2021 Mar;97:40-57
1*J:148693 Narimatsu M, Bose R, Pye M, Zhang L, Miller B, Ching P, Sakuma R, Luga V, Roncari L, Attisano L, Wrana JL, Regulation of planar cell polarity by Smurf ubiquitin ligases. Cell. 2009 Apr 17;137(2):295-307
3J:247259 Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M, New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266
2*J:69393 Naruse-Nakajima C, Asano M, Iwakura Y, Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1. Mech Dev. 2001 Apr;102(1-2):95-105
2J:65651 Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG, Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Mech Dev. 2000 Nov;98(1-2):77-94
1*J:207639 Nelson DO, Jin DX, Downs KM, Kamp TJ, Lyons GE, Irx4 identifies a chamber-specific cell population that contributes to ventricular myocardium development. Dev Dyn. 2014 Mar;243(3):381-92
1*J:293791 Ngo J, Hashimoto M, Hamada H, Wynshaw-Boris A, Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation. Dev Biol. 2020 Aug 15;464(2):161-175
1J:54067 Niederreither K, Subbarayan V, Dolle P, Chambon P, Embryonic retinoic acid synthesis is essential for early mouse post-implantation development [see comments]. Nat Genet. 1999 Apr;21(4):444-8
1J:324629 Nishio M, Matsuura T, Hibi S, Ohta S, Oka C, Sasai N, Ishida Y, Matsuda E, Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression. Cell Prolif. 2022 Apr;55(4):e13215
1*J:92968 Nishiyama M, Nakayama K, Tsunematsu R, Tsukiyama T, Kikuchi A, Nakayama KI, Early embryonic death in mice lacking the beta-catenin-binding protein Duplin. Mol Cell Biol. 2004 Oct;24(19):8386-94
2J:101311 Niu Z, Yu W, Zhang SX, Barron M, Belaguli NS, Schneider MD, Parmacek M, Nordheim A, Schwartz RJ, Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem. 2005 Sep 16;280(37):32531-8
2J:48467 Nomura M, Li E, Smad2 role in mesoderm formation, left-right patterning and craniofacial development [see comments]. Nature. 1998 Jun 25;393(6687):786-90
1*J:77125 Norris DP, Brennan J, Bikoff EK, Robertson EJ, The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo. Development. 2002 Jul;129(14):3455-68
2J:198687 Nowotschin S, Costello I, Piliszek A, Kwon GS, Mao CA, Klein WH, Robertson EJ, Hadjantonakis AK, The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo. Genes Dev. 2013 May 1;27(9):997-1002
1*J:185807 Nowotschin S, Ferrer-Vaquer A, Concepcion D, Papaioannou VE, Hadjantonakis AK, Interaction of Wnt3a, Msgn1 and Tbx6 in neural versus paraxial mesoderm lineage commitment and paraxial mesoderm differentiation in the mouse embryo. Dev Biol. 2012 Jul 1;367(1):1-14
1J:283357 Nowotschin S, Setty M, Kuo YY, Liu V, Garg V, Sharma R, Simon CS, Saiz N, Gardner R, Boutet SC, Church DM, Hoodless PA, Hadjantonakis AK, Pe'er D, The emergent landscape of the mouse gut endoderm at single-cell resolution. Nature. 2019 May;569(7756):361-367
2*J:69977 O'Carroll D, Erhardt S, Pagani M, Barton SC, Surani MA, Jenuwein T, The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol. 2001 Jul;21(13):4330-6
1*J:203737 Oda M, Oxley D, Dean W, Reik W, Regulation of lineage specific DNA hypomethylation in mouse trophectoderm. PLoS One. 2013;8(6):e68846
2J:116773 Oda M, Yamagiwa A, Yamamoto S, Nakayama T, Tsumura A, Sasaki H, Nakao K, Li E, Okano M, DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev. 2006 Dec 15;20(24):3382-94
3J:310742 Odaka YS, Tohmonda T, Toyoda A, Aruga J, An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3. Sci Rep. 2018 Oct 8;8(1):14954
1J:155001 Oh S, Lee D, Kim T, Kim TS, Oh HJ, Hwang CY, Kong YY, Kwon KS, Lim DS, Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol Cell Biol. 2009 Dec;29(23):6309-20
1J:354194 Oikonomakos I, Tedesco M, Motamedi FJ, Peitzsch M, Nef S, Bornstein SR, Schedl A, Steenblock C, Neirijnck Y, In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells. Stem Cell Reports. 2024 Sep 10;19(9):1289-1303
1*J:47012 Okuda A, Fukushima A, Nishimoto M, Orimo A, Yamagishi T, Nabeshima Y, Kuro-o M, Nabeshima Yi, Boon K, Keaveney M, Stunnenberg HG, Muramatsu M, UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. EMBO J. 1998 Apr 1;17(7):2019-32
3J:299536 Omelchenko T, Hall A, Anderson KV, beta-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo. Nat Commun. 2020 Nov 27;11(1):6066
3J:217373 Omelchenko T, Rabadan MA, Hernandez-Martinez R, Grego-Bessa J, Anderson KV, Hall A, beta-Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryo. Genes Dev. 2014 Dec 15;28(24):2764-77
1*J:330741 Orchard P, White JS, Thomas PE, Mychalowych A, Kiseleva A, Hensley J, Allen B, Parker SCJ, Keegan CE, Genome-wide chromatin accessibility and transcriptome profiling show minimal epigenome changes and coordinated transcriptional dysregulation of hedgehog signaling in Danforth's short tail mice. Hum Mol Genet. 2019 Mar 1;28(5):736-750
9*J:41559 Palis J, Robertson S, Kennedy M, Wall C, Keller G, Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development. 1999 Nov;126(22):5073-84
4J:346126 Pappas MP, Kawakami H, Corcoran D, Chen KQ, Scott EP, Wong J, Gearhart MD, Nishinakamura R, Nakagawa Y, Kawakami Y, Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm. Development. 2024 Mar 1;151(5)
1*J:163834 Paudyal A, Damrau C, Patterson VL, Ermakov A, Formstone C, Lalanne Z, Wells S, Lu X, Norris DP, Dean CH, Henderson DJ, Murdoch JN, The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC Dev Biol. 2010;10:87
1*J:54640 Pearce JJ, Penny G, Rossant J, A mouse cerberus/Dan-related gene family. Dev Biol. 1999 May 1;209(1):98-110
3J:88053 Perea-Gomez A, Camus A, Moreau A, Grieve K, Moneron G, Dubois A, Cibert C, Collignon J, Initiation of gastrulation in the mouse embryo is preceded by an apparent shift in the orientation of the anterior-posterior axis. Curr Biol. 2004 Feb 3;14(3):197-207
1*J:67152 Perea-Gomez A, Lawson KA, Rhinn M, Zakin L, Brulet P, Mazan S, Ang SL, Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo. Development. 2001 Mar;128(5):753-65
2*J:53656 Perea-Gomez A, Shawlot W, Sasaki H, Behringer RR, Ang S, HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Development. 1999 Oct;126(20):4499-511
7J:81339 Perea-Gomez A, Vella FD, Shawlot W, Oulad-Abdelghani M, Chazaud C, Meno C, Pfister V, Chen L, Robertson E, Hamada H, Behringer RR, Ang SL, Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks. Dev Cell. 2002 Nov;3(5):745-56
2J:187710 Pereira PN, Dobreva MP, Maas E, Cornelis FM, Moya IM, Umans L, Verfaillie CM, Camus A, de Sousa Lopes SM, Huylebroeck D, Zwijsen A, Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion. Development. 2012 Sep;139(18):3343-54
1J:112181 Petersen PH, Tang H, Zou K, Zhong W, The enigma of the numb-Notch relationship during mammalian embryogenesis. Dev Neurosci. 2006;28(1-2):156-68
1J:65690 Pfendler KC, Yoon J, Taborn GU, Kuehn MR, Iannaccone PM, Nodal and bone morphogenetic protein 5 interact in murine mesoderm formation and implantation. Genesis. 2000 Sep;28(1):1-14
1*J:99573 Phan HM, Xu AW, Coco C, Srajer G, Wyszomierski S, Evrard YA, Eckner R, Dent SY, GCN5 and p300 share essential functions during early embryogenesis. Dev Dyn. 2005 Aug;233(4):1337-47
1J:138699 Piette D, Hendrickx M, Willems E, Kemp CR, Leyns L, An optimized procedure for whole-mount in situ hybridization on mouse embryos and embryoid bodies. Nat Protoc. 2008;3(7):1194-201
3J:205747 Polydorou C, Georgiades P, Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation. Nat Commun. 2013;4:1658
2J:157256 Powers SE, Taniguchi K, Yen W, Melhuish TA, Shen J, Walsh CA, Sutherland AE, Wotton D, Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. Development. 2010 Jan;137(2):249-59
1*J:320381 Prakash R, Freyer L, Saiz N, Gavrilov S, Wang RQ, Romanienko PJ, Lacy E, Hadjantonakis AK, Jasin M, XRCC3 loss leads to midgestational embryonic lethality in mice. DNA Repair (Amst). 2021 Dec;108:103227
1*J:80018 Przemeck GK, Heinzmann U, Beckers J, Hrabe De Angelis M, Node and midline defects are associated with left-right development in Delta1 mutant embryos. Development. 2003 Jan;130(1):3-13
1J:214731 Pulina M, Liang D, Astrof S, Shape and position of the node and notochord along the bilateral plane of symmetry are regulated by cell-extracellular matrix interactions. Biol Open. 2014;3(7):583-90
2J:173656 Pulina MV, Hou SY, Mittal A, Julich D, Whittaker CA, Holley SA, Hynes RO, Astrof S, Essential roles of fibronectin in the development of the left-right embryonic body plan. Dev Biol. 2011 Jun 15;354(2):208-20
2J:321351 Pulina MV, Sahr KE, Nowotschin S, Baron MH, Hadjantonakis AK, A conditional mutant allele for analysis of Mixl1 function in the mouse. Genesis. 2014 May;52(5):417-23
3J:171894 Qian L, Mahaffey JP, Alcorn HL, Anderson KV, Tissue-specific roles of Axin2 in the inhibition and activation of Wnt signaling in the mouse embryo. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8692-7
1*J:326159 Qin Y, Ni P, Zhang Q, Wang X, Du X, Yin Z, Wang L, Ye L, Chen L, Hbxip is essential for murine embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1. Development. 2022 Jun 15;149(12):dev200527
1*J:229516 Qiu Z, Elsayed Z, Peterkin V, Alkatib S, Bennett D, Landry JW, Ino80 is essential for proximal-distal axis asymmetry in part by regulating Bmp4 expression. BMC Biol. 2016;14(1):18
1J:344102 Racedo SE, Liu Y, Shi L, Zheng D, Morrow BE, Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals. Dev Biol. 2024 Feb;506:72-84
4*J:276571 Rajderkar S, Mann JM, Panaretos C, Yumoto K, Li HD, Mishina Y, Ralston B, Kaartinen V, Trim33 is required for appropriate development of pre-cardiogenic mesoderm. Dev Biol. 2019 Jun 15;450(2):101-114
2J:119028 Rakeman AS, Anderson KV, Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching. Development. 2006 Aug;133(16):3075-83
1J:227336 Ramkumar N, Harvey BM, Lee JD, Alcorn HL, Silva-Gagliardi NF, McGlade CJ, Bestor TH, Wijnholds J, Haltiwanger RS, Anderson KV, Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2. PLoS Genet. 2015 Oct;11(10):e1005551
3J:238551 Ramkumar N, Omelchenko T, Silva-Gagliardi NF, McGlade CJ, Wijnholds J, Anderson KV, Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation. Nat Cell Biol. 2016 Dec;18(12):1281-1291
2J:93573 Rana AA, Barbera JP, Rodriguez TA, Lynch D, Hirst E, Smith JC, Beddington RS, Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates. Development. 2004 Oct;131(20):4999-5007
1J:161528 Rantakari P, Nikkila J, Jokela H, Ola R, Pylkas K, Lagerbohm H, Sainio K, Poutanen M, Winqvist R, Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice. Hum Mol Genet. 2010 Aug 1;19(15):3021-9
4J:19634 Rappolee DA, Basilico C, Patel Y, Werb Z, Expression and function of FGF-4 in peri-implantation development in mouse embryos. Development. 1994 Aug;120(8):2259-69
1J:303230 Ray AT, Mazot P, Brewer JR, Catela C, Dinsmore CJ, Soriano P, FGF signaling regulates development by processes beyond canonical pathways. Genes Dev. 2020 Dec 1;34(23-24):1735-1752
1J:83923 Rayasam GV, Wendling O, Angrand PO, Mark M, Niederreither K, Song L, Lerouge T, Hager GL, Chambon P, Losson R, NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J. 2003 Jun 16;22(12):3153-63
1*J:103820 Reiter JF, Skarnes WC, Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes Dev. 2006 Jan 1;20(1):22-7
3J:29666 Rennebeck GM, Lader E, Chen Q, Bohm RA, Cai ZS, Faust C, Magnuson T, Pease LR, Artzt K, Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Dev Biol. 1995 Nov;172(1):206-17
2J:144016 Ribes V, Le Roux I, Rhinn M, Schuhbaur B, Dolle P, Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways. Development. 2009 Feb;136(4):665-76
2J:139732 Ribes V, Stutzmann F, Bianchetti L, Guillemot F, Dolle P, Le Roux I, Combinatorial signalling controls Neurogenin2 expression at the onset of spinal neurogenesis. Dev Biol. 2008 Sep 15;321(2):470-81
1J:117243 Rivera-Perez JA, Diefes H, Magnuson T, A simple enzymatic method for parietal yolk sac removal in early postimplantation mouse embryos. Dev Dyn. 2007 Feb;236(2):489-93
5J:104836 Rivera-Perez JA, Magnuson T, Primitive streak formation in mice is preceded by localized activation of Brachyury and Wnt3. Dev Biol. 2005 Dec 15;288(2):363-71
1*J:27458 Robb L, Lyons I, Li R, Hartley L, Kontgen F, Harvey RP, Metcalf D, Begley CG, Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7075-9
5J:75491 Roberts C, Sutherland HF, Farmer H, Kimber W, Halford S, Carey A, Brickman JM, Wynshaw-Boris A, Scambler PJ, Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality. Mol Cell Biol. 2002 Apr;22(7):2318-28
1J:85863 Robertson EJ, Norris DP, Brennan J, Bikoff EK, Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling. Philos Trans R Soc Lond B Biol Sci. 2003 Aug 29;358(1436):1351-7; discussion 1357
4J:166040 Rocha PP, Scholze M, Bleiss W, Schrewe H, Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling. Development. 2010 Aug;137(16):2723-31
2*J:266577 Rodrigo Albors A, Halley PA, Storey KG, Lineage tracing of axial progenitors using Nkx1-2CreER(T2) mice defines their trunk and tail contributions. Development. 2018 Oct 2;145(19):dev164319
2J:252106 Rodriguez AM, Downs KM, Visceral endoderm and the primitive streak interact to build the fetal-placental interface of the mouse gastrula. Dev Biol. 2017 Dec 1;432(1):98-124
3*J:242135 Rodriguez AM, Jin DX, Wolfe AD, Mikedis MM, Wierenga L, Hashmi MP, Viebahn C, Downs KM, Brachyury drives formation of a distinct vascular branchpoint critical for fetal-placental arterial union in the mouse gastrula. Dev Biol. 2017 May 15;425(2):208-222
1J:190202 Rouleau M, Medawar A, Hamon L, Shivtiel S, Wolchinsky Z, Zhou H, De Rosa L, Candi E, de la Forest Divonne S, Mikkola ML, van Bokhoven H, Missero C, Melino G, Puceat M, Aberdam D, TAp63 is important for cardiac differentiation of embryonic stem cells and heart development. Stem Cells. 2011 Nov;29(11):1672-83
2J:321506 Royer C, Sandham E, Slee E, Schneider F, Lagerholm CB, Godwin J, Veits N, Hathrell H, Zhou F, Leonavicius K, Garratt J, Narendra T, Vincent A, Jones C, Child T, Coward K, Graham C, Fritzsche M, Lu X, Srinivas S, ASPP2 maintains the integrity of mechanically stressed pseudostratified epithelia during morphogenesis. Nat Commun. 2022 Feb 17;13(1):941
1J:67553 Ruland J, Sirard C, Elia A, MacPherson D, Wakeham A, Li L, de la Pompa JL, Cohen SN, Mak TW, p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1859-64
1*J:60897 Russ AP, Wattler S, Colledge WH, Aparicio SA, Carlton MB, Pearce JJ, Barton SC, Surani MA, Ryan K, Nehls MC, Wilson V, Evans MJ, Eomesodermin is required for mouse trophoblast development and mesoderm formation. Nature. 2000 Mar 2;404(6773):95-9
1*J:205665 Ryazanova LV, Rondon LJ, Zierler S, Hu Z, Galli J, Yamaguchi TP, Mazur A, Fleig A, Ryazanov AG, TRPM7 is essential for Mg(2+) homeostasis in mammals. Nat Commun. 2010;1:109
1*J:49903 Saga Y, Genetic rescue of segmentation defect in MesP2-deficient mice by MesP1 gene replacement. Mech Dev. 1998 Jul;75(1-2):53-66
2*J:55840 Saga Y, Miyagawa-Tomita S, Takagi A, Kitajima S, Miyazaki Ji, Inoue T, MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube. Development. 1999 Aug;126(15):3437-47
1J:82703 Saijoh Y, Oki S, Ohishi S, Hamada H, Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol. 2003 Apr 1;256(1):160-72
1J:85862 Saitou M, Payer B, Lange UC, Erhardt S, Barton SC, Surani MA, Specification of germ cell fate in mice. Philos Trans R Soc Lond B Biol Sci. 2003 Aug 29;358(1436):1363-70
1J:253831 Salbaum JM, Kruger C, MacGowan J, Herion NJ, Burk D, Kappen C, Novel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse Strain. Sci Rep. 2015 Nov 23;5:16917
1J:342640 Sampath Kumar A, Tian L, Bolondi A, Hernandez AA, Stickels R, Kretzmer H, Murray E, Wittler L, Walther M, Barakat G, Haut L, Elkabetz Y, Macosko EZ, Guignard L, Chen F, Meissner A, Spatiotemporal transcriptomic maps of whole mouse embryos at the onset of organogenesis. Nat Genet. 2023 Jul;55(7):1176-1185
5J:306614 Sasaki K, Oguchi A, Cheng K, Murakawa Y, Okamoto I, Ohta H, Yabuta Y, Iwatani C, Tsuchiya H, Yamamoto T, Seita Y, Saitou M, The embryonic ontogeny of the gonadal somatic cells in mice and monkeys. Cell Rep. 2021 May 4;35(5):109075
2J:106551 Satoh W, Gotoh T, Tsunematsu Y, Aizawa S, Shimono A, Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis. Development. 2006 Mar;133(6):989-99
1J:135313 Satoh W, Matsuyama M, Takemura H, Aizawa S, Shimono A, Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse. Genesis. 2008 Feb;46(2):92-103
3J:154904 Savory JG, Bouchard N, Pierre V, Rijli FM, De Repentigny Y, Kothary R, Lohnes D, Cdx2 regulation of posterior development through non-Hox targets. Development. 2009 Dec;136(24):4099-110
2J:131426 Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, Sasaki H, Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol. 2008 May;28(10):3177-89
1J:307834 Scheibner K, Schirge S, Burtscher I, Buttner M, Sterr M, Yang D, Bottcher A, Ansarullah, Irmler M, Beckers J, Cernilogar FM, Schotta G, Theis FJ, Lickert H, Epithelial cell plasticity drives endoderm formation during gastrulation. Nat Cell Biol. 2021 Jul;23(7):692-703
7J:43170 Schmidt C, Wilson V, Stott D, Beddington RS, T promoter activity in the absence of functional T protein during axis formation and elongation in the mouse. Dev Biol. 1997 Sep 15;189(2):161-73
1J:243030 Schmitz-Rohmer D, Probst S, Yang ZZ, Laurent F, Stadler MB, Zuniga A, Zeller R, Hynx D, Hemmings BA, Hergovich A, NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development. PLoS One. 2015;10(8):e0136566
5J:341093 Schule KM, Weckerle J, Probst S, Wehmeyer AE, Zissel L, Schroder CM, Tekman M, Kim GJ, Schlagl IM, Sagar, Arnold SJ, Eomes restricts Brachyury functions at the onset of mouse gastrulation. Dev Cell. 2023 Sep 25;58(18):1627-1642.e7
1*J:88955 Schwabe GC, Trepczik B, Suring K, Brieske N, Tucker AS, Sharpe PT, Minami Y, Mundlos S, Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome. Dev Dyn. 2004 Feb;229(2):400-10
1*J:253683 Schwartz B, Marks M, Wittler L, Werber M, Wahrisch S, Nordheim A, Herrmann BG, Grote P, SRF is essential for mesodermal cell migration during elongation of the embryonic body axis. Mech Dev. 2014 Aug;133:23-35
1J:165572 Sebastiano V, Dalvai M, Gentile L, Schubart K, Sutter J, Wu GM, Tapia N, Esch D, Ju JY, Hubner K, Bravo MJ, Scholer HR, Cavaleri F, Matthias P, Oct1 regulates trophoblast development during early mouse embryogenesis. Development. 2010 Nov;137(21):3551-60
1J:202124 Seidl S, Braun U, Roos N, Li S, Ludtke TH, Kispert A, Leitges M, Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5. PLoS One. 2013;8(5):e62756
2J:222377 Seldin DC, Lou DY, Toselli P, Landesman-Bollag E, Dominguez I, Gene targeting of CK2 catalytic subunits. Mol Cell Biochem. 2008 Sep;316(1-2):141-7
2J:195133 Semba K, Araki K, Matsumoto K, Suda H, Ando T, Sei A, Mizuta H, Takagi K, Nakahara M, Muta M, Yamada G, Nakagata N, Iida A, Ikegawa S, Nakamura Y, Araki M, Abe K, Yamamura K, Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice. PLoS Genet. 2013 Feb;9(2):e1003204
1J:275024 Senft AD, Bikoff EK, Robertson EJ, Costello I, Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse. Nat Commun. 2019 Mar 6;10(1):1089
1*J:229383 Serth K, Beckers A, Schuster-Gossler K, Pavlova MN, Muller J, Paul MC, Reinhardt R, Gossler A, Generation of an 870 kb deletion encompassing the Skt/Etl4 locus by combination of inter- and intra-chromosomal recombination. BMC Genet. 2015;16:143
1J:39764 Sharan SK, Morimatsu M, Albrecht U, Lim DS, Regel E, Dinh C , Sands A , Eichele G , Hasty P , Bradley A, Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 [see comments]. Nature. 1997 Apr 24;386(6627):804-10
3*J:160194 Shaw L, Johnson PA, Kimber SJ, Gene expression profiling of the developing mouse kidney and embryo. In Vitro Cell Dev Biol Anim. 2010 Feb;46(2):155-65
2*J:24115 Shawlot W, Behringer RR, Requirement for Lim1 in head-organizer function [see comments]. Nature. 1995 Mar 30;374(6521):425-30
3J:51834 Shen SX, Weaver Z, Xu X, Li C, Weinstein M, Chen L, Guan XY, Ried T, Deng CX, A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene. 1998 Dec 17;17(24):3115-24
1*J:262744 Shetty R, Joshi D, Jain M, Vasudevan M, Paul JC, Bhat G, Banerjee P, Abe T, Kiyonari H, VijayRaghavan K, Inamdar MS, Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning. Sci Rep. 2018 Apr 4;8(1):5632
1*J:62177 Shi ZZ, Osei-Frimpong J, Kala G, Kala SV, Barrios RJ, Habib GM, Lukin DJ, Danney CM, Matzuk MM, Lieberman MW, Glutathione synthesis is essential for mouse development but not for cell growth in culture. Proc Natl Acad Sci U S A. 2000 May 9;97(10):5101-6
3J:178936 Shibata M, Blauvelt KE, Liem KF Jr, Garcia-Garcia MJ, TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues. Development. 2011 Dec;138(24):5333-43
1J:119736 Shiota M, Heike T, Haruyama M, Baba S, Tsuchiya A, Fujino H, Kobayashi H, Kato T, Umeda K, Yoshimoto M, Nakahata T, Isolation and characterization of bone marrow-derived mesenchymal progenitor cells with myogenic and neuronal properties. Exp Cell Res. 2007 Mar 10;313(5):1008-23
1J:87319 Showell C, Binder O, Conlon FL, T-box genes in early embryogenesis. Dev Dyn. 2004 Jan;229(1):201-18
1*J:244313 Simon CS, Downes DJ, Gosden ME, Telenius J, Higgs DR, Hughes JR, Costello I, Bikoff EK, Robertson EJ, Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo. Development. 2017 Apr 01;144(7):1249-1260
2*J:268273 Simon CS, Zhang L, Wu T, Cai W, Saiz N, Nowotschin S, Cai CL, Hadjantonakis AK, A Gata4 nuclear GFP transcriptional reporter to study endoderm and cardiac development in the mouse. Biol Open. 2018 Dec 10;7(12):bio036517
3J:212358 Singh AP, Archer TK, Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. Nucleic Acids Res. 2014 Mar;42(5):2958-75
1*J:45399 Sirard C, de la Pompa JL, Elia A, Itie A, Mirtsos C, Cheung A, Hahn S, Wakeham A, Schwartz L, Kern SE, Rossant J, Mak TW, The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 1998 Jan 1;12(1):107-19
1*J:3684 Smith DE, Franco del Amo F, Gridley T, Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: its expression pattern suggests multiple roles during postimplantation development [published erratum appears in Development 1993 Mar;117(3):preceding table of contents]. Development. 1992 Dec;116(4):1033-9
1J:81766 Smits P, Lefebvre V, Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs. Development. 2003 Mar;130(6):1135-48
2*J:57262 Song J, Oh SP, Schrewe H, Nomura M, Lei H, Okano M, Gridley T, Li E, The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev Biol. 1999 Sep 1;213(1):157-69
3*J:235456 Song L, Chen J, Peng G, Tang K, Jing N, Dynamic Heterogeneity of Brachyury in Mouse Epiblast Stem Cells Mediates Distinct Response to Extrinsic Bone Morphogenetic Protein (BMP) Signaling. J Biol Chem. 2016 Jul 15;291(29):15212-25
3J:239945 Souilhol C, Perea-Gomez A, Camus A, Beck-Cormier S, Vandormael-Pournin S, Escande M, Collignon J, Cohen-Tannoudji M, NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo. Development. 2015 Nov 01;142(21):3649-60
2*J:26244 Sowden J, Putt W, Morrison K, Beddington R, Edwards Y, The embryonic RNA helicase gene (ERH): a new member of the DEAD box family of RNA helicases. Biochem J. 1995 Jun 15;308(Pt 3):839-46
4*J:38063 Sowden JC, Morrison K, Putt W, Beddington R, Edwards YH, The identification of novel sequences expressed in the mouse notochord. Mamm Genome. 1997 Jan;8(1):42-4
1J:163670 Spruce T, Pernaute B, Di-Gregorio A, Cobb BS, Merkenschlager M, Manzanares M, Rodriguez TA, An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo. Dev Cell. 2010 Aug 17;19(2):207-19
1*J:343201 Srinivasan S, He X, Mirza S, Mager J, Exosome complex components 1 and 2 are vital for early mammalian development. Gene Expr Patterns. 2024 March;51:119346
2J:103125 Stickens D, Zak BM, Rougier N, Esko JD, Werb Z, Mice deficient in Ext2 lack heparan sulfate and develop exostoses. Development. 2005 Nov;132(22):5055-68
2J:171680 Stuckey DW, Di Gregorio A, Clements M, Rodriguez TA, Correct patterning of the primitive streak requires the anterior visceral endoderm. PLoS One. 2011;6(3):e17620
1J:144999 Su H, Trombly MI, Chen J, Wang X, Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev. 2009 Feb 1;23(3):304-17
12J:346065 Su H, Zhi D, Song Y, Yang Y, Wang D, Li X, Cao G, Exploring the formation mechanism of short-tailed phenotypes in animals using mutant mice with the TBXT gene c.G334T developed by CRISPR/Cas9. Gene. 2024 Feb 23;910:148310
2J:272362 Su X, Wu C, Ye X, Zeng M, Zhang Z, Che Y, Zhang Y, Liu L, Lin Y, Yang R, Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development. Cell Death Dis. 2018 Feb 21;9(3):302
1*J:223915 Suckale J, Wendling O, Masjkur J, Jager M, Munster C, Anastassiadis K, Stewart AF, Solimena M, PTBP1 is required for embryonic development before gastrulation. PLoS One. 2011;6(2):e16992
1*J:51989 Suda Y, Nakabayashi J, Matsuo I, Aizawa S, Functional equivalency between Otx2 and Otx1 in development of the rostral head. Development. 1999 Feb;126(4):743-57
1J:245906 Sugrue KF, Zohn IE, Mechanism for generation of left isomerism in Ccdc40 mutant embryos. PLoS One. 2017;12(2):e0171180
2J:56519 Sun X, Meyers EN, Lewandoski M, Martin GR, Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev. 1999 Jul 15;13(14):1834-46
1J:152701 Suriben R, Kivimae S, Fisher DA, Moon RT, Cheyette BN, Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet. 2009 Sep;41(9):977-85
1J:40595 Suzuki A, de la Pompa JL, Hakem R, Elia A, Yoshida R, Mo R, Nishina H, Chuang T, Wakeham A, Itie A, Koo W, Billia P, Ho A, Fukumoto M, Hui CC, Mak TW, Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 1997 May 15;11(10):1242-52
1J:134487 Suzuki A, Sekiya S, Buscher D, Izpisua Belmonte JC, Taniguchi H, Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression. Development. 2008 May;135(9):1589-95
4*J:286074 Suzuki H, Dinh TTH, Daitoku Y, Tanimoto Y, Kato K, Azami T, Ema M, Murata K, Mizuno S, Sugiyama F, Generation of bicistronic reporter knockin mice for visualizing germ layers. Exp Anim. 2019 Nov 6;68(4):499-509
1J:136243 Szumska D, Pieles G, Essalmani R, Bilski M, Mesnard D, Kaur K, Franklyn A, El Omari K, Jefferis J, Bentham J, Taylor JM, Schneider JE, Arnold SJ, Johnson P, Tymowska-Lalanne Z, Stammers D, Clarke K, Neubauer S, Morris A, Brown SD, Shaw-Smith C, Cama A, Capra V, Ragoussis J, Constam D, Seidah NG, Prat A, Bhattacharya S, VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev. 2008 Jun 1;22(11):1465-77
1J:206836 Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, Nishinakamura R, Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell. 2014 Jan 2;14(1):53-67
8J:278240 Tahara N, Kawakami H, Chen KQ, Anderson A, Yamashita Peterson M, Gong W, Shah P, Hayashi S, Nishinakamura R, Nakagawa Y, Garry DJ, Kawakami Y, Sall4 regulates neuromesodermal progenitors and their descendants during body elongation in mouse embryos. Development. 2019 Jul 15;146(14):dev177659
5J:16716 Takada S, Stark KL, Shea MJ, Vassileva G, McMahon JA, McMahon AP, Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev. 1994 Jan;8(2):174-89
1*J:55332 Takeda S, Yonekawa Y, Tanaka Y, Okada Y, Nonaka S, Hirokawa N, Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. J Cell Biol. 1999 May 17;145(4):825-36
6*J:317900 Tamashiro DA, Alarcon VB, Marikawa Y, Nkx1-2 is a transcriptional repressor and is essential for the activation of Brachyury in P19 mouse embryonal carcinoma cell. Differentiation. 2012 Jun;83(5):282-92
1J:351035 Tan Z, Chen P, Dong X, Guo S, Leung VYL, Cheung JPY, Chan D, Richardson SM, Hoyland JA, To MKT, Cheah KSE, Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration. Cell Rep. 2024 Jun 25;43(6):114342
1*J:349949 Tanaka S, Kunath T, Hadjantonakis AK, Nagy A, Rossant J, Promotion of trophoblast stem cell proliferation by FGF4. Science. 1998;282(5396):2072-5
5J:199855 Tanaka SS, Nakane A, Yamaguchi YL, Terabayashi T, Abe T, Nakao K, Asashima M, Steiner KA, Tam PP, Nishinakamura R, Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. PLoS One. 2013;8(3):e57428
2*J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
3*J:48372 Tang SJ, Hoodless PA, Lu Z, Breitman ML, McInnes RR, Wrana JL , Buchwald M, The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development. 1998 May;125(10):1877-87
2J:151993 Tao H, Suzuki M, Kiyonari H, Abe T, Sasaoka T, Ueno N, Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14426-31
2J:327970 Tarazi S, Aguilera-Castrejon A, Joubran C, Ghanem N, Ashouokhi S, Roncato F, Wildschutz E, Haddad M, Oldak B, Gomez-Cesar E, Livnat N, Viukov S, Lokshtanov D, Naveh-Tassa S, Rose M, Hanna S, Raanan C, Brenner O, Kedmi M, Keren-Shaul H, Lapidot T, Maza I, Novershtern N, Hanna JH, Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs. Cell. 2022 Sep 1;185(18):3290-3306.e25
1*J:277394 Tellier AP, Archambault D, Tremblay KD, Mager J, The elongation factor Elof1 is required for mammalian gastrulation. PLoS One. 2019;14(7):e0219410
2J:282363 Tessier S, Madhu V, Johnson ZI, Shapiro IM, Risbud MV, NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis. Dev Biol. 2019 Nov 15;455(2):369-381
3*J:37194 Thomas P, Beddington R, Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo. Curr Biol. 1996 Nov 1;6(11):1487-96
3*J:46807 Thomas P, Brickman JM, Popperl H, Krumlauf R, Beddington RS, Axis duplication and anterior identity in the mouse embryo. Cold Spring Harb Symp Quant Biol. 1997;62:115-25
2*J:45579 Thomas PQ, Brown A, Beddington RS, Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development. 1998 Jan;125(1):85-94
1*J:74631 Tian E, Kimura C, Takeda N, Aizawa S, Matsuo I, Otx2 is required to respond to signals from anterior neural ridge for forebrain specification. Dev Biol. 2002 Feb 15;242(2):204-23
2J:51542 Tomihara-Newberger C, Haub O, Lee HG, Soares V, Manova K, Lacy E, The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives. Dev Biol. 1998 Dec 1;204(1):34-54
4*J:166847 Tonissoo T, Lulla S, Meier R, Saare M, Ruisu K, Pooga M, Karis A, Nucleotide exchange factor RIC-8 is indispensable in mammalian early development. Dev Dyn. 2010 Dec;239(12):3404-15
2*J:192194 Tortelote GG, Hernandez-Hernandez JM, Quaresma AJ, Nickerson JA, Imbalzano AN, Rivera-Perez JA, Wnt3 function in the epiblast is required for the maintenance but not the initiation of gastrulation in mice. Dev Biol. 2013 Feb 1;374(1):164-73
4J:282925 Tosic J, Kim GJ, Pavlovic M, Schroder CM, Mersiowsky SL, Barg M, Hofherr A, Probst S, Kottgen M, Hein L, Arnold SJ, Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state. Nat Cell Biol. 2019 Dec;21(12):1518-1531
2*J:186556 Trask MC, Tremblay KD, Mager J, Yin-Yang1 is required for epithelial-to-mesenchymal transition and regulation of Nodal signaling during mammalian gastrulation. Dev Biol. 2012 Aug 15;368(2):273-82
1*J:71998 Tremblay KD, Dunn NR, Robertson EJ, Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. Development. 2001 Sep;128(18):3609-21
2J:150707 Uehara M, Yashiro K, Takaoka K, Yamamoto M, Hamada H, Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning. Genes Dev. 2009 Jul 15;23(14):1689-98
2*J:138922 Uez N, Lickert H, Kohlhase J, de Angelis MH, Kuhn R, Wurst W, Floss T, Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo. Genesis. 2008 Sep 9;46(9):463-477
2*J:153634 Ukita K, Hirahara S, Oshima N, Imuta Y, Yoshimoto A, Jang CW, Oginuma M, Saga Y, Behringer RR, Kondoh H, Sasaki H, Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord. Mech Dev. 2009 Oct;126(10):791-803
1*J:75947 van den Akker E, Forlani S, Chawengsaksophak K, de Graaff W, Beck F, Meyer BI, Deschamps J, Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation. Development. 2002 May;129(9):2181-93
4J:185604 van Rooijen C, Simmini S, Bialecka M, Neijts R, van de Ven C, Beck F, Deschamps J, Evolutionarily conserved requirement of Cdx for post-occipital tissue emergence. Development. 2012 Jul;139(14):2576-83
1J:84300 Vincent SD, Dunn NR, Hayashi S, Norris DP, Robertson EJ, Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Genes Dev. 2003 Jul 1;17(13):1646-62
1*J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1*J:153642 Vlangos CN, O'Connor BC, Morley MJ, Krause AS, Osawa GA, Keegan CE, Caudal regression in adrenocortical dysplasia (acd) mice is caused by telomere dysfunction with subsequent p53-dependent apoptosis. Dev Biol. 2009 Oct 15;334(2):418-28
2J:82399 Voncken JW, Roelen BA, Roefs M, de Vries S, Verhoeven E, Marino S, Deschamps J, van Lohuizen M, Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2468-73
1J:46532 Waldrip WR, Bikoff EK, Hoodless PA, Wrana JL, Robertson EJ, Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell. 1998 Mar 20;92(6):797-808
2J:146397 Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y, GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol Biol Cell. 2007 Oct;18(10):3764-75
1*J:190157 Wang C, Lee JE, Cho YW, Xiao Y, Jin Q, Liu C, Ge K, UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15324-9
1J:108512 Wang J, Hamblet NS, Mark S, Dickinson ME, Brinkman BC, Segil N, Fraser SE, Chen P, Wallingford JB, Wynshaw-Boris A, Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development. 2006 May;133(9):1767-78
1J:287165 Wang J, Lee JE, Riemondy K, Yu Y, Marquez SM, Lai EC, Yi R, XPO5 promotes primary miRNA processing independently of RanGTP. Nat Commun. 2020 Apr 15;11(1):1845
1*J:217019 Wang L, Wansleeben C, Zhao S, Miao P, Paschen W, Yang W, SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development. EMBO Rep. 2014 Aug;15(8):878-85
1J:340402 Wang R, Yang X, Chen J, Zhang L, Griffiths JA, Cui G, Chen Y, Qian Y, Peng G, Li J, Wang L, Marioni JC, Tam PPL, Jing N, Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation. Nat Commun. 2023 Sep 14;14(1):5675
5J:106144 Ware SM, Harutyunyan KG, Belmont JW, Zic3 is critical for early embryonic patterning during gastrulation. Dev Dyn. 2006 Mar;235(3):776-85
8J:138862 Warr N, Powles-Glover N, Chappell A, Robson J, Norris D, Arkell RM, Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation. Hum Mol Genet. 2008 Oct 1;17(19):2986-96
1J:238549 Warrier S, Nuwayhid S, Sabatino JA, Sugrue KF, Zohn IE, Supt20 is required for development of the axial skeleton. Dev Biol. 2017 Jan 15;421(2):245-257
1*J:58413 Wasiak S, Lohnes D, Retinoic acid affects left-right patterning. Dev Biol. 1999 Nov 15;215(2):332-42
1J:354668 Watanabe K, Kamiya D, Nishiyama A, Katayama T, Nozaki S, Kawasaki H, Watanabe Y, Mizuseki K, Sasai Y, Directed differentiation of telencephalic precursors from embryonic stem cells. Nat Neurosci. 2005 Mar;8(3):288-96
1J:296971 Wehn AK, Farkas DR, Sedlock CE, Subedi D, Chapman DL, Functionally distinct roles for T and Tbx6 during mouse development. Biol Open. 2020 Aug 27;9(8):bio054692
2*J:19896 Weinstein DC, Ruiz i Altaba A, Chen WS, Hoodless P, Prezioso VR, Jessell TM, Darnell JE Jr, The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell. 1994 Aug 26;78(4):575-88
3*J:49084 Weinstein M, Yang X, Li C, Xu X, Gotay J, Deng CX, Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9378-83
3*J:52223 Weisberg E, Winnier GE, Chen X, Farnsworth CL, Hogan BL, Whitman M, A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. Mech Dev. 1998 Dec;79(1-2):17-27
5*J:64329 Welsh IC, O'Brien TP, Loss of late primitive streak mesoderm and interruption of left-right morphogenesis in the Ednrb(s-1Acrg) mutant mouse. Dev Biol. 2000 Sep 1;225(1):151-68
1J:78934 Werling U, Schorle H, Transcription factor gene AP-2 gamma essential for early murine development. Mol Cell Biol. 2002 May;22(9):3149-56
1*J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
12*J:21262 Wilkinson DG, Bhatt S, Herrmann BG, Expression pattern of the mouse T gene and its role in mesoderm formation [see comments]. Nature. 1990 Feb 15;343(6259):657-9
2*J:93435 Willer T, Prados B, Falcon-Perez JM, Renner-Muller I, Przemeck GK, Lommel M, Coloma A, Valero MC, de Angelis MH, Tanner W, Wolf E, Strahl S, Cruces J, Targeted disruption of the Walker-Warburg syndrome gene Pomt1 in mouse results in embryonic lethality. (Correction: 2004;101(45):16081). Proc Natl Acad Sci U S A. 2004 Oct 28;101(39):14126-31
2*J:45352 Wilson V, Beddington R, Expression of T protein in the primitive streak is necessary and sufficient for posterior mesoderm movement and somite differentiation. Dev Biol. 1997 Dec 1;192(1):45-58
3*J:23779 Wilson V, Manson L, Skarnes WC, Beddington RS, The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation. Development. 1995 Mar;121(3):877-86
1*J:11870 Wilson V, Rashbass P, Beddington RS, Chimeric analysis of T (Brachyury) gene function. Development. 1993 Apr;117(4):1321-31
2*J:28717 Winnier G, Blessing M, Labosky PA, Hogan BL, Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 1995 Sep 1;9(17):2105-16
2J:103454 Woda JM, Calzonetti T, Hilditch-Maguire P, Duyao MP, Conlon RA, MacDonald ME, Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo. BMC Dev Biol. 2005 Aug 18;5:17
1*J:180644 Wolf XA, Klein T, Garcia R, Hyttel P, Serup P, Identification of a conserved cis-acting region driving expression of mouse Eomesodermin to the primitive streak, node, and definitive endoderm. Gene Expr Patterns. 2012 Jan;12(1-2):85-93
1*J:210985 Wolfe AD, Downs KM, Mixl1 localizes to putative axial stem cell reservoirs and their posterior descendants in the mouse embryo. Gene Expr Patterns. 2014 May;15(1):8-20
3*J:242062 Wolfe AD, Rodriguez AM, Downs KM, STELLA collaborates in distinct mesendodermal cell subpopulations at the fetal-placental interface in the mouse gastrula. Dev Biol. 2017 May 01;425(1):44-57
3J:185554 Wu CI, Hoffman JA, Shy BR, Ford EM, Fuchs E, Nguyen H, Merrill BJ, Function of Wnt/beta-catenin in counteracting Tcf3 repression through the Tcf3-beta-catenin interaction. Development. 2012 Jun;139(12):2118-29
18J:229981 Wymeersch FJ, Huang Y, Blin G, Cambray N, Wilkie R, Wong FC, Wilson V, Position-dependent plasticity of distinct progenitor types in the primitive streak. Elife. 2016;5:e10042
1J:345828 Xia B, Zhang W, Zhao G, Zhang X, Bai J, Brosh R, Wudzinska A, Huang E, Ashe H, Ellis G, Pour M, Zhao Y, Coelho C, Zhu Y, Miller A, Dasen JS, Maurano MT, Kim SY, Boeke JD, Yanai I, On the genetic basis of tail-loss evolution in humans and apes. Nature. 2024 Feb;626(8001):1042-1048
2*J:86912 Xiao C, Shim JH, Kluppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S, Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 2003 Dec 1;17(23):2933-49
2J:177837 Xiao Z, Patrakka J, Nukui M, Chi L, Niu D, Betsholtz C, Pikkarainen T, Vainio S, Tryggvason K, Deficiency in crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice. Dev Dyn. 2011 Dec;240(12):2646-56
1J:342639 Xie G, Lee JE, Senft AD, Park YK, Jang Y, Chakraborty S, Thompson JJ, McKernan K, Liu C, Macfarlan TS, Rocha PP, Peng W, Ge K, MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner. Nat Genet. 2023 Apr;55(4):693-705
1*J:51595 Xu C, Liguori G, Persico MG, Adamson ED, Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. Development. 1999 Feb;126(3):483-94
1J:65002 Xu W, Edmondson DG, Evrard YA, Wakamiya M, Behringer RR, Roth SY, Loss of gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nat Genet. 2000 Oct;26(2):229-32
3J:54222 Xu X, Li C, Takahashi K, Slavkin HC, Shum L, Deng CX, Murine fibroblast growth factor receptor 1alpha isoforms mediate node regression and are essential for posterior mesoderm development. Dev Biol. 1999 Apr 15;208(2):293-306
3*J:68215 Xue Y, Wang X, Li Z, Gotoh N, Chapman D, Skolnik EY, Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK). Development. 2001 May;128(9):1559-72
2*J:52600 Yamaguchi TP, Bradley A, McMahon AP, Jones S, A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development. 1999 Mar;126(6):1211-23
2J:22117 Yamaguchi TP, Harpal K, Henkemeyer M, Rossant J, fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev. 1994 Dec 15;8(24):3032-44
1J:59271 Yamaguchi TP, Takada S, Yoshikawa Y, Wu N, McMahon AP, T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification. Genes Dev. 1999 Dec 15;13(24):3185-90
3J:69593 Yamamoto M, Meno C, Sakai Y, Shiratori H, Mochida K, Ikawa Y, Saijoh Y, Hamada H, The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev. 2001 May 15;15(10):1242-56
1*J:215393 Yamamoto S, Yamazaki T, Komazaki S, Yamashita T, Osaki M, Matsubayashi M, Kidoya H, Takakura N, Yamazaki D, Kakizawa S, Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity. Dev Biol. 2014 Sep 1;393(1):33-43
3J:130469 Yamanaka Y, Tamplin OJ, Beckers A, Gossler A, Rossant J, Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms. Dev Cell. 2007 Dec;13(6):884-96
1*J:76736 Yamashita T, Wada R, Sasaki T, Deng C, Bierfreund U, Sandhoff K, Proia RL, A vital role for glycosphingolipid synthesis during development and differentiation. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9142-7
1*J:85760 Yan J, Walz K, Nakamura H, Carattini-Rivera S, Zhao Q, Vogel H, Wei N, Justice MJ, Bradley A, Lupski JR, COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. Mol Cell Biol. 2003 Oct;23(19):6798-808
1*J:256597 Yang CS, Melhuish TA, Spencer A, Ni L, Hao Y, Jividen K, Harris TE, Snow C, Frierson HF Jr, Wotton D, Paschal BM, The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression. Prostate. 2017 Nov;77(15):1452-1467
1J:228522 Yang SL, Yang M, Herrlinger S, Liang C, Lai F, Chen JF, MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation. Dev Biol. 2015 Dec 1;408(1):140-50
1J:172232 Yang X, Gong Y, Friesel R, Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function. PLoS One. 2011;6(4):e18374
2*J:46852 Yang X, Li C, Xu X, Deng C, The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3667-72
1J:86402 Yao Y, Li W, Wu J, Germann UA, Su MS, Kuida K, Boucher DM, Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12759-64
2J:111701 Yeh JR, Ju R, Brdlik CM, Zhang W, Zhang Y, Matyskiela ME, Shotwell JD, Crews CM, Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10379-84
1J:158149 Yen WW, Williams M, Periasamy A, Conaway M, Burdsal C, Keller R, Lu X, Sutherland A, PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation. Development. 2009 Jun;136(12):2039-48
1J:70892 Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, Makela TP, Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science. 2001 Aug 17;293(5533):1323-6
1J:312414 Yogosawa S, Ohkido M, Horii T, Okazaki Y, Nakayama J, Yoshida S, Toyokuni S, Hatada I, Morimoto M, Yoshida K, Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient. Commun Biol. 2021 Oct 20;4(1):1204
4*J:62914 Yoon JK, Moon RT, Wold B, The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypes. Dev Biol. 2000 Jun 15;222(2):376-91
1J:66514 Yoon JK, Wold B, The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesoderm. Genes Dev. 2000 Dec 15;14(24):3204-14
1*J:190555 Yoon Y, Cowley DO, Gallant J, Jones SN, Van Dyke T, Rivera-Perez JA, Conditional Aurora A deficiency differentially affects early mouse embryo patterning. Dev Biol. 2012 Nov 1;371(1):77-85
1J:225541 Yoon Y, Huang T, Tortelote GG, Wakamiya M, Hadjantonakis AK, Behringer RR, Rivera-Perez JA, Extra-embryonic Wnt3 regulates the establishment of the primitive streak in mice. Dev Biol. 2015 Jul 1;403(1):80-8
2*J:208424 Yoshida M, Uchikawa M, Rizzoti K, Lovell-Badge R, Takemoto T, Kondoh H, Regulation of mesodermal precursor production by low-level expression of B1 Sox genes in the caudal lateral epiblast. Mech Dev. 2014 May;132:59-68
1*J:102143 Yoshikawa T, Piao Y, Zhong J, Matoba R, Carter MG, Wang Y, Goldberg I, Ko MS, High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Gene Expr Patterns. 2006 Jan;6(2):213-24
1J:154781 Young T, Rowland JE, van de Ven C, Bialecka M, Novoa A, Carapuco M, van Nes J, de Graaff W, Duluc I, Freund JN, Beck F, Mallo M, Deschamps J, Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Dev Cell. 2009 Oct;17(4):516-26
2*J:49126 Zachgo J, Korn R, Gossler A, Genetic interactions suggest that Danforth's short tail (Sd) is a gain-of-function mutation. Dev Genet. 1998;23(1):86-96
2*J:98379 Zakin L, Reversade B, Kuroda H, Lyons KM, De Robertis EM, Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. Development. 2005 May;132(10):2489-99
1*J:209127 Zaltsman Y, Shachnai L, Yivgi-Ohana N, Schwarz M, Maryanovich M, Houtkooper RH, Vaz FM, De Leonardis F, Fiermonte G, Palmieri F, Gillissen B, Daniel PT, Jimenez E, Walsh S, Koehler CM, Roy SS, Walter L, Hajnoczky G, Gross A, MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat Cell Biol. 2010 Jun;12(6):553-62
1J:338206 Zeng H, Liu A, TMEM132A regulates mouse hindgut morphogenesis and caudal development. Development. 2023 Jul 15;150(14)
2*J:57046 Zhadanov AB, Provance DW Jr, Speer CA, Coffin JD, Goss D, Blixt JA, Reichert CM, Mercer JA, Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development. Curr Biol. 1999 Aug 26;9(16):880-8
2J:340447 Zhai J, Guo J, Wan H, Qi L, Liu L, Xiao Z, Yan L, Schmitz DA, Xu Y, Yu D, Wu X, Zhao W, Yu K, Jiang X, Guo F, Wu J, Wang H, Primate gastrulation and early organogenesis at single-cell resolution. Nature. 2022 Dec;612(7941):732-738
2J:206311 Zhao T, Gan Q, Stokes A, Lassiter RN, Wang Y, Chan J, Han JX, Pleasure DE, Epstein JA, Zhou CJ, beta-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development. 2014 Jan;141(1):148-57
1J:325944 Zhao T, McMahon M, Reynolds K, Saha SK, Stokes A, Zhou CJ, The role of Lrp6-mediated Wnt/beta-catenin signaling in the development and intervention of spinal neural tube defects in mice. Dis Model Mech. 2022 Jun 1;15(6):dmm049517
8J:221162 Zhao W, Ajima R, Ninomiya Y, Saga Y, Segmental border is defined by Ripply2-mediated Tbx6 repression independent of Mesp2. Dev Biol. 2015 Apr 1;400(1):105-17
1*J:302074 Zhao ZA, Yu Y, Ma HX, Wang XX, Lu X, Zhai Y, Zhang X, Wang H, Li L, The roles of ERAS during cell lineage specification of mouse early embryonic development. Open Biol. 2015 Aug;5(8)
3J:218057 Zheng HJ, Tsukahara M, Liu E, Ye L, Xiong H, Noguchi S, Suzuki K, Ji ZS, The Novel Helicase helG (DHX30) Is Expressed During Gastrulation in Mice and Has a Structure Similar to a Human DExH Box Helicase. Stem Cells Dev. 2015 Feb 1;24(3):372-83
2*J:169569 Zhou X, Takatoh J, Wang F, The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation. PLoS One. 2011;6(1):e16358
2J:106348 Zohn IE, Li Y, Skolnik EY, Anderson KV, Han J, Niswander L, p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell. 2006 Jun 2;125(5):957-69
1J:87046 Zoltewicz JS, Stewart NJ, Leung R, Peterson AS, Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis. Development. 2004 Jan;131(1):3-14
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