Gene Expression Literature Summary
|
Symbol Name ID |
Runx2
runt related transcription factor 2 MGI:99829 |
| Age | E1.5 | E2 | E2.5 | E3 | E3.5 | E4.5 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E19.5 | E | P |
| Immunohistochemistry (section) | 1 | 1 | 5 | 2 | 28 | 2 | 30 | 3 | 31 | 6 | 23 | 4 | 35 | 3 | 17 | 5 | 23 | 1 | 33 | ||||||||||||
| In situ RNA (section) | 1 | 3 | 2 | 4 | 13 | 9 | 44 | 8 | 54 | 11 | 69 | 10 | 48 | 8 | 60 | 5 | 16 | 5 | 38 | 2 | 6 | 36 | |||||||||
| Immunohistochemistry (whole mount) | 1 | 1 | 1 | 1 | 1 | ||||||||||||||||||||||||||
| In situ RNA (whole mount) | 1 | 7 | 14 | 3 | 15 | 8 | 3 | 1 | |||||||||||||||||||||||
| In situ reporter (knock in) | 1 | 1 | 2 | 1 | 3 | 1 | 1 | 2 | 2 | 1 | 3 | ||||||||||||||||||||
| Northern blot | 1 | 1 | 1 | 6 | |||||||||||||||||||||||||||
| Western blot | 1 | 4 | 5 | 7 | 2 | 1 | 1 | 1 | 5 | 1 | 8 | ||||||||||||||||||||
| RT-PCR | 1 | 1 | 1 | 1 | 1 | 1 | 5 | 1 | 2 | 10 | 13 | 2 | 17 | 2 | 16 | 2 | 21 | 2 | 17 | 13 | 4 | 24 | 1 | 2 | 58 | ||||||
| cDNA clones | 1 | 1 | |||||||||||||||||||||||||||||
| Nuclease S1 | 1 | 1 |
| Runx2 runt related transcription factor 2 (Synonyms: AML3, Cbfa1, Osf2, PEBP2aA, PEBP2 alpha A, Pebpa2a, polyomavirus enhancer binding factor 2 (PEBP2), SL3-3 enhancer factor 1) | |
| Results | Reference |
| 1* | J:162064 Abe M, Michikami I, Fukushi T, Abe A, Maeda Y, Ooshima T, Wakisaka S, Hand2 regulates chondrogenesis in vitro and in vivo. Bone. 2010 May;46(5):1359-68 |
| 1 | J:98096 Aberg T, Rice R, Rice D, Thesleff I, Waltimo-Siren J, Chondrogenic potential of mouse calvarial mesenchyme. J Histochem Cytochem. 2005 May;53(5):653-63 |
| 3* | J:92174 Aberg T, Wang XP, Kim JH, Yamashiro T, Bei M, Rice R, Ryoo HM, Thesleff I, Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol. 2004 Jun 1;270(1):76-93 |
| 2 | J:124269 Abzhanov A, Rodda SJ, McMahon AP, Tabin CJ, Regulation of skeletogenic differentiation in cranial dermal bone. Development. 2007 Sep;134(17):3133-44 |
| 1 | J:56557 Acampora D, Merlo GR, Paleari L, Zerega B, Postiglione MP, Mantero S, Bober E, Barbieri O, Simeone A, Levi G, Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5. Development. 1999 Sep;126(17):3795-809 |
| 1 | J:89752 Akiyama H, Chaboissier MC, Behringer RR, Rowitch DH, Schedl A, Epstein JA, de Crombrugghe B, Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6502-7 |
| 2 | J:79879 Akiyama H, Chaboissier MC, Martin JF, Schedl A, De Crombrugghe B, The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 2002 Nov 1;16(21):2813-28 |
| 1 | J:90567 Akiyama H, Lyons JP, Mori-Akiyama Y, Yang X, Zhang R, Zhang Z, Deng JM, Taketo MM, Nakamura T, Behringer RR, McCrea PD, de Crombrugghe B, Interactions between Sox9 and beta-catenin control chondrocyte differentiation. Genes Dev. 2004 May 1;18(9):1072-87 |
| 2 | J:304831 Alhazmi N, Carroll SH, Kawasaki K, Woronowicz KC, Hallett SA, Macias Trevino C, Li EB, Baron R, Gori F, Yelick PC, Harris MP, Liao EC, Synergistic roles of Wnt modulators R-spondin2 and R-spondin3 in craniofacial morphogenesis and dental development. Sci Rep. 2021 Mar 12;11(1):5871 |
| 2 | J:310856 Almubarak A, Lavy R, Srnic N, Hu Y, Maripuri DP, Kume T, Berry FB, Loss of Foxc1 and Foxc2 function in chondroprogenitor cells disrupts endochondral ossification. J Biol Chem. 2021 Jul 29;297(3):101020 |
| 1 | J:353623 Almubarak A, Zhang Q, Zhang CH, Abdelwahab N, Kume T, Lassar AB, Berry FB, FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton. Development. 2024 Aug 15;151(16) |
| 2 | J:309392 Amano K, Densmore MJ, Lanske B, Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation. J Bone Miner Res. 2015 Dec;30(12):2262-72 |
| 4* | J:198100 Andreeva V, Cardarelli J, Yelick PC, Rb1 mRNA expression in developing mouse teeth. Gene Expr Patterns. 2012 Mar-Apr;12(3-4):130-5 |
| 5 | J:326693 Angelozzi M, Pellegrino da Silva R, Gonzalez MV, Lefebvre V, Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors. Cell Rep. 2022 Jul 12;40(2):111045 |
| 1 | J:136394 Anthwal N, Chai Y, Tucker AS, The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary. Dev Dyn. 2008 Jun;237(6):1604-13 |
| 4 | J:91667 Antonopoulou I, Mavrogiannis LA, Wilkie AO, Morriss-Kay GM, Alx4 and Msx2 play phenotypically similar and additive roles in skull vault differentiation. J Anat. 2004 Jun;204(6):487-99 |
| 1* | J:138140 Aqeilan RI, Hassan MQ, de Bruin A, Hagan JP, Volinia S, Palumbo T, Hussain S, Lee SH, Gaur T, Stein GS, Lian JB, Croce CM, The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. J Biol Chem. 2008 Aug 1;283(31):21629-39 |
| 1 | J:119152 Arnold MA, Kim Y, Czubryt MP, Phan D, McAnally J, Qi X, Shelton JM, Richardson JA, Bassel-Duby R, Olson EN, MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell. 2007 Mar;12(3):377-89 |
| 2 | J:170583 Baek JA, Lan Y, Liu H, Maltby KM, Mishina Y, Jiang R, Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011 Feb 15;350(2):520-31 |
| 2 | J:152830 Balic A, Adams D, Mina M, Prx1 and Prx2 cooperatively regulate the morphogenesis of the medial region of the mandibular process. Dev Dyn. 2009 Sep 23;238(10):2599-2613 |
| 1 | J:118257 Bandyopadhyay A, Tsuji K, Cox K, Harfe BD, Rosen V, Tabin CJ, Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis. PLoS Genet. 2006 Dec 22;2(12):e216 |
| 1 | J:87136 Barbieri O, Astigiano S, Morini M, Tavella S, Schito A, Corsi A, Di Martino D, Bianco P, Cancedda R, Garofalo S, Depletion of cartilage collagen fibrils in mice carrying a dominant negative Col2a1 transgene affects chondrocyte differentiation. Am J Physiol Cell Physiol. 2003 Dec;285(6):C1504-12 |
| 4 | J:173619 Barron F, Woods C, Kuhn K, Bishop J, Howard MJ, Clouthier DE, Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis. Development. 2011 Jun;138(11):2249-59 |
| 1 | J:316273 Bashur LA, Chen D, Chen Z, Liang B, Pardi R, Murakami S, Zhou G, Loss of jab1 in osteochondral progenitor cells severely impairs embryonic limb development in mice. J Cell Physiol. 2014 Nov;229(11):1607-17 |
| 1 | J:224290 Bauer O, Sharir A, Kimura A, Hantisteanu S, Takeda S, Groner Y, Loss of osteoblast Runx3 produces severe congenital osteopenia. Mol Cell Biol. 2015 Apr;35(7):1097-109 |
| 1 | J:217339 Beiser KU, Glaser A, Kleinschmidt K, Scholl I, Roth R, Li L, Gretz N, Mechtersheimer G, Karperien M, Marchini A, Richter W, Rappold GA, Identification of novel SHOX target genes in the developing limb using a transgenic mouse model. PLoS One. 2014;9(6):e98543 |
| 5 | J:90056 Bialek P, Kern B, Yang X, Schrock M, Sosic D, Hong N, Wu H, Yu K, Ornitz DM, Olson EN, Justice MJ, Karsenty G, A twist code determines the onset of osteoblast differentiation. Dev Cell. 2004 Mar;6(3):423-35 |
| 1 | J:150764 Bildsoe H, Loebel DA, Jones VJ, Chen YT, Behringer RR, Tam PP, Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo. Dev Biol. 2009 Jul 15;331(2):176-88 |
| 1 | J:83660 Bobola N, Carapuco M, Ohnemus S, Kanzler B, Leibbrandt A, Neubuser A, Drouin J, Mallo M, Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1. Development. 2003 Aug;130(15):3403-14 |
| 1 | J:316302 Bosch PJ, Fuller LC, Weiner JA, An essential role for the nuclear protein Akirin2 in mouse limb interdigital tissue regression. Sci Rep. 2018 Aug 16;8(1):12240 |
| 1 | J:310741 Briot A, Jaroszewicz A, Warren CM, Lu J, Touma M, Rudat C, Hofmann JJ, Airik R, Weinmaster G, Lyons K, Wang Y, Kispert A, Pellegrini M, Iruela-Arispe ML, Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. Dev Cell. 2014 Dec 22;31(6):707-21 |
| 1* | J:142800 Brunskill EW, Aronow BJ, Georgas K, Rumballe B, Valerius MT, Aronow J, Kaimal V, Jegga AG, Yu J, Grimmond S, McMahon AP, Patterson LT, Little MH, Potter SS, Atlas of gene expression in the developing kidney at microanatomic resolution. (Erratum: Dev Cell 2009; 16:482). Dev Cell. 2008 Nov;15(5):781-91 |
| 1 | J:239074 Cai H, Liu A, Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14751-14756 |
| 1 | J:209730 Cardelli M, Zirngibl RA, Boetto JF, McKenzie KP, Troy TC, Turksen K, Aubin JE, Cartilage-specific overexpression of ERRgamma results in Chondrodysplasia and reduced chondrocyte proliferation. PLoS One. 2013;8(12):e81511 |
| 4* | J:231581 Cesario JM, Almaidhan AA, Jeong J, Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development. Gene Expr Patterns. 2016 Mar;20(2):111-9 |
| 4* | J:267540 Cesario JM, Landin Malt A, Chung JU, Khairallah MP, Dasgupta K, Asam K, Deacon LJ, Choi V, Almaidhan AA, Darwiche NA, Kim J, Johnson RL, Jeong J, Anti-osteogenic function of a LIM-homeodomain transcription factor LMX1B is essential to early patterning of the calvaria. Dev Biol. 2018 Nov 15;443(2):103-116 |
| 4 | J:181527 Chaible LM, Sanches DS, Cogliati B, Mennecier G, Dagli ML, Delayed osteoblastic differentiation and bone development in Cx43 knockout mice. Toxicol Pathol. 2011 Dec;39(7):1046-55 |
| 1 | J:185530 Chan KM, Wong HL, Jin G, Liu B, Cao R, Cao Y, Lehti K, Tryggvason K, Zhou Z, MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis. Dev Cell. 2012 Jun 12;22(6):1176-90 |
| 1 | J:238545 Chandler RL, Chandler KJ, McFarland KA, Mortlock DP, Bmp2 transcription in osteoblast progenitors is regulated by a distant 3' enhancer located 156.3 kilobases from the promoter. Mol Cell Biol. 2007 Apr;27(8):2934-51 |
| 3 | J:168154 Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T, Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-beta and Runx2 in bone is required for hearing. EMBO Rep. 2010 Oct;11(10):765-71 |
| 1 | J:325251 Chen A, Liao S, Cheng M, Ma K, Wu L, Lai Y, Qiu X, Yang J, Xu J, Hao S, Wang X, Lu H, Chen X, Liu X, Huang X, Li Z, Hong Y, Jiang Y, Peng J, Liu S, Shen M, Liu C, Li Q, Yuan Y, Wei X, Zheng H, Feng W, Wang Z, Liu Y, Wang Z, Yang Y, Xiang H, Han L, Qin B, Guo P, Lai G, Munoz-Canoves P, Maxwell PH, Thiery JP, Wu QF, Zhao F, Chen B, Li M, Dai X, Wang S, Kuang H, Hui J, Wang L, Fei JF, Wang O, Wei X, Lu H, Wang B, Liu S, Gu Y, Ni M, Zhang W, Mu F, Yin Y, Yang H, Lisby M, Cornall RJ, Mulder J, Uhlen M, Esteban MA, Li Y, Liu L, Xu X, Wang J, Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays. Cell. 2022 May 12;185(10):1777-1792.e21 |
| 1 | J:283477 Chen D, Bashur LA, Liang B, Panattoni M, Tamai K, Pardi R, Zhou G, The transcriptional co-regulator Jab1 is crucial for chondrocyte differentiation in vivo. J Cell Sci. 2013 Jan 1;126(Pt 1):234-43 |
| 2* | J:310847 Chen H, Ghori-Javed FY, Rashid H, Adhami MD, Serra R, Gutierrez SE, Javed A, Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation. J Bone Miner Res. 2014 Dec;29(12):2653-65 |
| 1 | J:269614 Chen H, Guo S, Xia Y, Yuan L, Lu M, Zhou M, Fang M, Meng L, Xiao Z, Ma J, The role of Rho-GEF Trio in regulating tooth root development through the p38 MAPK pathway. Exp Cell Res. 2018 Nov 15;372(2):158-167 |
| 2 | J:208766 Chen J, Tu X, Esen E, Joeng KS, Lin C, Arbeit JM, Ruegg MA, Hall MN, Ma L, Long F, WNT7B promotes bone formation in part through mTORC1. PLoS Genet. 2014 Jan;10(1):e1004145 |
| 2 | J:224562 Chen Q, Sinha K, Deng JM, Yasuda H, Krahe R, Behringer RR, de Crombrugghe B, Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation. J Bone Miner Res. 2015 Sep;30(9):1608-17 |
| 2 | J:223357 Chen Q, Zhang L, de Crombrugghe B, Krahe R, Mesenchyme-specific overexpression of nucleolar protein 66 in mice inhibits skeletal growth and bone formation. FASEB J. 2015 Jun;29(6):2555-65 |
| 5* | J:296805 Chen S, Gluhak-Heinrich J, Wang YH, Wu YM, Chuang HH, Chen L, Yuan GH, Dong J, Gay I, MacDougall M, Runx2, osx, and dspp in tooth development. J Dent Res. 2009 Oct;88(10):904-9 |
| 1* | J:311442 Chen W, Sheng P, Huang Z, Meng F, Kang Y, Huang G, Zhang Z, Liao W, Zhang Z, MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression. Int J Mol Sci. 2016 Aug 23;17(9):1377 |
| 1* | J:211539 Chen Y, Gridley T, Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis. J Bone Miner Res. 2013 Jun;28(6):1412-21 |
| 4* | J:329220 Chen Y, Wu J, Zhang S, Gao W, Liao Z, Zhou T, Li Y, Su D, Liu H, Yang X, Su P, Xu C, Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1alpha-glycolysis axis. Cell Death Dis. 2022 Sep 20;13(9):803 |
| 2 | J:232617 Chen Z, Yue SX, Zhou G, Greenfield EM, Murakami S, ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formation. J Bone Miner Res. 2015 May;30(5):765-74 |
| 5 | J:327334 Choi KY, Lee SW, Park MH, Bae YC, Shin HI, Nam S, Kim YJ, Kim HJ, Ryoo HM, Spatio-temporal expression patterns of Runx2 isoforms in early skeletogenesis. Exp Mol Med. 2002 Dec 31;34(6):426-33 |
| 1 | J:81798 Chuang PT, Kawcak T, McMahon AP, Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev. 2003 Feb 1;17(3):342-7 |
| 1* | J:166611 Chung IH, Han J, Iwata J, Chai Y, Msx1 and Dlx5 function synergistically to regulate frontal bone development. Genesis. 2010 Nov;48(11):645-55 |
| 1 | J:187424 Clendenning DE, Mortlock DP, The BMP ligand Gdf6 prevents differentiation of coronal suture mesenchyme in early cranial development. PLoS One. 2012;7(5):e36789 |
| 4 | J:107668 Cobb J, Dierich A, Huss-Garcia Y, Duboule D, A mouse model for human short-stature syndromes identifies Shox2 as an upstream regulator of Runx2 during long-bone development. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4511-5 |
| 1* | J:66902 Colnot C, Sidhu SS, Balmain N, Poirier F, Uncoupling of chondrocyte death and vascular invasion in mouse galectin 3 null mutant bones. Dev Biol. 2001 Jan 1;229(1):203-14 |
| 1 | J:217906 Cooley MA, Harikrishnan K, Oppel JA, Miler SF, Barth JL, Haycraft CJ, Reddy SV, Scott Argraves W, Fibulin-1 is required for bone formation and Bmp-2-mediated induction of Osterix. Bone. 2014 Dec;69:30-8 |
| 2* | J:124124 Core N, Caubit X, Metchat A, Boned A, Djabali M, Fasano L, Tshz1 is required for axial skeleton, soft palate and middle ear development in mice. Dev Biol. 2007 Aug 15;308(2):407-20 |
| 1* | J:152211 Coulpier F, Le Crom S, Maro GS, Manent J, Giovannini M, Maciorowski Z, Fischer A, Gessler M, Charnay P, Topilko P, Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Glia. 2009 Oct;57(13):1450-7 |
| 2 | J:293199 Crespo-Enriquez I, Hodgson T, Zakaria S, Cadoni E, Shah M, Allen S, Al-Khishali A, Mao Y, Yiu A, Petzold J, Villagomez-Olea G, Pitsillides AA, Irvine KD, Francis-West P, Dchs1-Fat4 regulation of osteogenic differentiation in mouse. Development. 2019 Jul 29;146(14):dev176776 |
| 9 | J:54817 D'Souza RN, Aberg T, Gaikwad J, Cavender A, Owen M, Karsenty G, Thesleff I, Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development. 1999 JUL;126(13):2911-2920 |
| 3* | J:89221 Dacquin R, Mee PJ, Kawaguchi J, Olmsted-Davis EA, Gallagher JA, Nichols J, Lee K, Karsenty G, Smith A, Knock-in of nuclear localised beta-galactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar. Dev Dyn. 2004 Apr;229(4):826-34 |
| 1 | J:282348 Dasgupta K, Chung JU, Asam K, Jeong J, Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling. Dev Biol. 2019 Nov 15;455(2):434-448 |
| 2 | J:304767 Dash S, Bhatt S, Falcon KT, Sandell LL, Trainor PA, Med23 Regulates Sox9 Expression during Craniofacial Development. J Dent Res. 2021 Apr;100(4):406-414 |
| 2 | J:98427 Day TF, Guo X, Garrett-Beal L, Yang Y, Wnt/beta-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis. Dev Cell. 2005 May;8(5):739-50 |
| 3 | J:146483 de Frutos CA, Dacquin R, Vega S, Jurdic P, Machuca-Gayet I, Nieto MA, Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation. EMBO J. 2009 Mar 18;28(6):686-96 |
| 4 | J:184618 Deckelbaum RA, Holmes G, Zhao Z, Tong C, Basilico C, Loomis CA, Regulation of cranial morphogenesis and cell fate at the neural crest-mesoderm boundary by engrailed 1. Development. 2012 Apr;139(7):1346-58 |
| 1 | J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41 |
| 1* | J:111160 Di Giacomo G, Koss M, Capellini TD, Brendolan A, Popperl H, Selleri L, Spatio-temporal expression of Pbx3 during mouse organogenesis. Gene Expr Patterns. 2006 Oct;6(7):747-757 |
| 1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
| 1 | J:353622 Dinesh NEH, Baratang N, Rosseau J, Mohapatra R, Li L, Mahalingam R, Tiedemann K, Campeau PM, Reinhardt DP, Fibronectin Isoforms Promote Postnatal Skeletal Development. Matrix Biol. 2024 Aug 17; |
| 4 | J:186281 Ding M, Lu Y, Abbassi S, Li F, Li X, Song Y, Geoffroy V, Im HJ, Zheng Q, Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal development. J Cell Physiol. 2012 Oct;227(10):3446-56 |
| 3* | J:317089 Du J, Wang Q, Yang P, Wang X, FHL2 mediates tooth development and human dental pulp cell differentiation into odontoblasts, partially by interacting with Runx2. J Mol Histol. 2016 Apr;47(2):195-202 |
| 11* | J:40781 Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G, Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 1997 May 30;89(5):747-54 |
| 4 | J:160718 Dykes IM, Lanier J, Eng SR, Turner EE, Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation. Neural Dev. 2010;5:3 |
| 2 | J:127545 Engleka KA, Wu M, Zhang M, Antonucci NB, Epstein JA, Menin is required in cranial neural crest for palatogenesis and perinatal viability. Dev Biol. 2007 Nov 15;311(2):524-37 |
| 1* | J:61381 Enomoto H, Enomoto-Iwamoto M, Iwamoto M, Nomura S, Himeno M, Kitamura Y, Kishimoto T, Komori T, Cbfa1 is a positive regulatory factor in chondrocyte maturation. J Biol Chem. 2000 Mar 24;275(12):8695-702 |
| 2 | J:92433 Eswarakumar VP, Horowitz MC, Locklin R, Morriss-Kay GM, Lonai P, A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12555-60 |
| 1* | J:77698 Eswarakumar VP, Monsonego-Ornan E, Pines M, Antonopoulou I, Morriss-Kay GM, Lonai P, The IIIc alternative of Fgfr2 is a positive regulator of bone formation. Development. 2002 Aug 15;129(16):3783-93 |
| 1 | J:294823 Fabik J, Kovacova K, Kozmik Z, Machon O, Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway. Biol Open. 2020 Jul 2;9(6):bio052043 |
| 3 | J:330128 Fabik J, Psutkova V, Machon O, Meis2 controls skeletal formation in the hyoid region. Front Cell Dev Biol. 2022;10:951063 |
| 1 | J:267941 Fakhouri WD, Metwalli K, Naji A, Bakhiet S, Quispe-Salcedo A, Nitschke L, Kousa YA, Schutte BC, Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development. Sci Rep. 2017 Aug 2;7(1):7129 |
| 4* | J:111429 Feng JQ, Zhang J, Dallas SL, Lu Y, Chen S, Tan X, Owen M, Harris SE, MacDougall M, Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. J Bone Miner Res. 2002 Oct;17(10):1822-31 |
| 2 | J:347134 Feng X, Molteni H, Gregory M, Lanza J, Polsani N, Gupta I, Wyetzner R, Hawkins MB, Holmes G, Hopyan S, Harris MP, Atit RP, Apical expansion of calvarial osteoblasts and suture patency is dependent on fibronectin cues. Development. 2024 Apr 1;151(7):dev202371 |
| 6* | J:57820 Ferguson C, Alpern E, Miclau T, Helms JA, Does adult fracture repair recapitulate embryonic skeletal formation?. Mech Dev. 1999 Sep;87(1-2):57-66 |
| 5 | J:250976 Ferrari N, Riggio AI, Mason S, McDonald L, King A, Higgins T, Rosewell I, Neil JC, Smalley MJ, Sansom OJ, Morris J, Cameron ER, Blyth K, Runx2 contributes to the regenerative potential of the mammary epithelium. Sci Rep. 2015 Oct 22;5:15658 |
| 1 | J:133699 Fischer A, Steidl C, Wagner TU, Lang E, Jakob PM, Friedl P, Knobeloch KP, Gessler M, Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res. 2007 Mar 30;100(6):856-63 |
| 6 | J:144188 Funato N, Chapman SL, McKee MD, Funato H, Morris JA, Shelton JM, Richardson JA, Yanagisawa H, Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2. Development. 2009 Feb;136(4):615-25 |
| 3 | J:217210 Funato N, Nakamura M, Richardson JA, Srivastava D, Yanagisawa H, Loss of Tbx1 induces bone phenotypes similar to cleidocranial dysplasia. Hum Mol Genet. 2015 Jan 15;24(2):424-35 |
| 1 | J:347133 Funato N, Srivastava D, Shibata S, Yanagisawa H, TBX1 Regulates Chondrocyte Maturation in the Spheno-occipital Synchondrosis. J Dent Res. 2020 Sep;99(10):1182-1191 |
| 1 | J:167570 Funato Y, Terabayashi T, Sakamoto R, Okuzaki D, Ichise H, Nojima H, Yoshida N, Miki H, Nucleoredoxin sustains Wnt/beta-catenin signaling by retaining a pool of inactive dishevelled protein. Curr Biol. 2010 Nov 9;20(21):1945-52 |
| 1 | J:288683 Gacem N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J, Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N, ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. Nat Commun. 2020 Jan 10;11(1):198 |
| 2* | J:203540 Gadi J, Jung SH, Lee MJ, Jami A, Ruthala K, Kim KM, Cho NH, Jung HS, Kim CH, Lim SK, The transcription factor protein Sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors. J Biol Chem. 2013 Aug 30;288(35):25400-13 |
| 1 | J:159210 Galli A, Robay D, Osterwalder M, Bao X, Benazet JD, Tariq M, Paro R, Mackem S, Zeller R, Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet. 2010;6(4):e1000901 |
| 4* | J:86790 Gitler AD, Lu MM, Jiang YQ, Epstein JA, Gruber PJ, Molecular markers of cardiac endocardial cushion development. Dev Dyn. 2003 Dec;228(4):643-50 |
| 4 | J:98430 Glass DA 2nd, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G, Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005 May;8(5):751-64 |
| 3* | J:132568 Glotzer DJ, Zelzer E, Olsen BR, Impaired skin and hair follicle development in Runx2 deficient mice. Dev Biol. 2008 Mar 15;315(2):459-73 |
| 2* | J:236374 Goldie SJ, Arhatari BD, Anderson P, Auden A, Partridge DD, Jane SM, Dworkin S, Mice lacking the conserved transcription factor Grainyhead-like 3 (Grhl3) display increased apposition of the frontal and parietal bones during embryonic development. BMC Dev Biol. 2016 Oct 18;16(1):37 |
| 3* | J:70829 Gollner H, Dani C, Phillips B, Philipsen S, Suske G, Impaired ossification in mice lacking the transcription factor Sp3. Mech Dev. 2001 Aug;106(1-2):77-83 |
| 1 | J:199943 Golovchenko S, Hattori T, Hartmann C, Gebhardt M, Gebhard S, Hess A, Pausch F, Schlund B, von der Mark K, Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation. Bone. 2013 Jul;55(1):102-12 |
| 1 | J:214984 Gonzalez-Martin MC, Mallo M, Ros MA, Long bone development requires a threshold of Hox function. Dev Biol. 2014 Aug 15;392(2):454-65 |
| 2 | J:189063 Goodnough LH, Chang AT, Treloar C, Yang J, Scacheri PC, Atit RP, Twist1 mediates repression of chondrogenesis by beta-catenin to promote cranial bone progenitor specification. Development. 2012 Dec;139(23):4428-38 |
| 1 | J:229313 Goodnough LH, Dinuoscio GJ, Atit RP, Twist1 contributes to cranial bone initiation and dermal condensation by maintaining wnt signaling responsiveness. Dev Dyn. 2016 Feb;245(2):144-56 |
| 4 | J:226667 Goodnough LH, Dinuoscio GJ, Ferguson JW, Williams T, Lang RA, Atit RP, Distinct requirements for cranial ectoderm and mesenchyme-derived wnts in specification and differentiation of osteoblast and dermal progenitors. PLoS Genet. 2014 Feb;10(2):e1004152 |
| 5 | J:74145 Gori F, Schipani E, Demay MB, Fibromodulin is expressed by both chondrocytes and osteoblasts during fetal bone development. J Cell Biochem. 2001 Apr 2-27;82(1):46-57 |
| 1 | J:295485 Goss M, Socorro M, Monier D, Verdelis K, Napierala D, Trps1 transcription factor regulates mineralization of dental tissues and proliferation of tooth organ cells. Mol Genet Metab. 2019 Apr;126(4):504-512 |
| 1 | J:107239 Govindarajan V, Overbeek PA, FGF9 can induce endochondral ossification in cranial mesenchyme. BMC Dev Biol. 2006;6:7 |
| 1 | J:178485 Gradus B, Alon I, Hornstein E, miRNAs control tracheal chondrocyte differentiation. Dev Biol. 2011 Dec 1;360(1):58-65 |
| 3* | J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257 |
| 1 | J:352713 Gregoire EP, De Cian MC, Migale R, Perea-Gomez A, Schaub S, Bellido-Carreras N, Stevant I, Mayere C, Neirijnck Y, Loubat A, Rivaud P, Sopena ML, Lachambre S, Linssen MM, Hohenstein P, Lovell-Badge R, Nef S, Chalmel F, Schedl A, Chaboissier MC, The -KTS splice variant of WT1 is essential for ovarian determination in mice. Science. 2023 Nov 3;382(6670):600-606 |
| 2 | J:191689 Gross S, Krause Y, Wuelling M, Vortkamp A, Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in mice. PLoS One. 2012;7(8):e43553 |
| 3* | J:138379 Gu S, Wei N, Yu L, Fei J, Chen Y, Shox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice. Mech Dev. 2008 Aug;125(8):729-42 |
| 1* | J:134348 Gu S, Wei N, Yu X, Jiang Y, Fei J, Chen Y, Mice with an anterior cleft of the palate survive neonatal lethality. Dev Dyn. 2008 May;237(5):1509-16 |
| 1* | J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004; |
| 1 | J:234748 Guemes M, Garcia AJ, Rigueur D, Runke S, Wang W, Zhao G, Mayorga VH, Atti E, Tetradis S, Peault B, Lyons K, Miranda-Carboni GA, Krum SA, GATA4 is essential for bone mineralization via ERalpha and TGFbeta/BMP pathways. J Bone Miner Res. 2014 Dec;29(12):2676-87 |
| 1 | J:199282 Gunschmann C, Stachelscheid H, Akyuz MD, Schmitz A, Missero C, Bruning JC, Niessen CM, Insulin/IGF-1 Controls Epidermal Morphogenesis via Regulation of FoxO-Mediated p63 Inhibition. Dev Cell. 2013 Jul 29;26(2):176-87 |
| 7* | J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85 |
| 1* | J:306057 Guo L, Iida A, Bhavani GS, Gowrishankar K, Wang Z, Xue JY, Wang J, Miyake N, Matsumoto N, Hasegawa T, Iizuka Y, Matsuda M, Nakashima T, Takechi M, Iseki S, Yambe S, Nishimura G, Koseki H, Shukunami C, Girisha KM, Ikegawa S, Deficiency of TMEM53 causes a previously unknown sclerosing bone disorder by dysregulation of BMP-SMAD signaling. Nat Commun. 2021 Apr 6;12(1):2046 |
| 1 | J:275314 Guo S, Zhang Y, Zhou T, Wang D, Weng Y, Wang L, Ma J, Role of GATA binding protein 4 (GATA4) in the regulation of tooth development via GNAI3. Sci Rep. 2017 May 8;7(1):1534 |
| 2* | J:323190 Guo T, Han X, He J, Feng J, Jing J, Janeckova E, Lei J, Ho TV, Xu J, Chai Y, KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. Elife. 2022 Feb 25;11:e74595 |
| 2* | J:93028 Guo X, Day TF, Jiang X, Garrett-Beal L, Topol L, Yang Y, Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. Genes Dev. 2004 Oct 1;18(19):2404-17 |
| 2 | J:150187 Guo X, Mak KK, Taketo MM, Yang Y, The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. PLoS One. 2009;4(6):e6067 |
| 2 | J:321579 Ha N, Sun J, Bian Q, Wu D, Wang X, Hdac4 Regulates the Proliferation of Neural Crest-Derived Osteoblasts During Murine Craniofacial Development. Front Physiol. 2022;13:819619 |
| 2* | J:125119 Han J, Ishii M, Bringas P Jr, Maas RL, Maxson RE Jr, Chai Y, Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development. Mech Dev. 2007 Sep-Oct;124(9-10):729-45 |
| 3 | J:300927 Han X, Feng J, Guo T, Loh YE, Yuan Y, Ho TV, Cho CK, Li J, Jing J, Janeckova E, He J, Pei F, Bi J, Song B, Chai Y, Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis. Elife. 2021 Jan 22;10:e62387 |
| 1 | J:287734 Harada M, Akita K, Mouse fibroblast growth factor 9 N143T mutation leads to wide chondrogenic condensation of long bones. Histochem Cell Biol. 2020 Apr;153(4):215-223 |
| 2 | J:146802 Harada M, Murakami H, Okawa A, Okimoto N, Hiraoka S, Nakahara T, Akasaka R, Shiraishi Y, Futatsugi N, Mizutani-Koseki Y, Kuroiwa A, Shirouzu M, Yokoyama S, Taiji M, Iseki S, Ornitz DM, Koseki H, FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion. Nat Genet. 2009 Mar;41(3):289-98 |
| 4 | J:309374 Haraguchi R, Kitazawa R, Kitazawa S, Epigenetic regulation of Tbx18 gene expression during endochondral bone formation. Cell Tissue Res. 2015 Feb;359(2):503-512 |
| 1 | J:167738 Hardouin SN, Guo R, Romeo PH, Nagy A, Aubin JE, Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts. Development. 2011 Jan;138(2):203-13 |
| 1 | J:338183 Hariri H, Kose O, Bezdjian A, Daniel SJ, St-Arnaud R, USP53 Regulates Bone Homeostasis by Controlling Rankl Expression in Osteoblasts and Bone Marrow Adipocytes. J Bone Miner Res. 2023 Apr;38(4):578-596 |
| 2 | J:298641 Hasan MR, Takatalo M, Ma H, Rice R, Mustonen T, Rice DP, RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1. Elife. 2020 Jul 14;9:e55829 |
| 4 | J:159025 Hattori T, Muller C, Gebhard S, Bauer E, Pausch F, Schlund B, Bosl MR, Hess A, Surmann-Schmitt C, von der Mark H, de Crombrugghe B, von der Mark K, SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification. Development. 2010 Mar;137(6):901-11 |
| 3 | J:245766 He F, Soriano P, Dysregulated PDGFRalpha signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification. Development. 2017 Nov 01;144(21):4026-4036 |
| 1 | J:309228 Hill C, Jacobs B, Kennedy L, Rohde S, Zhou B, Baldwin S, Goudy S, Cranial neural crest deletion of VEGFa causes cleft palate with aberrant vascular and bone development. Cell Tissue Res. 2015 Sep;361(3):711-22 |
| 4* | J:218259 Hill CR, Jacobs BH, Brown CB, Barnett JV, Goudy SL, Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis. Dev Dyn. 2015 Feb;244(2):122-33 |
| 4 | J:207974 Hill CR, Yuasa M, Schoenecker J, Goudy SL, Jagged1 is essential for osteoblast development during maxillary ossification. Bone. 2014 May;62:10-21 |
| 3 | J:98426 Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C, Canonical Wnt/beta-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes. Dev Cell. 2005 May;8(5):727-38 |
| 1* | J:233142 Hilton MJ, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, Kronenberg HM, Teitelbaum SL, Ross FP, Kopan R, Long F, Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008 Mar;14(3):306-14 |
| 4 | J:114686 Hinoi E, Bialek P, Chen YT, Rached MT, Groner Y, Behringer RR, Ornitz DM, Karsenty G, Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes Dev. 2006 Nov 1;20(21):2937-42 |
| 1 | J:185618 Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI, Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification. J Biol Chem. 2012 May 18;287(21):17860-9 |
| 1 | J:217455 Holm E, Aubin JE, Hunter GK, Beier F, Goldberg HA, Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization. Bone. 2015 Feb;71:145-54 |
| 2 | J:316922 Holmes G, Gonzalez-Reiche AS, Saturne M, Motch Perrine SM, Zhou X, Borges AC, Shewale B, Richtsmeier JT, Zhang B, van Bakel H, Jabs EW, Single-cell analysis identifies a key role for Hhip in murine coronal suture development. Nat Commun. 2021 Dec 8;12(1):7132 |
| 1 | J:286051 Holmes G, O'Rourke C, Motch Perrine SM, Lu N, van Bakel H, Richtsmeier JT, Jabs EW, Midface and upper airway dysgenesis in FGFR2-related craniosynostosis involves multiple tissue-specific and cell cycle effects. Development. 2018 Oct 5;145(19):dev166488 |
| 2 | J:149465 Holmes G, Rothschild G, Roy UB, Deng CX, Mansukhani A, Basilico C, Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology. Dev Biol. 2009 Apr 15;328(2):273-84 |
| 3* | J:220612 Holmes G, van Bakel H, Zhou X, Losic B, Jabs EW, BCL11B expression in intramembranous osteogenesis during murine craniofacial suture development. Gene Expr Patterns. 2015 Jan;17(1):16-25 |
| 1 | J:267950 Holzman MA, Bergmann JM, Feldman M, Landry-Truchon K, Jeannotte L, Mansfield JH, HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system. Int J Dev Biol. 2018;62(11-12):785-796 |
| 2 | J:78856 Horner A, Shum L, Ayres JA, Nonaka K, Nuckolls GH, Fibroblast growth factor signaling regulates Dach1 expression during skeletal development. Dev Dyn. 2002 Sep;225(1):35-45 |
| 1 | J:237341 Houben A, Kostanova-Poliakova D, Weissenbock M, Graf J, Teufel S, von der Mark K, Hartmann C, beta-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis. Development. 2016 Oct 15;143(20):3826-3838 |
| 2 | J:255577 Hsu WH, Chen CM, You LR, COUP-TFII is required for morphogenesis of the neural crest-derived tympanic ring. Sci Rep. 2017 Sep 28;7(1):12386 |
| 1 | J:332137 Hu H, Duan Y, Wang K, Fu H, Liao Y, Wang T, Zhang Z, Kang F, Zhang B, Zhang H, Huo F, Yin Y, Chen G, Hu H, Cai H, Tian W, Li Z, Dental niche cells directly contribute to tooth reconstitution and morphogenesis. Cell Rep. 2022 Dec 6;41(10):111737 |
| 1 | J:94274 Hu H, Hilton MJ, Tu X, Yu K, Ornitz DM, Long F, Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development. 2005 Jan;132(1):49-60 |
| 1 | J:213355 Hu J, Lu J, Lian G, Zhang J, Hecht JL, Sheen VL, Filamin B regulates chondrocyte proliferation and differentiation through Cdk1 signaling. PLoS One. 2014;9(2):e89352 |
| 3 | J:231474 Hung IH, Schoenwolf GC, Lewandoski M, Ornitz DM, A combined series of Fgf9 and Fgf18 mutant alleles identifies unique and redundant roles in skeletal development. Dev Biol. 2016 Mar 1;411(1):72-84 |
| 1 | J:122952 Hung IH, Yu K, Lavine KJ, Ornitz DM, FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod. Dev Biol. 2007 Jul 15;307(2):300-13 |
| 1 | J:253972 Hwang SH, White KA, Somatilaka BN, Shelton JM, Richardson JA, Mukhopadhyay S, The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner. Development. 2018 Jan 8;145(1):dev154054 |
| 2* | J:292270 Ideno H, Nakashima K, Komatsu K, Araki R, Abe M, Arai Y, Kimura H, Shinkai Y, Tachibana M, Nifuji A, G9a is involved in the regulation of cranial bone formation through activation of Runx2 function during development. Bone. 2020 Aug;137:115332 |
| 2 | J:289698 Iezaki T, Horie T, Fukasawa K, Kitabatake M, Nakamura Y, Park G, Onishi Y, Ozaki K, Kanayama T, Hiraiwa M, Kitaguchi Y, Kaneda K, Manabe T, Ishigaki Y, Ohno M, Hinoi E, Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis. Stem Cell Reports. 2018 Jul 10;11(1):228-241 |
| 1 | J:339059 Ihn HJ, Kim JA, Lim J, Nam SH, Hwang SH, Kim YK, Kim JY, Kim JE, Cho ES, Jiang R, Park EK, Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein. J Cell Physiol. 2021 Jan;236(1):480-488 |
| 1* | J:103991 Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, Zhao Y, Taniguchi N, Huang XL, Otu H, Wang H, Wang JF, Komiya S, Ducy P, Rahman MU, Flavell RA, Gravallese EM, Oettgen P, Libermann TA, Goldring MB, A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem. 2005 Nov 18;280(46):38544-55 |
| 3* | J:171508 Ikegami D, Akiyama H, Suzuki A, Nakamura T, Nakano T, Yoshikawa H, Tsumaki N, Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development. 2011 Apr;138(8):1507-19 |
| 6* | J:54095 Inada M, Yasui T, Nomura S, Miyake S, Deguchi K, Himeno M, Sato M, Yamagiwa H, Kimura T, Yasui N, Ochi T, Endo N, Kitamura Y, Kishimoto T, Komori T, Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn. 1999 Apr;214(4):279-90 |
| 3 | J:155543 Inose H, Ochi H, Kimura A, Fujita K, Xu R, Sato S, Iwasaki M, Sunamura S, Takeuchi Y, Fukumoto S, Saito K, Nakamura T, Siomi H, Ito H, Arai Y, Shinomiya K, Takeda S, A microRNA regulatory mechanism of osteoblast differentiation. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20794-9 |
| 2* | J:87044 Ishii M, Merrill AE, Chan YS, Gitelman I, Rice DP, Sucov HM, Maxson RE Jr, Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault. Development. 2003 Dec;130(24):6131-42 |
| 2* | J:219373 Islam MN, Itoh S, Yanagita T, Sumiyoshi K, Hayano S, Kuremoto K, Kurosaka H, Honjo T, Kawanabe N, Kamioka H, Sakai T, Ishimaru N, Taniuchi I, Yamashiro T, Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland. Dev Dyn. 2015 Mar;244(3):488-96 |
| 1 | J:153633 Ito T, Yadav N, Lee J, Furumatsu T, Yamashita S, Yoshida K, Taniguchi N, Hashimoto M, Tsuchiya M, Ozaki T, Lotz M, Bedford MT, Asahara H, Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC Dev Biol. 2009;9:47 |
| 2 | J:83260 Ivkovic S, Yoon BS, Popoff SN, Safadi FF, Libuda DE, Stephenson RC, Daluiski A, Lyons KM, Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development. 2003 Jun;130(12):2779-91 |
| 4 | J:191572 Iwasaki M, Piao J, Kimura A, Sato S, Inose H, Ochi H, Asou Y, Shinomiya K, Okawa A, Takeda S, Runx2 haploinsufficiency ameliorates the development of ossification of the posterior longitudinal ligament. PLoS One. 2012;7(8):e43372 |
| 6 | J:256071 Iyyanar PPR, Nazarali AJ, Hoxa2 Inhibits Bone Morphogenetic Protein Signaling during Osteogenic Differentiation of the Palatal Mesenchyme. Front Physiol. 2017;8:929 |
| 1 | J:119288 Jacob AL, Smith C, Partanen J, Ornitz DM, Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation. Dev Biol. 2006 Aug 15;296(2):315-28 |
| 5 | J:113301 James MJ, Jarvinen E, Wang XP, Thesleff I, Different roles of Runx2 during early neural crest-derived bone and tooth development. J Bone Miner Res. 2006 Jul;21(7):1034-44 |
| 1 | J:118173 Jarvinen E, Salazar-Ciudad I, Birchmeier W, Taketo MM, Jernvall J, Thesleff I, Continuous tooth generation in mouse is induced by activated epithelial Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18627-32 |
| 3 | J:258789 Jarvinen E, Shimomura-Kuroki J, Balic A, Jussila M, Thesleff I, Mesenchymal Wnt/beta-catenin signaling limits tooth number. Development. 2018 Feb 21;145(4):dev158048 |
| 2 | J:292597 Jarvis SE, Lee JE, Jewlal E, Barr K, Kelly GM, Laird DW, Willmore KE, Effects of reduced connexin43 function on skull development in the Cx43(I130T/+) mutant mouse that models oculodentodigital dysplasia. Bone. 2020 Jul;136:115365 |
| 4 | J:233766 Jiang Q, Qin X, Kawane T, Komori H, Matsuo Y, Taniuchi I, Ito K, Izumi S, Komori T, Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development. J Bone Miner Res. 2016 Jul;31(7):1391-404 |
| 1 | J:339746 Jin R, Zhang H, Lin C, Guo J, Zou W, Chen Z, Liu H, Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis. Exp Mol Med. 2023 Jan;55(1):69-80 |
| 3 | J:154905 Joeng KS, Long F, The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. Development. 2009 Dec;136(24):4177-85 |
| 2 | J:178499 Joeng KS, Schumacher CA, Zylstra-Diegel CR, Long F, Williams BO, Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo. Dev Biol. 2011 Nov 15;359(2):222-9 |
| 1 | J:182862 Jones GN, Pringle DR, Yin Z, Carlton MM, Powell KA, Weinstein MB, Toribio RE, La Perle KM, Kirschner LS, Neural crest-specific loss of Prkar1a causes perinatal lethality resulting from defects in intramembranous ossification. Mol Endocrinol. 2010 Aug;24(8):1559-68 |
| 2 | J:143588 Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y, BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 2008 Nov;135(22):3801-11 |
| 1* | J:156020 Kanamoto T, Mizuhashi K, Terada K, Minami T, Yoshikawa H, Furukawa T, Isolation and characterization of a novel plasma membrane protein, osteoblast induction factor (obif), associated with osteoblast differentiation. BMC Dev Biol. 2009;9:70 |
| 1* | J:99840 Kang JS, Alliston T, Delston R, Derynck R, Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J. 2005 Jul 20;24(14):2543-55 |
| 1 | J:149607 Kansara M, Tsang M, Kodjabachian L, Sims NA, Trivett MK, Ehrich M, Dobrovic A, Slavin J, Choong PF, Simmons PJ, Dawid IB, Thomas DM, Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J Clin Invest. 2009 Apr;119(4):837-51 |
| 2* | J:49163 Kanzler B, Kuschert SJ, Liu YH, Mallo M, Hoxa-2 restricts the chondrogenic domain and inhibits bone formation during development of the branchial area. Development. 1998 Jul;125(14):2587-97 |
| 4 | J:94393 Karreth F, Hoebertz A, Scheuch H, Eferl R, Wagner EF, The AP1 transcription factor Fra2 is required for efficient cartilage development. Development. 2004 Nov;131(22):5717-25 |
| 1 | J:226965 Kato K, Bhattaram P, Penzo-Mendez A, Gadi A, Lefebvre V, SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling. J Bone Miner Res. 2015 Sep;30(9):1560-71 |
| 4* | J:298035 Kelly NH, Huynh NPT, Guilak F, Single cell RNA-sequencing reveals cellular heterogeneity and trajectories of lineage specification during murine embryonic limb development. Matrix Biol. 2020 Jul;89:1-10 |
| 1 | J:127453 Kettunen P, Spencer-Dene B, Furmanek T, Kvinnsland IH, Dickson C, Thesleff I, Luukko K, Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. Mech Dev. 2007 Nov-Dec;124(11-12):868-83 |
| 1 | J:176975 Khavandgar Z, Poirier C, Clarke CJ, Li J, Wang N, McKee MD, Hannun YA, Murshed M, A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization. J Cell Biol. 2011 Jul 25;194(2):277-89 |
| 1* | J:161758 Kiefer SM, Robbins L, Barina A, Zhang Z, Rauchman M, SALL1 truncated protein expression in Townes-Brocks syndrome leads to ectopic expression of downstream genes. Hum Mutat. 2008 Sep;29(9):1133-40 |
| 3 | J:198327 Kim EJ, Cho SW, Shin JO, Lee MJ, Kim KS, Jung HS, Ihh and Runx2/Runx3 signaling interact to coordinate early chondrogenesis: a mouse model. PLoS One. 2013;8(2):e55296 |
| 9* | J:53540 Kim IS, Otto F, Zabel B, Mundlos S, Regulation of chondrocyte differentiation by Cbfa1. Mech Dev. 1999 Feb;80(2):159-70 |
| 2 | J:292609 Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O, Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JH, A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. Nat Commun. 2020 May 8;11(1):2289 |
| 3 | J:158761 Kimura A, Inose H, Yano F, Fujita K, Ikeda T, Sato S, Iwasaki M, Jinno T, Ae K, Fukumoto S, Takeuchi Y, Itoh H, Imamura T, Kawaguchi H, Chung UI, Martin JF, Iseki S, Shinomiya K, Takeda S, Runx1 and Runx2 cooperate during sternal morphogenesis. Development. 2010 Apr;137(7):1159-67 |
| 1 | J:143940 Kimura H, Kwan KM, Zhang Z, Deng JM, Darnay BG, Behringer RR, Nakamura T, de Crombrugghe B, Akiyama H, Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS One. 2008;3(9):e3174 |
| 4 | J:263685 Kitami K, Kitami M, Kaku M, Wang B, Komatsu Y, BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development. PLoS Genet. 2018 May;14(5):e1007340 |
| 1 | J:348423 Kitamura A, Yamamoto M, Hirouchi H, Watanabe G, Taniguchi S, Sekiya S, Ishizuka S, Jeong J, Higa K, Yamashita S, Abe S, Downregulation of SOX9 expression in developing entheses adjacent to intramembranous bone. PLoS One. 2024;19(5):e0301080 |
| 1* | J:222399 Kitazawa T, Fujisawa K, Narboux-Neme N, Arima Y, Kawamura Y, Inoue T, Wada Y, Kohro T, Aburatani H, Kodama T, Kim KS, Sato T, Uchijima Y, Maeda K, Miyagawa-Tomita S, Minoux M, Rijli FM, Levi G, Kurihara Y, Kurihara H, Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process. Dev Biol. 2015 Jun 15;402(2):162-74 |
| 7* | J:40783 Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K , Shimizu Y , Bronson RT , Gao YH , Inada M , Sato M , Okamoto R , Kitamura Y , Yoshiki S , Kishimoto T, Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 1997 May 30;89(5):755-64 |
| 1 | J:92212 Koziel L, Kunath M, Kelly OG, Vortkamp A, Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification. Dev Cell. 2004 Jun;6(6):801-13 |
| 3* | J:231594 Kumar M, Syed SM, Taketo MM, Tanwar PS, Epithelial Wnt/betacatenin signalling is essential for epididymal coiling. Dev Biol. 2016 Apr 15;412(2):234-49 |
| 1 | J:80669 Kundu M, Javed A, Jeon JP, Horner A, Shum L, Eckhaus M, Muenke M, Lian JB, Yang Y, Nuckolls GH, Stein GS, Liu PP, Cbfbeta interacts with Runx2 and has a critical role in bone development. Nat Genet. 2002 Dec;32(4):639-44 |
| 2 | J:288306 Kuriki M, Sato F, Arai HN, Sogabe M, Kaneko M, Kiyonari H, Kawakami K, Yoshimoto Y, Shukunami C, Sehara-Fujisawa A, Transient and lineage-restricted requirement of Ebf3 for sternum ossification. Development. 2020 May 12;147(9):dev186239 |
| 2 | J:224946 Kwon HJ, Park EK, Jia S, Liu H, Lan Y, Jiang R, Deletion of Osr2 Partially Rescues Tooth Development in Runx2 Mutant Mice. J Dent Res. 2015 Aug;94(8):1113-9 |
| 3 | J:233640 Kyrylkova K, Iwaniec UT, Philbrick KA, Leid M, BCL11B regulates sutural patency in the mouse craniofacial skeleton. Dev Biol. 2016 Jul 15;415(2):251-60 |
| 1 | J:202964 Lai LP, Lilley BN, Sanes JR, McMahon AP, Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19450-5 |
| 1 | J:127543 Lana-Elola E, Rice R, Grigoriadis AE, Rice DP, Cell fate specification during calvarial bone and suture development. Dev Biol. 2007 Nov 15;311(2):335-46 |
| 1* | J:308017 Langhans MT, Gao J, Tang Y, Wang B, Alexander P, Tuan RS, Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling. BMC Dev Biol. 2021 Jul 5;21(1):10 |
| 1* | J:294771 Lantz B, White C, Liu X, Wan Y, Gabriel G, Lo CWY, Szabo-Rogers HL, Finding the Unicorn, a New Mouse Model of Midfacial Clefting. Genes (Basel). 2020 Jan 11;11(1) |
| 1* | J:184934 Lee SH, Che X, Jeong JH, Choi JY, Lee YJ, Lee YH, Bae SC, Lee YM, Runx2 protein stabilizes hypoxia-inducible factor-1alpha through competition with von Hippel-Lindau protein (pVHL) and stimulates angiogenesis in growth plate hypertrophic chondrocytes. J Biol Chem. 2012 Apr 27;287(18):14760-71 |
| 2 | J:316198 Lei R, Zhang K, Liu K, Shao X, Ding Z, Wang F, Hong Y, Zhu M, Li H, Li H, Transferrin receptor facilitates TGF-beta and BMP signaling activation to control craniofacial morphogenesis. Cell Death Dis. 2016 Jun 30;7(6):e2282 |
| 2 | J:254756 Lei R, Zhang K, Wei Y, Chen M, Weinstein LS, Hong Y, Zhu M, Li H, Li H, G-Protein alpha-Subunit Gsalpha Is Required for Craniofacial Morphogenesis. PLoS One. 2016;11(2):e0147535 |
| 1 | J:178364 Lenton K, James AW, Manu A, Brugmann SA, Birker D, Nelson ER, Leucht P, Helms JA, Longaker MT, Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling. Genesis. 2011 Oct;49(10):784-96 |
| 2 | J:177991 Leung VY, Gao B, Leung KK, Melhado IG, Wynn SL, Au TY, Dung NW, Lau JY, Mak AC, Chan D, Cheah KS, SOX9 Governs Differentiation Stage-Specific Gene Expression in Growth Plate Chondrocytes via Direct Concomitant Transactivation and Repression. PLoS Genet. 2011 Nov;7(11):e1002356 |
| 6 | J:182649 Levi B, James AW, Nelson ER, Brugmann SA, Sorkin M, Manu A, Longaker MT, Role of Indian hedgehog signaling in palatal osteogenesis. Plast Reconstr Surg. 2011 Mar;127(3):1182-90 |
| 1 | J:243780 Li F, Fu G, Liu Y, Miao X, Li Y, Yang X, Zhang X, Yu D, Gan L, Qiu M, Chen Y, Zhang Z, Zhang Z, ISLET1-Dependent beta-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw. Mol Cell Biol. 2017 Apr 15;37(8) |
| 1 | J:320355 Li H, Zhao X, Yan X, Jessen WJ, Kim MO, Dombi E, Liu PP, Huang G, Wu J, Runx1 contributes to neurofibromatosis type 1 neurofibroma formation. Oncogene. 2016 Mar 17;35(11):1468-74 |
| 5 | J:245974 Li J, Cui Y, Xu J, Wang Q, Yang X, Li Y, Zhang X, Qiu M, Zhang Z, Zhang Z, Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development. J Biol Chem. 2017 Sep 22;292(38):15814-15825 |
| 2 | J:317557 Li X, Liu H, Gu S, Liu C, Sun C, Zheng Y, Chen Y, Replacing Shox2 with human SHOX leads to congenital disc degeneration of the temporomandibular joint in mice. Cell Tissue Res. 2014 Feb;355(2):345-54 |
| 1 | J:307236 Li Y, Yang S, Qin L, Yang S, TAZ is required for chondrogenesis and skeletal development. Cell Discov. 2021 Apr 20;7(1):26 |
| 2* | J:160257 Liakhovitskaia A, Lana-Elola E, Stamateris E, Rice DP, van 't Hof RJ, Medvinsky A, The essential requirement for Runx1 in the development of the sternum. Dev Biol. 2010 Apr 15;340(2):539-46 |
| 4 | J:319475 Liao C, Lu M, Hong Y, Mao C, Chen J, Ren C, Lin M, Chen W, Osteogenic and angiogenic profiles of the palatal process of the maxilla and the palatal process of the palatine bone. J Anat. 2022 Feb;240(2):385-397 |
| 3* | J:237528 Lilly AJ, Costa G, Largeot A, Fadlullah MZ, Lie-A-Ling M, Lacaud G, Kouskoff V, Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac. Development. 2016 Dec 01;143(23):4341-4351 |
| 1 | J:314657 Lin S, Zhang Q, Cao Z, Lu Y, Zhang H, Yan K, Liu Y, McKee MD, Qin C, Chen Z, Feng JQ, Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype. J Biol Chem. 2014 Aug 1;289(31):21533-43 |
| 1 | J:353576 Lin Y, Yang Q, Lin X, Liu X, Qian Y, Xu D, Cao N, Han X, Zhu Y, Hu W, He X, Yu Z, Kong X, Zhu L, Zhong Z, Liu K, Zhou B, Wang Y, Peng J, Zhu W, Wang J, Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation. Circulation. 2024 Feb 20;149(8):605-626 |
| 1 | J:306541 Lin YC, Niceta M, Muto V, Vona B, Pagnamenta AT, Maroofian R, Beetz C, van Duyvenvoorde H, Dentici ML, Lauffer P, Vallian S, Ciolfi A, Pizzi S, Bauer P, Gruning NM, Bellacchio E, Del Fattore A, Petrini S, Shaheen R, Tiosano D, Halloun R, Pode-Shakked B, Albayrak HM, Isik E, Wit JM, Dittrich M, Freire BL, Bertola DR, Jorge AAL, Barel O, Sabir AH, Al Tenaiji AMJ, Taji SM, Al-Sannaa N, Al-Abdulwahed H, Digilio MC, Irving M, Anikster Y, Bhavani GSL, Girisha KM, Haaf T, Taylor JC, Dallapiccola B, Alkuraya FS, Yang RB, Tartaglia M, SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling. Am J Hum Genet. 2021 Jan 7;108(1):115-133 |
| 2 | J:88635 Long F, Chung UI, Ohba S, McMahon J, Kronenberg HM, McMahon AP, Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development. 2004 Mar;131(6):1309-18 |
| 2 | J:196359 Lu Y, Abbassi S, Li F, Ding M, Wu G, Gu J, Zheng Q, Distinct function of P63 isoforms during embryonic skeletal development. Gene. 2013 May 1;519(2):251-9 |
| 2 | J:152843 Luo J, Zhou W, Zhou X, Li D, Weng J, Yi Z, Cho SG, Li C, Yi T, Wu X, Li XY, de Crombrugghe B, Hook M, Liu M, Regulation of bone formation and remodeling by G-protein-coupled receptor 48. Development. 2009 Aug;136(16):2747-56 |
| 1 | J:347800 Lv Y, Wang Q, Lin C, Zheng X, Zhang Y, Hu X, Overexpression of Fgf18 in cranial neural crest cells recapitulates Pierre Robin sequence in mice. Front Cell Dev Biol. 2024;12:1376814 |
| 3* | J:213450 Machida A, Okuhara S, Harada K, Iseki S, Difference in apical and basal growth of the frontal bone primordium in Foxc1(ch/ch) mice. Congenit Anom (Kyoto). 2014 Aug;54(3):172-7 |
| 4* | J:85738 MacLean HE, Kim JI, Glimcher MJ, Wang J, Kronenberg HM, Glimcher LH, Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development. Dev Biol. 2003 Oct 1;262(1):51-63 |
| 1 | J:244530 Maeda K, Enomoto A, Hara A, Asai N, Kobayashi T, Horinouchi A, Maruyama S, Ishikawa Y, Nishiyama T, Kiyoi H, Kato T, Ando K, Weng L, Mii S, Asai M, Mizutani Y, Watanabe O, Hirooka Y, Goto H, Takahashi M, Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells. Sci Rep. 2016 Feb 29;6:22288 |
| 3 | J:176467 Maeno T, Moriishi T, Yoshida CA, Komori H, Kanatani N, Izumi S, Takaoka K, Komori T, Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects. Bone. 2011 Oct;49(4):673-82 |
| 3* | J:74493 Maes C, Carmeliet P, Moermans K, Stockmans I, Smets N, Collen D, Bouillon R, Carmeliet G, Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF(164) and VEGF(188). Mech Dev. 2002 Feb;111(1-2):61-73 |
| 1 | J:156474 Maes C, Goossens S, Bartunkova S, Drogat B, Coenegrachts L, Stockmans I, Moermans K, Nyabi O, Haigh K, Naessens M, Haenebalcke L, Tuckermann JP, Tjwa M, Carmeliet P, Mandic V, David JP, Behrens A, Nagy A, Carmeliet G, Haigh JJ, Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J. 2010 Jan 20;29(2):424-41 |
| 1 | J:87618 Maes C, Stockmans I, Moermans K, Van Looveren R, Smets N, Carmeliet P, Bouillon R, Carmeliet G, Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J Clin Invest. 2004 Jan;113(2):188-99 |
| 1* | J:160674 Mai S, Wei K, Flenniken A, Adamson SL, Rossant J, Aubin JE, Gong SG, The missense mutation W290R in Fgfr2 causes developmental defects from aberrant IIIb and IIIc signaling. Dev Dyn. 2010 Jun;239(6):1888-900 |
| 1 | J:193853 Makino Y, Takahashi Y, Tanabe R, Tamamura Y, Watanabe T, Haraikawa M, Hamagaki M, Hata K, Kanno J, Yoneda T, Saga Y, Goseki-Sone M, Kaneko K, Yamaguchi A, Iimura T, Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: a model of spondylocostal dysostosis and spondylothoracic dysostosis. Bone. 2013 Mar;53(1):248-58 |
| 2 | J:339245 Maruyama T, Jiang M, Hsu W, Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development. J Bone Miner Res. 2013 May;28(5):1150-9 |
| 1 | J:152864 Matsunobu T, Torigoe K, Ishikawa M, de Vega S, Kulkarni AB, Iwamoto Y, Yamada Y, Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev Biol. 2009 Aug 15;332(2):325-38 |
| 2 | J:153980 Matsushita T, Chan YY, Kawanami A, Balmes G, Landreth GE, Murakami S, Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis. Mol Cell Biol. 2009 Nov;29(21):5843-57 |
| 1 | J:296737 Matsuura VKSK, Yoshida CA, Komori H, Sakane C, Yamana K, Jiang Q, Komori T, Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice. Int J Mol Sci. 2020 Apr 12;21(8):2682 |
| 1 | J:264139 Mead TJ, McCulloch DR, Ho JC, Du Y, Adams SM, Birk DE, Apte SS, The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification. JCI Insight. 2018 Apr 5;3(7) |
| 1 | J:151888 Mead TJ, Yutzey KE, Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14420-5 |
| 1* | J:186526 Michikami I, Fukushi T, Honma S, Yoshioka S, Itoh S, Muragaki Y, Kurisu K, Ooshima T, Wakisaka S, Abe M, Trps1 is necessary for normal temporomandibular joint development. Cell Tissue Res. 2012 Apr;348(1):131-40 |
| 1 | J:182340 Michikami I, Fukushi T, Tanaka M, Egusa H, Maeda Y, Ooshima T, Wakisaka S, Abe M, Kruppel-like factor 4 regulates membranous and endochondral ossification. Exp Cell Res. 2012 Feb 15;318(4):311-25 |
| 2 | J:149225 Miclea RL, Karperien M, Bosch CA, van der Horst G, van der Valk MA, Kobayashi T, Kronenberg HM, Rawadi G, Akcakaya P, Lowik CW, Fodde R, Wit JM, Robanus-Maandag EC, Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol. 2009;9:26 |
| 1* | J:153103 Mikura A, Okuhara S, Saito M, Ota M, Ueda K, Iseki S, Association of tenascin-W expression with mineralization in mouse calvarial development. Congenit Anom (Kyoto). 2009 Jun;49(2):77-84 |
| 3 | J:166753 Mirando AJ, Maruyama T, Fu J, Yu HM, Hsu W, beta-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis. BMC Dev Biol. 2010;10:116 |
| 2 | J:205339 Mis EK, Liem KF Jr, Kong Y, Schwartz NB, Domowicz M, Weatherbee SD, Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length. Dev Biol. 2014 Jan 1;385(1):67-82 |
| 1* | J:320853 Mitomo K, Yamaguchi A, Muramatsu T, Hypoplasia of medial pterygoid process in sphenoid bone relates to decreased mesenchymal cell proliferation in the Runx2-haploinsufficient cleidocranial dysplasia mouse model. Arch Oral Biol. 2022 Mar;135:105358 |
| 1* | J:280029 Mizutani Y, Kobayashi H, Iida T, Asai N, Masamune A, Hara A, Esaki N, Ushida K, Mii S, Shiraki Y, Ando K, Weng L, Ishihara S, Ponik SM, Conklin MW, Haga H, Nagasaka A, Miyata T, Matsuyama M, Kobayashi T, Fujii T, Yamada S, Yamaguchi J, Wang T, Woods SL, Worthley D, Shimamura T, Fujishiro M, Hirooka Y, Enomoto A, Takahashi M, Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis. Cancer Res. 2019 Oct 15;79(20):5367-5381 |
| 1 | J:327295 Mohamed FF, Ge C, Cowling RT, Lucas D, Hallett SA, Ono N, Binrayes AA, Greenberg B, Franceschi RT, The collagen receptor, discoidin domain receptor 2, functions in Gli1-positive skeletal progenitors and chondrocytes to control bone development. Bone Res. 2022 Feb 9;10(1):11 |
| 5 | J:173242 Moisan A, Rivera MN, Lotinun S, Akhavanfard S, Coffman EJ, Cook EB, Stoykova S, Mukherjee S, Schoonmaker JA, Burger A, Kim WJ, Kronenberg HM, Baron R, Haber DA, Bardeesy N, The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification. Dev Cell. 2011 May 17;20(5):583-96 |
| 1 | J:84790 Mori-Akiyama Y, Akiyama H, Rowitch DH, de Crombrugghe B, Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9360-5 |
| 2 | J:276880 Motch Perrine SM, Wu M, Stephens NB, Kriti D, van Bakel H, Jabs EW, Richtsmeier JT, Mandibular dysmorphology due to abnormal embryonic osteogenesis in FGFR2-related craniosynostosis mice. Dis Model Mech. 2019 May 30;12(5):dmm038513 |
| 2 | J:170647 Mundell NA, Labosky PA, Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates. Development. 2011 Feb;138(4):641-52 |
| 1 | J:344936 Musa RE, Lester KL, Quickstad G, Vardabasso S, Shumate TV, Salcido RT, Ge K, Shpargel KB, BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation. Development. 2024 Jan 15;151(2):dev202110 |
| 3 | J:316165 Nakamura E, Hata K, Takahata Y, Kurosaka H, Abe M, Abe T, Kihara M, Komori T, Kobayashi S, Murakami T, Inubushi T, Yamashiro T, Yamamoto S, Akiyama H, Kawaguchi M, Sakata N, Nishimura R, Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice. Commun Biol. 2021 Nov 3;4(1):1258 |
| 1* | J:74344 Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B, The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002 Jan 11;108(1):17-29 |
| 1 | J:160264 Nakatomi M, Wang XP, Key D, Lund JJ, Turbe-Doan A, Kist R, Aw A, Chen Y, Maas RL, Peters H, Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis. Dev Biol. 2010 Apr 15;340(2):438-49 |
| 2 | J:136877 Napierala D, Sam K, Morello R, Zheng Q, Munivez E, Shivdasani RA, Lee B, Uncoupling of chondrocyte differentiation and perichondrial mineralization underlies the skeletal dysplasia in tricho-rhino-phalangeal syndrome. Hum Mol Genet. 2008 Jul 15;17(14):2244-54 |
| 2* | J:179587 Nelson ER, Levi B, Sorkin M, James AW, Liu KJ, Quarto N, Longaker MT, Role of GSK-3beta in the osteogenic differentiation of palatal mesenchyme. PLoS One. 2011;6(10):e25847 |
| 1 | J:217206 Neufeld SJ, Wang F, Cobb J, Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb. Genetics. 2014 Nov;198(3):1117-26 |
| 1* | J:321553 Neupane S, Berardinelli SJ, Cameron DC, Grady RC, Komatsu DE, Percival CJ, Takeuchi M, Ito A, Liu TW, Nairn AV, Moremen KW, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development. Matrix Biol. 2022 Feb 12; |
| 1 | J:281436 Nicol B, Grimm SA, Chalmel F, Lecluze E, Pannetier M, Pailhoux E, Dupin-De-Beyssat E, Guiguen Y, Capel B, Yao HH, RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2. Nat Commun. 2019 Nov 11;10(1):5116 |
| 2* | J:171528 Nie X, Wang Q, Jiao K, Dicer activity in neural crest cells is essential for craniofacial organogenesis and pharyngeal arch artery morphogenesis. Mech Dev. 2011 Mar-Apr;128(3-4):200-7 |
| 1* | J:297164 Nie X, Zheng J, Cruciger M, Yang P, Mao JJ, mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics. Dev Biol. 2020 Nov 1;467(1-2):77-87 |
| 2 | J:263684 Nie X, Zheng J, Ricupero CL, He L, Jiao K, Mao JJ, mTOR acts as a pivotal signaling hub for neural crest cells during craniofacial development. PLoS Genet. 2018 Jul;14(7):e1007491 |
| 1 | J:165333 Nishikawa K, Nakashima T, Takeda S, Isogai M, Hamada M, Kimura A, Kodama T, Yamaguchi A, Owen MJ, Takahashi S, Takayanagi H, Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation. J Clin Invest. 2010 Oct 1;120(10):3455-65 |
| 1 | J:232190 Noda K, Kitami M, Kitami K, Kaku M, Komatsu Y, Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development. Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2589-97 |
| 2 | J:261902 Norrmen C, Figlia G, Pfistner P, Pereira JA, Bachofner S, Suter U, mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation. J Neurosci. 2018 May 16;38(20):4811-4828 |
| 1 | J:181485 Oh JH, Park SY, de Crombrugghe B, Kim JE, Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification. Biochem Biophys Res Commun. 2012 Feb 24;418(4):634-40 |
| 3 | J:90053 Ohazama A, Hu Y, Schmidt-Ullrich R, Cao Y, Scheidereit C, Karin M, Sharpe PT, A dual role for Ikk alpha in tooth development. Dev Cell. 2004 Feb;6(2):219-27 |
| 4 | J:75880 Ohbayashi N, Shibayama M, Kurotaki Y, Imanishi M, Fujimori T, Itoh N, Takada S, FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev. 2002 Apr 1;16(7):870-9 |
| 4* | J:319569 Ohira T, Spear D, Azimi N, Andreeva V, Yelick PC, Chemerin-ChemR23 signaling in tooth development. J Dent Res. 2012 Dec;91(12):1147-53 |
| 2 | J:140208 Oka K, Oka S, Hosokawa R, Bringas P Jr, Brockhoff HC 2nd, Nonaka K, Chai Y, TGF-beta mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible development. Dev Biol. 2008 Sep 15;321(2):303-9 |
| 1 | J:118794 Oka K, Oka S, Sasaki T, Ito Y, Bringas P Jr, Nonaka K, Chai Y, The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev Biol. 2007 Mar 1;303(1):391-404 |
| 2* | J:50937 Okada H, Watanabe T, Niki M, Takano H, Chiba N, Yanai N, Tani K, Hibino H, Asano S, Mucenski ML, Ito Y, Noda T, Satake M, AML1(-/-) embryos do not express certain hematopoiesis-related gene transcripts including those of the PU.1 gene. Oncogene. 1998 Nov 5;17(18):2287-93 |
| 1 | J:315498 Ookuma YF, Kiyoshima T, Kobayashi I, Nagata K, Wada H, Fujiwara H, Yamaza H, Nonaka K, Sakai H, Multiple functional involvement of thymosin beta-4 in tooth germ development. Histochem Cell Biol. 2013 Feb;139(2):355-70 |
| 6* | J:40784 Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR , Stamp GW , Beddington RS , Mundlos S , Olsen BR , Selby PB , Owen MJ, Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. 1997 May 30;89(5):765-71 |
| 1 | J:337005 Ozekin YH, O'Rourke R, Bates EA, Single cell sequencing of the mouse anterior palate reveals mesenchymal heterogeneity. Dev Dyn. 2023 Jun;252(6):713-727 |
| 2 | J:179841 Pacheco M, Valencia M, Caparros-Martin JA, Mulero F, Goodship JA, Ruiz-Perez VL, Evc works in chondrocytes and osteoblasts to regulate multiple aspects of growth plate development in the appendicular skeleton and cranial base. Bone. 2012 Jan;50(1):28-41 |
| 1* | J:265842 Palagano E, Zuccarini G, Prontera P, Borgatti R, Stangoni G, Elisei S, Mantero S, Menale C, Forlino A, Uva P, Oppo M, Vezzoni P, Villa A, Merlo GR, Sobacchi C, Mutations in the Neuroblastoma Amplified Sequence gene in a family affected by Acrofrontofacionasal Dysostosis type 1. Bone. 2018 Sep;114:125-136 |
| 4 | J:112504 Park MH, Shin HI, Choi JY, Nam SH, Kim YJ, Kim HJ, Ryoo HM, Differential expression patterns of Runx2 isoforms in cranial suture morphogenesis. J Bone Miner Res. 2001 May;16(5):885-92 |
| 1 | J:309481 Park NR, Lim KE, Han MS, Che X, Park CY, Kim JE, Taniuchi I, Bae SC, Choi JY, Core Binding Factor beta Plays a Critical Role During Chondrocyte Differentiation. J Cell Physiol. 2016 Jan;231(1):162-71 |
| 2 | J:258274 Patra D, DeLassus E, Mueller J, Abou-Ezzi G, Sandell LJ, Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice. Biol Open. 2018 Feb 22;7(2):bio032094 |
| 1 | J:135374 Patra D, Xing X, Davies S, Bryan J, Franz C, Hunziker EB, Sandell LJ, Site-1 protease is essential for endochondral bone formation in mice. J Cell Biol. 2007 Nov 19;179(4):687-700 |
| 2 | J:153100 Pauws E, Hoshino A, Bentley L, Prajapati S, Keller C, Hammond P, Martinez-Barbera JP, Moore GE, Stanier P, Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes. Hum Mol Genet. 2009 Nov 1;18(21):4171-9 |
| 1* | J:239525 Peskett E, Kumar S, Baird W, Jaiswal J, Li M, Patel P, Britto JA, Pauws E, Analysis of the Fgfr2C342Y mouse model shows condensation defects due to misregulation of Sox9 expression in prechondrocytic mesenchyme. Biol Open. 2017 Feb 15;6(2):223-231 |
| 2* | J:340391 Pina JO, Raju R, Roth DM, Winchester EW, Chattaraj P, Kidwai F, Faucz FR, Iben J, Mitra A, Campbell K, Fridell G, Esnault C, Cotney JL, Dale RK, D'Souza RN, Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis. Nat Commun. 2023 Sep 14;14(1):5687 |
| 1 | J:352719 Pina JO, Raju R, Roth DM, Winchester EW, Padilla C, Iben J, Faucz FR, Cotney JL, D'Souza RN, Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in Palatogenesis'. J Dent Res. 2024 Jun 23;:220345241256600 |
| 1* | J:214651 Pischon N, Maki JM, Weisshaupt P, Heng N, Palamakumbura AH, N'Guessan P, Ding A, Radlanski R, Renz H, Bronckers TA, Myllyharju J, Kielbassa AM, Kleber BM, Bernimoulin JP, Trackman PC, Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype. Calcif Tissue Int. 2009 Aug;85(2):119-26 |
| 1 | J:350324 Polsani N, Yung T, Thomas E, Phung-Rojas M, Gupta I, Denker J, Lau K, Feng X, Ibarra B, Hopyan S, Atit RP, Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion. Development. 2024 Jun 15;151(12):dev202596 |
| 1* | J:186534 Porntaveetus T, Ohazama A, Choi HY, Herz J, Sharpe PT, Wnt signaling in the murine diastema. Eur J Orthod. 2012 Aug;34(4):518-24 |
| 1 | J:209351 Prashar P, Yadav PS, Samarjeet F, Bandyopadhyay A, Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Dev Biol. 2014 May 15;389(2):192-207 |
| 1 | J:101361 Pratap J, Javed A, Languino LR, van Wijnen AJ, Stein JL, Stein GS, Lian JB, The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol. 2005 Oct;25(19):8581-91 |
| 1* | J:199462 Probst S, Zeller R, Zuniga A, The hedgehog target Vlk genetically interacts with Gli3 to regulate chondrocyte differentiation during mouse long bone development. Differentiation. 2013 Apr-Jun;85(4-5):121-30 |
| 3 | J:219841 Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi T, Taniuchi I, Ito K, Kawai Y, Rokutanda S, Izumi S, Komori T, Cbfb regulates bone development by stabilizing runx family proteins. J Bone Miner Res. 2015 Apr;30(4):706-14 |
| 5 | J:299239 Qin X, Jiang Q, Nagano K, Moriishi T, Miyazaki T, Komori H, Ito K, Mark KV, Sakane C, Kaneko H, Komori T, Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS Genet. 2020 Nov;16(11):e1009169 |
| 1 | J:335153 Qiu T, Huteckova B, Seppala M, Cobourne MT, Chen Z, Hovorakova M, Buchtova M, Tucker AS, Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling. Development. 2023 Apr 1;150(7):dev201464 |
| 2 | J:152118 Quarto N, Behr B, Li S, Longaker MT, Differential FGF ligands and FGF receptors expression pattern in frontal and parietal calvarial bones. Cells Tissues Organs. 2009;190(3):158-69 |
| 2 | J:345597 Quilez S, Dumontier E, Baim C, Kam J, Cloutier JF, Loss of Neogenin alters branchial arch development and leads to craniofacial skeletal defects. Front Cell Dev Biol. 2024;12:1256465 |
| 2 | J:282858 Ramachandran J, Liu Z, Gray RS, Vokes SA, PRMT5 is necessary to form distinct cartilage identities in the knee and long bone. Dev Biol. 2019 Dec 15;456(2):154-163 |
| 1 | J:102870 Razzaque MS, Soegiarto DW, Chang D, Long F, Lanske B, Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation. J Pathol. 2005 Dec;207(4):453-61 |
| 1 | J:335294 Redhead Y, Gibbins D, Lana-Elola E, Watson-Scales S, Dobson L, Krause M, Liu KJ, Fisher EMC, Green JBA, Tybulewicz VLJ, Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077 |
| 1 | J:147287 Retting KN, Song B, Yoon BS, Lyons KM, BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development. 2009 Apr;136(7):1093-104 |
| 1 | J:163175 Rice DP, Connor EC, Veltmaat JM, Lana-Elola E, Veistinen L, Tanimoto Y, Bellusci S, Rice R, Gli3Xt-J/Xt-J mice exhibit lambdoid suture craniosynostosis which results from altered osteoprogenitor proliferation and differentiation. Hum Mol Genet. 2010 Sep 1;19(17):3457-67 |
| 5 | J:84142 Rice DP, Rice R, Thesleff I, Molecular mechanisms in calvarial bone and suture development, and their relation to craniosynostosis. Eur J Orthod. 2003 Apr;25(2):139-48 |
| 2* | J:85739 Rice R, Rice DP, Olsen BR, Thesleff I, Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4. Dev Biol. 2003 Oct 1;262(1):75-87 |
| 2* | J:71486 Rini D, Calabi F, Identification and comparative analysis of a second runx3 promoter. Gene. 2001 Jul 25;273(1):13-22 |
| 2 | J:97176 Robert-Moreno A, Espinosa L, de la Pompa JL, Bigas A, RBPj{kappa}-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells. Development. 2005 Mar;132(5):1117-26 |
| 1 | J:76480 Robledo RF, Rajan L, Li X, Lufkin T, The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development. Genes Dev. 2002 May 1;16(9):1089-101 |
| 1 | J:149460 Rokutanda S, Fujita T, Kanatani N, Yoshida CA, Komori H, Liu W, Mizuno A, Komori T, Akt regulates skeletal development through GSK3, mTOR, and FoxOs. Dev Biol. 2009 Apr 1;328(1):78-93 |
| 2 | J:340735 Rose KP, Manilla G, Milon B, Zalzman O, Song Y, Coate TM, Hertzano R, Spatially distinct otic mesenchyme cells show molecular and functional heterogeneity patterns before hearing onset. iScience. 2023 Oct 20;26(10):107769 |
| 3* | J:77813 Rossi F, MacLean HE, Yuan W, Francis RO, Semenova E, Lin CS, Kronenberg HM, Cobrinik D, p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development. Dev Biol. 2002 Jul 15;247(2):271-85 |
| 2* | J:306391 Roth DM, Baddam P, Lin H, Vidal-Garcia M, Aponte JD, De Souza ST, Godziuk D, Watson AES, Footz T, Schachter NF, Egan SE, Hallgrimsson B, Graf D, Voronova A, The Chromatin Regulator Ankrd11 Controls Palate and Cranial Bone Development. Front Cell Dev Biol. 2021;9:645386 |
| 2 | J:306205 Ruengsinpinya L, Murakami T, Nakamura E, Takahata Y, Hata K, Nakaminami Y, Okae H, Nishimura R, G protein subunit beta1 is an important mediator of the late stage of endochondral ossification. Biochem Biophys Res Commun. 2020 Nov 26;533(1):90-96 |
| 5 | J:340421 Ruscitto A, Chen P, Tosa I, Wang Z, Zhou G, Safina I, Wei R, Morel MM, Koch A, Forman M, Reeve G, Lecholop MK, Wilson M, Bonthius D, Chen M, Ono M, Wang TC, Yao H, Embree MC, Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity. Cell Stem Cell. 2023 Sep 7;30(9):1179-1198.e7 |
| 3 | J:161526 Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H, Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med. 2010 Jun;16(6):678-86 |
| 1* | J:164801 Samaan G, Yugo D, Rajagopalan S, Wall J, Donnell R, Goldowitz D, Gopalakrishnan R, Venkatachalam S, Foxn3 is essential for craniofacial development in mice and a putative candidate involved in human congenital craniofacial defects. Biochem Biophys Res Commun. 2010 Sep 10;400(1):60-5 |
| 1 | J:277246 Sarper SE, Inubushi T, Kurosaka H, Ono Minagi H, Murata Y, Kuremoto KI, Sakai T, Taniuchi I, Yamashiro T, Anterior cleft palate due to Cbfb deficiency and its rescue by folic acid. Dis Model Mech. 2019 Jun 27;12(6):dmm038851 |
| 2 | J:105169 Sasaki T, Ito Y, Bringas P Jr, Chou S, Urata MM, Slavkin H, Chai Y, TGF{beta}-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development. Development. 2006 Jan;133(2):371-81 |
| 3* | J:22982 Satake M, Nomura S, Yamaguchi-Iwai Y, Takahama Y, Hashimoto Y, Niki M, Kitamura Y, Ito Y, Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development. Mol Cell Biol. 1995 Mar;15(3):1662-70 |
| 1* | J:50165 Sato M, Morii E, Komori T, Kawahata H, Sugimoto M, Terai K, Shimizu H, Yasui T, Ogihara H, Yasui N, Ochi T, Kitamura Y, Ito Y, Nomura S, Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues. Oncogene. 1998 Sep 24;17(12):1517-25 |
| 4 | J:142447 Sato S, Kimura A, Ozdemir J, Asou Y, Miyazaki M, Jinno T, Ae K, Liu X, Osaki M, Takeuchi Y, Fukumoto S, Kawaguchi H, Haro H, Shinomiya K, Karsenty G, Takeda S, The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: Findings in murine models and in human disease. Arthritis Rheum. 2008 Sep;58(9):2764-75 |
| 1 | J:61509 Satokata I, Ma L, Ohshima H, Bei M, Woo I, Nishizawa K, Maeda T, Takano Y, Uchiyama M, Heaney S, Peters H, Tang Z, Maxson R, Maas R, Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation. Nat Genet. 2000 Apr;24(4):391-5 |
| 1 | J:208432 Schwarz D, Varum S, Zemke M, Scholer A, Baggiolini A, Draganova K, Koseki H, Schubeler D, Sommer L, Ezh2 is required for neural crest-derived cartilage and bone formation. Development. 2014 Feb;141(4):867-77 |
| 2 | J:281204 Sen R, Pezoa SA, Carpio Shull L, Hernandez-Lagunas L, Niswander LA, Artinger KB, Kat2a and Kat2b Acetyltransferase Activity Regulates Craniofacial Cartilage and Bone Differentiation in Zebrafish and Mice. J Dev Biol. 2018 Nov 12;6(4) |
| 3 | J:153638 Seo HS, Serra R, Tgfbr2 is required for development of the skull vault. Dev Biol. 2009 Oct 15;334(2):481-90 |
| 7 | J:140421 Shibata S, Yokohama-Tamaki T, An in situ hybridization study of Runx2, Osterix, and Sox9 in the anlagen of mouse mandibular condylar cartilage in the early stages of embryogenesis. J Anat. 2008 Sep;213(3):274-83 |
| 1 | J:235082 Shimazu J, Wei J, Karsenty G, Smurf1 Inhibits Osteoblast Differentiation, Bone Formation, and Glucose Homeostasis through Serine 148. Cell Rep. 2016 Apr 5;15(1):27-35 |
| 3* | J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754 |
| 11 | J:117765 Shimizu T, Participation of Runx2 in mandibular condylar cartilage development. Eur J Med Res. 2006 Nov 30;11(11):455-61 |
| 1* | J:291218 Shirai Y, Kawabe K, Tosa I, Tsukamoto S, Yamada D, Takarada T, Runx2 function in cells of neural crest origin during intramembranous ossification. Biochem Biophys Res Commun. 2019 Feb 19;509(4):1028-1033 |
| 4 | J:294895 Shpargel KB, Mangini CL, Xie G, Ge K, Magnuson T, The KMT2D Kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology. Development. 2020 Jul 17;147(21):dev187997 |
| 1 | J:194442 Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, Hilton MJ, Wang Y, Chen D, BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci. 2011 Oct 15;124(Pt 20):3428-40 |
| 2 | J:187998 Shung CY, Ota S, Zhou ZQ, Keene DR, Hurlin PJ, Disruption of a Sox9-beta-catenin circuit by mutant Fgfr3 in thanatophoric dysplasia type II. Hum Mol Genet. 2012 Nov 1;21(21):4628-44 |
| 1 | J:196596 Singh N, Gupta M, Trivedi CM, Singh MK, Li L, Epstein JA, Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Dev Biol. 2013 May 15;377(2):333-44 |
| 17 | J:95959 Smith N, Dong Y, Lian JB, Pratap J, Kingsley PD, van Wijnen AJ, Stein JL, Schwarz EM, O'keefe RJ, Stein GS, Drissi MH, Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development. J Cell Physiol. 2005 Apr;203(1):133-43 |
| 2 | J:88817 Smits P, Dy P, Mitra S, Lefebvre V, Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. J Cell Biol. 2004 Mar 1;164(5):747-58 |
| 1* | J:80666 Smits P, Li P, Mandel J, Zhang Z, Deng JM, Behringer RR, de Croumbrugghe B, Lefebvre V, The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Dev Cell. 2001 Aug;1(2):277-90 |
| 4 | J:159823 Sohaskey ML, Jiang Y, Zhao JJ, Mohr A, Roemer F, Harland RM, Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. J Cell Biol. 2010 May 3;189(3):511-25 |
| 2 | J:137353 Sohaskey ML, Yu J, Diaz MA, Plaas AH, Harland RM, JAWS coordinates chondrogenesis and synovial joint positioning. Development. 2008 Jul;135(13):2215-20 |
| 3 | J:295946 Sohn WJ, Gwon GJ, Kim HS, Neupane S, Cho SJ, Lee JH, Yamamoto H, Choi JY, An CH, Lee Y, Shin HI, Lee S, Kim JY, Mesenchymal signaling in dorsoventral differentiation of palatal epithelium. Cell Tissue Res. 2015 Dec;362(3):541-56 |
| 2 | J:119030 Spater D, Hill TP, O'sullivan RJ, Gruber M, Conner DA, Hartmann C, Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Development. 2006 Aug;133(15):3039-49 |
| 2 | J:245905 Spieker J, Mudersbach T, Vogel-Hopker A, Layer PG, Endochondral Ossification Is Accelerated in Cholinesterase-Deficient Mice and in Avian Mesenchymal Micromass Cultures. PLoS One. 2017;12(1):e0170252 |
| 3* | J:57297 St-Jacques B, Hammerschmidt M, McMahon AP, Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation [published erratum appears in Genes Dev 1999 Oct 1;13(19):2617]. Genes Dev. 1999 Aug 15;13(16):2072-86 |
| 1 | J:199299 Stewart K, Uetani N, Hendriks W, Tremblay ML, Bouchard M, Inactivation of LAR family phosphatase genes Ptprs and Ptprf causes craniofacial malformations resembling Pierre-Robin sequence. Development. 2013 Aug;140(16):3413-22 |
| 8* | J:76263 Stricker S, Fundele R, Vortkamp A, Mundlos S, Role of Runx genes in chondrocyte differentiation. Dev Biol. 2002 May 1;245(1):95-108 |
| 2 | J:171003 Sugito H, Shibukawa Y, Kinumatsu T, Yasuda T, Nagayama M, Yamada S, Minugh-Purvis N, Pacifici M, Koyama E, Ihh signaling regulates mandibular symphysis development and growth. J Dent Res. 2011 May;90(5):625-31 |
| 3 | J:333326 Suh J, Kim NK, Shim W, Lee SH, Kim HJ, Moon E, Sesaki H, Jang JH, Kim JE, Lee YS, Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis. Cell Metab. 2023 Feb 7;35(2):345-360.e7 |
| 1 | J:194058 Sun J, Ishii M, Ting MC, Maxson R, Foxc1 controls the growth of the murine frontal bone rudiment by direct regulation of a Bmp response threshold of Msx2. Development. 2013 Mar;140(5):1034-44 |
| 1 | J:267193 Sun Z, da Fontoura CSG, Moreno M, Holton NE, Sweat M, Sweat Y, Lee MK, Arbon J, Bidlack FB, Thedens DR, Nopoulos P, Cao H, Eliason S, Weinberg SM, Martin JF, Moreno-Uribe L, Amendt BA, FoxO6 regulates Hippo signaling and growth of the craniofacial complex. PLoS Genet. 2018 Oct;14(10):e1007675 |
| 1* | J:285711 Sweat YY, Sweat M, Mansaray M, Cao H, Eliason S, Adeyemo WL, Gowans LJJ, Eshete MA, Anand D, Chalkley C, Saadi I, Lachke SA, Butali A, Amendt BA, Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation. Dev Biol. 2020 Feb 15;458(2):246-256 |
| 1 | J:205050 Swinehart IT, Schlientz AJ, Quintanilla CA, Mortlock DP, Wellik DM, Hox11 genes are required for regional patterning and integration of muscle, tendon and bone. Development. 2013 Nov;140(22):4574-82 |
| 2 | J:336752 Taieb M, Ghannoum D, Barre L, Ouzzine M, Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate. Cell Death Dis. 2023 Jun 9;14(6):355 |
| 2 | J:314589 Takahata Y, Hagino H, Kimura A, Urushizaki M, Kobayashi S, Wakamori K, Fujiwara C, Nakamura E, Yu K, Kiyonari H, Bando K, Murakami T, Komori T, Hata K, Nishimura R, Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2. Commun Biol. 2021 Oct 19;4(1):1199 |
| 2 | J:146554 Takarada T, Yoneda Y, Transactivation by Runt related factor-2 of matrix metalloproteinase-13 in astrocytes. Neurosci Lett. 2009 Feb 20;451(2):99-104 |
| 8* | J:67784 Takeda S, Bonnamy JP, Owen MJ, Ducy P, Karsenty G, Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev. 2001 Feb 15;15(4):467-81 |
| 1* | J:180593 Tang W, Yang F, Li Y, de Crombrugghe B, Jiao H, Xiao G, Zhang C, Transcriptional regulation of Vascular Endothelial Growth Factor (VEGF) by osteoblast-specific transcription factor Osterix (Osx) in osteoblasts. J Biol Chem. 2012 Jan 13;287(3):1671-8 |
| 1 | J:125052 Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara K, Komiya S, Maruyama I, Lotz M, Bianchi ME, Asahara H, Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification. Mol Cell Biol. 2007 Aug;27(16):5650-63 |
| 2* | J:186504 Tanimoto Y, Veistinen L, Alakurtti K, Takatalo M, Rice DP, Prevention of premature fusion of calvarial suture in GLI-Kruppel family member 3 (Gli3)-deficient mice by removing one allele of Runt-related transcription factor 2 (Runx2). J Biol Chem. 2012 Jun 15;287(25):21429-38 |
| 5* | J:91894 Terry A, Kilbey A, Vaillant F, Stewart M, Jenkins A, Cameron E, Neil JC, Conservation and expression of an alternative 3' exon of Runx2 encoding a novel proline-rich C-terminal domain. Gene. 2004 Jul 7;336(1):115-25 |
| 1* | J:56452 Thesleff I, Aberg T, Molecular regulation of tooth development. Bone. 1999 Jul;25(1):123-5 |
| 1* | J:87170 Thomas G, Moffatt P, Salois P, Gaumond MH, Gingras R, Godin E, Miao D, Goltzman D, Lanctot C, Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. J Biol Chem. 2003 Dec 12;278(50):50563-71 |
| 1 | J:187204 Thomas PS, Sridurongrit S, Ruiz-Lozano P, Kaartinen V, Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development. PLoS One. 2012;7(4):e35539 |
| 5* | J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23 |
| 1 | J:146459 Ting MC, Wu NL, Roybal PG, Sun J, Liu L, Yen Y, Maxson RE Jr, EphA4 as an effector of Twist1 in the guidance of osteogenic precursor cells during calvarial bone growth and in craniosynostosis. Development. 2009 Mar;136(5):855-64 |
| 5 | J:245879 Tischfield MA, Robson CD, Gilette NM, Chim SM, Sofela FA, DeLisle MM, Gelber A, Barry BJ, MacKinnon S, Dagi LR, Nathans J, Engle EC, Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura. Dev Cell. 2017 Sep 11;42(5):445-461.e5 |
| 1 | J:155773 Tkatchenko TV, Moreno-Rodriguez RA, Conway SJ, Molkentin JD, Markwald RR, Tkatchenko AV, Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Physiol Genomics. 2009 Nov 6;39(3):160-8 |
| 1 | J:166907 Tran TH, Jarrell A, Zentner GE, Welsh A, Brownell I, Scacheri PC, Atit R, Role of canonical Wnt signaling/ss-catenin via Dermo1 in cranial dermal cell development. Development. 2010 Dec;137(23):3973-84 |
| 2* | J:55583 Tribioli C, Lufkin T, The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Development. 1999 Dec;126(24):5699-711 |
| 1 | J:63680 Tsuji K, Noda M, Identification and expression of a novel 3'-exon of mouse Runx1/Pebp2alphaB/Cbfa2/AML1 gene. Biochem Biophys Res Commun. 2000 Jul 21;274(1):171-6 |
| 1 | J:326353 Tsujikawa K, Saito K, Nagasaka A, Miyata T, Developmentally interdependent stretcher-compressor relationship between the embryonic brain and the surrounding scalp in the preosteogenic head. Dev Dyn. 2022 Jul;251(7):1107-1122 |
| 5* | J:344830 Tsutsumi-Arai C, Arai Y, Tran A, Salinas M, Nakai Y, Orikasa S, Ono W, Ono N, A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2. J Dent Res. 2024 Jan;103(1):91-100 |
| 1 | J:183534 Tu X, Chen J, Lim J, Karner CM, Lee SY, Heisig J, Wiese C, Surendran K, Kopan R, Gessler M, Long F, Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet. 2012 Mar;8(3):e1002577 |
| 1* | J:180304 Tu X, Joeng KS, Long F, Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiation. Dev Biol. 2012 Feb 1;362(1):76-82 |
| 1 | J:88584 Tucker AS, Watson RP, Lettice LA, Yamada G, Hill RE, Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution. Development. 2004 Mar;131(6):1235-45 |
| 3 | J:68793 Ueta C, Iwamoto M, Kanatani N, Yoshida C, Liu Y, Enomoto-Iwamoto M, Ohmori T, Enomoto H, Nakata K, Takada K, Kurisu K, Komori T, Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol. 2001 Apr 2;153(1):87-100 |
| 1 | J:277201 Ulici V, Kelley KL, Longobardi L, McNulty MA, Livingston EW, Bateman TA, Seguin CA, Louer CR, Loeser RF, Impaired Annulus Fibrosus Development and Vertebral Fusion Cause Severe Scoliosis in Mice with Deficiency of c-Jun NH2-Terminal Kinases 1 and 2. Am J Pathol. 2019 Apr;189(4):868-885 |
| 1 | J:344644 Ulschmid CM, Sun MR, Jabbarpour CR, Steward AC, Rivera-Gonzalez KS, Cao J, Martin AA, Barnes M, Wicklund L, Madrid A, Papale LA, Joseph DB, Vezina CM, Alisch RS, Lipinski RJ, Disruption of DNA methylation-mediated cranial neural crest proliferation and differentiation causes orofacial clefts in mice. Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2317668121 |
| 2 | J:345132 Umar M, Dong C, He F, Characterizing expression pattern of Six2Cre during mouse craniofacial development. Genesis. 2023 Sep;61(5):e23516 |
| 5 | J:340401 Varadinkova S, Oralova V, Clarke M, Frampton J, Knopfova L, Lesot H, Bartos P, Matalova E, Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor. Front Cell Dev Biol. 2023;11:1168866 |
| 1 | J:222958 Vasudevan HN, Mazot P, He F, Soriano P, Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways. Elife. 2015 May 7;4 |
| 2 | J:94631 Vega RB, Matsuda K, Oh J, Barbosa AC, Yang X, Meadows E, McAnally J, Pomajzl C, Shelton JM, Richardson JA, Karsenty G, Olson EN, Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell. 2004 Nov 12;119(4):555-66 |
| 1* | J:289500 Veistinen L, Takatalo M, Tanimoto Y, Kesper DA, Vortkamp A, Rice DP, Loss-of-Function of Gli3 in Mice Causes Abnormal Frontal Bone Morphology and Premature Synostosis of the Interfrontal Suture. Front Physiol. 2012;3:121 |
| 1 | J:309718 Veistinen LK, Mustonen T, Hasan MR, Takatalo M, Kobayashi Y, Kesper DA, Vortkamp A, Rice DP, Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets. Front Physiol. 2017;8:1036 |
| 1* | J:313286 Vesela B, Kratochvilova A, Svandova E, Benes P, Rihova K, Poliard A, Matalova E, Caspase-12 Is Present During Craniofacial Development and Participates in Regulation of Osteogenic Markers. Front Cell Dev Biol. 2020;8:589136 |
| 2* | J:320741 Vesela B, Svandova E, Hovorakova M, Peterkova R, Kratochvilova A, Pasovska M, Ramesova A, Lesot H, Matalova E, Specification of Sprouty2 functions in osteogenesis in in vivo context. Organogenesis. 2019;15(4):111-119 |
| 4 | J:161451 Villavicencio-Lorini P, Kuss P, Friedrich J, Haupt J, Farooq M, Turkmen S, Duboule D, Hecht J, Mundlos S, Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation. J Clin Invest. 2010 Jun 1;120(6):1994-2004 |
| 1* | J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6 |
| 3 | J:137357 Vivatbutsiri P, Ichinose S, Hytonen M, Sainio K, Eto K, Iseki S, Impaired meningeal development in association with apical expansion of calvarial bone osteogenesis in the Foxc1 mutant. J Anat. 2008 May;212(5):603-11 |
| 1* | J:215297 Voronov D, Gromova A, Liu D, Zoukhri D, Medvinsky A, Meech R, Makarenkova HP, Transcription factors Runx1 to 3 are expressed in the lacrimal gland epithelium and are involved in regulation of gland morphogenesis and regeneration. Invest Ophthalmol Vis Sci. 2013 May;54(5):3115-25 |
| 3 | J:300455 Vu TH, Takechi M, Shimizu M, Kitazawa T, Higashiyama H, Iwase A, Kurihara H, Iseki S, Dlx5-augmentation in neural crest cells reveals early development and differentiation potential of mouse apical head mesenchyme. Sci Rep. 2021 Jan 22;11(1):2092 |
| 2 | J:311534 Wan Y, Lantz B, Cusack BJ, Szabo-Rogers HL, Prickle1 regulates differentiation of frontal bone osteoblasts. Sci Rep. 2018 Dec 21;8(1):18021 |
| 1 | J:316121 Wang JR, Wang CJ, Xu CY, Wu XK, Hong D, Shi W, Gong Y, Chen HX, Long F, Wu XM, Signaling Cascades Governing Cdc42-Mediated Chondrogenic Differentiation and Mensenchymal Condensation. Genetics. 2016 Mar;202(3):1055-69 |
| 1 | J:257921 Wang JS, Infante CR, Park S, Menke DB, PITX1 promotes chondrogenesis and myogenesis in mouse hindlimbs through conserved regulatory targets. Dev Biol. 2018 Feb 1;434(1):186-195 |
| 1 | J:132462 Wang K, Yamamoto H, Chin JR, Werb Z, Vu TH, Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J Biol Chem. 2004 Dec 17;279(51):53848-56 |
| 1 | J:255705 Wang L, Huang J, Moore DC, Zuo C, Wu Q, Xie L, von der Mark K, Yuan X, Chen D, Warman ML, Ehrlich MG, Yang W, SHP2 Regulates the Osteogenic Fate of Growth Plate Hypertrophic Chondrocytes. Sci Rep. 2017 Oct 5;7(1):12699 |
| 5 | J:286823 Wang L, Tang Q, Xu J, Li H, Yang T, Li L, Machon O, Hu T, Chen Y, The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice. J Biol Chem. 2020 Apr 17;295(16):5449-5460 |
| 3 | J:112376 Wang Y, Belflower RM, Dong YF, Schwarz EM, O'Keefe RJ, Drissi H, Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis. J Bone Miner Res. 2005 Sep;20(9):1624-36 |
| 2 | J:177115 Wang Y, Liu C, Rohr J, Liu H, He F, Yu J, Sun C, Li L, Gu S, Chen Y, Tissue interaction is required for glenoid fossa development during temporomandibular joint formation. Dev Dyn. 2011 Nov;240(11):2466-73 |
| 1 | J:158773 Wang Y, Sun M, Uhlhorn VL, Zhou X, Peter I, Martinez-Abadias N, Hill CA, Percival CJ, Richtsmeier JT, Huso DL, Jabs EW, Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice. BMC Dev Biol. 2010;10:22 |
| 1 | J:351706 Wang Y, Wang J, Xu T, Yang S, Wang X, Zhu L, Li N, Liu B, Xiao J, Liu C, Ectopic Activation of Fgf8 in Dental Mesenchyme Causes Incisor Agenesis and Molar Microdontia. Int J Mol Sci. 2024 Jun 27;25(13) |
| 1 | J:190491 Wang Y, Zhou X, Oberoi K, Phelps R, Couwenhoven R, Sun M, Rezza A, Holmes G, Percival CJ, Friedenthal J, Krejci P, Richtsmeier JT, Huso DL, Rendl M, Jabs EW, p38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare-Stevenson mice. J Clin Invest. 2012 Jun 1;122(6):2153-64 |
| 4 | J:321350 Warner DR, Wells JP, Greene RM, Pisano MM, Gene expression changes in the secondary palate and mandible of Prdm16(-/-) mice. Cell Tissue Res. 2013 Mar;351(3):445-52 |
| 1 | J:320628 Watanabe-Takano H, Ochi H, Chiba A, Matsuo A, Kanai Y, Fukuhara S, Ito N, Sako K, Miyazaki T, Tainaka K, Harada I, Sato S, Sawada Y, Minamino N, Takeda S, Ueda HR, Yasoda A, Mochizuki N, Mechanical load regulates bone growth via periosteal Osteocrin. Cell Rep. 2021 Jul 13;36(2):109380 |
| 1 | J:185130 Wei J, Shi Y, Zheng L, Zhou B, Inose H, Wang J, Guo XE, Grosschedl R, Karsenty G, miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J Cell Biol. 2012 May 14;197(4):509-21 |
| 10 | J:223511 Wei J, Shimazu J, Makinistoglu MP, Maurizi A, Kajimura D, Zong H, Takarada T, Lezaki T, Pessin JE, Hinoi E, Karsenty G, Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation. Cell. 2015 Jun 18;161(7):1576-91 |
| 1 | J:229488 Wiszniak S, Harvey N, Schwarz Q, Cell autonomous roles of Nedd4 in craniofacial bone formation. Dev Biol. 2016 Feb 1;410(1):98-107 |
| 1 | J:203994 Wiszniak S, Kabbara S, Lumb R, Scherer M, Secker G, Harvey N, Kumar S, Schwarz Q, The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties. Dev Biol. 2013 Nov 15;383(2):186-200 |
| 1 | J:163602 Witte F, Chan D, Economides AN, Mundlos S, Stricker S, Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14211-6 |
| 4 | J:219328 Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY,, Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell. 2015 Jan 15;160(1-2):269-84 |
| 2 | J:214660 Wu M, Li C, Zhu G, Wang Y, Jules J, Lu Y, McConnell M, Wang YJ, Shao JZ, Li YP, Chen W, Deletion of core-binding factor beta (Cbfbeta) in mesenchymal progenitor cells provides new insights into Cbfbeta/Runxs complex function in cartilage and bone development. Bone. 2014 Aug;65:49-59 |
| 4 | J:137730 Wu M, Li J, Engleka KA, Zhou B, Lu MM, Plotkin JB, Epstein JA, Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice. J Clin Invest. 2008 Jun;118(6):2076-87 |
| 2 | J:148141 Wu Q, Chen D, Zuscik MJ, O'Keefe RJ, Rosier RN, Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin. J Bone Miner Res. 2008 Apr;23(4):552-63 |
| 3* | J:306094 Xiao Y, Lin YX, Cui Y, Zhang Q, Pei F, Zuo HY, Liu H, Chen Z, Zeb1 Promotes Odontoblast Differentiation in a Stage-Dependent Manner. J Dent Res. 2021 Jun;100(6):648-657 |
| 1* | J:240559 Xiong F, Ji Z, Liu Y, Zhang Y, Hu L, Yang Q, Qiu Q, Zhao L, Chen D, Tian Z, Shang X, Zhang L, Wei X, Liu C, Yu Q, Zhang M, Cheng J, Xiong J, Li D, Wu X, Yuan H, Zhang W, Xu X, Mutation in SSUH2 Causes Autosomal-Dominant Dentin Dysplasia Type I. Hum Mutat. 2017 Jan;38(1):95-104 |
| 6 | J:281388 Xu J, Huang Z, Wang W, Tan X, Li H, Zhang Y, Tian W, Hu T, Chen YP, FGF8 Signaling Alters the Osteogenic Cell Fate in the Hard Palate. J Dent Res. 2018 May;97(5):589-596 |
| 1 | J:309090 Xu J, Liu H, Lan Y, Adam M, Clouthier DE, Potter S, Jiang R, Hedgehog signaling patterns the oral-aboral axis of the mandibular arch. Elife. 2019 Jan 14;8:e40315 |
| 1 | J:287549 Xu J, Liu H, Lan Y, Park JS, Jiang R, Genome-wide Identification of Foxf2 Target Genes in Palate Development. J Dent Res. 2020 Apr;99(4):463-471 |
| 4 | J:283053 Xu J, Wang L, Li H, Yang T, Zhang Y, Hu T, Huang Z, Chen Y, Shox2 regulates osteogenic differentiation and pattern formation during hard palate development in mice. J Biol Chem. 2019 Nov 29;294(48):18294-18305 |
| 2 | J:102996 Yamaai T, Nakanishi T, Asano M, Nawachi K, Yoshimichi G, Ohyama K, Komori T, Sugimoto T, Takigawa M, Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant mice in late stage of embryonic development. J Bone Miner Metab. 2005;23(4):280-8 |
| 1 | J:320420 Yamaguchi H, Kitami M, Uchima Koecklin KH, He L, Wang J, Lagor WR, Perrien DS, Komatsu Y, Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice. Dev Biol. 2022 Feb;482:91-100 |
| 1* | J:308829 Yamaguchi H, Meyer MD, He L, Senavirathna L, Pan S, Komatsu Y, The molecular complex of ciliary and golgin protein is crucial for skull development. Development. 2021 Jul 1;148(13):dev199559 |
| 1 | J:341094 Yamaguchi H, Swaminathan S, Mishina Y, Komatsu Y, Enhanced BMP signaling leads to enlarged nasal cartilage formation in mice. Biochem Biophys Res Commun. 2023 Oct 20;678:173-178 |
| 6* | J:81317 Yamashiro T, Aberg T, Levanon D, Groner Y, Thesleff I, Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Mech Dev. 2002 Dec;119 Suppl 1:S107-10 |
| 5 | J:94929 Yamashiro T, Wang XP, Li Z, Oya S, Aberg T, Fukunaga T, Kamioka H, Speck NA, Takano-Yamamoto T, Thesleff I, Possible roles of Runx1 and Sox9 in incipient intramembranous ossification. J Bone Miner Res. 2004 Oct;19(10):1671-7 |
| 3 | J:263887 Yan J, Li J, Hu J, Zhang L, Wei C, Sultana N, Cai X, Zhang W, Cai CL, Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development. J Biol Chem. 2018 Jun 15;293(24):9162-9175 |
| 1* | J:165583 Yang F, Tang W, So S, de Crombrugghe B, Zhang C, Sclerostin is a direct target of osteoblast-specific transcription factor osterix. Biochem Biophys Res Commun. 2010 Oct 1;400(4):684-8 |
| 2 | J:320311 Yang L, Gu S, Ye W, Song Y, Chen Y, Augmented Indian hedgehog signaling in cranial neural crest cells leads to craniofacial abnormalities and dysplastic temporomandibular joint in mice. Cell Tissue Res. 2016 Apr;364(1):105-15 |
| 3 | J:326460 Yang R, Li R, Huang Z, Zuo Y, Yue H, Wu H, Gu F, Wang F, He M, Bian Z, Mycn deficiency underlies the development of orofacial clefts in mice and humans. Hum Mol Genet. 2022 Mar 3;31(5):803-815 |
| 1* | J:256083 Yang T, Moore M, He F, Pten regulates neural crest proliferation and differentiation during mouse craniofacial development. Dev Dyn. 2018 Feb;247(2):304-314 |
| 1 | J:172232 Yang X, Gong Y, Friesel R, Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function. PLoS One. 2011;6(4):e18374 |
| 3* | J:81355 Yang Y, Topol L, Lee H, Wu J, Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development. 2003 Mar;130(5):1003-15 |
| 7 | J:350264 Yano-Sakamoto K, Kitai Y, Toriu N, Yamamoto S, Mizuta K, Saitou M, Tsukiyama T, Taniuchi I, Osato M, Yanagita M, Expression pattern of Runt-related transcription factor (RUNX) family members and the role of RUNX1 during kidney development. Biochem Biophys Res Commun. 2024 Aug 30;722:150155 |
| 2 | J:235737 Ye W, Song Y, Huang Z, Osterwalder M, Ljubojevic A, Xu J, Bobick B, Abassah-Oppong S, Ruan N, Shamby R, Yu D, Zhang L, Cai CL, Visel A, Zhang Y, Cobb J, Chen Y, A unique stylopod patterning mechanism by Shox2-controlled osteogenesis. Development. 2016 Jul 15;143(14):2548-60 |
| 2 | J:306388 Yen YT, Chien M, Wu PY, Hung SC, PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation. Commun Biol. 2021 Jun 2;4(1):658 |
| 1 | J:111482 Ylonen R, Kyronlahti T, Sund M, Ilves M, Lehenkari P, Tuukkanen J, Pihlajaniemi T, Type XIII collagen strongly affects bone formation in transgenic mice. J Bone Miner Res. 2005 Aug;20(8):1381-93 |
| 2* | J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48 |
| 3 | J:276208 Yoon H, Kim HL, Chun YS, Shin DH, Lee KH, Shin CS, Lee DY, Kim HH, Lee ZH, Ryoo HM, Lee MN, Oh GT, Park JW, NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2. Nat Commun. 2014 Nov 7;5:5176 |
| 2* | J:80668 Yoshida CA, Furuichi T, Fujita T, Fukuyama R, Kanatani N, Kobayashi S, Satake M, Takada K, Komori T, Core-binding factor beta interacts with Runx2 and is required for skeletal development. Nat Genet. 2002 Dec;32(4):633-8 |
| 1 | J:221866 Yoshida M, Hata K, Takashima R, Ono K, Nakamura E, Takahata Y, Murakami T, Iseki S, Takano-Yamamoto T, Nishimura R, Yoneda T, The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification. Nat Commun. 2015;6:6653 |
| 2* | J:334015 Yoshioka H, Komura S, Kuramitsu N, Goto A, Hasegawa T, Amizuka N, Ishimoto T, Ozasa R, Nakano T, Imai Y, Akiyama H, Deletion of Tfam in Prx1-Cre expressing limb mesenchyme results in spontaneous bone fractures. J Bone Miner Metab. 2022 Sep;40(5):839-852 |
| 1 | J:95960 Young DW, Pratap J, Javed A, Weiner B, Ohkawa Y, van Wijnen A, Montecino M, Stein GS, Stein JL, Imbalzano AN, Lian JB, SWI/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation. J Cell Biochem. 2005 Mar 1;94(4):720-30 |
| 1 | J:90391 Yu K, Xu J, Liu Z, Sosic D, Shao J, Olson EN, Towler DA, Ornitz DM, Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development. 2003 Jul;130(13):3063-74 |
| 3* | J:122558 Yu L, Liu H, Yan M, Yang J, Long F, Muneoka K, Chen Y, Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Dev Biol. 2007 Jun 15;306(2):549-59 |
| 4 | J:329949 Yuan H, Xie B, Yu X, Lin C, Li M, Zhang Y, Zou X, Lu M, Zhao M, Wen X, A potential role of p75NTR in the regulation of circadian rhythm and incremental growth lines during tooth development. Front Physiol. 2022;13:981311 |
| 2 | J:313945 Yuan Y, Loh YE, Han X, Feng J, Ho TV, He J, Jing J, Groff K, Wu A, Chai Y, Spatiotemporal cellular movement and fate decisions during first pharyngeal arch morphogenesis. Sci Adv. 2020 Dec;6(51) |
| 1 | J:97498 Yunker LA, Undersander A, Lian JB, Stein GS, Carlson CS, Mauro LJ, The tyrosine phosphatase, OST-PTP, is expressed in mesenchymal progenitor cells early during skeletogenesis in the mouse. J Cell Biochem. 2004 Nov 1;93(4):761-73 |
| 2 | J:108930 Zaragoza C, Lopez-Rivera E, Garcia-Rama C, Saura M, Martinez-Ruiz A, Lizarbe TR, Martin-de-Lara F, Lamas S, Cbfa-1 mediates nitric oxide regulation of MMP-13 in osteoblasts. J Cell Sci. 2006 May 1;119(Pt 9):1896-902 |
| 3 | J:195329 Zee T, Boller S, Gyory I, Makinistoglu MP, Tuckermann JP, Grosschedl R, Karsenty G, The transcription factor early B-cell factor 1 regulates bone formation in an osteoblast-nonautonomous manner. FEBS Lett. 2013 Mar 18;587(6):711-6 |
| 3* | J:70830 Zelzer E, Glotzer DJ, Hartmann C, Thomas D, Fukai N, Soker S, Olsen BR, Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2. Mech Dev. 2001 Aug;106(1-2):97-106 |
| 1 | J:195577 Zhang C, Tang W, Li Y, Matrix metalloproteinase 13 (MMP13) is a direct target of osteoblast-specific transcription factor osterix (Osx) in osteoblasts. PLoS One. 2012;7(11):e50525 |
| 1 | J:178091 Zhang C, Tang W, Li Y, Yang F, Dowd DR, MacDonald PN, Osteoblast-specific transcription factor Osterix increases vitamin D receptor gene expression in osteoblasts. PLoS One. 2011;6(10):e26504 |
| 1 | J:331689 Zhang CH, Gao Y, Hung HH, Zhuo Z, Grodzinsky AJ, Lassar AB, Creb5 coordinates synovial joint formation with the genesis of articular cartilage. Nat Commun. 2022 Nov 26;13(1):7295 |
| 2 | J:233350 Zhang F, Xu L, Xu L, Xu Q, Li D, Yang Y, Karsenty G, Chen CD, JMJD3 promotes chondrocyte proliferation and hypertrophy during endochondral bone formation in mice. J Mol Cell Biol. 2015 Feb;7(1):23-34 |
| 7 | J:168525 Zhang S, Xiao Z, Luo J, He N, Mahlios J, Quarles LD, Dose-dependent effects of Runx2 on bone development. J Bone Miner Res. 2009 Nov;24(11):1889-904 |
| 7 | J:202215 Zhang X, Ting K, Bessette CM, Culiat CT, Sung SJ, Lee H, Chen F, Shen J, Wang JJ, Kuroda S, Soo C, Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in Runx2(+/-) mice. J Bone Miner Res. 2011 Apr;26(4):777-91 |
| 6 | J:202210 Zhang X, Ting K, Pathmanathan D, Ko T, Chen W, Chen F, Lee H, James AW, Siu RK, Shen J, Culiat CT, Soo C, Calvarial cleidocraniodysplasia-like defects with ENU-induced Nell-1 deficiency. J Craniofac Surg. 2012 Jan;23(1):61-6 |
| 1 | J:183887 Zhang Y, Blackwell EL, McKnight MT, Knutsen GR, Vu WT, Ruest LB, Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2. Dev Dyn. 2012 May;241(5):924-40 |
| 3* | J:87163 Zhang Z, Song Y, Zhang X, Tang J, Chen J, Chen Y, Msx1/Bmp4 genetic pathway regulates mammalian alveolar bone formation via induction of Dlx5 and Cbfa1. Mech Dev. 2003 Dec;120(12):1469-79 |
| 1 | J:177881 Zhang Z, Wlodarczyk BJ, Niederreither K, Venugopalan S, Florez S, Finnell RH, Amendt BA, Fuz regulates craniofacial development through tissue specific responses to signaling factors. PLoS One. 2011;6(9):e24608 |
| 2 | J:218833 Zhao H, Zhou W, Yao Z, Wan Y, Cao J, Zhang L, Zhao J, Li H, Zhou R, Li B, Wei G, Zhang Z, French CA, Dekker JD, Yang Y, Fisher SE, Tucker HO, Guo X, Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Dev Biol. 2015 Feb 15;398(2):242-54 |
| 3* | J:125598 Zheng L, Iohara K, Ishikawa M, Into T, Takano-Yamamoto T, Matsushita K, Nakashima M, Runx3 negatively regulates Osterix expression in dental pulp cells. Biochem J. 2007 Jul 1;405(1):69-75 |
| 1 | J:238902 Zhou G, Jiang X, Zhang H, Lu Y, Liu A, Ma X, Yang G, Yang R, Shen H, Zheng J, Hu Y, Yang X, Zhang WJ, Xie Z, Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes via repression of Sox9. Development. 2015 Jan 15;142(2):385-93 |
| 2 | J:118268 Zhou G, Zheng Q, Engin F, Munivez E, Chen Y, Sebald E, Krakow D, Lee B, Dominance of SOX9 function over RUNX2 during skeletogenesis. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19004-9 |
| 1 | J:316215 Zhou N, Li N, Liu J, Wang Y, Gao J, Wu Y, Chen X, Liu C, Xiao J, Persistent Wnt/beta-catenin signaling in mouse epithelium induces the ectopic Dspp expression in cheek mesenchyme. Organogenesis. 2019;15(1):1-12 |
| 1 | J:292430 Zhou T, Gao B, Fan Y, Liu Y, Feng S, Cong Q, Zhang X, Zhou Y, Yadav PS, Lin J, Wu N, Zhao L, Huang D, Zhou S, Su P, Yang Y, Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ss-catenin. Elife. 2020 Mar 18;9:e52779 |
| 1 | J:219364 Zhou ZQ, Ota S, Deng C, Akiyama H, Hurlin PJ, Mutant activated FGFR3 impairs endochondral bone growth by preventing SOX9 downregulation in differentiating chondrocytes. Hum Mol Genet. 2015 Mar 15;24(6):1764-73 |
| 4 | J:172282 Zhou ZQ, Shung CY, Ota S, Akiyama H, Keene DR, Hurlin PJ, Sequential and coordinated actions of c-Myc and N-Myc control appendicular skeletal development. PLoS One. 2011;6(4):e18795 |
| 1 | J:228857 Zhu X, Wang F, Zhao Y, Yang P, Chen J, Sun H, Liu L, Li W, Pan L, Guo Y, Kou Z, Zhang Y, Zhou C, He J, Zhang X, Li J, Han W, Li J, Liu G, Gao S, Yang Z, A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice. PLoS Genet. 2014 Oct;10(10):e1004589 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
Analysis Tools