Recombinase (cre) Activity

MGI collects and annotates expression and activity data for recombinase-containing transgenes and knock-in alleles.

Access Data

Find recombinase-carrying alleles

Recombinase activity profile

	Detected	Not detected

and nowhere else AND Recombinase driven by

Retrieve all alleles

Retrieve a list of all recombinase-containing transgenes and knock-in alleles.

FAQs

How do I...

find existing recombinase-expressing transgenes and knock-ins that have a given promoter (driver)? FAQ
find the promoter (driver) that I'm looking for if it is not on the selection list? FAQ
find a recombinase-containing transgene or knock-in that is expressed in a specific tissue? FAQ
get a full list of all transgenes and knock-ins that express recombinase? FAQ
order mice with a desired recombinase construct? FAQ

Recombinase Allele Data Include

22 Apr 2025

1,694	Recombinase-containing knock-in alleles
2,288	Recombinase-containing transgenes
5,150	Total recombinase transgenes and alleles
932	Drivers in recombinase transgenes
953	Drivers in recombinase knock-in alleles
4,624	Tissues in recombinase specificity assays

More...

Recombinase Project News

29 Oct 2009

Data about cre-containing transgenes and knock-ins and their tissue specific activity are being curated from the scientific literature and integrated from projects underway at collaborating organizations. (See the Collaborators tab, below).
We are part of the CREATE (Coordination of resources for conditional expression of mutated mouse alleles) consortium.
List of available strains expressing cre

Cre is currently the most commonly used recombinase. It catalyzes site-specific recombination of DNA between loxP sites, thus making possible conditional mutagenesis, where specific genes can be knocked out in particular tissues and at particular developmental time points. Other non-cre recombinases (such as Flp, Dre, phiC31, etc.) and various inducible forms of recombinases have been and are being developed. We are curating data about all recombinase-containing transgenes and knock-ins developed in mice to provide a comprehensive resource delineating known activity patterns and allowing users to find relevant mouse resources for their studies.

Available data will continue to increase. To retrieve all recombinase-containing transgenes and knock-in alleles, use RETRIEVE ALL ALLELES, above.

The Recombinase Activity project is funded by NIH grants OD011190 and HD062499.

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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