Gene Expression Literature Summary
|
Symbol Name ID |
T
brachyury, T-box transcription factor T MGI:98472 |
| Age | E1.5 | E2 | E2.5 | E3 | E3.5 | E4 | E4.5 | E5 | E5.5 | E6 | E6.5 | E7 | E7.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14.5 | E15 | E15.5 | E16.5 | E17.5 | E18.5 | E | P |
| Immunohistochemistry (section) | 4 | 2 | 18 | 18 | 46 | 17 | 29 | 7 | 14 | 11 | 2 | 4 | 1 | 1 | 2 | 2 | 9 | 2 | |||||||||||||||
| In situ RNA (section) | 1 | 1 | 21 | 9 | 45 | 15 | 26 | 4 | 13 | 1 | 10 | 1 | 5 | 3 | 3 | 3 | 1 | 4 | 1 | ||||||||||||||
| Immunohistochemistry (whole mount) | 10 | 13 | 24 | 12 | 17 | 5 | 13 | 5 | 2 | 2 | 1 | 1 | 1 | 4 | |||||||||||||||||||
| In situ RNA (whole mount) | 1 | 1 | 1 | 5 | 8 | 73 | 55 | 189 | 53 | 148 | 17 | 88 | 4 | 31 | 2 | 10 | 1 | 5 | 5 | 2 | 2 | 17 | |||||||||||
| In situ reporter (knock in) | 2 | 2 | 1 | 3 | 1 | ||||||||||||||||||||||||||||
| Northern blot | 1 | 1 | 2 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | ||||||||||||||||||||||
| Western blot | 3 | 1 | 4 | 1 | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | |||||||||||||||||||||
| RT-PCR | 3 | 2 | 2 | 1 | 4 | 3 | 3 | 5 | 1 | 20 | 8 | 34 | 5 | 25 | 3 | 20 | 1 | 12 | 1 | 6 | 6 | 5 | 4 | 1 | 2 | 1 | 1 | 7 | 7 | ||||
| cDNA clones | 1 | 2 | 1 | 1 |
| T brachyury, T-box transcription factor T (Synonyms: Bra, T1, Tbxt) | |
| Results | Reference |
| 4* | J:91405 Abdelkhalek HB, Beckers A, Schuster-Gossler K, Pavlova MN, Burkhardt H, Lickert H, Rossant J, Reinhardt R, Schalkwyk LC, Muller I, Herrmann BG, Ceolin M, Rivera-Pomar R, Gossler A, The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev. 2004 Jul 15;18(14):1725-36 |
| 1 | J:314668 Abrams SR, Reiter JF, Ciliary Hedgehog signaling regulates cell survival to build the facial midline. Elife. 2021 Oct 21;10:e68558 |
| 2 | J:67399 Abu-Abed S, Dolle P, Metzger D, Beckett B, Chambon P, Petkovich M, The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures. Genes Dev. 2001 Jan 15;15(2):226-40 |
| 1* | J:81583 Abu-Abed S, Dolle P, Metzger D, Wood C, MacLean G, Chambon P, Petkovich M, Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1. Development. 2003 Apr;130(7):1449-59 |
| 1* | J:49817 Acampora D, Avantaggiato V, Tuorto F, Briata P, Corte G, Simeone A, Visceral endoderm-restricted translation of otx1 mediates recovery of otx2 requirements for specification of anterior neural plate and normal gastrulation. Development. 1998 Dec;125(24):5091-104 |
| 2* | J:153562 Acampora D, Di Giovannantonio LG, Di Salvio M, Mancuso P, Simeone A, Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm. Mech Dev. 2009 Oct;126(10):882-97 |
| 2 | J:191079 Acampora D, Di Giovannantonio LG, Simeone A, Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition. Development. 2013 Jan 1;140(1):43-55 |
| 2* | J:29276 Acampora D, Mazan S, Lallemand Y, Avantaggiato V, Maury M, Simeone A, Brulet P, Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 1995 Oct;121(10):3279-90 |
| 2 | J:238298 Acampora D, Omodei D, Petrosino G, Garofalo A, Savarese M, Nigro V, Di Giovannantonio LG, Mercadante V, Simeone A, Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast. Cell Rep. 2016 Jun 21;15(12):2651-64 |
| 2* | J:254332 Acharya D, Hainer SJ, Yoon Y, Wang F, Bach I, Rivera-Perez JA, Fazzio TG, KAT-Independent Gene Regulation by Tip60 Promotes ESC Self-Renewal but Not Pluripotency. Cell Rep. 2017 Apr 25;19(4):671-679 |
| 1 | J:86265 Adhikary S, Peukert K, Karsunky H, Beuger V, Lutz W, Elsasser HP, Moroy T, Eilers M, Miz1 is required for early embryonic development during gastrulation. Mol Cell Biol. 2003 Nov;23(21):7648-57 |
| 4* | J:272567 Aires R, de Lemos L, Novoa A, Jurberg AD, Mascrez B, Duboule D, Mallo M, Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes. Dev Cell. 2019 Feb 11;48(3):383-395.e8 |
| 7* | J:236309 Aires R, Jurberg AD, Leal F, Novoa A, Cohn MJ, Mallo M, Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity. Dev Cell. 2016 Aug 8;38(3):262-74 |
| 4 | J:311976 Ajima R, Sakakibara Y, Sakurai-Yamatani N, Muraoka M, Saga Y, Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice. Development. 2021 Oct 15;148(20):dev194613 |
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| 2 | J:340418 Amadei G, Handford CE, Qiu C, De Jonghe J, Greenfeld H, Tran M, Martin BK, Chen DY, Aguilera-Castrejon A, Hanna JH, Elowitz MB, Hollfelder F, Shendure J, Glover DM, Zernicka-Goetz M, Embryo model completes gastrulation to neurulation and organogenesis. Nature. 2022 Oct;610(7930):143-153 |
| 1* | J:78010 Amieux PS, Howe DG, Knickerbocker H, Lee DC, Su T, Laszlo GS, Idzerda RL, McKnight GS, Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J Biol Chem. 2002 Jul 26;277(30):27294-304 |
| 9 | J:239303 Amin S, Neijts R, Simmini S, van Rooijen C, Tan SC, Kester L, van Oudenaarden A, Creyghton MP, Deschamps J, Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche. Cell Rep. 2016 Dec 20;17(12):3165-3177 |
| 1* | J:155226 Andersson ER, Bryjova L, Biris K, Yamaguchi TP, Arenas E, Bryja V, Genetic interaction between Lrp6 and Wnt5a during mouse development. Dev Dyn. 2009 Sep 30;239(1):237-245 |
| 2 | J:127541 Andersson O, Bertolino P, Ibanez CF, Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol. 2007 Nov 15;311(2):500-11 |
| 4* | J:108723 Andersson O, Reissmann E, Jornvall H, Ibanez CF, Synergistic interaction between Gdf1 and Nodal during anterior axis development. Dev Biol. 2006 May 15;293(2):370-81 |
| 5 | J:220460 Andre P, Song H, Kim W, Kispert A, Yang Y, Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27 |
| 2* | J:30828 Ang SL, Jin O, Rhinn M, Daigle N, Stevenson L, Rossant J, A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development. 1996 Jan;122(1):243-52 |
| 3* | J:19895 Ang SL, Rossant J, HNF-3 beta is essential for node and notochord formation in mouse development. Cell. 1994 Aug 26;78(4):561-74 |
| 1 | J:145732 Aoto K, Shikata Y, Imai H, Matsumaru D, Tokunaga T, Shioda S, Yamada G, Motoyama J, Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis. Dev Biol. 2009 Mar 1;327(1):106-20 |
| 1* | J:184591 Aoyama M, Sun-Wada GH, Yamamoto A, Yamamoto M, Hamada H, Wada Y, Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway. Dev Cell. 2012 Jun 12;22(6):1163-75 |
| 3* | J:290235 Archambault D, Cheong A, Iverson E, Tremblay KD, Mager J, Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development. Dev Biol. 2020 Jul 3;465(1):1-10 |
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| 4* | J:50876 Arsenian S, Weinhold B, Oelgeschlager M, Ruther U, Nordheim A, Serum response factor is essential for mesoderm formation during mouse embryogenesis. EMBO J. 1998 Nov 2;17(21):6289-99 |
| 3 | J:290418 Ashokkumar D, Zhang Q, Much C, Bledau AS, Naumann R, Alexopoulou D, Dahl A, Goveas N, Fu J, Anastassiadis K, Stewart AF, Kranz A, MLL4 is required after implantation, whereas MLL3 becomes essential during late gestation. Development. 2020 Jun 17;147(12):dev186999 |
| 1 | J:88851 Aulehla A, Wehrle C, Brand-Saberi B, Kemler R, Gossler A, Kanzler B, Herrmann BG, Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell. 2003 Mar;4(3):395-406 |
| 1 | J:76369 Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T, Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development. Development. 2002 Jun;129(11):2733-47 |
| 3 | J:314663 Bang J, Han M, Yoo TJ, Qiao L, Jung J, Na J, Carlson BA, Gladyshev VN, Hatfield DL, Kim JH, Kim LK, Lee BJ, Identification of Signaling Pathways for Early Embryonic Lethality and Developmental Retardation in Sephs1(-/-) Mice. Int J Mol Sci. 2021 Oct 28;22(21) |
| 4* | J:110714 Barrionuevo F, Taketo MM, Scherer G, Kispert A, Sox9 is required for notochord maintenance in mice. Dev Biol. 2006 Jul 1;295(1):128-40 |
| 1 | J:173672 Barrott JJ, Cash GM, Smith AP, Barrow JR, Murtaugh LC, Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12752-7 |
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| 1 | J:253960 Basilicata MF, Frank M, Solter D, Brabletz T, Stemmler MP, Inappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation. Sci Rep. 2016 May 24;6:26562 |
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| 1 | J:208632 Bazzi H, Anderson KV, Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1491-500 |
| 1 | J:251816 Bazzi H, Soroka E, Alcorn HL, Anderson KV, STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10928-E10936 |
| 1 | J:81247 Beck S, Le Good JA, Guzman M, Ben Haim N, Roy K, Beermann F, Constam DB, Extraembryonic proteases regulate Nodal signalling during gastrulation. Nat Cell Biol. 2002 Dec;4(12):981-5 |
| 6 | J:257034 Beisaw A, Tsaytler P, Koch F, Schmitz SU, Melissari MT, Senft AD, Wittler L, Pennimpede T, Macura K, Herrmann BG, Grote P, BRACHYURY directs histone acetylation to target loci during mesoderm development. EMBO Rep. 2018 Jan;19(1):118-134 |
| 1* | J:49955 Belaoussoff M, Farrington SM, Baron MH, Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo. Development. 1998 Dec;125(24):5009-18 |
| 3* | J:329966 Bell CJ, Gupta N, Tremblay KD, Mager J, Borcs6 is required for endo-lysosomal degradation during early development. Mol Reprod Dev. 2022 Aug;89(8):337-350 |
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| 2* | J:173623 Biechele S, Cox BJ, Rossant J, Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos. Dev Biol. 2011 Jul 15;355(2):275-85 |
| 1* | J:125766 Biris KK, Dunty WC Jr, Yamaguchi TP, Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed during somitogenesis. Dev Dyn. 2007 Nov;236(11):3167-72 |
| 1* | J:83956 Bladt F, Aippersbach E, Gelkop S, Strasser GA, Nash P, Tafuri A, Gertler FB, Pawson T, The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol. 2003 Jul;23(13):4586-97 |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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