Gene Expression Literature Summary

• Symbol: Thbd
• Name: thrombomodulin
• ID: MGI:98736

25 matching records from 25 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7	E7.5	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E19.5	P
Immunohistochemistry (section)	1		4	3	2		4		3	1	3	3	1		3	1	1		2	3	1	5
In situ RNA (section)				1									2
In situ RNA (whole mount)												2			1
In situ reporter (knock in)		1	1	1	1	1																1
Northern blot		1			1			1						1				1				1
RT-PCR			1	1	2		1		1	1	1	1	2							1		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Thbd  thrombomodulin   (Synonyms: CD141, TM)
Results	Reference
1*	J:325730 Ahuja N, Hiltabidle MS, Rajasekhar H, Voss S, Lu SZ, Barlow HR, Cowdin MA, Daniel E, Vaddaraju V, Anandakumar T, Black E, Cleaver O, Maynard C, Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
4*	J:36690 Buck CA, Edelman JM, Buck CE, Kennedy G, Baldwin HS, Expression patterns of adhesion receptors in the developing mouse lung: functional implications. Cell Adhes Commun. 1996 Aug;4(2):69-87
1	J:206313 Chiplunkar AR, Curtis BC, Eades GL, Kane MS, Fox SJ, Haar JL, Lloyd JA, The Kruppel-like factor 2 and Kruppel-like factor 4 genes interact to maintain endothelial integrity in mouse embryonic vasculogenesis. BMC Dev Biol. 2013;13:40
1*	J:148410 Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P, Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Dev Dyn. 2009 May;238(5):1033-41
2	J:77480 Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, Nemery B, Dewerchin M, Van Veldhoven P, Plate K, Moons L, Collen D, Carmeliet P, Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med. 2002 Jul;8(7):702-10
1*	J:116022 Coveney D, Ross AJ, Slone JD, Capel B, A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation.(Correction: 2008; 8:529-537). Gene Expr Patterns. 2007 Jan;7(1-2):82-92
8*	J:80863 Crawley JT, Gu JM, Ferrell G, Esmon CT, Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development. Thromb Haemost. 2002 Aug;88(2):259-66
1	J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
15	J:14532 Ford VA, Wilkinson JE, Kennel SJ, Thrombomodulin distribution during murine development. Roux Arch Dev Biol. 1993 Aug;202(6):364-370
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
4*	J:294890 Hatzopoulos AK, Rigotti A, Rosenberg RD, Krieger M, Temporal and spatial pattern of expression of the HDL receptor SR-BI during murine embryogenesis. J Lipid Res. 1998 Mar;39(3):495-508
2*	J:65677 Healy AM, Morgenthau L, Zhu X, Farber HW, Cardoso WV, VEGF is deposited in the subepithelial matrix at the leading edge of branching airways and stimulates neovascularization in the murine embryonic lung. Dev Dyn. 2000 Nov;219(3):341-52
1	J:83701 Hemberger M, Nozaki T, Masutani M, Cross JC, Differential expression of angiogenic and vasodilatory factors by invasive trophoblast giant cells depending on depth of invasion. Dev Dyn. 2003 Jun;227(2):185-91
1*	J:196646 Imada M, Imada S, Iwasaki H, Kume A, Yamaguchi H, Moore EE, Fetomodulin: marker surface protein of fetal development which is modulatable by cyclic AMP. Dev Biol. 1987 Aug;122(2):483-91
2*	J:32341 Imada S, Yamaguchi H, Nagumo M, Katayanagi S, Iwasaki H, Imada M, Identification of fetomodulin, a surface marker protein of fetal development, as thrombomodulin by gene cloning and functional assays. Dev Biol. 1990 Jul;140(1):113-22
1	J:162793 Iwasaki H, Arai F, Kubota Y, Dahl M, Suda T, Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver. Blood. 2010 Jul 29;116(4):544-53
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
2	J:303717 Maroney SA, Westrick RJ, Cleuren AC, Martinez ND, Siebert AE, Zogg M, Ginsburg D, Weiler H, Mast AE, Tissue factor pathway inhibitor is required for cerebrovascular development in mice. Blood. 2021 Jan 14;137(2):258-268
9*	J:74089 Ong K, Horsfall W, Conway EM, Schuh AC, Early embryonic expression of murine coagulation system components. Thromb Haemost. 2000 Dec;84(6):1023-30
1	J:203464 Sims-Lucas S, Schaefer C, Bushnell D, Ho J, Logar A, Prochownik E, Gittes G, Bates CM, Endothelial Progenitors Exist within the Kidney and Lung Mesenchyme. PLoS One. 2013;8(6):e65993
1	J:81698 Stalmans I, Lambrechts D, De Smet F, Jansen S, Wang J, Maity S, Kneer P, Von Der Ohe M, Swillen A, Maes C, Gewillig M, Molin DG, Hellings P, Boetel T, Haardt M, Compernolle V, Dewerchin M, Plaisance S, Vlietinck R, Emanuel B, Gittenberger-De Groot AC, Scambler P, Morrow B, Driscol DA, Moons L, Esguerra CV, Carmeliet G, Behn-Krappa A, Devriendt K, Collen D, Conway SJ, Carmeliet P, VEGF: A modifier of the del22q11 (DiGeorge) syndrome?. Nat Med. 2003 Feb;9(2):173-82
7*	J:34180 Weiler-Guettler H, Aird WC, Rayburn H, Husain M, Rosenberg RD, Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos. Development. 1996 Jul;122(7):2271-81
1*	J:286311 Wu J, Li H, Han L, Sun T, Tian Y, Wang X, The spatiotemporal expression pattern of Syndecans in murine embryonic teeth. Gene Expr Patterns. 2020 Mar 24;36:119109
2	J:145436 Zwerts F, Lupu F, De Vriese A, Pollefeyt S, Moons L, Altura RA, Jiang Y, Maxwell PH, Hill P, Oh H, Rieker C, Collen D, Conway SJ, Conway EM, Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure. Blood. 2007 Jun 1;109(11):4742-52