Gene Expression Literature Summary

• Symbol: Brd2
• Name: bromodomain containing 2
• ID: MGI:99495

16 matching records from 16 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E2.5	E3	E3.5	E4.5	E7	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	P
Immunohistochemistry (section)									1		1		1	1	1					1
In situ RNA (section)							1							1				1	3			1		1		1	3
Immunohistochemistry (whole mount)			1	1	1	1
In situ RNA (whole mount)								1		2		2							1		2
In situ reporter (knock in)																	1
Northern blot							1	1		1						1			1				1	1	1		2
Western blot																											1
RT-PCR	1	1	1	1	1	1				1		1							1						1		2
cDNA clones																											1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Brd2  bromodomain containing 2   (Synonyms: D17H6S113E, Frg-1, Fsrg1, Ring3, Rnf3)
Results	Reference
3*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
7	J:92224 Crowley T, Brunori M, Rhee K, Wang X, Wolgemuth DJ, Change in nuclear-cytoplasmic localization of a double-bromodomain protein during proliferation and differentiation of mouse spinal cord and dorsal root ganglia. Brain Res Dev Brain Res. 2004 May 19;149(2):93-101
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:337771 El-Saafin F, Bergamasco MI, Chen Y, May RE, Esakky P, Hediyeh-Zadeh S, Dixon M, Wilcox S, Davis MJ, Strasser A, Smyth GK, Thomas T, Voss AK, Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. Cell Death Differ. 2022 May;29(5):1013-1027
3*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
2*	J:258756 Gyuris A, Donovan DJ, Seymour KA, Lovasco LA, Smilowitz NR, Halperin AL, Klysik JE, Freiman RN, The chromatin-targeting protein Brd2 is required for neural tube closure and embryogenesis. Biochim Biophys Acta. 2009 May;1789(5):413-21
1	J:350444 Martinez-Mayer J, Brinkmeier ML, O'Connell SP, Ukagwu A, Marti MA, Miras M, Forclaz MV, Benzrihen MG, Cheung LYM, Camper SA, Ellsworth BS, Raetzman LT, Perez-Millan MI, Davis SW, Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
4*	J:60127 Pascolo S, Tsoukatou D, Mamalaki C, Identification of thymus specific and developmentally regulated genes by an improved version of the mRNA differential display technique. Dev Immunol. 1999;7(1):1-7
13	J:51809 Rhee K, Brunori M, Besset V, Trousdale R, Wolgemuth DJ, Expression and potential role of Fsrg1, a murine bromodomain-containing homologue of the Drosophila gene female sterile homeotic. J Cell Sci. 1998 Dec;111(Pt 23):3541-50
1*	J:147040 Shang E, Wang X, Wen D, Greenberg DA, Wolgemuth DJ, Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse. Dev Dyn. 2009 Apr;238(4):908-17
4	J:188139 Tsume M, Kimura-Yoshida C, Mochida K, Shibukawa Y, Amazaki S, Wada Y, Hiramatsu R, Shimokawa K, Matsuo I, Brd2 is required for cell cycle exit and neuronal differentiation through the E2F1 pathway in mouse neuroepithelial cells. Biochem Biophys Res Commun. 2012 Sep 7;425(4):762-8
4*	J:326575 Tsume-Kajioka M, Kimura-Yoshida C, Mochida K, Ueda Y, Matsuo I, BET proteins are essential for the specification and maintenance of the epiblast lineage in mouse preimplantation embryos. BMC Biol. 2022 Mar 9;20(1):64
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
2	J:123923 Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA, A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell. 2007 Jul;13(1):103-14