Gene Expression Literature Summary

• Symbol: Tpbpa
• Name: trophoblast specific protein alpha
• ID: MGI:98795

201 matching records from 201 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E6.5	E7.5	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14.5	E15.5	E16.5	E17	E17.5	E18.5	E19.5	E	P
Immunohistochemistry (section)						1	3	1	5		4		4	3	5	5	1		1	3		1	15
In situ RNA (section)			4	5	28		48	4	36	1	12	1	24	13	23	14	11	1	7	13	1	6	89
In situ RNA (whole mount)							1															1	1
In situ reporter (knock in)									1
Northern blot					2		2		2		2			2	1	2	1		1	1	1	1	4
Western blot																1			1				1
RT-PCR	1	1		2	4		11		10	1	5		9	6	10	3	5		5	7		2	37
cDNA clones													1	1					1				3
RNase protection																1							1
Primer Extension																1							1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tpbpa  trophoblast specific protein alpha   (Synonyms: 4311, clone 4311, Tb-1, Tb1, Tpbp)
Results	Reference
1	J:148987 Abell AN, Granger DA, Johnson NL, Vincent-Jordan N, Dibble CF, Johnson GL, Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol Cell Biol. 2009 May;29(10):2748-61
1*	J:344836 Abou-Jaoude A, Huang CY, Flores JC, Ravichandran M, Lei R, Chrysanthou S, Dawlaty MM, Idax and Rinf facilitate expression of Tet enzymes to promote neural and suppress trophectodermal programs during differentiation of embryonic stem cells. Stem Cell Res. 2022 May;61:102770
2	J:70681 Ait-Azzouzene D, Caucheteux S, Tchang F, Wantyghem J, Moutier R, Langkopf A, Gendron MC, Kanellopoulos-Langevin C, Transgenic major histocompatibility complex class i antigen expressed in mouse trophoblast affects maternal immature b cells. Biol Reprod. 2001 Aug;65(2):337-44
2*	J:194130 Appelbe OK, Yevtodiyenko A, Muniz-Talavera H, Schmidt JV, Conditional deletions refine the embryonic requirement for Dlk1. Mech Dev. 2013 Feb;130(2-3):143-59
2	J:112884 Arima T, Hata K, Tanaka S, Kusumi M, Li E, Kato K, Shiota K, Sasaki H, Wake N, Loss of the maternal imprint in Dnmt3Lmat-/- mice leads to a differentiation defect in the extraembryonic tissue. Dev Biol. 2006 Sep 15;297(2):361-73
4*	J:124707 Asanoma K, Kato H, Yamaguchi S, Shin CH, Liu ZP, Kato K, Inoue T, Miyanari Y, Yoshikawa K, Sonoda K, Fukushima K, Wake N, HOP/NECC1, a novel regulator of mouse trophoblast differentiation. J Biol Chem. 2007 Aug 17;282(33):24065-74
2	J:314901 Bao H, Liu D, Xu Y, Sun Y, Mu C, Yu Y, Wang C, Han Q, Liu S, Cai H, Liu F, Kong S, Deng W, Cao B, Wang H, Wang Q, Lu J, Hyperactivated Wnt-beta-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2. BMC Biol. 2020 Oct 27;18(1):151
1	J:54094 Basyuk E, Cross JC, Corbin J, Nakayama H, Hunter P, Nait-Oumesmar B , Lazzarini RA, Murine Gcm1 gene is expressed in a subset of placental trophoblast cells. Dev Dyn. 1999 Apr;214(4):303-11
2	J:307822 Beal R, Alonso-Carriazo Fernandez A, Grammatopoulos DK, Matter K, Balda MS, ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis. Front Cell Dev Biol. 2021;9:658006
2	J:293009 Bhattacharya B, Home P, Ganguly A, Ray S, Ghosh A, Islam MR, French V, Marsh C, Gunewardena S, Okae H, Arima T, Paul S, Atypical protein kinase C iota (PKClambda/iota) ensures mammalian development by establishing the maternal-fetal exchange interface. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14280-14291
3	J:301740 Bian X, Liu J, Yang Q, Liu Y, Jia W, Zhang X, Li YX, Shao X, Wang YL, MicroRNA-210 regulates placental adaptation to maternal hypoxic stress during pregnancy. Biol Reprod. 2021 Feb 11;104(2):418-429
1	J:48920 Bilinski P, Roopenian D, Gossler A, Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice. Genes Dev. 1998 Jul 15;12(14):2234-43
2	J:307956 Blake GET, Zhao X, Yung HW, Burton GJ, Ferguson-Smith AC, Hamilton RS, Watson ED, Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker. Nat Commun. 2021 Jun 17;12(1):3714
2	J:266304 Bogutz AB, Oh-McGinnis R, Jacob KJ, Ho-Lau R, Gu T, Gertsenstein M, Nagy A, Lefebvre L, Transcription factor ASCL2 is required for development of the glycogen trophoblast cell lineage. PLoS Genet. 2018 Aug;14(8):e1007587
2	J:278550 Boing M, Brand-Saberi B, Napirei M, Murine transcription factor Math6 is a regulator of placenta development. Sci Rep. 2018 Oct 9;8(1):14997
1	J:239317 Bourke LM, Del Monte-Nieto G, Outhwaite JE, Bharti V, Pollock PM, Simmons DG, Adam A, Hur SS, Maghzal GJ, Whitelaw E, Stocker R, Suter CM, Harvey RP, Harten SK, Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart development in the mouse. Differentiation. 2017 Mar - Apr;94:8-20
2	J:229091 Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ, Dean W, Hemberger M, Reik W, Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell. 2016 Jan 25;36(2):152-63
4	J:29042 Calzonetti T, Stevenson L, Rossant J, A novel regulatory region is required for trophoblast-specific transcription in transgenic mice. Dev Biol. 1995 Oct;171(2):615-26
2	J:202633 Cao Q, Chen H, Deng Z, Yue J, Chen Q, Cao Y, Ning L, Lei X, Duan E, Genetic deletion of Cxcl14 in mice alters uterine NK cells. Biochem Biophys Res Commun. 2013 Jun 14;435(4):664-70
2*	J:157036 Charalambous M, Cowley M, Geoghegan F, Smith FM, Radford EJ, Marlow BP, Graham CF, Hurst LD, Ward A, Maternally-inherited Grb10 reduces placental size and efficiency. Dev Biol. 2010 Jan 1;337(1):1-8
7	J:231798 Chen CY, Chan CH, Chen CM, Tsai YS, Tsai TY, Wu Lee YH, You LR, Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 July 15;25(14):2905-2922
2	J:182838 Chen X, Liu Z, Xu J, The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival. Mol Endocrinol. 2010 Oct;24(10):1917-34
11	J:241566 Chi L, Ahmed A, Roy AR, Vuong S, Cahill LS, Caporiccio L, Sled JG, Caniggia I, Wilson MD, Delgado-Olguin P, G9a controls placental vascular maturation by activating the Notch Pathway. Development. 2017 Jun 01;144(11):1976-1987
3	J:144707 Chiu SY, Asai N, Costantini F, Hsu W, SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol. 2008 Dec 16;6(12):e310
3*	J:275147 Chou AM, Sem KP, Lam WJ, Ahmed S, Lim CY, Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development. Sci Rep. 2017 Jan 9;7:40485
4*	J:148428 Chrostowski MK, McGonnigal BG, Stabila JP, Padbury JF, LAT-1 expression in pre- and post-implantation embryos and placenta. Placenta. 2009 Mar;30(3):270-6
3*	J:64703 Cocchia M, Huber R, Pantano S, Chen EY, Ma P, Forabosco A, Ko MS, Schlessinger D, PLAC1, an Xq26 gene with placenta-specific expression. Genomics. 2000 Sep 15;68(3):305-12
1	J:119854 Cowden Dahl KD, Fryer BH, Mack FA, Compernolle V, Maltepe E, Adelman DM, Carmeliet P, Simon MC, Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation. Mol Cell Biol. 2005 Dec;25(23):10479-91
3	J:307092 De Clercq K, Perez-Garcia V, Van Bree R, Pollastro F, Peeraer K, Voets T, Vriens J, Mapping the expression of transient receptor potential channels across murine placental development. Cell Mol Life Sci. 2021 Jun;78(11):4993-5014
2	J:175907 Denda K, Nakao-Wakabayashi K, Okamoto N, Kitamura N, Ryu JY, Tagawa Y, Ichisaka T, Yamanaka S, Komada M, Nrk, an X-linked Protein Kinase in the Germinal Center Kinase Family, Is Required for Placental Development and Fetoplacental Induction of Labor. J Biol Chem. 2011 Aug 19;286(33):28802-10
11*	J:74618 Deussing J, Kouadio M, Rehman S, Werber I, Schwinde A, Peters C, Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13. Genomics. 2002 Feb;79(2):225-40
2	J:190411 Dong Y, Zhang L, Zhang S, Bai Y, Chen H, Sun X, Yong W, Li W, Colvin SC, Rhodes SJ, Shou W, Zhang ZY, Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein. J Biol Chem. 2012 Sep 14;287(38):32172-9
2	J:214531 Du X, Dong Y, Shi H, Li J, Kong S, Shi D, Sun LV, Xu T, Deng K, Tao W, Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis. PLoS One. 2014;9(3):e90701
1	J:150813 Dupressoir A, Vernochet C, Bawa O, Harper F, Pierron G, Opolon P, Heidmann T, Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene. Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12127-32
8	J:180242 Dupressoir A, Vernochet C, Harper F, Guegan J, Dessen P, Pierron G, Heidmann T, A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1164-73
4	J:249801 Duval C, Dilworth MR, Tunster SJ, Kimber SJ, Glazier JD, PTHrP is essential for normal morphogenetic and functional development of the murine placenta. Dev Biol. 2017 Oct 15;430(2):325-336
3	J:285119 Eaton M, Davies AH, Devine J, Zhao X, Simmons DG, Mariusdottir E, Natale DRC, Matyas JR, Bering EA, Workentine ML, Hallgrimsson B, Cross JC, Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction. PLoS One. 2020;15(1):e0226735
4*	J:81004 Finkenzeller D, Fischer B, Lutz S, Schrewe H, Shimizu T, Zimmermann W, Carcinoembryonic antigen-related cell adhesion molecule 10 expressed specifically early in pregnancy in the decidua is dispensable for normal murine development. Mol Cell Biol. 2003 Jan;23(1):272-9
2	J:77648 Finkenzeller D, Fischer B, McLaughlin J, Schrewe H, Ledermann B, Zimmermann W, Trophoblast cell-specific carcinoembryonic antigen cell adhesion molecule 9 is not required for placental development or a positive outcome of allotypic pregnancies. Mol Cell Biol. 2000 Oct;20(19):7140-5
2	J:89444 Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M, The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 2004 Apr 15;18(8):901-11
1*	J:58692 Frank D, Mendelsohn CL, Ciccone E, Svensson K, Ohlsson R, Tycko B, A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. Mamm Genome. 1999 Dec;10(12):1150-9
1	J:54197 Giroux S, Tremblay M, Bernard D, Cardin-Girard JF, Aubry S, Larouche L, Rousseau S, Huot J, Landry J, Jeannotte L, Charron J, Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr Biol. 1999 Apr 8;9(7):369-72
6	J:320683 Gu Y, Wan J, Yao L, Peng NN, Chang WL, Plac1 Expression Pattern at the Mouse Fetomaternal Interface and Involvement in Trophoblast Differentiation. Cell Physiol Biochem. 2017;43(5):2001-2009
1*	J:23260 Guillemot F, Caspary T, Tilghman SM, Copeland NG, Gilbert DJ, Jenkins NA, Anderson DJ, Joyner AL, Rossant J, Nagy A, Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nat Genet. 1995 Mar;9(3):235-42
3*	J:20553 Guillemot F, Nagy A, Auerbach A, Rossant J, Joyner AL, Essential role of Mash-2 in extraembryonic development. Nature. 1994 Sep 22;371(6495):333-6
1	J:120082 Hamada Y, Hiroe T, Suzuki Y, Oda M, Tsujimoto Y, Coleman JR, Tanaka S, Notch2 is required for formation of the placental circulatory system, but not for cell-type specification in the developing mouse placenta. Differentiation. 2007 Mar;75(3):268-78
6*	J:218174 Hasan MZ, Ikawati M, Tocharus J, Kawaichi M, Oka C, Abnormal development of placenta in HtrA1-deficient mice. Dev Biol. 2015 Jan 1;397(1):89-102
2*	J:192195 Himes KP, Koppes E, Chaillet JR, Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth. Dev Biol. 2013 Jan 1;373(1):72-82
2	J:335203 Hiver S, Shimizu-Mizuno N, Ikawa Y, Kajikawa E, Sai X, Nishimura H, Takaoka K, Nishimura O, Kuraku S, Tanaka S, Hamada H, Gse1, a component of the CoREST complex, is required for placenta development in the mouse. Dev Biol. 2023 Apr 4;498:97-105
3	J:176596 Hu D, Cross JC, Ablation of Tpbpa-positive trophoblast precursors leads to defects in maternal spiral artery remodeling in the mouse placenta. Dev Biol. 2011 Oct 1;358(1):231-9
4	J:202357 Hu D, Scott IC, Snider F, Geary-Joo C, Zhao X, Simmons DG, Cross JC, The basic helix-loop-helix transcription factor Hand1 regulates mouse development as a homodimer. Dev Biol. 2013 Oct 15;382(2):470-81
1*	J:200767 Hughes M, Natale BV, Simmons DG, Natale DR, Ly6e expression is restricted to syncytiotrophoblast cells of the mouse placenta. Placenta. 2013 Sep;34(9):831-5
2*	J:52602 Hunter PJ, Swanson BJ, Haendel MA, Lyons GE, Cross JC, Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development. Development. 1999 Mar;126(6):1247-58
1	J:52605 Ishikawa T, Tamai Y, Zorn AM, Yoshida H, Seldin MF, Nishikawa S, Taketo MM, Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development. 2001 Jan;128(1):25-33
2	J:153222 Iwawaki T, Akai R, Yamanaka S, Kohno K, Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62
1*	J:86791 Jackson M, Baird JW, Nichols J, Wilkie R, Ansell JD, Graham G, Forrester LM, Expression of a novel homeobox gene Ehox in trophoblast stem cells and pharyngeal pouch endoderm. Dev Dyn. 2003 Dec;228(4):740-4
1*	J:160012 Jerome-Majewska LA, Achkar T, Luo L, Lupu F, Lacy E, The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Dev Biol. 2010 May 1;341(1):154-66
4	J:304176 Jeyarajah MJ, Jaju Bhattad G, Hillier DM, Renaud SJ, The Transcription Factor OVOL2 Represses ID2 and Drives Differentiation of Trophoblast Stem Cells and Placental Development in Mice. Cells. 2020 Mar 31;9(4):840
2	J:137276 Kanasaki K, Palmsten K, Sugimoto H, Ahmad S, Hamano Y, Xie L, Parry S, Augustin HG, Gattone VH, Folkman J, Strauss JF, Kalluri R, Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature. 2008 Jun 19;453(7198):1117-21
2	J:173620 Kashif M, Hellwig A, Kolleker A, Shahzad K, Wang H, Lang S, Wolter J, Thati M, Vinnikov I, Bierhaus A, Nawroth PP, Isermann B, p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth. Development. 2011 Jun;138(11):2235-47
2	J:149149 Katsanou V, Milatos S, Yiakouvaki A, Sgantzis N, Kotsoni A, Alexiou M, Harokopos V, Aidinis V, Hemberger M, Kontoyiannis DL, The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol. 2009 May;29(10):2762-76
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10	J:215340 Kibschull M, Colaco K, Matysiak-Zablocki E, Winterhager E, Lye SJ, Connexin31.1 (gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development. Stem Cells Dev. 2014 Nov 1;23(21):2649-60
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2	J:294595 Koppes E, Shaffer B, Sadovsky E, Himes K, Barak Y, Sadovsky Y, Chaillet JR, Klf14 is an imprinted transcription factor that regulates placental growth. Placenta. 2019 Dec;88:61-67
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2	J:263810 Langford MB, Outhwaite JE, Hughes M, Natale DRC, Simmons DG, Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice. Sci Rep. 2018 Mar 2;8(1):3961
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3	J:323371 Lee JG, Kim G, Park SG, Yon JM, Yeom J, Song HE, Cheong SA, Lim JS, Sung YH, Kim K, Yoo HJ, Hong EJ, Nam KH, Seong JK, Kim CJ, Nam SY, Baek IJ, Lipid signatures reflect the function of the murine primary placentation. Biol Reprod. 2022 Mar 19;106(3):583-596
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2	J:70738 Ma GT, Soloveva V, Tzeng SJ, Lowe LA, Pfendler KC, Iannaccone PM, Kuehn MR, Linzer DI, Nodal regulates trophoblast differentiation and placental development. Dev Biol. 2001 Aug 1;236(1):124-35
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2*	J:260526 Min S, Natale BV, Natale DRC, Temporal and spatial expression of glyceraldehyde 3-phosphate dehydrogenase (Gapdh) in the mouse placenta. Placenta. 2017 Sep;57:170-174
1	J:241560 Molotkov A, Mazot P, Brewer JR, Cinalli RM, Soriano P, Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency. Dev Cell. 2017 Jun 05;41(5):511-526.e4
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2*	J:52247 Morasso MI, Grinberg A, Robinson G, Sargent TD, Mahon KA, Placental failure in mice lacking the homeobox gene Dlx3. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):162-7
1*	J:87675 Moser M, Li Y, Vaupel K, Kretzschmar D, Kluge R, Glynn P, Buettner R, Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice. Mol Cell Biol. 2004 Feb;24(4):1667-79
1*	J:187742 Mould A, Morgan MA, Li L, Bikoff EK, Robertson EJ, Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta. Genes Dev. 2012 Sep 15;26(18):2063-74
1*	J:73417 Mudgett JS, Ding J, Guh-Siesel L, Chartrain NA, Yang L, Gopal S, Shen MM, Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10454-9
1	J:185555 Mugford JW, Yee D, Magnuson T, Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation. Development. 2012 Jun;139(12):2130-8
2	J:141347 Muthig V, Gilsbach R, Haubold M, Philipp M, Ivacevic T, Gessler M, Hein L, Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of alpha 2B-adrenoceptor deficient mice. Circ Res. 2007 Sep 28;101(7):682-91
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