Gene Expression Literature Summary

• Symbol: Tmod1
• Name: tropomodulin 1
• ID: MGI:98775

19 matching records from 19 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8	E8.5	E9	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	P
Immunohistochemistry (section)		1	3	1	3	2	1	1			2		1	5
In situ RNA (section)		1			1		1	1		2	1	1		1
In situ RNA (whole mount)				1
In situ reporter (knock in)	1	3	2	1	3	2	1	2	2	1				1
Western blot			2		3	1	1	1		1	2			5
RT-PCR						1			1	1	1		1
cDNA clones														1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tmod1  tropomodulin 1   (Synonyms: erythrocyte tropomodulin, E-Tmod)
Results	Reference
7	J:89956 Chu X, Chen J, Reedy MC, Vera C, Sung KL, Sung LA, E-Tmod capping of actin filaments at the slow-growing end is required to establish mouse embryonic circulation. Am J Physiol Heart Circ Physiol. 2003 May;284(5):H1827-38
2*	J:83752 Cox PR, Fowler V, Xu B, Sweatt JD, Paylor R, Zoghbi HY, Mice lacking Tropomodulin-2 show enhanced long-term potentiation, hyperactivity, and deficits in learning and memory. Mol Cell Neurosci. 2003 May;23(1):1-12
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
16*	J:87158 Fritz-Six KL, Cox PR, Fischer RS, Xu B, Gregorio CC, Zoghbi HY, Fowler VM, Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality. J Cell Biol. 2003 Dec 8;163(5):1033-44
1	J:331853 Gao R, Liang X, Cheedipudi S, Cordero J, Jisng X, Zhang Q, Caputo L, Gunther S, Kuenne C, Ren Y, Bhattacharya S, Yuan X, Barreto G, Chen Y, Braun T, Evans SM, Sun Y, Dobreva G, Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate. Cell Res. 2019 Jun;29(6):486-501
4	J:158797 Gokhin DS, Lewis RA, McKeown CR, Nowak RB, Kim NE, Littlefield RS, Lieber RL, Fowler VM, Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology. J Cell Biol. 2010 Apr 5;189(1):95-109
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
1*	J:263030 Hu J, Shi Y, Xia M, Liu Z, Zhang R, Luo H, Zhang T, Yang Z, Yuan B, WDR1-regulated actin dynamics is required for outflow tract and right ventricle development. Dev Biol. 2018 Jun 15;438(2):124-137
7*	J:22993 Ito M, Swanson B, Sussman MA, Kedes L, Lyons G, Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis. Dev Biol. 1995 Jan;167(1):317-28
1*	J:211921 McKeown CR, Nowak RB, Gokhin DS, Fowler VM, Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo. Dev Dyn. 2014 Jun;243(6):800-17
7*	J:155368 McKeown CR, Nowak RB, Moyer J, Sussman MA, Fowler VM, Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development. Circ Res. 2008 Nov 21;103(11):1241-8
2*	J:227272 Pappas CT, Mayfield RM, Henderson C, Jamilpour N, Cover C, Hernandez Z, Hutchinson KR, Chu M, Nam KH, Valdez JM, Wong PK, Granzier HL, Gregorio CC, Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality. Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13573-8
1	J:328990 Patel T, Hammelman J, Aziz S, Jang S, Closser M, Michaels TL, Blum JA, Gifford DK, Wichterle H, Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro. Nat Commun. 2022 Sep 15;13(1):5427
2*	J:208725 Sui Z, Nowak RB, Bacconi A, Kim NE, Liu H, Li J, Wickrema A, An XL, Fowler VM, Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver. Blood. 2014 Jan 30;123(5):758-67
1	J:256068 Ushijima T, Fujimoto N, Matsuyama S, Kan-O M, Kiyonari H, Shioi G, Kage Y, Yamasaki S, Takeya R, Sumimoto H, The actin-organizing formin protein Fhod3 is required for postnatal development and functional maintenance of the adult heart in mice. J Biol Chem. 2018 Jan 5;293(1):148-162
3	J:256653 Wu T, Mu Y, Bogomolovas J, Fang X, Veevers J, Nowak RB, Pappas CT, Gregorio CC, Evans SM, Fowler VM, Chen J, HSPB7 is indispensable for heart development by modulating actin filament assembly. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11956-11961
9*	J:221197 Yao W, Chu X, Sung LA, Cell type-restricted expression of erythrocyte tropomodulin Isoform41 in exon 1 knockout/LacZ knock-in heterozygous mice. Gene Expr Patterns. 2015 Jan;17(1):45-55
3*	J:171573 Yoon H, Lee DJ, Kim MH, Bok J, Identification of genes concordantly expressed with Atoh1 during inner ear development. Anat Cell Biol. 2011 Mar;44(1):69-78
2	J:211364 Yuan B, Wan P, Chu D, Nie J, Cao Y, Luo W, Lu S, Chen J, Yang Z, A Cardiomyocyte-Specific Wdr1 Knockout Demonstrates Essential Functional Roles for Actin Disassembly during Myocardial Growth and Maintenance in Mice. Am J Pathol. 2014 Jul;184(7):1967-80