Gene Expression Literature Summary

• Symbol: Itpr2
• Name: inositol 1,4,5-triphosphate receptor 2
• ID: MGI:99418

18 matching records from 18 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2.5	E3.5	E8	E8.5	E9.5	E10	E10.5	E11.5	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)						1	1	1												1
In situ RNA (section)												1						1		1
In situ RNA (whole mount)					1	1		1
In situ reporter (knock in)						1		1	1		1			1			1	1
Western blot	1	1	1			2				1			1							5
RT-PCR	1			1	2	2		1	2	2	1	2		1	1	2		2	1	6

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Itpr2  inositol 1,4,5-triphosphate receptor 2   (Synonyms: Ip3r2, Itpr5)
Results	Reference
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
5*	J:79406 Faure AV, Grunwald D, Moutin MJ, Hilly M, Mauger JP, Marty I, De Waard M, Villaz M, Albrieux M, Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex. Eur J Neurosci. 2001 Nov;14(10):1613-22
2	J:294971 Fecher-Trost C, Lux F, Busch KM, Raza A, Winter M, Hielscher F, Belkacemi T, van der Eerden B, Boehm U, Freichel M, Weissgerber P, Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development. J Bone Miner Res. 2019 Apr;34(4):699-710
1*	J:306226 Firulli BA, George RM, Harkin J, Toolan KP, Gao H, Liu Y, Zhang W, Field LJ, Liu Y, Shou W, Payne RM, Rubart-von der Lohe M, Firulli AB, HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure. Cardiovasc Res. 2020 Mar 1;116(3):605-618
7	J:285717 Ishizaki-Asami R, Uchida K, Tsuchihashi T, Shibata A, Kodo K, Emoto K, Mikoshiba K, Takahashi T, Yamagishi H, Inositol 1,4,5-trisphosphate receptor 2 as a novel marker of vasculature to delineate processes of cardiopulmonary development. Dev Biol. 2020 Feb 15;458(2):237-245
1	J:263568 Kim GE, Ross JL, Xie C, Su KN, Zaha VG, Wu X, Palmeri M, Ashraf M, Akar JG, Russell KS, Akar FG, Young LH, LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation. Cardiovasc Res. 2015 Oct 1;108(1):197-208
1	J:286844 Kim J, Kim K, Mo JS, Lee Y, Atm deficiency in the DNA polymerase beta null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation. Nucleic Acids Res. 2020 Apr 17;48(7):3678-3691
3	J:312490 Mei R, Huang L, Wu M, Jiang C, Yang A, Tao H, Zheng K, Yang J, Shen W, Chen X, Zhao X, Qiu M, Evidence That ITPR2-Mediated Intracellular Calcium Release in Oligodendrocytes Regulates the Development of Carbonic Anhydrase II + Type I/II Oligodendrocytes and the Sizes of Myelin Fibers. Front Cell Neurosci. 2021;15:751439
2	J:186596 Nakamura TY, Jeromin A, Mikoshiba K, Wakabayashi S, Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals. Circ Res. 2011 Aug 19;109(5):512-23
1	J:281436 Nicol B, Grimm SA, Chalmel F, Lecluze E, Pannetier M, Pailhoux E, Dupin-De-Beyssat E, Guiguen Y, Capel B, Yao HH, RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2. Nat Commun. 2019 Nov 11;10(1):5116
1	J:269319 Nicol B, Grimm SA, Gruzdev A, Scott GJ, Ray MK, Yao HH, Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonads. Hum Mol Genet. 2018 Dec 15;27(24):4273-4287
6	J:51101 Parrington J, Brind S, De Smedt H, Gangeswaran R, Lai FA, Wojcikiewicz R, Carroll J, Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization. Dev Biol. 1998 Nov 15;203(2):451-61
1	J:72798 Pin CL, Rukstalis JM, Johnson C, Konieczny SF, The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J Cell Biol. 2001 Nov 12;155(4):519-30
1	J:112566 Stolk M, Leon-Ponte M, Merrill M, Ahern GP, O'Connell PJ, IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1. J Leukoc Biol. 2006 Sep;80(3):651-8
2	J:238633 Tyser RC, Miranda AM, Chen CM, Davidson SM, Srinivas S, Riley PR, Calcium handling precedes cardiac differentiation to initiate the first heartbeat. Elife. 2016 Oct 11;5:e17113
12	J:165022 Uchida K, Aramaki M, Nakazawa M, Yamagishi C, Makino S, Fukuda K, Nakamura T, Takahashi T, Mikoshiba K, Yamagishi H, Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis. PLoS One. 2010;5(9)
4	J:236405 Uchida K, Nakazawa M, Yamagishi C, Mikoshiba K, Yamagishi H, Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development. Dev Biol. 2016 Oct 1;418(1):89-97
5	J:200792 Wang P, Tang M, Gao L, Luo H, Wang G, Ma X, Duan Y, Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development. J Cell Biochem. 2013 Aug;114(8):1852-62