Gene Expression Literature Summary

• Symbol: Ryr1
• Name: ryanodine receptor 1, skeletal muscle
• ID: MGI:99659

39 matching records from 39 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E5.5	E6.5	E7.5	E8.5	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)										2	1	1		2	1		1	1		1	1		11
In situ RNA (section)	1	1	1	1	1	1				1		1		2		1	1						2
Immunohistochemistry (whole mount)																1	1		1		2		2
In situ reporter (knock in)																							1
Northern blot										1													1
Western blot							1	1			1	1	1		1		2	1		3	2		9
RT-PCR						1		1	1	2		1	2	2			2			1	4	2	8
cDNA clones																							1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ryr1  ryanodine receptor 1, skeletal muscle   (Synonyms: calcium release channel isoform 1, Ryr, skrr)
Results	Reference
1*	J:217579 Anderson DM, Anderson KM, Chang CL, Makarewich CA, Nelson BR, McAnally JR, Kasaragod P, Shelton JM, Liou J, Bassel-Duby R, Olson EN, A micropeptide encoded by a putative long noncoding RNA regulates muscle performance. Cell. 2015 Feb 12;160(4):595-606
1	J:226616 Araujo DJ, Anderson AG, Berto S, Runnels W, Harper M, Ammanuel S, Rieger MA, Huang HC, Rajkovich K, Loerwald KW, Dekker JD, Tucker HO, Dougherty JD, Gibson JR, Konopka G, FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Genes Dev. 2015 Oct 15;29(20):2081-96
1	J:253754 Arora H, Boulberdaa M, Qureshi R, Bitirim V, Gasser A, Messaddeq N, Dolle P, Nebigil CG, Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development. Sci Rep. 2016 May 6;6:25541
1	J:31270 Aruga J, Yokota N, Hashimoto M, Furuichi T, Fukuda M, Mikoshiba K, A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem. 1994 Nov;63(5):1880-90
1	J:267377 Baskin KK, Makarewich CA, DeLeon SM, Ye W, Chen B, Beetz N, Schrewe H, Bassel-Duby R, Olson EN, MED12 regulates a transcriptional network of calcium-handling genes in the heart. JCI Insight. 2017 Jul 20;2(14)
1	J:317547 Bernadzki KM, Gawor M, Pezinski M, Mazurek P, Niewiadomski P, Redowicz MJ, Proszynski TJ, Liprin-alpha-1 is a novel component of the murine neuromuscular junction and is involved in the organization of the postsynaptic machinery. Sci Rep. 2017 Aug 22;7(1):9116
2*	J:45244 Bertocchini F, Ovitt CE, Conti A, Barone V, Scholer HR, Bottinelli R, Reggiani C, Sorrentino V, Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles. EMBO J. 1997 Dec 1;16(23):6956-63
1	J:136876 Buj-Bello A, Fougerousse F, Schwab Y, Messaddeq N, Spehner D, Pierson CR, Durand M, Kretz C, Danos O, Douar AM, Beggs AH, Schultz P, Montus M, Denefle P, Mandel JL, AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis. Hum Mol Genet. 2008 Jul 15;17(14):2132-43
1	J:321108 Campiglio M, Kaplan MM, Flucher BE, STAC3 incorporation into skeletal muscle triads occurs independent of the dihydropyridine receptor. J Cell Physiol. 2018 Dec;233(12):9045-9051
1	J:199157 Caruso N, Herberth B, Bartoli M, Puppo F, Dumonceaux J, Zimmermann A, Denadai S, Lebosse M, Roche S, Geng L, Magdinier F, Attarian S, Bernard R, Maina F, Levy N, Helmbacher F, Deregulation of the Protocadherin Gene FAT1 Alters Muscle Shapes: Implications for the Pathogenesis of Facioscapulohumeral Dystrophy. PLoS Genet. 2013 Jun;9(6):e1003550
1	J:272180 Cowling BS, Prokic I, Tasfaout H, Rabai A, Humbert F, Rinaldi B, Nicot AS, Kretz C, Friant S, Roux A, Laporte J, Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation. J Clin Invest. 2017 Dec 1;127(12):4477-4487
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:276784 Estan MC, Fernandez-Nunez E, Zaki MS, Esteban MI, Donkervoort S, Hawkins C, Caparros-Martin JA, Saade D, Hu Y, Bolduc V, Chao KR, Nevado J, Lamuedra A, Largo R, Herrero-Beaumont G, Regadera J, Hernandez-Chico C, Tizzano EF, Martinez-Glez V, Carvajal JJ, Zong R, Nelson DL, Otaify GA, Temtamy S, Aglan M, Issa M, Bonnemann CG, Lapunzina P, Yoon G, Ruiz-Perez VL, Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy. Nat Commun. 2019 Feb 15;10(1):797
13*	J:79406 Faure AV, Grunwald D, Moutin MJ, Hilly M, Mauger JP, Marty I, De Waard M, Villaz M, Albrieux M, Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex. Eur J Neurosci. 2001 Nov;14(10):1613-22
2	J:294971 Fecher-Trost C, Lux F, Busch KM, Raza A, Winter M, Hielscher F, Belkacemi T, van der Eerden B, Boehm U, Freichel M, Weissgerber P, Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development. J Bone Miner Res. 2019 Apr;34(4):699-710
4	J:56913 Flucher BE, Conti A, Takeshima H, Sorrentino V, Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers. J Cell Biol. 1999 Aug 9;146(3):621-30
7*	J:22418 Futatsugi A, Kuwajima G, Mikoshiba K, Tissue-specific and developmentally regulated alternative splicing in mouse skeletal muscle ryanodine receptor mRNA. Biochem J. 1995 Jan 15;305(Pt 2):373-8
3*	J:224393 Gartz Hanson M, Niswander LA, Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos. Dev Biol. 2015 Aug 15;404(2):76-87
1	J:213153 Harms MJ, Ishibashi J, Wang W, Lim HW, Goyama S, Sato T, Kurokawa M, Won KJ, Seale P, Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Cell Metab. 2014 Apr 1;19(4):593-604
1	J:271303 Kaplan MM, Sultana N, Benedetti A, Obermair GJ, Linde NF, Papadopoulos S, Dayal A, Grabner M, Flucher BE, Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation. Cell Rep. 2018 Jun 26;23(13):3891-3904
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:299737 Lee J, Sutani A, Kaneko R, Takeuchi J, Sasano T, Kohda T, Ihara K, Takahashi K, Yamazoe M, Morio T, Furukawa T, Ishino F, In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix. Nat Commun. 2020 Sep 3;11(1):4283
3	J:63370 Mori F, Fukaya M, Abe H, Wakabayashi K, Watanabe M, Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain. Neurosci Lett. 2000 May 5;285(1):57-60
1	J:222015 Nelson BR, Wu F, Liu Y, Anderson DM, McAnally J, Lin W, Cannon SC, Bassel-Duby R, Olson EN, Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11881-6
1*	J:174169 Osheroff H, Hatten ME, Gene expression profiling of preplate neurons destined for the subplate: genes involved in transcription, axon extension, neurotransmitter regulation, steroid hormone signaling, and neuronal survival. Cereb Cortex. 2009 Jul;19 Suppl 1:i126-34
6	J:82992 Pisaniello A, Serra C, Rossi D, Vivarelli E, Sorrentino V, Molinaro M, Bouche M, The block of ryanodine receptors selectively inhibits fetal myoblast differentiation. J Cell Sci. 2003 Apr 15;116(Pt 8):1589-97
4	J:194896 Pistocchi A, Gaudenzi G, Foglia E, Monteverde S, Moreno-Fortuny A, Pianca A, Cossu G, Cotelli F, Messina G, Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution. Development. 2013 Apr;140(7):1528-36
1	J:298043 Prokic I, Cowling BS, Kutchukian C, Kretz C, Tasfaout H, Gache V, Hergueux J, Wendling O, Ferry A, Toussaint A, Gavriilidis C, Nattarayan V, Koch C, Laine J, Combe R, Tiret L, Jacquemond V, Pilot-Storck F, Laporte J, Differential physiological role of BIN1 isoforms in skeletal muscle development, function and regeneration. Dis Model Mech. 2020 Sep 29;:dmm044354
2	J:176499 Rederstorff M, Castets P, Arbogast S, Laine J, Vassilopoulos S, Beuvin M, Dubourg O, Vignaud A, Ferry A, Krol A, Allamand V, Guicheney P, Ferreiro A, Lescure A, Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy. PLoS One. 2011;6(8):e23094
11*	J:53109 Rosemblit N, Moschella MC, Ondriasa E, Gutstein DE, Ondrias K, Marks AR, Intracellular calcium release channel expression during embryogenesis. Dev Biol. 1999 Feb 15;206(2):163-77
1*	J:181604 Seth M, Li T, Graham V, Burch J, Finch E, Stiber JA, Rosenberg PB, Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation. Dev Dyn. 2012 Apr;241(4):639-47
1	J:319888 Son JS, Chae SA, Zhao L, Wang H, de Avila JM, Zhu MJ, Jiang Z, Du M, Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling. EBioMedicine. 2022 Jan 23;76:103842
1*	J:145505 Stiber J, Hawkins A, Zhang ZS, Wang S, Burch J, Graham V, Ward CC, Seth M, Finch E, Malouf N, Williams RS, Eu JP, Rosenberg P, STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle. Nat Cell Biol. 2008 Jun;10(6):688-97
4	J:112566 Stolk M, Leon-Ponte M, Merrill M, Ahern GP, O'Connell PJ, IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1. J Leukoc Biol. 2006 Sep;80(3):651-8
1*	J:283448 Sun SC, Ma D, Li MY, Zhang RX, Huang C, Huang HJ, Xie YZ, Wang ZJ, Liu J, Cai DC, Liu CX, Yang Q, Bao FX, Gong XL, Li JR, Hui Z, Wei XF, Zhong JM, Zhou WJ, Shang X, Zhang C, Liu XG, Tang BS, Xiong F, Xu XM, Mutations in C1orf194, encoding a calcium regulator, cause dominant Charcot-Marie-Tooth disease. Brain. 2019 Aug 1;142(8):2215-2229
5	J:72636 Takekura H, Flucher BE, Franzini-Armstrong C, Sequential Docking, Molecular Differentiation, and Positioning of T-Tubule/SR Junctions in Developing Mouse Skeletal Muscle. Dev Biol. 2001 Nov 15;239(2):204-14
2*	J:42099 Tarroni P, Rossi D, Conti A, Sorrentino V, Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells. J Biol Chem. 1997 Aug 8;272(32):19808-13
5	J:200792 Wang P, Tang M, Gao L, Luo H, Wang G, Ma X, Duan Y, Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development. J Cell Biochem. 2013 Aug;114(8):1852-62
1	J:344238 Zheng Y, Zhao C, Song Q, Xu L, Zhang B, Hu G, Kong X, Li S, Li X, Shen Y, Zhuang L, Wu M, Liu Y, Zhou Y, Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities. Cell Rep. 2023 Dec 26;42(12):113496