Gene Expression Literature Summary

• Symbol: Tcf3
• Name: transcription factor 3
• ID: MGI:98510

39 matching records from 39 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)	1			1						2				1		1
In situ RNA (section)			1		1			4		3	1	5		4		3	1	1			1	4		7
In situ RNA (whole mount)			1	2	1	2		1				1			1	2
Northern blot	1				1			1		1	1	1		2		1	1			1	1			3
Western blot			1							1		1		2		1								2
RT-PCR		1	1	1			2		1	2	2		1	3	2	1	1		2	1	1	2		4
cDNA clones							1												1				1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tcf3  transcription factor 3   (Synonyms: A1, ALF2, bHLHb21, E12, E2A, E47, Pan1, Pan2, Tcfe2a)
Results	Reference
2*	J:67011 Bain G, Maandag EC, Izon DJ, Amsen D, Kruisbeek AM, Weintraub BC, Krop I, Schlissel MS, Feeney AJ, van Roon M, et al., E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell. 1994 Dec 2;79(5):885-92
3*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
1	J:38665 Chen B, Lim RW, Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression. J Biol Chem. 1997 Jan 24;272(4):2459-63
4*	J:119560 Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA, A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development. Development. 2006 Oct;133(20):4119-29
1	J:42215 Dear TN, Hainzl T, Follo M, Nehls M, Wilmore H, Matena K, Boehm T, Identification of interaction partners for the basic-helix-loop-helix protein E47. Oncogene. 1997 Feb 27;14(8):891-8
1*	J:74716 DeKoter RP, Lee HJ, Singh H, PU.1 Regulates Expression of the Interleukin-7 Receptor in Lymphoid Progenitors. Immunity. 2002 Feb;16(2):297-309
1	J:326362 Feng S, Li J, Wen H, Liu K, Gui Y, Wen Y, Wang X, Yuan S, hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells. Nat Commun. 2022 Jun 23;13(1):3588
1	J:125313 Flora A, Garcia JJ, Thaller C, Zoghbi HY, The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15382-7
1*	J:152838 Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, Stiles CD, A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci. 2009 Sep 9;29(36):11399-408
3	J:244024 Fukuda R, Gunawan F, Beisaw A, Jimenez-Amilburu V, Maischein HM, Kostin S, Kawakami K, Stainier DY, Proteolysis regulates cardiomyocyte maturation and tissue integration. Nat Commun. 2017 Feb 17;8:14495
1	J:37090 Gradwohl G, Fode C, Guillemot F, Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors. Dev Biol. 1996 Nov 25;180(1):227-41
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
9*	J:80041 Heng JI, Tan SS, Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain. J Biol Chem. 2002 Nov 8;277(45):43152-9
1	J:256001 Jung EM, Moffat JJ, Liu J, Dravid SM, Gurumurthy CB, Kim WY, Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior. Nat Neurosci. 2017 Dec;20(12):1694-1707
3*	J:331303 Kantzer CG, Yang W, Grommisch D, Patikl KV, Mak KH, Shirokova V, Genander M, ID1 and CEBPA coordinate epidermal progenitor cell differentiation. Development. 2022 Nov;149(22)
1	J:217820 Larabee SM, Coia H, Jones S, Cheung E, Gallicano GI, miRNA-17 Members that Target Bmpr2 Influence Signaling Mechanisms Important for Embryonic Stem Cell Differentiation In Vitro and Gastrulation in Embryos. Stem Cells Dev. 2015 Feb 1;24(3):354-71
10	J:299678 Li H, Zhu Y, Morozov YM, Chen X, Page SC, Rannals MD, Maher BJ, Rakic P, Disruption of TCF4 regulatory networks leads to abnormal cortical development and mental disabilities. Mol Psychiatry. 2019 Aug;24(8):1235-1246
6	J:185188 Li S, Mattar P, Zinyk D, Singh K, Chaturvedi CP, Kovach C, Dixit R, Kurrasch DM, Ma YC, Chan JA, Wallace V, Dilworth FJ, Brand M, Schuurmans C, GSK3 Temporally Regulates Neurogenin 2 Proneural Activity in the Neocortex. J Neurosci. 2012 Jun 6;32(23):7791-805
1*	J:311994 Livnat I, Finkelshtein D, Ghosh I, Arai H, Reiner O, PAF-AH Catalytic Subunits Modulate the Wnt Pathway in Developing GABAergic Neurons. Front Cell Neurosci. 2010;4
4	J:301718 Lowenstein ED, Rusanova A, Stelzer J, Hernaiz-Llorens M, Schroer AE, Epifanova E, Bladt F, Isik EG, Buchert S, Jia S, Tarabykin V, Hernandez-Miranda LR, Olig3 regulates early cerebellar development. Elife. 2021 Feb 16;10:e64684
1*	J:119649 Meier N, Krpic S, Rodriguez P, Strouboulis J, Monti M, Krijgsveld J, Gering M, Patient R, Hostert A, Grosveld F, Novel binding partners of Ldb1 are required for haematopoietic development. Development. 2006 Dec;133(24):4913-23
4*	J:260421 Mesman S, Kruse SJ, Smidt MP, Expression analyzes of early factors in midbrain differentiation programs. Gene Expr Patterns. 2018 Jan;27:8-15
7	J:306706 Metais A, Lamsoul I, Melet A, Uttenweiler-Joseph S, Poincloux R, Stefanovic S, Valiere A, Gonzalez de Peredo A, Stella A, Burlet-Schiltz O, Zaffran S, Lutz PG, Moog-Lutz C, Asb2alpha-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development. Circ Res. 2018 Mar 16;122(6):e34-e48
1	J:92533 Murakami M, Kataoka K, Tominaga J, Nakagawa O, Kurihara H, Differential cooperation between dHAND and three different E-proteins. Biochem Biophys Res Commun. 2004 Oct 8;323(1):168-174
2	J:245925 Pfurr S, Chu YH, Bohrer C, Greulich F, Beattie R, Mammadzada K, Hils M, Arnold SJ, Taylor V, Schachtrup K, Uhlenhaut NH, Schachtrup C, The E2A splice variant E47 regulates the differentiation of projection neurons via p57(KIP2) during cortical development. Development. 2017 Nov 01;144(21):3917-3931
7	J:134786 Ravanpay AC, Olson JM, E protein dosage influences brain development more than family member identity. J Neurosci Res. 2008 May 15;86(7):1472-81
2*	J:291475 Roychoudhury K, Salomone J, Qin S, Cain B, Adam M, Potter SS, Nakafuku M, Gebelein B, Campbell K, Physical interactions between Gsx2 and Ascl1 balance progenitor expansion versus neurogenesis in the mouse lateral ganglionic eminence. Development. 2020 Apr 10;147(7):dev185348
3	J:335660 Scott IC, Anson-Cartwright L, Riley P, Reda D, Cross JC, The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. Mol Cell Biol. 2000 Jan;20(2):530-41
3	J:150518 Sobrado VR, Moreno-Bueno G, Cubillo E, Holt LJ, Nieto MA, Portillo F, Cano A, The class I bHLH factors E2-2A and E2-2B regulate EMT. J Cell Sci. 2009 Apr 1;122(Pt 7):1014-24
4	J:340405 Talley MJ, Nardini D, Ehrman LA, Lu QR, Waclaw RR, Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon. Neural Dev. 2023 Sep 8;18(1):5
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:232386 Van Nguyen T, Angkasekwinai P, Dou H, Lin FM, Lu LS, Cheng J, Chin YE, Dong C, Yeh ET, SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation. Mol Cell. 2012 Jan 27;45(2):210-21
1*	J:288669 Wedel M, Frob F, Elsesser O, Wittmann MT, Lie DC, Reis A, Wegner M, Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Nucleic Acids Res. 2020 May 21;48(9):4839-4857
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
3*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1*	J:312074 Yu W, Zhang Y, Ruest LB, Svoboda KK, Analysis of Snail1 function and regulation by Twist1 in palatal fusion. Front Physiol. 2013;4:12
1	J:248901 Zhao Q, Chang C, Gonzalez JP, Alzahrani K, Button JL, Fraidenraich D, Combined Id1 and Id3 Deletion Leads to Severe Erythropoietic Disturbances. PLoS One. 2016;11(4):e0154480
2*	J:22134 Zhuang Y, Soriano P, Weintraub H, The helix-loop-helix gene E2A is required for B cell formation. Cell. 1994 Dec 2;79(5):875-84