Gene Expression Literature Summary

• Symbol: Hira
• Name: histone cell cycle regulator
• ID: MGI:99430

16 matching records from 16 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7	E7.5	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E17	E18	E	P
Immunohistochemistry (section)												1				1						1
In situ RNA (section)									1						1		1					1
Immunohistochemistry (whole mount)							1
In situ RNA (whole mount)	1	1	1	1	1		1
In situ reporter (knock in)							1						1
Northern blot		1						1								1			1			2
Western blot											1	1				1				1
RT-PCR				1	2	2	8			2		1	1	2	2			2	1	1	1	6
cDNA clones									2													1
RNase protection											1											1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Hira  histone cell cycle regulator   (Synonyms: D16Ertd95e, Gm15797, Tuple1)
Results	Reference
2	J:307956 Blake GET, Zhao X, Yung HW, Burton GJ, Ferguson-Smith AC, Hamilton RS, Watson ED, Defective folate metabolism causes germline epigenetic instability and distinguishes Hira as a phenotype inheritance biomarker. Nat Commun. 2021 Jun 17;12(1):3714
3	J:236915 Dilg D, Saleh RN, Phelps SE, Rose Y, Dupays L, Murphy C, Mohun T, Anderson RH, Scambler PJ, Chapgier AL, HIRA Is Required for Heart Development and Directly Regulates Tnni2 and Tnnt3. PLoS One. 2016;11(8):e0161096
3*	J:316220 Jeanne M, Vuillaume ML, Ung DC, Vancollie VE, Wagner C, Collins SC, Vonwill S, Haye D, Chelloug N, Pfundt R, Kummeling J, Moizard MP, Marouillat S, Kleefstra T, Yalcin B, Laumonnier F, Toutain A, Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth. Hum Genet. 2021 Jun;140(6):885-896
3	J:213451 Karpinski BA, Maynard TM, Fralish MS, Nuwayhid S, Zohn IE, Moody SA, LaMantia AS, Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome. Dis Model Mech. 2014 Feb;7(2):245-57
5	J:246099 Li Y, Jiao J, Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via beta-catenin. J Cell Biol. 2017 Jul 03;216(7):1975-1992
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:191130 Maynard TM, Gopalakrishna D, Meechan DW, Paronett EM, Newbern JM, Lamantia AS, 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013 Jan 15;22(2):300-12
1*	J:74505 Maynard TM, Haskell GT, Bhasin N, Lee JM, Gassman AA, Lieberman JA, LaMantia AS, RanBP1, a velocardiofacial/DiGeorge syndrome candidate gene, is expressed at sites of mesenchymal/epithelial induction. Mech Dev. 2002 Feb;111(1-2):177-80
8*	J:86704 Maynard TM, Haskell GT, Peters AZ, Sikich L, Lieberman JA, LaMantia AS, A comprehensive analysis of 22q11 gene expression in the developing and adult brain. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14433-8
3	J:116629 Meechan DW, Maynard TM, Wu Y, Gopalakrishna D, Lieberman JA, Lamantia AS, Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome. Mol Cell Neurosci. 2006 Dec;33(4):412-28
6	J:153232 Meechan DW, Tucker ES, Maynard TM, LaMantia AS, Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome. Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16434-45
1	J:235630 Paronett EM, Meechan DW, Karpinski BA, LaMantia AS, Maynard TM, Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation. Cereb Cortex. 2015 Oct;25(10):3977-93
2*	J:98850 Prescott K, Ivins S, Hubank M, Lindsay E, Baldini A, Scambler P, Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome. Hum Genet. 2005 May;116(6):486-96
3	J:75491 Roberts C, Sutherland HF, Farmer H, Kimber W, Halford S, Carey A, Brickman JM, Wynshaw-Boris A, Scambler PJ, Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality. Mol Cell Biol. 2002 Apr;22(7):2318-28
3*	J:32513 Scamps C, Lorain S, Lamour V, Lipinski M, The HIR protein family: isolation and characterization of a complete murine cDNA. Biochim Biophys Acta. 1996 Apr 10;1306(1):5-8
16*	J:38619 Wilming LG, Snoeren CA, van Rijswijk A, Grosveld F, Meijers C, The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients. Hum Mol Genet. 1997 Feb;6(2):247-58