Gene Expression Literature Summary

• Symbol: Xist
• Name: inactive X specific transcripts
• ID: MGI:98974

81 matching records from 81 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4	E4.5	E5	E5.5	E6	E6.5	E7	E7.5	E8	E8.5	E9.5	E10.5	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)					1		1
In situ RNA (section)		1		1	2	3	4	1	3	1	2		5	2	6	2	2	1				1			1	1			1			1		2	6
Immunohistochemistry (whole mount)			1	1	1	1		1
In situ RNA (whole mount)	1		1	2	5	5	11	5	4	1	2		5	1	4	1	3	1	3			3		1											1
Northern blot																	1							2											1
RT-PCR	2	3	1	3	4	6	8	4	1		2	1	2		2		4	5	7	6	2	5	1	8		3	1	2		1	1		2	1	18
cDNA clones																		1	1			1											1
RNase protection																																1			2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Xist  inactive X specific transcripts
Results	Reference
5*	J:239949 Amakawa Y, Sakata Y, Hoki Y, Arata S, Shioda S, Fukagawa T, Sasaki H, Sado T, A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects. Development. 2015 Dec 15;142(24):4299-308
4*	J:29257 Beard C, Li E, Jaenisch R, Loss of methylation activates Xist in somatic but not in embryonic cells. Genes Dev. 1995 Oct 1;9(19):2325-34
1	J:28401 Bettenhausen B, Gossler A, Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
4*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
3	J:257205 Borensztein M, Okamoto I, Syx L, Guilbaud G, Picard C, Ancelin K, Galupa R, Diabangouaya P, Servant N, Barillot E, Surani A, Saitou M, Chen CJ, Anastassiadis K, Heard E, Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass. Nat Commun. 2017 Nov 3;8(1):1297
1	J:320748 Borensztein M, Syx L, Ancelin K, Diabangouaya P, Picard C, Liu T, Liang JB, Vassilev I, Galupa R, Servant N, Barillot E, Surani A, Chen CJ, Heard E, Xist-dependent imprinted X inactivation and the early developmental consequences of its failure. Nat Struct Mol Biol. 2017 Mar;24(3):226-233
2	J:100324 Bulfone A, Carotenuto P, Faedo A, Aglio V, Garzia L, Bello AM, Basile A, Andre A, Cocchia M, Guardiola O, Ballabio A, Rubenstein JL, Zollo M, Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. J Neurosci. 2005 Aug 17;25(33):7586-600
4	J:21784 Buzin CH, Mann JR, Singer-Sam J, Quantitative RT-PCR assays show Xist RNA levels are low in mouse female adult tissue, embryos and embryoid bodies. Development. 1994 Dec;120(12):3529-36
2	J:335822 Capriati M, Hao C, D'Cruz SC, Monfort C, Chevrier C, Warembourg C, Smagulova F, Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites. Sci Rep. 2023 May 17;13(1):8003
2*	J:35234 Carrel L, Hunt PA, Willard HF, Tissue and lineage-specific variation in inactive X chromosome expression of the murine Smcx gene. Hum Mol Genet. 1996 Sep;5(9):1361-6
3	J:148744 Chiba H, Hirasawa R, Kaneda M, Amakawa Y, Li E, Sado T, Sasaki H, De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes. Genesis. 2008 Dec;46(12):768-74
2	J:240642 Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova TB, Anil-Kirmizitas B, Bassett A, Kooistra SM, Agger K, Helin K, Heard E, Brockdorff N, Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nat Commun. 2016 Nov 28;7:13661
3*	J:194052 Corbel C, Diabangouaya P, Gendrel AV, Chow JC, Heard E, Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells. Development. 2013 Feb;140(4):861-72
2*	J:58604 Debrand E, Chureau C, Arnaud D, Avner P, Heard E, Functional analysis of the DXPas34 locus, a 3' regulator of Xist expression. Mol Cell Biol. 1999 Dec;19(12):8513-25
1	J:276965 Delbridge ARD, Kueh AJ, Ke F, Zamudio NM, El-Saafin F, Jansz N, Wang GY, Iminitoff M, Beck T, Haupt S, Hu Y, May RE, Whitehead L, Tai L, Chiang W, Herold MJ, Haupt Y, Smyth GK, Thomas T, Blewitt ME, Strasser A, Voss AK, Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects. Cell Rep. 2019 Apr 9;27(2):442-454.e5
10	J:226026 Deuve JL, Bonnet-Garnier A, Beaujean N, Avner P, Morey C, Antagonist Xist and Tsix co-transcription during mouse oogenesis and maternal Xist expression during pre-implantation development calls into question the nature of the maternal imprint on the X chromosome. Epigenetics. 2015 Oct 3;10(10):931-42
9*	J:22243 Dolci S, Geremia R, Albanesi C, Rossi P, Expression of the Xist gene in urogenital ridges of midgestation male embryos. Biochem Biophys Res Commun. 1994 Nov 30;205(1):334-40
4*	J:74092 Eriksson A, Nordqvist K, Protocol for using signal peptide differential display and representational difference analysis to isolate differentially expressed cDNAs from fetal mouse brain. Brain Res Brain Res Protoc. 2001 Feb;6(3):119-28
3	J:152865 Georgas K, Rumballe B, Valerius MT, Chiu HS, Thiagarajan RD, Lesieur E, Aronow BJ, Brunskill EW, Combes AN, Tang D, Taylor D, Grimmond SM, Potter SS, McMahon AP, Little MH, Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol. 2009 Aug 15;332(2):273-86
2	J:267576 Gontan C, Mira-Bontenbal H, Magaraki A, Dupont C, Barakat TS, Rentmeester E, Demmers J, Gribnau J, REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice. Nat Commun. 2018 Nov 12;9(1):4752
1	J:191565 Grote P, Wittler L, Hendrix D, Koch F, Wahrisch S, Beisaw A, Macura K, Blass G, Kellis M, Werber M, Herrmann BG, The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse. Dev Cell. 2013 Jan 28;24(2):206-14
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3*	J:275851 Harris C, Cloutier M, Trotter M, Hinten M, Gayen S, Du Z, Xie W, Kalantry S, Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2. Elife. 2019 Apr 2;8:e44258
3	J:173577 Hoki Y, Ikeda R, Mise N, Sakata Y, Ohhata T, Sasaki H, Abe K, Sado T, Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse. Development. 2011 Jul;138(13):2649-59
1	J:142921 Hoki Y, Kimura N, Kanbayashi M, Amakawa Y, Ohhata T, Sasaki H, Sado T, A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse. Development. 2009 Jan;136(1):139-46
1	J:87102 Huynh KD, Lee JT, Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature. 2003 Dec 18;426(6968):857-62
4	J:272571 Inoue A, Chen Z, Yin Q, Zhang Y, Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells. Genes Dev. 2018 Dec 1;32(23-24):1525-1536
4*	J:39159 Jamieson RV, Zhou SX, Tan SS, Tam PP, X-chromosome inactivation during the development of the male urogenital ridge of the mouse. Int J Dev Biol. 1997 Feb;41(1):49-55
5	J:99563 Jeong KS, Park JH, Lee S, The analysis of X-chromosome inactivation-related gene expression from single mouse embryo with sex-determination. Biochem Biophys Res Commun. 2005 Aug 5;333(3):803-7
4	J:49849 Johnston CM, Nesterova TB, Formstone EJ, Newall AE, Duthie SM, Sheardown SA, Brockdorff N, Developmentally regulated Xist promoter switch mediates initiation of X inactivation. Cell. 1998 Sep 18;94(6):809-17
3	J:115851 Kalantry S, Magnuson T, The Polycomb group protein EED is dispensable for the initiation of random X-chromosome inactivation. PLoS Genet. 2006 May;2(5):e66
6	J:150959 Kalantry S, Purushothaman S, Bowen RB, Starmer J, Magnuson T, Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation. Nature. 2009 Jul 30;460(7255):647-51
1	J:18553 Kay GF, Barton SC, Surani MA, Rastan S, Imprinting and X chromosome counting mechanisms determine Xist expression in early mouse development. Cell. 1994 Jun 3;77(5):639-50
3	J:169234 Kim JD, Kim H, Ekram MB, Yu S, Faulk C, Kim J, Rex1/Zfp42 as an epigenetic regulator for genomic imprinting. Hum Mol Genet. 2011 Apr 1;20(7):1353-62
5*	J:173437 Kobayashi S, Fujihara Y, Mise N, Kaseda K, Abe K, Ishino F, Okabe M, The X-linked imprinted gene family Fthl17 shows predominantly female expression following the two-cell stage in mouse embryos. Nucleic Acids Res. 2010 Jun 1;38(11):3672-81
1	J:106336 Kobayashi S, Isotani A, Mise N, Yamamoto M, Fujihara Y, Kaseda K, Nakanishi T, Ikawa M, Hamada H, Abe K, Okabe M, Comparison of gene expression in male and female mouse blastocysts revealed imprinting of the X-linked gene, Rhox5/Pem, at preimplantation stages. Curr Biol. 2006 Jan 24;16(2):166-72
2*	J:24369 Latham KE, Rambhatla L, Hayashizaki Y, Chapman VM, Stage-specific induction and regulation by genomic imprinting of the mouse U2afbp-rs gene during preimplantation development. Dev Biol. 1995 Apr;168(2):670-6
3*	J:26784 Lebon JM, Tam PP, Singer-Sam J, Riggs AD, Tan SS, Mouse endogenous X-linked genes do not show lineage-specific delayed inactivation during development. Genet Res. 1995 Jun;65(3):223-7
5	J:100635 Ma M, Strauss WM, Analysis of the Xist RNA isoforms suggests two distinctly different forms of regulation. Mamm Genome. 2005 Jun;16(6):391-404
1	J:282554 Mandelbaum AD, Kredo-Russo S, Aronowitz D, Myers N, Yanowski E, Klochendler A, Swisa A, Dor Y, Hornstein E, miR-17-92 and miR-106b-25 clusters regulate beta cell mitotic checkpoint and insulin secretion in mice. Diabetologia. 2019 Sep;62(9):1653-1666
1	J:38094 Marahrens Y, Panning B, Dausman J, Strauss W, Jaenisch R, Xist-deficient mice are defective in dosage compensation but not spermatogenesis. Genes Dev. 1997 JAN 15;11(2):156-166
6	J:70372 Matsui J, Goto Y, Takagi N, Control of Xist expression for imprinted and random X chromosome inactivation in mice. Hum Mol Genet. 2001 Jun 15;10(13):1393-401
1	J:312431 Matsuura R, Nakajima T, Ichihara S, Sado T, Ectopic Splicing Disturbs the Function of Xist RNA to Establish the Stable Heterochromatin State. Front Cell Dev Biol. 2021;9:751154
1	J:305254 Mei H, Kozuka C, Hayashi R, Kumon M, Koseki H, Inoue A, H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos. Nat Genet. 2021 Apr;53(4):539-550
4*	J:81347 Menke DB, Page DC, Sexually dimorphic gene expression in the developing mouse gonad. Gene Expr Patterns. 2002 Dec;2(3-4):359-67
4*	J:55015 Mise N, Goto Y, Nakajima N, Takagi N, Molecular cloning of antisense transcripts of the mouse Xist gene. Biochem Biophys Res Commun. 1999 May 19;258(3):537-41
1	J:185555 Mugford JW, Yee D, Magnuson T, Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation. Development. 2012 Jun;139(12):2130-8
5	J:96532 Nolen LD, Gao S, Han Z, Mann MR, Gie Chung Y, Otte AP, Bartolomei MS, Latham KE, X chromosome reactivation and regulation in cloned embryos. Dev Biol. 2005 Mar 15;279(2):525-40
1	J:116773 Oda M, Yamagiwa A, Yamamoto S, Nakayama T, Tsumura A, Sasaki H, Nakao K, Li E, Okano M, DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev. 2006 Dec 15;20(24):3382-94
2	J:130425 Ohhata T, Hoki Y, Sasaki H, Sado T, Crucial role of antisense transcription across the Xist promoter in Tsix-mediated Xist chromatin modification. Development. 2008 Jan;135(2):227-35
5	J:93084 Okamoto I, Otte AP, Allis CD, Reinberg D, Heard E, Epigenetic dynamics of imprinted X inactivation during early mouse development. Science. 2004 Jan 30;303(5658):644-9
1	J:304858 Olthof AM, White AK, Mieruszynski S, Doggett K, Lee MF, Chakroun A, Abdel Aleem AK, Rousseau J, Magnani C, Roifman CM, Campeau PM, Heath JK, Kanadia RN, Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns. Nucleic Acids Res. 2021 Apr 6;49(6):3524-3545
6*	J:42759 Panning B, Dausman J, Jaenisch R, X chromosome inactivation is mediated by Xist RNA stabilization. Cell. 1997 Sep 5;90(5):907-16
2	J:35056 Panning B, Jaenisch R, DNA hypomethylation can activate Xist expression and silence X-linked genes. Genes Dev. 1996 Aug 15;10(16):1991-2002
1	J:144190 Redrup L, Branco MR, Perdeaux ER, Krueger C, Lewis A, Santos F, Nagano T, Cobb BS, Fraser P, Reik W, The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development. 2009 Feb;136(4):525-30
2*	J:99399 Sado T, Hoki Y, Sasaki H, Tsix Silences Xist through Modification of Chromatin Structure. Dev Cell. 2005 Jul;9(1):159-165
2*	J:297196 Sado T, Hoki Y, Sasaki H, Tsix defective in splicing is competent to establish Xist silencing. Development. 2006;133(24):4925-31
1	J:266555 Sakakibara Y, Nagao K, Blewitt M, Sasaki H, Obuse C, Sado T, Role of SmcHD1 in establishment of epigenetic states required for the maintenance of the X-inactivated state in mice. Development. 2018 Sep 25;145(18):dev166462
1	J:243417 Sakata Y, Nagao K, Hoki Y, Sasaki H, Obuse C, Sado T, Defects in dosage compensation impact global gene regulation in the mouse trophoblast. Development. 2017 Aug 01;144(15):2784-2797
4	J:324716 Samanta MK, Gayen S, Harris C, Maclary E, Murata-Nakamura Y, Malcore RM, Porter RS, Garay PM, Vallianatos CN, Samollow PB, Iwase S, Kalantry S, Activation of Xist by an evolutionarily conserved function of KDM5C demethylase. Nat Commun. 2022 May 11;13(1):2602
2*	J:227628 Sarkar MK, Gayen S, Kumar S, Maclary E, Buttigieg E, Hinten M, Kumari A, Harris C, Sado T, Kalantry S, An Xist-activating antisense RNA required for X-chromosome inactivation. Nat Commun. 2015;6:8564
4	J:112954 Savarese F, Flahndorfer K, Jaenisch R, Busslinger M, Wutz A, Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation. Mol Cell Biol. 2006 Oct;26(19):7167-77
2	J:154764 Schoeftner S, Blanco R, de Silanes IL, Munoz P, Gomez-Lopez G, Flores JM, Blasco MA, Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19393-8
7	J:43430 Sheardown SA, Duthie SM, Johnston CM, Newall AE, Formstone EJ, Arkell RM, Nesterova TB, Alghisi GC, Rastan S, Brockdorff N, Stabilization of Xist RNA mediates initiation of X chromosome inactivation. Cell. 1997 Oct 3;91(1):99-107
2	J:213272 Shin J, Wallingford MC, Gallant J, Marcho C, Jiao B, Byron M, Bossenz M, Lawrence JB, Jones SN, Mager J, Bach I, RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast. Nature. 2014 Jul 3;511(7507):86-9
6*	J:275903 Shiura H, Abe K, Xist/Tsix expression dynamics during mouse peri-implantation development revealed by whole-mount 3D RNA-FISH. Sci Rep. 2019 Mar 6;9(1):3637
1*	J:260691 Soma M, Fujihara Y, Okabe M, Ishino F, Kobayashi S, Ftx is dispensable for imprinted X-chromosome inactivation in preimplantation mouse embryos. Sci Rep. 2014 Jun 5;4:5181
4	J:316300 Sousa EJ, Stuart HT, Bates LE, Ghorbani M, Nichols J, Dietmann S, Silva JCR, Exit from Naive Pluripotency Induces a Transient X Chromosome Inactivation-like State in Males. Cell Stem Cell. 2018 Jun 1;22(6):919-928.e6
1	J:38063 Sowden JC, Morrison K, Putt W, Beddington R, Edwards YH, The identification of novel sequences expressed in the mouse notochord. Mamm Genome. 1997 Jan;8(1):42-4
5	J:123745 Sugimoto M, Abe K, X chromosome reactivation initiates in nascent primordial germ cells in mice. PLoS Genet. 2007 Jul 27;3(7):e116
2	J:227859 Sun S, Payer B, Namekawa S, An JY, Press W, Catalan-Dibene J, Sunwoo H, Lee JT, Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14415-22
1	J:356218 Szakats S, McAtamney A, Cross H, Wilson MJ, Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes. Biol Sex Differ. 2023 Sep 7;14(1):57
1	J:345819 Wang F, Chander A, Yoon Y, Welton JM, Wallingford MC, Espejo-Serrano C, Bustos F, Findlay GM, Mager J, Bach I, Roles of the Rlim-Rex1 axis during X chromosome inactivation in mice. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2313200120
2	J:238025 Wang F, Shin J, Shea JM, Yu J, Boskovic A, Byron M, Zhu X, Shalek AK, Regev A, Lawrence JB, Torres EM, Zhu LJ, Rando OJ, Bach I, Regulation of X-linked gene expression during early mouse development by Rlim. Elife. 2016 Sep 19;5:e19127
1	J:318869 Wang J, Li X, Wang L, Li J, Zhao Y, Bou G, Li Y, Jiao G, Shen X, Wei R, Liu S, Xie B, Lei L, Li W, Zhou Q, Liu Z, A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two-cell embryos. EMBO Rep. 2016 Oct;17(10):1452-1470
4	J:292644 Whiley PAF, O'Donnell L, Moody SC, Handelsman DJ, Young JC, Richards EA, Almstrup K, Western PS, Loveland KL, Activin A Determines Steroid Levels and Composition in the Fetal Testis. Endocrinology. 2020 Jul 1;161(7)
6	J:171449 Williams LH, Kalantry S, Starmer J, Magnuson T, Transcription precedes loss of Xist coating and depletion of H3K27me3 during X-chromosome reprogramming in the mouse inner cell mass. Development. 2011 May;138(10):2049-57
2	J:206774 Wolstenholme JT, Rissman EF, Bekiranov S, Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. Genes Brain Behav. 2013 Mar;12(2):166-80
2	J:331895 Zengeler KE, Shapiro DA, Bruch KR, Lammert CR, Ennerfelt H, Lukens JR, SSRI treatment modifies the effects of maternal inflammation on in utero physiology and offspring neurobiology. Brain Behav Immun. 2022 Nov 4;108:80-97
1	J:282261 Zhao J, Tian Y, Zhang H, Qu L, Chen Y, Liu Q, Luo Y, Wu X, p53 Mutant p53(N236S) Induces Neural Tube Defects in Female Embryos. Int J Biol Sci. 2019;15(9):2006-2015
1	J:223924 Zhao W, Jiang B, Hu H, Zhang S, Lv S, Yuan J, Qian Y, Zou Y, Li X, Jiang H, Liu F, Shao C, Gong Y, Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. Hum Mol Genet. 2015 Aug 15;24(16):4686-97