Gene Expression Literature Summary

• Symbol: Tbx1
• Name: T-box 1
• ID: MGI:98493

225 matching records from 225 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E2.5	E3.5	E4	E4.5	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)						2	4	3	18	3	9		6		2		1		2	3		4	2		1	1	2
In situ RNA (section)		1			2	2	10	5	39	5	30	1	8		10	1	6	2	7	1		4	1	1	4	4
Immunohistochemistry (whole mount)					1	1			1																	1
In situ RNA (whole mount)					2	6	13	6	58	7	21	3	3		3		4		1	3						4
In situ reporter (knock in)						2	5	5	8	1	8		3		8		6		7	4		3			4		1
Northern blot									1				1														3
Western blot									3										1		1						2
RT-PCR	1	1	1	1	1	1	7	2	28	3	21		3	1	3		6	1	5	2	1	2	4	1	3	6	12
cDNA clones						1	1								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tbx1  T-box 1   (Synonyms: nmf219)
Results	Reference
1	J:78687 Abu-Issa R, Smyth G, Smoak I, Yamamura K, Meyers EN, Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse. Development. 2002 Oct;129(19):4613-25
1	J:284172 Adachi N, Bilio M, Baldini A, Kelly RG, Cardiopharyngeal mesoderm origins of musculoskeletal and connective tissues in the mammalian pharynx. Development. 2020 Feb 3;147(3):dev185256
3	J:163487 Aggarwal VS, Carpenter C, Freyer L, Liao J, Petti M, Morrow BE, Mesodermal Tbx1 is required for patterning the proximal mandible in mice. Dev Biol. 2010 Aug 15;344(2):669-81
2	J:114854 Aggarwal VS, Liao J, Bondarev A, Schimmang T, Lewandoski M, Locker J, Shanske A, Campione M, Morrow BE, Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy. Hum Mol Genet. 2006 Nov 1;15(21):3219-28
4	J:120112 Amati F, Biancolella M, Farcomeni A, Giallonardi S, Bueno S, Minella D, Vecchione L, Chillemi G, Desideri A, Novelli G, Dynamic changes in gene expression profiles of 22q11 and related orthologous genes during mouse development. Gene. 2007 Apr 15;391(1-2):91-102
1	J:266263 Andersen P, Tampakakis E, Jimenez DV, Kannan S, Miyamoto M, Shin HK, Saberi A, Murphy S, Sulistio E, Chelko SP, Kwon C, Precardiac organoids form two heart fields via Bmp/Wnt signaling. Nat Commun. 2018 Aug 7;9(1):3140
7	J:105980 Arnold JS, Werling U, Braunstein EM, Liao J, Nowotschin S, Edelmann W, Hebert JM, Morrow BE, Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development. 2006 Mar;133(5):977-87
3	J:288982 Assenza MR, Barbagallo F, Barrios F, Cornacchione M, Campolo F, Vivarelli E, Gianfrilli D, Auletta L, Soricelli A, Isidori AM, Lenzi A, Pellegrini M, Naro F, Critical role of phosphodiesterase 2A in mouse congenital heart defects. Cardiovasc Res. 2018 May 1;114(6):830-845
5	J:83662 Bachiller D, Klingensmith J, Shneyder N, Tran U, Anderson R, Rossant J, De Robertis EM, The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome. Development. 2003 Aug;130(15):3567-78
1	J:237523 Bain VE, Gordon J, O'Neil JD, Ramos I, Richie ER, Manley NR, Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate. Development. 2016 Nov 01;143(21):4027-4037
1*	J:193413 Bildsoe H, Loebel DA, Jones VJ, Hor AC, Braithwaite AW, Chen YT, Behringer RR, Tam PP, The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function. Dev Biol. 2013 Feb 15;374(2):295-307
1	J:214677 Bohnenpoll T, Trowe MO, Wojahn I, Taketo MM, Petry M, Kispert A, Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear. Dev Biol. 2014 Jul 1;391(1):54-65
1	J:169004 Bok J, Raft S, Kong KA, Koo SK, Drager UC, Wu DK, Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear. Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):161-6
10*	J:18978 Bollag RJ, Siegfried Z, Cebra-Thomas JA, Garvey N, Davison EM, Silver LM, An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus. Nat Genet. 1994 Jul;7(3):383-9
1	J:213872 Borromeo MD, Meredith DM, Castro DS, Chang JC, Tung KC, Guillemot F, Johnson JE, A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord. Development. 2014 Jul;141(14):2803-12
3	J:175160 Braunstein EM, Crenshaw EB 3rd, Morrow BE, Adams JC, Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation. J Assoc Res Otolaryngol. 2008 Mar;9(1):33-43
4	J:150080 Braunstein EM, Monks DC, Aggarwal VS, Arnold JS, Morrow BE, Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis. BMC Dev Biol. 2009;9:31
1	J:180898 Brown AS, Epstein DJ, Otic ablation of smoothened reveals direct and indirect requirements for Hedgehog signaling in inner ear development. Development. 2011 Sep;138(18):3967-76
3*	J:88814 Brown CB, Wenning JM, Lu MM, Epstein DJ, Meyers EN, Epstein JA, Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse. Dev Biol. 2004 Mar 1;267(1):190-202
1*	J:85710 Bush JO, Maltby KM, Cho ES, Jiang R, The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis. Gene Expr Patterns. 2003 Aug;3(4):533-8
1	J:100584 Byrd NA, Meyers EN, Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo. Dev Biol. 2005 Aug 1;284(1):233-45
4	J:152319 Calmont A, Ivins S, Van Bueren KL, Papangeli I, Kyriakopoulou V, Andrews WD, Martin JF, Moon AM, Illingworth EA, Basson MA, Scambler PJ, Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm. Development. 2009 Sep;136(18):3173-83
3*	J:166613 Cao H, Florez S, Amen M, Huynh T, Skobe Z, Baldini A, Amendt BA, Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21. Dev Biol. 2010 Nov 15;347(2):289-300
1	J:216364 Caprio C, Baldini A, p53 suppression partially rescues the mutant phenotype in mouse models of DiGeorge syndrome. Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13385-90
3	J:304609 Caprio C, Lania G, Bilio M, Ferrentino R, Chen L, Baldini A, EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm. Dis Model Mech. 2021 Feb 19;:dmm.046789
8*	J:149254 Caton J, Luder HU, Zoupa M, Bradman M, Bluteau G, Tucker AS, Klein O, Mitsiadis TA, Enamel-free teeth: Tbx1 deletion affects amelogenesis in rodent incisors. Dev Biol. 2009 Apr 15;328(2):493-505
7*	J:34541 Chapman DL, Garvey N, Hancock S, Alexiou M, Agulnik SI, Gibson-Brown JJ, Cebra-Thomas J, Bollag RJ, Silver LM, Papaioannou VE, Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. Dev Dyn. 1996 Aug;206(4):379-90
1	J:183479 Chen L, Fulcoli FG, Ferrentino R, Martucciello S, Illingworth EA, Baldini A, Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a. PLoS Genet. 2012 Mar;8(3):e1002571
5	J:169957 Chen L, Fulcoli FG, Tang S, Baldini A, Tbx1 regulates proliferation and differentiation of multipotent heart progenitors. Circ Res. 2009 Oct 23;105(9):842-51
5	J:159824 Chen L, Mupo A, Huynh T, Cioffi S, Woods M, Jin C, McKeehan W, Thompson-Snipes L, Baldini A, Illingworth E, Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol. 2010 May 3;189(3):417-24
2	J:183832 Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E, An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration. Nature. 2012 May 3;485(7396):104-8
2*	J:216507 Chervenak AP, Bank LM, Thomsen N, Glanville-Jones HC, Jonathan S, Millen KJ, Arkell RM, Barald KF, The role of Zic genes in inner ear development in the mouse: Exploring mutant mouse phenotypes. Dev Dyn. 2014 Nov;243(11):1487-98
1*	J:198578 Chervenak AP, Hakim IS, Barald KF, Spatiotemporal expression of zic genes during vertebrate inner ear development. Dev Dyn. 2013 Jul;242(7):897-908
2*	J:146769 Choi M, Klingensmith J, Chordin is a modifier of tbx1 for the craniofacial malformations of 22q11 deletion syndrome phenotypes in mouse. PLoS Genet. 2009 Feb;5(2):e1000395
1	J:217502 Chojnowski JL, Masuda K, Trau HA, Thomas K, Capecchi M, Manley NR, Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse. Development. 2014 Oct;141(19):3697-708
1	J:298672 Christ A, Marczenke M, Willnow TE, LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation. Hum Mol Genet. 2020 Nov 25;29(19):3183-3196
2*	J:216287 Czajkowski MT, Rassek C, Lenhard DC, Brohl D, Birchmeier C, Divergent and conserved roles of Dll1 signaling in development of craniofacial and trunk muscle. Dev Biol. 2014 Nov 15;395(2):307-16
1	J:291919 Darrigrand JF, Valente M, Comai G, Martinez P, Petit M, Nishinakamura R, Osorio DS, Renault G, Marchiol C, Ribes V, Cadot B, Dullard-mediated Smad1/5/8 inhibition controls mouse cardiac neural crest cells condensation and outflow tract septation. Elife. 2020 Feb 27;9:e50325
3	J:117244 Dastjerdi A, Robson L, Walker R, Hadley J, Zhang Z, Rodriguez-Niedenfuhr M, Ataliotis P, Baldini A, Scambler P, Francis-West P, Tbx1 regulation of myogenic differentiation in the limb and cranial mesoderm. Dev Dyn. 2007 Feb;236(2):353-63
3	J:266570 De Bono C, Thellier C, Bertrand N, Sturny R, Jullian E, Cortes C, Stefanovic S, Zaffran S, Theveniau-Ruissy M, Kelly RG, T-box genes and retinoic acid signaling regulate the segregation of arterial and venous pole progenitor cells in the murine second heart field. Hum Mol Genet. 2018 Nov 1;27(21):3747-3760
2	J:283391 de Soysa TY, Ranade SS, Okawa S, Ravichandran S, Huang Y, Salunga HT, Schricker A, Del Sol A, Gifford CA, Srivastava D, Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects. Nature. 2019 Aug;572(7767):120-124
1	J:80024 Delot EC, Bahamonde ME, Zhao M, Lyons KM, BMP signaling is required for septation of the outflow tract of the mammalian heart. Development. 2003 Jan;130(1):209-20
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:119660 Dong F, Sun X, Liu W, Ai D, Klysik E, Lu MF, Hadley J, Antoni L, Chen L, Baldini A, Francis-West P, Martin JF, Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle. Development. 2006 Dec;133(24):4891-9
6	J:353561 Dumas CE, Rousset C, De Bono C, Cortes C, Jullian E, Lescroart F, Zaffran S, Adachi N, Kelly RG, Retinoic acid signalling regulates branchiomeric neck muscle development at the head/trunk interface. Development. 2024 Aug 15;151(16):dev202905
1*	J:308709 Duran Alonso MB, Vendrell V, Lopez-Hernandez I, Alonso MT, Martin DM, Giraldez F, Carramolino L, Giovinazzo G, Vazquez E, Torres M, Schimmang T, Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea. Front Cell Dev Biol. 2021;9:679325
1	J:342149 Edwards W, Bussey OK, Conlon FL, The Tbx20-TLE interaction is essential for the maintenance of the second heart field. Development. 2023 Nov 1;150(21):dev201677
3*	J:229008 Escot S, Blavet C, Faure E, Zaffran S, Duband JL, Fournier-Thibault C, Disruption of CXCR4 signaling in pharyngeal neural crest cells causes DiGeorge syndrome-like malformations. Development. 2016 Feb 15;143(4):582-8
4	J:143603 Esibizione D, Cui CY, Schlessinger D, Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice. Gene. 2008 Dec 31;427(1-2):42-6
6	J:117856 Fagman H, Liao J, Westerlund J, Andersson L, Morrow BE, Nilsson M, The 22q11 deletion syndrome candidate gene Tbx1 determines thyroid size and positioning. Hum Mol Genet. 2007 Feb 1;16(3):276-85
1	J:241099 Flore G, Cioffi S, Bilio M, Illingworth E, Cortical Development Requires Mesodermal Expression of Tbx1, a Gene Haploinsufficient in 22q11.2 Deletion Syndrome. Cereb Cortex. 2017 Mar 01;27(3):2210-2225
1	J:316286 Francou A, Saint-Michel E, Mesbah K, Kelly RG, TBX1 regulates epithelial polarity and dynamic basal filopodia in the second heart field. Development. 2014 Nov;141(22):4320-31
2	J:78685 Frank DU, Fotheringham LK, Brewer JA, Muglia LJ, Tristani-Firouzi M, Capecchi MR, Moon AM, An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome. Development. 2002 Oct;129(19):4591-603
2*	J:204435 Freyer L, Nowotschin S, Pirity MK, Baldini A, Morrow BE, Conditional and constitutive expression of a Tbx1-GFP fusion protein in mice. BMC Dev Biol. 2013 Aug 23;13(1):33
1*	J:98114 Friedman RA, Makmura L, Biesiada E, Wang X, Keithley EM, Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development. Mech Dev. 2005 May;122(5):625-34
3	J:207648 Fu Y, Li F, Zhao DY, Zhang JS, Lv Y, Li-Ling J, Interaction between Tbx1 and Hoxd10 and connection with TGFbeta-BMP signal pathway during kidney development. Gene. 2014 Feb 15;536(1):197-202
1*	J:219361 Fuchs JC, Linden JF, Baldini A, Tucker AS, A defect in early myogenesis causes Otitis media in two mouse models of 22q11.2 Deletion Syndrome. Hum Mol Genet. 2015 Apr 1;24(7):1869-82
1*	J:229950 Fujita M, Sakabe M, Ioka T, Watanabe Y, Kinugasa-Katayama Y, Tsuchihashi T, Utset MF, Yamagishi H, Nakagawa O, Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor. Mech Dev. 2016 Feb;139:65-73
1	J:239907 Fulcoli FG, Franzese M, Liu X, Zhang Z, Angelini C, Baldini A, Rebalancing gene haploinsufficiency in vivo by targeting chromatin. Nat Commun. 2016 Jun 03;7:11688
5	J:183770 Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H, Tbx1 regulates oral epithelial adhesion and palatal development. Hum Mol Genet. 2012 Jun 1;21(11):2524-37
4	J:217210 Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H, Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia. Hum Mol Genet. 2015 Jan 15;24(2):424-35
2	J:347133 Funato N, Srivastava D, Shibata S, Yanagisawa H, TBX1 Regulates Chondrocyte Maturation in the Spheno-occipital Synchondrosis. J Dent Res. 2020 Sep;99(10):1182-1191
1*	J:270507 Funato N, Yanagisawa H, Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans. Arch Oral Biol. 2018 Nov;95:149-155
4*	J:72986 Funke B, Epstein JA, Kochilas LK, Lu MM, Pandita RK, Liao J, Bauerndistel R, Schuler T, Schorle H, Brown MC, Adams J, Morrow BE, Mice overexpressing genes from the 22q11 region deleted in velo-cardio-facial syndrome/DiGeorge syndrome have middle and inner ear defects. Hum Mol Genet. 2001 Oct 15;10(22):2549-56
8*	J:70279 Garg V, Yamagishi C, Hu T, Kathiriya IS, Yamagishi H, Srivastava D, Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development. Dev Biol. 2001 Jul 1;235(1):62-73
1	J:326089 Ghnaimawi S, Zhang S, Baum JI, Huang Y, The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis. Front Physiol. 2022;13:881624
1	J:135134 Goddeeris MM, Schwartz R, Klingensmith J, Meyers EN, Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development. Development. 2007 Apr;134(8):1593-604
4	J:337033 Greulich F, Rudat C, Farin HF, Christoffels VM, Kispert A, Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development. PLoS One. 2016;11(6):e0156787
6*	J:139636 Grifone R, Jarry T, Dandonneau M, Grenier J, Duprez D, Kelly RG, Properties of branchiomeric and somite-derived muscle development in Tbx1 mutant embryos. Dev Dyn. 2008 Sep 24;237(10):3071-3078
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
4	J:358135 Guijarro C, Song S, Aigouy B, Clement R, Villoutreix P, Kelly RG, Single-cell morphometrics reveals T-box gene-dependent patterns of epithelial tension in the Second Heart field. Nat Commun. 2024 Nov 4;15(1):9512
4	J:172023 Guo C, Sun Y, Zhou B, Adam RM, Li X, Pu WT, Morrow BE, Moon A, Li X, A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest. 2011 Apr 1;121(4):1585-95
1	J:123620 Hakim ZS, DiMichele LA, Doherty JT, Homeister JW, Beggs HE, Reichardt LF, Schwartz RJ, Brackhan J, Smithies O, Mack CP, Taylor JM, Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment. Mol Cell Biol. 2007 Aug;27(15):5352-64
4	J:191738 Harel I, Maezawa Y, Avraham R, Rinon A, Ma HY, Cross JW, Leviatan N, Hegesh J, Roy A, Jacob-Hirsch J, Rechavi G, Carvajal J, Tole S, Kioussi C, Quaggin S, Tzahor E, Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18839-44
1	J:261899 Hasten E, McDonald-McGinn DM, Crowley TB, Zackai E, Emanuel BS, Morrow BE, Racedo SE, Dysregulation of TBX1 dosage in the anterior heart field results in congenital heart disease resembling the 22q11.2 duplication syndrome. Hum Mol Genet. 2018 Jun 1;27(11):1847-1857
2	J:279006 Hasten E, Morrow BE, Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndrome. PLoS Genet. 2019 Aug;15(8):e1008301
1	J:170963 Heallen T, Zhang M, Wang J, Bonilla-Claudio M, Klysik E, Johnson RL, Martin JF, Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science. 2011 Apr 22;332(6028):458-61
1	J:161382 Heude E, Bouhali K, Kurihara Y, Kurihara H, Couly G, Janvier P, Levi G, Jaw muscularization requires Dlx expression by cranial neural crest cells. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11441-6
5*	J:125749 Hou J, Charters AM, Lee SC, Zhao Y, Wu MK, Jones SJ, Marra MA, Hoodless PA, A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE). BMC Dev Biol. 2007;7:92
2	J:93588 Hu T, Yamagishi H, Maeda J, McAnally J, Yamagishi C, Srivastava D, Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development. 2004 Nov;131(21):5491-502
1	J:150516 Hu Z, Wang C, Xiao Y, Sheng N, Chen Y, Xu Y, Zhang L, Mo W, Jing N, Hu G, NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development. J Cell Sci. 2009 Apr 15;122(Pt 8):1145-54
4	J:158677 Huh SH, Ornitz DM, Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1. Development. 2010 Apr;137(7):1137-47
1	J:229246 Huh SH, Warchol ME, Ornitz DM, Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling. Elife. 2015;4
1	J:164582 Hurd EA, Poucher HK, Cheng K, Raphael Y, Martin DM, The ATP-dependent chromatin remodeling enzyme CHD7 regulates pro-neural gene expression and neurogenesis in the inner ear. Development. 2010 Sep;137(18):3139-50
1	J:102844 Ishii M, Han J, Yen HY, Sucov HM, Chai Y, Maxson RE Jr, Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development. 2005 Nov;132(22):4937-50
1	J:101263 Ivins S, Lammerts van Beuren K, Roberts C, James C, Lindsay E, Baldini A, Ataliotis P, Scambler PJ, Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1. Dev Biol. 2005 Sep 15;285(2):554-69
1*	J:213586 Jackson A, Kasah S, Mansour SL, Morrow B, Basson MA, Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis. Dev Dyn. 2014 Sep;243(9):1143-51
2	J:305429 Kaiser M, Wojahn I, Rudat C, Ludtke TH, Christoffels VM, Moon A, Kispert A, Trowe MO, Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651
3	J:213451 Karpinski BA, Maynard TM, Fralish MS, Nuwayhid S, Zohn IE, Moody SA, LaMantia AS, Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome. Dis Model Mech. 2014 Feb;7(2):245-57
2*	J:94411 Kelly RG, Jerome-Majewska LA, Papaioannou VE, The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis. Hum Mol Genet. 2004 Nov 15;13(22):2829-40
1	J:282804 Kim HT, Yin W, Nakamichi Y, Panza P, Grohmann B, Buettner C, Guenther S, Ruppert C, Kobayashi Y, Guenther A, Stainier DYR, WNT/RYK signaling restricts goblet cell differentiation during lung development and repair. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25697-25706
4	J:213620 Kong P, Racedo SE, Macchiarulo S, Hu Z, Carpenter C, Guo T, Wang T, Zheng D, Morrow BE, Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication. Hum Mol Genet. 2014 Aug 15;23(16):4215-31
3	J:170405 Kueh AJ, Dixon MP, Voss AK, Thomas T, HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development. Mol Cell Biol. 2011 Feb;31(4):845-60
1*	J:99326 Kuhnert F, Campagnolo L, Xiong JW, Lemons D, Fitch MJ, Zou Z, Kiosses WB, Gardner H, Stuhlmann H, Dosage-dependent requirement for mouse Vezf1 in vascular system development. Dev Biol. 2005 Jul 1;283(1):140-156
3	J:187316 Kyrylkova K, Kyryachenko S, Biehs B, Klein O, Kioussi C, Leid M, BCL11B regulates epithelial proliferation and asymmetric development of the mouse mandibular incisor. PLoS One. 2012;7(5):e37670
2	J:243177 Lania G, Ferrentino R, Baldini A, TBX1 Represses Vegfr2 Gene Expression and Enhances the Cardiac Fate of VEGFR2+ Cells. PLoS One. 2015;10(9):e0138525
1	J:330214 Lania G, Franzese M, Adachi N, Bilio M, Flore G, Russo A, D'Agostino E, Angelini C, Kelly RG, Baldini A, A phenotypic rescue approach identifies lineage regionalization defects in a mouse model of DiGeorge syndrome. Dis Model Mech. 2022 Sep 1;15(9):dmm049415
1*	J:149463 Lania G, Zhang Z, Huynh T, Caprio C, Moon AM, Vitelli F, Baldini A, Early thyroid development requires a Tbx1-Fgf8 pathway. Dev Biol. 2009 Apr 1;328(1):109-17
1	J:252133 Lee S, Shin JO, Sagong B, Kim UK, Bok J, Spatiotemporal expression patterns of clusterin in the mouse inner ear. Cell Tissue Res. 2017 Oct;370(1):89-97
1	J:216613 Liang D, Wang X, Mittal A, Dhiman S, Hou SY, Degenhardt K, Astrof S, Mesodermal expression of integrin alpha5beta1 regulates neural crest development and cardiovascular morphogenesis. Dev Biol. 2014 Nov 15;395(2):232-44
4*	J:135407 Liao J, Aggarwal VS, Nowotschin S, Bondarev A, Lipner S, Morrow BE, Identification of downstream genetic pathways of Tbx1 in the second heart field. Dev Biol. 2008 Apr 15;316(2):524-37
1*	J:110602 Lin L, Bu L, Cai CL, Zhang X, Evans S, Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev Biol. 2006 Jul 15;295(2):756-63
2	J:67409 Lindsay EA, Vitelli F, Su H, Morishima M, Huynh T, Pramparo T, Jurecic V, Ogunrinu G, Sutherland HF, Scambler PJ, Bradley A, Baldini A, Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice. Nature. 2001 Mar 1;410(6824):97-101
3	J:291487 Liu D, Kousa AI, O'Neill KE, Rouse P, Popis M, Farley AM, Tomlinson SR, Ulyanchenko S, Guillemot F, Seymour PA, Jorgensen MC, Serup P, Koch U, Radtke F, Blackburn CC, Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development. Development. 2020 Jun 22;147(12):dev178582
3*	J:121311 Liu Z, Yu S, Manley NR, Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia. Dev Biol. 2007 May 1;305(1):333-46
1	J:238888 Luo W, Zhao X, Jin H, Tao L, Zhu J, Wang H, Hemmings BA, Yang Z, Akt1 signaling coordinates BMP signaling and beta-catenin activity to regulate second heart field progenitor development. Development. 2015 Feb 15;142(4):732-42
3	J:247916 Macchiarulo S, Morrow BE, Tbx1 and Jag1 act in concert to modulate the fate of neurosensory cells of the mouse otic vesicle. Biol Open. 2017 Oct 15;6(10):1472-1482
1*	J:146220 Maclean G, Dolle P, Petkovich M, Genetic disruption of CYP26B1 severely affects development of neural crest derived head structures, but does not compromise hindbrain patterning. Dev Dyn. 2009 Mar;238(3):732-45
1	J:327414 Manivannan S, Mansfield C, Zhang X, Kodigepalli KM, Majumdar U, Garg V, Basu M, Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia. Commun Biol. 2022 Aug 15;5(1):820
2*	J:95019 Manley NR, Selleri L, Brendolan A, Gordon J, Cleary ML, Abnormalities of caudal pharyngeal pouch development in Pbx1 knockout mice mimic loss of Hox3 paralogs. Dev Biol. 2004 Dec 15;276(2):301-12
3	J:305417 Martucciello S, Turturo MG, Bilio M, Cioffi S, Chen L, Baldini A, Illingworth E, A dual role for Tbx1 in cardiac lymphangiogenesis through genetic interaction with Vegfr3. FASEB J. 2020 Nov;34(11):15062-15079
1	J:349775 Matern MS, Durruthy-Durruthy R, Birol O, Darmanis S, Scheibinger M, Groves AK, Heller S, Transcriptional dynamics of delaminating neuroblasts in the mouse otic vesicle. Cell Rep. 2023 Jun 27;42(6):112545
1	J:191130 Maynard TM, Gopalakrishna D, Meechan DW, Paronett EM, Newbern JM, Lamantia AS, 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013 Jan 15;22(2):300-12
1*	J:74505 Maynard TM, Haskell GT, Bhasin N, Lee JM, Gassman AA, Lieberman JA, LaMantia AS, RanBP1, a velocardiofacial/DiGeorge syndrome candidate gene, is expressed at sites of mesenchymal/epithelial induction. Mech Dev. 2002 Feb;111(1-2):177-80
6*	J:86704 Maynard TM, Haskell GT, Peters AZ, Sikich L, Lieberman JA, LaMantia AS, A comprehensive analysis of 22q11 gene expression in the developing and adult brain. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14433-8
2	J:208359 Mc Laughlin D, Murphy P, Puri P, Altered Tbx1 gene expression is associated with abnormal oesophageal development in the adriamycin mouse model of oesophageal atresia/tracheo-oesophageal fistula. Pediatr Surg Int. 2014 Feb;30(2):143-9
5	J:116629 Meechan DW, Maynard TM, Wu Y, Gopalakrishna D, Lieberman JA, Lamantia AS, Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome. Mol Cell Neurosci. 2006 Dec;33(4):412-28
1	J:153232 Meechan DW, Tucker ES, Maynard TM, LaMantia AS, Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16434-45
7	J:67796 Merscher S, Funke B, Epstein JA, Heyer J, Puech A, Lu MM, Xavier RJ, Demay MB, Russell RG, Factor S, Tokooya K, Jore BS, Lopez M, Pandita RK, Lia M, Carrion D, Xu H, Schorle H, Kobler JB, Scambler P, Wynshaw-Boris A, Skoultchi AI, Morrow BE, KucherlapatiR, TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell. 2001 Feb 23;104(4):619-29
3	J:181153 Mesbah K, Rana MS, Francou A, van Duijvenboden K, Papaioannou VE, Moorman AF, Kelly RG, Christoffels VM, Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis. Hum Mol Genet. 2012 Mar 15;21(6):1217-29
1*	J:161209 Michell AC, Braganca J, Broadbent C, Joyce B, Franklyn A, Schneider JE, Bhattacharya S, Bamforth SD, A novel role for transcription factor Lmo4 in thymus development through genetic interaction with Cited2. Dev Dyn. 2010 Jul;239(7):1988-94
1	J:214961 Milgrom-Hoffman M, Michailovici I, Ferrara N, Zelzer E, Tzahor E, Endothelial cells regulate neural crest and second heart field morphogenesis. Biol Open. 2014;3(8):679-88
1*	J:130823 Mitsiadis TA, Drouin J, Deletion of the Pitx1 genomic locus affects mandibular tooth morphogenesis and expression of the Barx1 and Tbx1 genes. Dev Biol. 2008 Jan 15;313(2):887-96
2	J:164590 Mitsiadis TA, Graf D, Luder H, Gridley T, Bluteau G, BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation. Development. 2010 Sep;137(18):3025-35
7*	J:139189 Mitsiadis TA, Tucker AS, De Bari C, Cobourne MT, Rice DP, A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination. Dev Biol. 2008 Aug 1;320(1):39-48
1	J:312369 Miyamoto M, Andersen P, Sulistio E, Liu X, Murphy S, Kannan S, Nam L, Miyamoto W, Tampakakis E, Hibino N, Uosaki H, Kwon C, Noncanonical Notch signals have opposing roles during cardiac development. Biochem Biophys Res Commun. 2021 Nov 5;577:12-16
1	J:356509 Mo Q, Salley J, Roshan T, Baer LA, May FJ, Jaehnig EJ, Lehnig AC, Guo X, Tong Q, Nuotio-Antar AM, Shamsi F, Tseng YH, Stanford KI, Chen MH, Identification and characterization of a supraclavicular brown adipose tissue in mice. JCI Insight. 2017 Jun 2;2(11)
3	J:182749 Moncaut N, Cross JW, Siligan C, Keith A, Taylor K, Rigby PW, Carvajal JJ, Musculin and TCF21 coordinate the maintenance of myogenic regulatory factor expression levels during mouse craniofacial development. Development. 2012 Mar;139(5):958-67
1	J:181273 Monks DC, Morrow BE, Identification of putative retinoic acid target genes downstream of mesenchymal Tbx1 during inner ear development. Dev Dyn. 2012 Mar;241(3):563-73
5*	J:96463 Moraes F, Novoa A, Jerome-Majewska LA, Papaioannou VE, Mallo M, Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development. Mech Dev. 2005 Feb;122(2):199-212
1*	J:85487 Morishima M, Yanagisawa H, Yanagisawa M, Baldini A, Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis. Dev Dyn. 2003 Sep;228(1):95-104
1	J:172819 Nakazawa M, Uchida K, Aramaki M, Kodo K, Yamagishi C, Takahashi T, Mikoshiba K, Yamagishi H, Inositol 1,4,5-trisphosphate receptors are essential for the development of the second heart field. J Mol Cell Cardiol. 2011 Jul;51(1):58-66
1*	J:135997 Nie X, Deng CX, Wang Q, Jiao K, Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. Dev Biol. 2008 Apr 15;316(2):417-30
4	J:315702 Nomaru H, Liu Y, De Bono C, Righelli D, Cirino A, Wang W, Song H, Racedo SE, Dantas AG, Zhang L, Cai CL, Angelini C, Christiaen L, Kelly RG, Baldini A, Zheng D, Morrow BE, Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm. Nat Commun. 2021 Nov 17;12(1):6645
1	J:188836 Norden J, Greulich F, Rudat C, Taketo MM, Kispert A, Wnt/beta-catenin signaling maintains the mesenchymal precursor pool for murine sinus horn formation. Circ Res. 2011 Sep 2;109(6):e42-50
3	J:107397 Nowotschin S, Liao J, Gage PJ, Epstein JA, Campione M, Morrow BE, Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development. 2006 Apr;133(8):1565-73
1*	J:80764 Ohnemus S, Kanzler B, Jerome-Majewska LA, Papaioannou VE, Boehm T, Mallo M, Aortic arch and pharyngeal phenotype in the absence of BMP-dependent neural crest in the mouse. Mech Dev. 2002 Dec;119(2):127-35
1*	J:105983 Ohyama T, Mohamed OA, Taketo MM, Dufort D, Groves AK, Wnt signals mediate a fate decision between otic placode and epidermis. Development. 2006 Mar;133(5):865-75
3*	J:187968 Okano J, Kimura W, Papaioannou VE, Miura N, Yamada G, Shiota K, Sakai Y, The regulation of endogenous retinoic acid level through CYP26B1 is required for elevation of palatal shelves. Dev Dyn. 2012 Nov;241(11):1744-56
5	J:139633 Okano J, Sakai Y, Shiota K, Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice. Dev Dyn. 2008 Sep 24;237(10):3059-3070
4	J:167713 Okubo T, Kawamura A, Takahashi J, Yagi H, Morishima M, Matsuoka R, Takada S, Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives in mice. Development. 2011 Jan;138(2):339-48
1*	J:267181 Pane LS, Fulcoli FG, Cirino A, Altomonte A, Ferrentino R, Bilio M, Baldini A, Tbx1 represses Mef2c gene expression and is correlated with histone 3 deacetylation of the anterior heart field enhancer. Dis Model Mech. 2018 Aug 30;11(9):dmm029967
2	J:183773 Pane LS, Zhang Z, Ferrentino R, Huynh T, Cutillo L, Baldini A, Tbx1 is a negative modulator of Mef2c. Hum Mol Genet. 2012 Jun 1;21(11):2485-96
4	J:212881 Papangeli I, Scambler PJ, Tbx1 genetically interacts with the transforming growth factor-beta/bone morphogenetic protein inhibitor Smad7 during great vessel remodeling. Circ Res. 2013 Jan 4;112(1):90-102
1	J:235630 Paronett EM, Meechan DW, Karpinski BA, LaMantia AS, Maynard TM, Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation. Cereb Cortex. 2015 Oct;25(10):3977-93
4	J:110101 Paylor R, Glaser B, Mupo A, Ataliotis P, Spencer C, Sobotka A, Sparks C, Choi CH, Oghalai J, Curran S, Murphy KC, Monks S, Williams N, O'Donovan MC, Owen MJ, Scambler PJ, Lindsay E, Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7729-34
1	J:254695 Peng Y, Song L, Li D, Kesterson R, Wang J, Wang L, Rokosh G, Wu B, Wang Q, Jiao K, Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice. Cardiovasc Res. 2016 Nov 1;112(2):532-542
2	J:284143 Phillips HM, Stothard CA, Shaikh Qureshi WM, Kousa AI, Briones-Leon JA, Khasawneh RR, O'Loughlin C, Sanders R, Mazzotta S, Dodds R, Seidel K, Bates T, Nakatomi M, Cockell SJ, Schneider JE, Mohun TJ, Maehr R, Kist R, Peters H, Bamforth SD, Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis. Development. 2019 Sep 23;146(18):dev177618
2*	J:98850 Prescott K, Ivins S, Hubank M, Lindsay E, Baldini A, Scambler P, Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome. Hum Genet. 2005 May;116(6):486-96
3	J:242314 Racedo SE, Hasten E, Lin M, Devakanmalai GS, Guo T, Ozbudak EM, Cai CL, Zheng D, Morrow BE, Reduced dosage of beta-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome. PLoS Genet. 2017 Mar;13(3):e1006687
5*	J:89188 Raft S, Nowotschin S, Liao J, Morrow BE, Suppression of neural fate and control of inner ear morphogenesis by Tbx1. Development. 2004 Apr;131(8):1801-12
1	J:246236 Rana MS, Theveniau-Ruissy M, De Bono C, Mesbah K, Francou A, Rammah M, Dominguez JN, Roux M, Laforest B, Anderson RH, Mohun T, Zaffran S, Christoffels VM, Kelly RG, Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart. Circ Res. 2014 Oct 10;115(9):790-9
6	J:154590 Randall V, McCue K, Roberts C, Kyriakopoulou V, Beddow S, Barrett AN, Vitelli F, Prescott K, Shaw-Smith C, Devriendt K, Bosman E, Steffes G, Steel KP, Simrick S, Basson MA, Illingworth E, Scambler PJ, Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J Clin Invest. 2009 Nov;119(11):3301-10
1	J:313346 Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AM, Tbx5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. Elife. 2021 Oct 13;10:e69288
3	J:214094 Reeh KA, Cardenas KT, Bain VE, Liu Z, Laurent M, Manley NR, Richie ER, Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis. Development. 2014 Aug;141(15):2950-8
3	J:79100 Riccomagno MM, Martinu L, Mulheisen M, Wu DK, Epstein DJ, Specification of the mammalian cochlea is dependent on Sonic hedgehog. Genes Dev. 2002 Sep 15;16(18):2365-78
2	J:124278 Rinon A, Lazar S, Marshall H, Buchmann-Moller S, Neufeld A, Elhanany-Tamir H, Taketo MM, Sommer L, Krumlauf R, Tzahor E, Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis. Development. 2007 Sep;134(17):3065-75
1*	J:117754 Roberts C, Ivins S, Cook AC, Baldini A, Scambler PJ, Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick. Hum Mol Genet. 2006 Dec 1;15(23):3394-410
2	J:129204 Robertson EJ, Charatsi I, Joyner CJ, Koonce CH, Morgan M, Islam A, Paterson C, Lejsek E, Arnold SJ, Kallies A, Nutt SL, Bikoff EK, Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice. Development. 2007 Dec;134(24):4335-45
2*	J:226322 Roux M, Laforest B, Capecchi M, Bertrand N, Zaffran S, Hoxb1 regulates proliferation and differentiation of second heart field progenitors in pharyngeal mesoderm and genetically interacts with Hoxa1 during cardiac outflow tract development. Dev Biol. 2015 Oct 15;406(2):247-58
2	J:170865 Ryckebusch L, Bertrand N, Mesbah K, Bajolle F, Niederreither K, Kelly RG, Zaffran S, Decreased levels of embryonic retinoic acid synthesis accelerate recovery from arterial growth delay in a mouse model of DiGeorge syndrome. Circ Res. 2010 Mar 5;106(4):686-94
1	J:156467 Saxena A, Tabin CJ, miRNA-processing enzyme Dicer is necessary for cardiac outflow tract alignment and chamber septation. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):87-91
1	J:161587 Schleiffarth JR, Person AD, Martinsen BJ, Sukovich DJ, Neumann A, Baker CV, Lohr JL, Cornfield DN, Ekker SC, Petryk A, Wnt5a is required for cardiac outflow tract septation in mice. Pediatr Res. 2007 Apr;61(4):386-91
2	J:119303 Seo S, Kume T, Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. Dev Biol. 2006 Aug 15;296(2):421-36
2*	J:120320 Shih HP, Gross MK, Kioussi C, Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5907-12
2	J:306135 Shimizu R, Ishihara K, Kawashita E, Sago H, Yamakawa K, Mizutani KI, Akiba S, Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models. Biochem Biophys Res Commun. 2021 Jan 8;535:87-92
3	J:264983 Shin JO, Lee JJ, Kim M, Chung YW, Min H, Kim JY, Kim HP, Bok J, CTCF Regulates Otic Neurogenesis via Histone Modification in the Neurog1 Locus. Mol Cells. 2018 Jul 31;41(7):695-702
1*	J:185606 Simrick S, Szumska D, Gardiner JR, Jones K, Sagar K, Morrow B, Bhattacharya S, Basson MA, Biallelic expression of Tbx1 protects the embryo from developmental defects caused by increased receptor tyrosine kinase signaling. Dev Dyn. 2012 Aug;241(8):1310-24
1	J:332291 Song H, Morrow BE, Tbx2 and Tbx3 regulate cell fate progression of the otic vesicle for inner ear development. Dev Biol. 2022 Dec 12;494:71-84
2	J:81698 Stalmans I, Lambrechts D, De Smet F, Jansen S, Wang J, Maity S, Kneer P, Von Der Ohe M, Swillen A, Maes C, Gewillig M, Molin DG, Hellings P, Boetel T, Haardt M, Compernolle V, Dewerchin M, Plaisance S, Vlietinck R, Emanuel B, Gittenberger-De Groot AC, Scambler P, Morrow B, Driscol DA, Moons L, Esguerra CV, Carmeliet G, Behn-Krappa A, Devriendt K, Collen D, Conway SJ, Carmeliet P, VEGF: A modifier of the del22q11 (DiGeorge) syndrome?. Nat Med. 2003 Feb;9(2):173-82
2*	J:338018 Stathopoulou A, Wang P, Thellier C, Kelly RG, Zheng D, Scambler PJ, CHARGE syndrome-associated CHD7 acts at ISL1-regulated enhancers to modulate second heart field gene expression. Cardiovasc Res. 2023 Apr 13;
1	J:302497 Stefanovic S, Laforest B, Desvignes JP, Lescroart F, Argiro L, Maurel-Zaffran C, Salgado D, Plaindoux E, De Bono C, Pazur K, Theveniau-Ruissy M, Beroud C, Puceat M, Gavalas A, Kelly RG, Zaffran S, Hox-dependent coordination of mouse cardiac progenitor cell patterning and differentiation. Elife. 2020 Aug 17;9:e55124
1*	J:162660 Stoller JZ, Huang L, Tan CC, Huang F, Zhou DD, Yang J, Gelb BD, Epstein JA, Ash2l interacts with Tbx1 and is required during early embryogenesis. Exp Biol Med (Maywood). 2010 May;235(5):569-76
2	J:320909 Stothard CA, Mazzotta S, Vyas A, Schneider JE, Mohun TJ, Henderson DJ, Phillips HM, Bamforth SD, Pax9 and Gbx2 Interact in the Pharyngeal Endoderm to Control Cardiovascular Development. J Cardiovasc Dev Dis. 2020 May 25;7(2):20
2	J:270109 Sugrue KF, Sarkar AA, Leatherbury L, Zohn IE, The ubiquitin ligase HECTD1 promotes retinoic acid signaling required for development of the aortic arch. Dis Model Mech. 2019 Jan 11;12(1):dmm036491
1	J:134487 Suzuki A, Sekiya S, Buscher D, Izpisua Belmonte JC, Taniguchi H, Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression. Development. 2008 May;135(9):1589-95
1	J:308790 Sweat M, Sweat Y, Yu W, Su D, Leonard RJ, Eliason SL, Amendt BA, The miR-200 family is required for ectodermal organ development through the regulation of the epithelial stem cell niche. Stem Cells. 2021 Jun;39(6):761-775
1*	J:292863 Tejedor G, Laplace-Builhe B, Luz-Crawford P, Assou S, Barthelaix A, Mathieu M, Kissa K, Jorgensen C, Collignon J, Chuchana P, Djouad F, Whole embryo culture, transcriptomics and RNA interference identify TBX1 and FGF11 as novel regulators of limb development in the mouse. Sci Rep. 2020 Feb 27;10(1):3597
4*	J:231098 Theveniau-Ruissy M, Perez-Pomares JM, Parisot P, Baldini A, Miquerol L, Kelly RG, Coronary stem development in wild-type and Tbx1 null mouse hearts. Dev Dyn. 2016 Apr;245(4):445-59
1	J:212416 Thomas PS, Rajderkar S, Lane J, Mishina Y, Kaartinen V, AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity. Dev Biol. 2014 Jun 15;390(2):191-207
1*	J:278988 Tian C, Johnson KR, TBX1 is required for normal stria vascularis and semicircular canal development. Dev Biol. 2019 Sep 21;
2	J:160473 Trowe MO, Shah S, Petry M, Airik R, Schuster-Gossler K, Kist R, Kispert A, Loss of Sox9 in the periotic mesenchyme affects mesenchymal expansion and differentiation, and epithelial morphogenesis during cochlea development in the mouse. Dev Biol. 2010 Jun 1;342(1):51-62
4	J:303268 Tyser RCV, Ibarra-Soria X, McDole K, Arcot Jayaram S, Godwin J, van den Brand TAH, Miranda AMA, Scialdone A, Keller PJ, Marioni JC, Srinivas S, Characterization of a common progenitor pool of the epicardium and myocardium. Science. 2021 Mar 5;371(6533)
1	J:222450 Uribe V, Badia-Careaga C, Casanova JC, Dominguez JN, de la Pompa JL, Sanz-Ezquerro JJ, Arid3b is essential for second heart field cell deployment and heart patterning. Development. 2014 Nov;141(21):4168-81
3	J:175465 Urness LD, Bleyl SB, Wright TJ, Moon AM, Mansour SL, Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development. Dev Biol. 2011 Aug 15;356(2):383-97
2	J:293345 Urness LD, Wang X, Doan H, Shumway N, Noyes CA, Gutierrez-Magana E, Lu R, Mansour SL, Spatial and temporal inhibition of FGFR2b ligands reveals continuous requirements and novel targets in mouse inner ear morphogenesis. Development. 2018 Dec 18;145(24):dev170142
2*	J:160266 van Bueren KL, Papangeli I, Rochais F, Pearce K, Roberts C, Calmont A, Szumska D, Kelly RG, Bhattacharya S, Scambler PJ, Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome. Dev Biol. 2010 Apr 15;340(2):369-80
4*	J:221397 Vanyai HK, Thomas T, Voss AK, Mesodermal expression of Moz is necessary for cardiac septum development. Dev Biol. 2015 Jul 1;403(1):22-9
4	J:142115 Vazquez-Echeverria C, Dominguez-Frutos E, Charnay P, Schimmang T, Pujades C, Analysis of mouse kreisler mutants reveals new roles of hindbrain-derived signals in the establishment of the otic neurogenic domain. Dev Biol. 2008 Oct 1;322(1):167-78
1	J:81969 Vermot J, Niederreither K, Garnier JM, Chambon P, Dolle P, Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1763-8
3	J:213584 Vincent SD, Mayeuf-Louchart A, Watanabe Y, Brzezinski JA 4th, Miyagawa-Tomita S, Kelly RG, Buckingham M, Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo. Hum Mol Genet. 2014 Oct 1;23(19):5087-101
1	J:97317 Vincentz JW, McWhirter JR, Murre C, Baldini A, Furuta Y, Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract. Genesis. 2005 Apr;41(4):192-201
2	J:146886 Vitelli F, Huynh T, Baldini A, Gain of function of Tbx1 affects pharyngeal and heart development in the mouse. Genesis. 2009 Mar;47(3):188-95
1	J:175333 Vitelli F, Lania G, Huynh T, Baldini A, Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8. J Mol Cell Cardiol. 2010 Nov;49(5):836-40
7*	J:76173 Vitelli F, Morishima M, Taddei I, Lindsay EA, Baldini A, Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways. Hum Mol Genet. 2002 Apr 15;11(8):915-22
1	J:78686 Vitelli F, Taddei I, Morishima M, Meyers EN, Lindsay EA, Baldini A, A genetic link between Tbx1 and fibroblast growth factor signaling. Development. 2002 Oct;129(19):4605-11
6*	J:85072 Vitelli F, Viola A, Morishima M, Pramparo T, Baldini A, Lindsay E, TBX1 is required for inner ear morphogenesis. Hum Mol Genet. 2003 Aug 15;12(16):2041-8
2	J:110620 Vitelli F, Zhang Z, Huynh T, Sobotka A, Mupo A, Baldini A, Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants. Dev Biol. 2006 Jul 15;295(2):559-70
6	J:188772 Voss AK, Vanyai HK, Collin C, Dixon MP, McLennan TJ, Sheikh BN, Scambler P, Thomas T, MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome. Dev Cell. 2012 Sep 11;23(3):652-63
5	J:202467 Wang J, Bai Y, Li H, Greene SB, Klysik E, Yu W, Schwartz RJ, Williams TJ, Martin JF, MicroRNA-17-92, a direct Ap-2alpha transcriptional target, modulates T-box factor activity in orofacial clefting. PLoS Genet. 2013 Sep;9(9):e1003785
3	J:169047 Wang J, Greene SB, Bonilla-Claudio M, Tao Y, Zhang J, Bai Y, Huang Z, Black BL, Wang F, Martin JF, Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell. 2010 Dec 14;19(6):903-12
1	J:84053 Wang T, Tamakoshi T, Uezato T, Shu F, Kanzaki-Kato N, Fu Y, Koseki H, Yoshida N, Sugiyama T, Miura N, Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate. Dev Biol. 2003 Jul 1;259(1):83-94
4	J:201607 Wu G, Han D, Gong Y, Sebastiano V, Gentile L, Singhal N, Adachi K, Fischedick G, Ortmeier C, Sinn M, Radstaak M, Tomilin A, Scholer HR, Establishment of totipotency does not depend on Oct4A. Nat Cell Biol. 2013 Sep;15(9):1089-97
1	J:283063 Wu L, Belyaeva OV, Adams MK, Klyuyeva AV, Lee SA, Goggans KR, Kesterson RA, Popov KM, Kedishvili NY, Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands. J Biol Chem. 2019 Nov 8;294(45):17060-17074
8	J:128008 Xu H, Chen L, Baldini A, In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea. Dev Biol. 2007 Oct 15;310(2):329-40
4	J:91013 Xu H, Morishima M, Wylie JN, Schwartz RJ, Bruneau BG, Lindsay EA, Baldini A, Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development. 2004 Jul;131(13):3217-27
6	J:119950 Xu H, Viola A, Zhang Z, Gerken CP, Lindsay-Illingworth EA, Baldini A, Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells. Dev Biol. 2007 Feb 15;302(2):670-82
3	J:81296 Yamagishi H, Maeda J, Hu T, McAnally J, Conway SJ, Kume T, Meyers EN, Yamagishi C, Srivastava D, Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Genes Dev. 2003 Jan 15;17(2):269-81
1*	J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
1*	J:190655 Yee KK, Yagi H, Matsuoka R, Nakanishi T, Furukawa T, Transrepression activity of T-box1 in a gene regulation network in mouse cells. Gene. 2012 Dec 1;510(2):162-70
1	J:262085 Yu Z, Tang PL, Wang J, Bao S, Shieh JT, Leung AW, Zhang Z, Gao F, Wong SY, Hui AL, Gao Y, Dung N, Zhang ZG, Fan Y, Zhou X, Zhang Y, Wong DS, Sham PC, Azhar A, Kwok PY, Tam PP, Lian Q, Cheah KS, Wang B, Song YQ, Mutations in Hnrnpa1 cause congenital heart defects. JCI Insight. 2018 Jan 25;3(2)
1	J:313945 Yuan Y, Loh YE, Han X, Feng J, Ho TV, He J, Jing J, Groff K, Wu A, Chai Y, Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis. Sci Adv. 2020 Dec;6(51)
1	J:192700 Zhang J, Liu J, Huang Y, Chang JY, Liu L, McKeehan WL, Martin JF, Wang F, FRS2alpha-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity. Circ Res. 2012 Feb 17;110(4):e29-39
1	J:243036 Zhang R, Cao P, Yang Z, Wang Z, Wu JL, Chen Y, Pan Y, Heparan Sulfate Biosynthesis Enzyme, Ext1, Contributes to Outflow Tract Development of Mouse Heart via Modulation of FGF Signaling. PLoS One. 2015;10(8):e0136518
1*	J:130110 Zhang Z, Baldini A, In vivo response to high-resolution variation of Tbx1 mRNA dosage. Hum Mol Genet. 2008 Jan 1;17(1):150-7
3*	J:166754 Zhang Z, Baldini A, Manipulation of endogenous regulatory elements and transgenic analyses of the Tbx1 gene. Mamm Genome. 2010 Dec;21(11-12):556-64
3*	J:102843 Zhang Z, Cerrato F, Xu H, Vitelli F, Morishima M, Vincentz J, Furuta Y, Ma L, Martin JF, Baldini A, Lindsay E, Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development. Development. 2005 Dec;132(23):5307-15
4	J:112457 Zhang Z, Huynh T, Baldini A, Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development. 2006 Sep;133(18):3587-95
1	J:206589 Zhao C, Guo H, Li J, Myint T, Pittman W, Yang L, Zhong W, Schwartz RJ, Schwarz JJ, Singer HA, Tallquist MD, Wu M, Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development. 2014 Jan;141(2):281-95
1	J:310132 Zhou L, Liu J, Olson P, Zhang K, Wynne J, Xie L, Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation. J Mol Cell Cardiol. 2015 Aug;85:1-12
1	J:124492 Zhu H, Wlodarczyk BJ, Scott M, Yu W, Merriweather M, Gelineau-van Waes J, Schwartz RJ, Finnell RH, Cardiovascular abnormalities in Folr1 knockout mice and folate rescue. Birth Defects Res A Clin Mol Teratol. 2007 Apr;79(4):257-68
2	J:354246 Zhu S, Huo S, Wang Z, Huang C, Li C, Song H, Yang X, He R, Ding C, Qiu M, Zhu XJ, Follistatin controls the number of murine teeth by limiting TGF-beta signaling. iScience. 2024 Sep 20;27(9):110785
2*	J:122594 Zohn IE, Anderson KV, Niswander L, The Hectd1 ubiquitin ligase is required for development of the head mesenchyme and neural tube closure. Dev Biol. 2007 Jun 1;306(1):208-21
1	J:108725 Zou D, Silvius D, Davenport J, Grifone R, Maire P, Xu PX, Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1. Dev Biol. 2006 May 15;293(2):499-512
5	J:263025 Zoupa M, Xavier GM, Bryan S, Theologidis I, Arno M, Cobourne MT, Gene expression profiling in the developing secondary palate in the absence of Tbx1 function. BMC Genomics. 2018 Jun 4;19(1):429