Gene Expression Literature Summary

• Symbol: Tfrc
• Name: transferrin receptor
• ID: MGI:98822

50 matching records from 50 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E	P
Immunohistochemistry (section)		1	2	4	1	2		1		1					2				1		3	11
In situ RNA (section)				1	1				1		1		2	1
Immunohistochemistry (whole mount)			1																			1
In situ RNA (whole mount)															1
Northern blot	1						1							1	1	1		1				2
Western blot				1						1		1	1				1			2		13
RT-PCR		1		3		3		1		3		2	1		1				1	1		10

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tfrc  transferrin receptor   (Synonyms: 2610028K12Rik, CD71, E430033M20Rik, Mtvr-1, Mtvr1, p90, TfR1, Trfr)
Results	Reference
1*	J:142647 Best D, Adams IR, Sdmg1 is a component of secretory granules in mouse secretory exocrine tissues. Dev Dyn. 2008 Dec 18;238(1):223-231
1	J:144610 Boda E, Pini A, Hoxha E, Parolisi R, Tempia F, Selection of Reference Genes for Quantitative Real-time RT-PCR Studies in Mouse Brain. J Mol Neurosci. 2009 Mar;37(3):238-53
1	J:54097 Bruckner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R, EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron. 1999 Mar;22(3):511-24
3	J:331974 Cao C, Fleming MD, Loss of the placental iron exporter ferroportin 1 causes embryonic demise in late-gestation mouse pregnancy. Development. 2022 Dec 1;149(23):dev201160
1	J:229427 Carton-Garcia F, Overeem AW, Nieto R, Bazzocco S, Dopeso H, Macaya I, Bilic J, Landolfi S, Hernandez-Losa J, Schwartz S Jr, Ramon y Cajal S, van Ijzendoorn SC, Arango D, Myo5b knockout mice as a model of microvillus inclusion disease. Sci Rep. 2015;5:12312
2	J:329317 Chakraborty S, Andrieux G, Kastl P, Adlung L, Altamura S, Boehm ME, Schwarzmuller LE, Abdullah Y, Wagner MC, Helm B, Grone HJ, Lehmann WD, Boerries M, Busch H, Muckenthaler MU, Schilling M, Klingmuller U, Erythropoietin-driven dynamic proteome adaptations during erythropoiesis prevent iron overload in the developing embryo. Cell Rep. 2022 Sep 20;40(12):111360
3	J:224823 Chen AC, Donovan A, Ned-Sykes R, Andrews NC, Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11714-9
1*	J:32191 Copp AJ, Estibeiro JP, Brook FA, Downs KM, Exogenous transferrin is taken up and localized by the neurulation-stage mouse embryo in vitro. Dev Biol. 1992 Oct;153(2):312-23
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:224837 Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP, Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Rep. 2015 Jul 21;12(3):371-9
2	J:317814 Fan L, Ou YJ, Zhu YX, Liang YD, Zhou Y, Wang YN, Lif Deficiency Leads to Iron Transportation Dysfunction in Ameloblasts. J Dent Res. 2022 Jan;101(1):63-72
1	J:346124 Feng Z, Liu S, Su M, Song C, Lin C, Zhao F, Li Y, Zeng X, Zhu Y, Hou Y, Ren C, Zhang H, Yi P, Ji Y, Wang C, Li H, Ma M, Luo L, Li L, TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry. Nat Commun. 2024 Mar 15;15(1):2371
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:35167 Hoyle C, Henderson DJ, Matthews DJ, Copp AJ, Transferrin and its receptor in the development of genetically determined neural tube defects in the mouse embryo. Dev Dyn. 1996 Sep;207(1):35-46
3	J:157214 Iacovelli J, Mlodnicka AE, Veldman P, Ying GS, Dunaief JL, Schumacher A, Brain and retinal ferroportin 1 dysregulation in polycythaemia mice. Brain Res. 2009 Sep 15;1289:85-95
2	J:304067 Kammerer L, Mohammad G, Wolna M, Robbins PA, Lakhal-Littleton S, Fetal liver hepcidin secures iron stores in utero. Blood. 2020 Sep 24;136(13):1549-1557
1	J:186500 Kaneko H, Kobayashi E, Yamamoto M, Shimizu R, N- and C-terminal transactivation domains of GATA1 protein coordinate hematopoietic program. J Biol Chem. 2012 Jun 15;287(25):21439-49
2	J:55580 Komada M, Soriano P, Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. Genes Dev. 1999 Jun 1;13(11):1475-85
3	J:316198 Lei R, Zhang K, Liu K, Shao X, Ding Z, Wang F, Hong Y, Zhu M, Li H, Li H, Transferrin receptor facilitates TGF-beta and BMP signaling activation to control craniofacial morphogenesis. Cell Death Dis. 2016 Jun 30;7(6):e2282
3	J:144982 Li JY, Paragas N, Ned RM, Qiu A, Viltard M, Leete T, Drexler IR, Chen X, Sanna-Cherchi S, Mohammed F, Williams D, Lin CS, Schmidt-Ott KM, Andrews NC, Barasch J, Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev Cell. 2009 Jan;16(1):35-46
5	J:250166 Liu K, Lei R, Li Q, Wang XX, Wu Q, An P, Zhang J, Zhu M, Xu Z, Hong Y, Wang F, Shen Y, Li H, Li H, Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Sci Rep. 2016 Feb 16;6:21019
1	J:191676 Manceau V, Kremmer E, Nabel EG, Maucuer A, The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS One. 2012;7(8):e43946
1	J:330324 Masuda T, Amann L, Monaco G, Sankowski R, Staszewski O, Krueger M, Del Gaudio F, He L, Paterson N, Nent E, Fernandez-Klett F, Yamasaki A, Frosch M, Fliegauf M, Bosch LFP, Ulupinar H, Hagemeyer N, Schreiner D, Dorrier C, Tsuda M, Grothe C, Joutel A, Daneman R, Betsholtz C, Lendahl U, Knobeloch KP, Lammermann T, Priller J, Kierdorf K, Prinz M, Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature. 2022 Apr;604(7907):740-748
1	J:178094 Mishima T, Miner JH, Morizane M, Stahl A, Sadovsky Y, The expression and function of fatty acid transport protein-2 and -4 in the murine placenta. PLoS One. 2011;6(10):e25865
1	J:158450 Mochida GH, Mahajnah M, Hill AD, Basel-Vanagaite L, Gleason D, Hill RS, Bodell A, Crosier M, Straussberg R, Walsh CA, A truncating mutation of TRAPPC9 is associated with autosomal-recessive intellectual disability and postnatal microcephaly. Am J Hum Genet. 2009 Dec;85(6):897-902
3	J:176655 Moroishi T, Nishiyama M, Takeda Y, Iwai K, Nakayama KI, The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo. Cell Metab. 2011 Sep 7;14(3):339-51
2	J:7235 Muller R, Verma IM, Adamson ED, Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion. EMBO J. 1983;2(5):679-84
1	J:154029 Munger SC, Aylor DL, Syed HA, Magwene PM, Threadgill DW, Capel B, Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. Genes Dev. 2009 Nov 1;23(21):2521-36
5	J:58508 Nakajima O, Takahashi S, Harigae H, Furuyama K, Hayashi N, Sassa S, Yamamoto M, Heme deficiency in erythroid lineage causes differentiation arrest and cytoplasmic iron overload. EMBO J. 1999 Nov 15;18(22):6282-9
1*	J:52144 Newman LS, McKeever MO, Okano HJ, Darnell RB, Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein. Cell. 1995 Sep 8;82(5):773-83
1	J:272251 Noguchi S, Honda S, Saitoh T, Matsumura H, Nishimura E, Akira S, Shimizu S, Beclin 1 regulates recycling endosome and is required for skin development in mice. Commun Biol. 2019;2:37
1	J:139209 Okamura Y, Saga Y, Pofut1 is required for the proper localization of the Notch receptor during mouse development. Mech Dev. 2008 Aug;125(8):663-73
1	J:186666 Pang CJ, Lemsaddek W, Alhashem YN, Bondzi C, Redmond LC, Ah-Son N, Dumur CI, Archer KJ, Haar JL, Lloyd JA, Trudel M, Kruppel-like factor 1 (KLF1), KLF2, and Myc control a regulatory network essential for embryonic erythropoiesis. Mol Cell Biol. 2012 Jul;32(13):2628-44
1*	J:150963 Pavlinkova G, Salbaum JM, Kappen C, Maternal diabetes alters transcriptional programs in the developing embryo. BMC Genomics. 2009;10:274
1	J:244545 Peraki I, Palis J, Mavrothalassitis G, The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis. Mol Cell Biol. 2017 Oct 01;37(19)
2	J:294006 Rutkowski TP, Purcell RH, Pollak RM, Grewenow SM, Gafford GM, Malone T, Khan UA, Schroeder JP, Epstein MP, Bassell GJ, Warren ST, Weinshenker D, Caspary T, Mulle JG, Behavioral changes and growth deficits in a CRISPR engineered mouse model of the schizophrenia-associated 3q29 deletion. Mol Psychiatry. 2019;
1	J:137609 Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J, Essential role for Nix in autophagic maturation of erythroid cells. Nature. 2008 Jul 10;454(7201):232-5
1	J:350266 Sangkhae V, Yu V, Coffey R, O'Brien KO, Ganz T, Nemeth E, Erythroferrone contributes to iron mobilization for embryo erythropoiesis in iron-deficient mouse pregnancies. Am J Hematol. 2022 Oct;97(10):1348-1358
5	J:97543 Sekyere EO, Dunn LL, Richardson DR, Examination of the distribution of the transferrin homologue, melanotransferrin (tumour antigen p97), in mouse and human. Biochim Biophys Acta. 2005 Mar 11;1722(2):131-42
2	J:122680 Shimizu R, Trainor CD, Nishikawa K, Kobayashi M, Ohneda K, Yamamoto M, GATA-1 self-association controls erythroid development in vivo. J Biol Chem. 2007 May 25;282(21):15862-71
2*	J:77275 Shivdasani RA, Orkin SH, Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8690-4
3*	J:230794 Stumpo DJ, Trempus CS, Tucker CJ, Huang W, Li L, Kluckman K, Bortner DM, Blackshear PJ, Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. Development. 2016 Apr 15;143(8):1424-33
1	J:290543 Vidal VP, Jian-Motamedi F, Rekima S, Gregoire EP, Szenker-Ravi E, Leushacke M, Reversade B, Chaboissier MC, Schedl A, R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors. Elife. 2020 May 1;9:e53895
3	J:220468 Walentin K, Hinze C, Werth M, Haase N, Varma S, Morell R, Aue A, Potschke E, Warburton D, Qiu A, Barasch J, Purfurst B, Dieterich C, Popova E, Bader M, Dechend R, Staff AC, Yurtdas ZY, Kilic E, Schmidt-Ott KM, A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Development. 2015 Mar 15;142(6):1125-36
4	J:244710 Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama KI, FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells. Mol Cell Biol. 2017 Apr 15;37(8)
1	J:172232 Yang X, Gong Y, Friesel R, Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function. PLoS One. 2011;6(4):e18374
3*	J:116886 Yoon D, Pastore YD, Divoky V, Liu E, Mlodnicka AE, Rainey K, Ponka P, Semenza GL, Schumacher A, Prchal JT, Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development. J Biol Chem. 2006 Sep 1;281(35):25703-11
2	J:301391 Yu Y, Jiang L, Wang H, Shen Z, Cheng Q, Zhang P, Wang J, Wu Q, Fang X, Duan L, Wang S, Wang K, An P, Shao T, Chung RT, Zheng S, Min J, Wang F, Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis. Blood. 2020 Aug 6;136(6):726-739
2	J:346630 Zhang X, He H, Yu H, Teng X, Wang Z, Li C, Li J, Yang H, Shen J, Wu T, Zhang F, Zhang Y, Wu Q, Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature. Commun Biol. 2024 Mar 23;7(1):363
1	J:330612 Zheng X, Huang W, He Z, Li Y, Li S, Song Y, Effects of Fam83h truncation mutation on enamel developmental defects in male C57/BL6J mice. Bone. 2022 Oct 20;166:116595