Symbol Name ID |
Tlx1
T cell leukemia, homeobox 1 MGI:98769 |
Age | E8 | E8.5 | E9 | E9.5 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16.5 | E17.5 | E18 | E18.5 | E | P |
Immunohistochemistry (section) | 2 | 1 | 1 | 1 | |||||||||||||||||
In situ RNA (section) | 1 | 2 | 1 | 2 | 5 | 1 | 5 | 1 | 8 | 10 | 8 | 2 | 2 | 2 | 1 | 3 | |||||
Immunohistochemistry (whole mount) | 1 | 1 | 1 | 1 | |||||||||||||||||
In situ RNA (whole mount) | 3 | 2 | 4 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
In situ reporter (knock in) | 1 | 3 | 4 | 3 | 1 | 3 | 1 | 1 | 1 | 1 | 2 | 1 | |||||||||
Northern blot | 1 | ||||||||||||||||||||
RT-PCR | 1 | 1 | 2 | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | |||||||||
cDNA clones | 1 | ||||||||||||||||||||
Primer Extension | 1 |
Tlx1 T cell leukemia, homeobox 1 (Synonyms: Hox-11, Hox11) | |
Results | Reference |
2 | J:77612 Akazawa H, Komuro I, Sugitani Y, Yazaki Y, Nagai R, Noda T, Targeted disruption of the homeobox transcription factor Bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation. Genes Cells. 2000 Jun;5(6):499-513 |
2* | J:41823 Arai Y, Hatano M, Tokuhisa T, A negative regulatory region of the murine Hox11 gene. Gene. 1997 Jul 1;193(1):73-9 |
7 | J:99062 Brendolan A, Ferretti E, Salsi V, Moses K, Quaggin S, Blasi F, Cleary ML, Selleri L, A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny. Development. 2005 Jul;132(13):3113-26 |
8* | J:18559 Cheng SH, Mak TW, Molecular characterisation of three murine Hox11-Related homeobox genes, TLX-1, -2,and -3, and restricted expression of TLX-1 during embryogenesis. Dev Growth Differ. 1993 Dec;35(6):655-663 |
8* | J:28700 Dear TN, Colledge WH, Carlton MB, Lavenir I, Larson T, Smith AJ, Warren AJ, Evans MJ, Sofroniew MV, Rabbitts TH, The Hox11 gene is essential for cell survival during spleen development. Development. 1995 Sep;121(9):2909-15 |
1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
2* | J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257 |
2* | J:51064 Greene WK, Bahn S, Masson N, Rabbitts TH, The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development. Mol Cell Biol. 1998 Dec;18(12):7030-7 |
1* | J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004; |
1* | J:93234 Hecksher-Sorensen J, Watson RP, Lettice LA, Serup P, Eley L, De Angelis C, Ahlgren U, Hill RE, The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2. Development. 2004 Oct;131(19):4665-75 |
4 | J:174762 Hornblad A, Eriksson AU, Sock E, Hill RE, Ahlgren U, Impaired spleen formation perturbs morphogenesis of the gastric lobe of the pancreas. PLoS One. 2011;6(6):e21753 |
12* | J:107696 Kanzler B, Dear TN, Hox11 acts cell autonomously in spleen development and its absence results in altered cell fate of mesenchymal spleen precursors. Dev Biol. 2001 Jun 1;234(1):231-43 |
1* | J:94411 Kelly RG, Jerome-Majewska LA, Papaioannou VE, The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis. Hum Mol Genet. 2004 Nov 15;13(22):2829-40 |
1* | J:141674 Kelly RG, Papaioannou VE, Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene. Dev Dyn. 2007 Mar;236(3):821-8 |
4 | J:128378 Kim BM, Miletich I, Mao J, McMahon AP, Sharpe PA, Shivdasani RA, Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development. 2007 Oct;134(20):3603-13 |
5* | J:62067 Kobayashi T, Tonai S, Ishihara Y, Koga R, Okabe S, Watanabe T, Koehler K, Franz T, Dear TN, Hox11 is required to maintain normal Wt1 mRNA levels in the developing spleen. Dev Dyn. 2000 May;218(1):201-6 |
2 | J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26 |
2* | J:237064 Lenti E, Farinello D, Yokoyama KK, Penkov D, Castagnaro L, Lavorgna G, Wuputra K, Sandell LL, Tjaden NE, Bernassola F, Caridi N, De Antoni A, Wagner M, Kozinc K, Niederreither K, Blasi F, Pasini D, Majdic G, Tonon G, Trainor PA, Brendolan A, Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development. J Clin Invest. 2016 Jul 01;126(7):2452-64 |
1* | J:57112 Lettice LA, Purdie LA, Carlson GJ, Kilanowski F, Dorin J, Hill RE, The mouse bagpipe gene controls development of axial skeleton, skull, and spleen. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9695-700 |
1* | J:99697 Liu W, Selever J, Murali D, Sun X, Brugger SM, Ma L, Schwartz RJ, Maxson R, Furuta Y, Martin JF, Threshold-specific requirements for Bmp4 in mandibular development. Dev Biol. 2005 Jul 15;283(2):282-93 |
3* | J:64068 Lu J, Chang P, Richardson JA, Gan L, Weiler H, Olson EN, The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9525-30 |
1 | J:196292 Marinic M, Aktas T, Ruf S, Spitz F, An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape. Dev Cell. 2013 Mar 11;24(5):530-42 |
2 | J:258875 Mona B, Uruena A, Kollipara RK, Ma Z, Borromeo MD, Chang JC, Johnson JE, Repression by PRDM13 is critical for generating precision in neuronal identity. Elife. 2017 Aug 29;6:e25787 |
2 | J:297165 Mona B, Villarreal J, Savage TK, Kollipara RK, Boisvert BE, Johnson JE, Positive autofeedback regulation of Ptf1a transcription generates the levels of PTF1A required to generate itch circuit neurons. Genes Dev. 2020 May 1;34(9-10):621-636 |
1 | J:72062 Qian Y, Fritzsch B, Shirasawa S, Chen CL, Choi Y, Ma Q, Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3. Genes Dev. 2001 Oct 1;15(19):2533-45 |
12* | J:16396 Raju K, Tang S, Dube ID, Kamel-Reid S, Bryce DM, Breitman ML, Characterization and developmental expression of Tlx-1, the murine homolog of HOX11. Mech Dev. 1993 Nov;44(1):51-64 |
8* | J:17695 Roberts CW, Shutter JR, Korsmeyer SJ, Hox11 controls the genesis of the spleen. Nature. 1994 Apr 21;368(6473):747-9 |
12* | J:25198 Roberts CW, Sonder AM, Lumsden A, Korsmeyer SJ, Development expression of Hox11 and specification of splenic cell fate. Am J Pathol. 1995 May;146(5):1089-101 |
5* | J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23 |
1 | J:166759 Villasenor A, Chong DC, Henkemeyer M, Cleaver O, Epithelial dynamics of pancreatic branching morphogenesis. Development. 2010 Dec;137(24):4295-305 |
1* | J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6 |
10* | J:30628 Yamamoto H, Hatano M, Iitsuka Y, Mahyar NS, Yamamoto M, Tokuhisa T, Two forms of Hox11 a T cell leukemia oncogene, are expressed in fetal spleen but not in primary lymphocytes. Mol Immunol. 1995 Nov;32(16):1177-82 |
1* | J:327901 Ye Q, Bhojwani A, Hu JK, Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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