Gene Expression Literature Summary

• Symbol: Yy1
• Name: YY1 transcription factor
• ID: MGI:99150

39 matching records from 39 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4.5	E5	E5.5	E6	E6.5	E7	E7.5	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)								1	1	1	1	1	1	4		1	4		3	1	1		4			1	2				1				4		1	5
In situ RNA (section)																									1		1											2
Immunohistochemistry (whole mount)	2	1	1		1	1	3
In situ RNA (whole mount)														2	1		1	1	2		1	1	1						1
Western blot	1	1			1	1	1										1				1		3		1		2		1	1	1			1	1			3
RT-PCR			1	1	1	1	1	1						1	2	1	4		2		2		2	1	1	1	2	1	2	1		1	1		3	1		9

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Yy1  YY1 transcription factor   (Synonyms: delta transcription factor, NF-E1, UCRBP transcription factor, Yin Yang 1)
Results	Reference
1*	J:290235 Archambault D, Cheong A, Iverson E, Tremblay KD, Mager J, Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development. Dev Biol. 2020 Jul 3;465(1):1-10
1	J:221142 Beketaev I, Zhang Y, Kim EY, Yu W, Qian L, Wang J, Critical role of YY1 in cardiac morphogenesis. Dev Dyn. 2015 May;244(5):669-80
1*	J:229171 Beketaev I, Zhang Y, Weng KC, Rhee S, Yu W, Liu Y, Mager J, Wang J, cis-regulatory control of Mesp1 expression by YY1 and SP1 during mouse embryogenesis. Dev Dyn. 2016 Mar;245(3):379-87
3	J:239777 Boucherat O, Landry-Truchon K, Berube-Simard FA, Houde N, Beuret L, Lezmi G, Foulkes WD, Delacourt C, Charron J, Jeannotte L, Epithelial inactivation of Yy1 abrogates lung branching morphogenesis. Development. 2015 Sep 01;142(17):2981-95
1*	J:290961 Chen F, Zhou J, Li Y, Zhao Y, Yuan J, Cao Y, Wang L, Zhang Z, Zhang B, Wang CC, Cheung TH, Wu Z, Wong CC, Sun H, Wang H, YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells. EMBO J. 2019 May 15;38(10)
2	J:338403 Cho KW, Andrade M, Bae S, Kim S, Eyun Kim J, Jang EY, Lee S, Husain A, Sutliff RL, Calvert JW, Park C, Yoon YS, Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis. Circulation. 2023 Jun 13;147(24):1823-1842
1	J:123395 Deshpande AM, Akunowicz JD, Reveles XT, Patel BB, Saria EA, Gorlick RG, Naylor SL, Leach RJ, Hansen MF, PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors. Oncogene. 2007 Mar 15;26(12):1714-22
6	J:305174 Dong X, Kwan KM, Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis. Mol Brain. 2020 Jul 23;13(1):104
8*	J:57857 Donohoe ME, Zhang X, McGinnis L, Biggers J, Li E, Shi Y, Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol. 1999 Oct;19(10):7237-44
4*	J:152909 Drews D, Klar M, Dame C, Brauer AU, Developmental expression profile of the YY2 gene in mice. BMC Dev Biol. 2009;9:45
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
3	J:212854 Gregoire S, Karra R, Passer D, Deutsch MA, Krane M, Feistritzer R, Sturzu A, Domian I, Saga Y, Wu SM, Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation. Circ Res. 2013 Mar 15;112(6):900-10
8	J:253444 Gregoire S, Li G, Sturzu AC, Schwartz RJ, Wu SM, YY1 Expression Is Sufficient for the Maintenance of Cardiac Progenitor Cell State. Stem Cells. 2017 Aug;35(8):1913-1923
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
2	J:169234 Kim JD, Kim H, Ekram MB, Yu S, Faulk C, Kim J, Rex1/Zfp42 as an epigenetic regulator for genomic imprinting. Hum Mol Genet. 2011 Apr 1;20(7):1353-62
2*	J:316543 Kim JS, Chae JH, Cheon YP, Kim CG, Reciprocal localization of transcription factors YY1 and CP2c in spermatogonial stem cells and their putative roles during spermatogenesis. Acta Histochem. 2016 Sep;118(7):685-692
1	J:119650 Kim SY, Paylor SW, Magnuson T, Schumacher A, Juxtaposed Polycomb complexes co-regulate vertebral identity. Development. 2006 Dec;133(24):4957-68
5	J:240472 Kumar N, Srivillibhuthur M, Joshi S, Walton KD, Zhou A, Faller WJ, Perekatt AO, Sansom OJ, Gumucio DL, Xing J, Bonder EM, Gao N, White E, Verzi MP, A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development. 2016 Oct 15;143(20):3711-3722
1	J:132025 Labialle S, Yang L, Ruan X, Villemain A, Schmidt JV, Hernandez A, Wiltshire T, Cermakian N, Naumova AK, Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes. Hum Mol Genet. 2008 Jan 1;17(1):15-26
6	J:315115 Li R, Song XT, Guo SW, Zhao N, He M, He CQ, Ding NZ, YY1 and RTCB in mouse uterine decidualization and embryo implantation. Reproduction. 2021 Nov 10;162(6):461-472
3	J:324240 Liu D, Yang KY, Chan VW, Ye W, Chong CCN, Wang CC, Wang H, Zhou B, Cheng KKY, Lui KO, YY1 Regulates Glucose Homeostasis Through Controlling Insulin Transcription in Pancreatic beta-Cells. Diabetes. 2022 May 1;71(5):961-977
1*	J:111577 Mao C, Tai WC, Bai Y, Poizat C, Lee AS, In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4. J Biol Chem. 2006 Mar 31;281(13):8877-87
2	J:352717 Pereira A, Diwakar J, Masserdotti G, Beskardes S, Simon T, So Y, Martin-Loarte L, Bergemann F, Vasan L, Schauer T, Danese A, Bocchi R, Colome-Tatche M, Schuurmans C, Philpott A, Straub T, Bonev B, Gotz M, Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1. Nat Neurosci. 2024 Jul;27(7):1260-1273
5	J:199892 Rhee S, Guerrero-Zayas MI, Wallingford MC, Ortiz-Pineda P, Mager J, Tremblay KD, Visceral endoderm expression of Yin-Yang1 (YY1) is required for VEGFA maintenance and yolk sac development. PLoS One. 2013;8(3):e58828
5*	J:344099 Sakamoto M, Abe S, Miki Y, Miyanari Y, Sasaki H, Ishiuchi T, Dynamic nucleosome remodeling mediated by YY1 underlies early mouse development. Genes Dev. 2023 Jul 1;37(13-14):590-604
2	J:75034 Tan DP, Nonaka K, Nuckolls GH, Liu YH, Maxson RE, Slavkin HC, Shum L, YY1 activates Msx2 gene independent of bone morphogenetic protein signaling. Nucleic Acids Res. 2002 Mar 1;30(5):1213-23
3*	J:186556 Trask MC, Tremblay KD, Mager J, Yin-Yang1 is required for epithelial-to-mesenchymal transition and regulation of Nodal signaling during mammalian gastrulation. Dev Biol. 2012 Aug 15;368(2):273-82
2*	J:284490 Varum S, Baggiolini A, Zurkirchen L, Atak ZK, Cantu C, Marzorati E, Bossart R, Wouters J, Hausel J, Tuncer E, Zingg D, Veen D, John N, Balz M, Levesque MP, Basler K, Aerts S, Zamboni N, Dummer R, Sommer L, Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Cell Stem Cell. 2019 Apr 4;24(4):637-653.e9
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:196667 Vogl MR, Reiprich S, Kuspert M, Kosian T, Schrewe H, Nave KA, Wegner M, Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. J Neurosci. 2013 Apr 10;33(15):6679-90
6*	J:213978 Vuong L, Brobst DE, Saadi A, Ivanovic I, Al-Ubaidi MR, Pattern of expression of p53, its family members, and regulators during early ocular development and in the post-mitotic retina. Invest Ophthalmol Vis Sci. 2012 Jul;53(8):4821-31
1*	J:199572 Wallingford MC, Angelo JR, Mager J, Morphogenetic analysis of peri-implantation development. Dev Dyn. 2013 Sep;242(9):1110-20
12*	J:290529 Wallingford MC, Hiller J, Zhang K, Mager J, YY1 Is Required for Posttranscriptional Stability of SOX2 and OCT4 Proteins. Cell Reprogram. 2017 Aug;19(4):263-269
1	J:212272 Wu J, Bao J, Kim M, Yuan S, Tang C, Zheng H, Mastick GS, Xu C, Yan W, Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis. Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):E2851-7
2	J:318371 Ye A, He H, Kim J, PEG3 binds to H19-ICR as a transcriptional repressor. Epigenetics. 2016 Dec;11(12):889-900
2*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1*	J:324720 Zhao Q, Yan S, Lu J, Parker DJ, Wu H, Sun Q, Crossman DK, Liu S, Wang Q, Sesaki H, Mitra K, Liu K, Jiao K, Drp1 regulates transcription of ribosomal protein genes in embryonic hearts. J Cell Sci. 2022 Feb 15;135(4):jcs258956
10	J:275567 Zurkirchen L, Varum S, Giger S, Klug A, Hausel J, Bossart R, Zemke M, Cantu C, Atak ZK, Zamboni N, Basler K, Sommer L, Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nat Commun. 2019 May 16;10(1):2192