Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Abca1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ABCA1
- Mouse genes Abca1
- Rat genes Abca1
- Zfish genes abca1a,abca1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abca1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034186	apolipoprotein A-I binding	ABCA1	IPI	UniProtKB:P02647	Human	PMID:11162594
Molecular Function	GO:0034186	apolipoprotein A-I binding	ABCA1	IPI	UniProtKB:P02647	Human	PMID:16443932
Molecular Function	GO:0034188	apolipoprotein A-I receptor activity	ABCA1	IDA		Human	PMID:16443932
Molecular Function	GO:0034185	apolipoprotein binding	ABCA1	IPI	UniProtKB:P02652	Human	PMID:11162594
Molecular Function	GO:0005524	ATP binding	ABCA1	IDA		Human	PMID:11700048
Molecular Function	GO:0051117	ATPase binding	ABCA1	IPI	UniProtKB:Q86UK0	Human	PMID:23931754
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	Abca1	IDA		Rat	PMID:12909583\|RGD:1304419
Molecular Function	GO:0120020	cholesterol transfer activity	ABCA1	IDA		Human	PMID:12084722
Molecular Function	GO:0120020	cholesterol transfer activity	Abca1	IDA		Mouse	PMID:15520449
Molecular Function	GO:0120020	cholesterol transfer activity	Abca1	IMP		Mouse	PMID:15520449
Molecular Function	GO:0140328	floppase activity	ABCA1	IDA		Human	PMID:16702602
Molecular Function	GO:0140328	floppase activity	ABCA1	IDA		Human	PMID:24097981
Molecular Function	GO:0008035	high-density lipoprotein particle binding	Abca1	IDA		Rat	PMID:15907796\|RGD:1598535
Molecular Function	GO:0031210	phosphatidylcholine binding	ABCA1	IDA		Human	PMID:24097981
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	ABCA1	IDA		Human	PMID:16702602
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	ABCA1	IDA		Human	PMID:24097981
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	ABCA1	IMP		Human	PMID:35974019
Molecular Function	GO:0090556	phosphatidylserine floppase activity	ABCA1	IDA		Human	PMID:24097981
Molecular Function	GO:0005548	phospholipid transporter activity	ABCA1	IGI	UniProtKB:P02647\|UniProtKB:P02649	Human	PMID:28373057
Molecular Function	GO:0005548	phospholipid transporter activity	Abca1	IDA		Mouse	PMID:15520449
Molecular Function	GO:0005548	phospholipid transporter activity	Abca1	IMP		Mouse	PMID:15520449
Molecular Function	GO:0005515	protein binding	ABCA1	IPI	UniProtKB:P02647	Human	PMID:12084722
Molecular Function	GO:0005515	protein binding	ABCA1	IPI	UniProtKB:P02649	Human	PMID:14754908
Molecular Function	GO:0005515	protein binding	ABCA1	IPI	UniProtKB:O75955	Human	PMID:15469992
Molecular Function	GO:0005515	protein binding	ABCA1	IPI	UniProtKB:Q86Y82	Human	PMID:15469992
Molecular Function	GO:0005515	protein binding	ABCA1	IPI	UniProtKB:Q13424	Human	PMID:16192269
Molecular Function	GO:0005515	protein binding	ABCA1	IPI	UniProtKB:Q13884	Human	PMID:16192269
Molecular Function	GO:0005515	protein binding	ABCA1	IPI	UniProtKB:P60953	Human	PMID:16443932
Molecular Function	GO:0005515	protein binding	ABCA1	IPI	UniProtKB:Q86UK0	Human	PMID:23931754
Molecular Function	GO:0005515	protein binding	ABCA1	IPI	UniProtKB:P27824	Human	PMID:25170080
Molecular Function	GO:0005515	protein binding	ABCA1	IPI	UniProtKB:P02647	Human	PMID:30458687
Molecular Function	GO:0005515	protein binding	Abca1	IPI	MGI:MGI:2676312	Mouse	PMID:23931754
Molecular Function	GO:0005515	protein binding	Abca1	IPI	PR:O35704	Mouse	PMID:8751592
Molecular Function	GO:0005515	protein binding	Abca1	IPI	PR:Q00623	Mouse	PMID:16204232
Molecular Function	GO:0005515	protein binding	Abca1	IPI	PR:Q60644	Mouse	PMID:23931754
Molecular Function	GO:0008320	protein transmembrane transporter activity	Abca1	IMP		Mouse	MGI:MGI:6207500\|PMID:29937375
Molecular Function	GO:0005102	signaling receptor binding	ABCA1	IPI	UniProtKB:P55055	Human	PMID:23931754
Molecular Function	GO:0031267	small GTPase binding	ABCA1	IPI	UniProtKB:P60953	Human	PMID:16443932
Molecular Function	GO:0046623	sphingolipid floppase activity	ABCA1	IDA		Human	PMID:24097981
Molecular Function	GO:0019905	syntaxin binding	ABCA1	IPI	UniProtKB:Q86Y82	Human	PMID:15469992
Cellular Component	GO:0016323	basolateral plasma membrane	Abca1	IDA		Rat	PMID:28660384\|RGD:21203516
Cellular Component	GO:0009986	cell surface	Abca1	IDA		Rat	PMID:15907796\|RGD:1598535
Cellular Component	GO:0030139	endocytic vesicle	ABCA1	IDA		Human	PMID:14747463
Cellular Component	GO:0005768	endosome	ABCA1	IDA		Human	PMID:24097981
Cellular Component	GO:0009897	external side of plasma membrane	Abca1	IDA		Mouse	PMID:23931754
Cellular Component	GO:0005794	Golgi apparatus	Abca1	IDA		Mouse	PMID:10878804
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	Abca1	IDA		Mouse	PMID:10878804
Cellular Component	GO:0097708	intracellular vesicle	ABCA1	IDA		Human	PMID:28373057
Cellular Component	GO:0016020	membrane	Abca1	IDA		Rat	PMID:17526932\|RGD:2308820
Cellular Component	GO:0045121	membrane raft	ABCA1	IDA		Human	PMID:15469992
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ABCA1	IDA		Human	PMID:23931754
Cellular Component	GO:0045335	phagocytic vesicle	ABCA1	IDA		Human	PMID:15469992
Cellular Component	GO:0005886	plasma membrane	ABCA1	IDA		Human	PMID:10525055
Cellular Component	GO:0005886	plasma membrane	ABCA1	IDA		Human	PMID:19556522
Cellular Component	GO:0005886	plasma membrane	ABCA1	IDA		Human	PMID:23931754
Cellular Component	GO:0005886	plasma membrane	ABCA1	IDA		Human	PMID:24097981
Cellular Component	GO:0005886	plasma membrane	ABCA1	IMP		Human	PMID:35974019
Cellular Component	GO:0005886	plasma membrane	ABCA1	IDA		Human	PMID:28373057
Cellular Component	GO:0005886	plasma membrane	Abca1	IDA		Mouse	PMID:10878804
Cellular Component	GO:0005886	plasma membrane	Abca1	IDA		Mouse	PMID:15520449
Cellular Component	GO:0005886	plasma membrane	Abca1	IDA		Mouse	PMID:12869555
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	ABCA1	IMP		Human	PMID:14701824
Biological Process	GO:0071397	cellular response to cholesterol	Abca1	IEP		Rat	PMID:15907796\|RGD:1598535
Biological Process	GO:0071397	cellular response to cholesterol	Abca1	IEP		Rat	PMID:17526932\|RGD:2308820
Biological Process	GO:0071345	cellular response to cytokine stimulus	Abca1	IEP		Rat	PMID:25445438\|RGD:21408555
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Abca1	IDA		Mouse	MGI:MGI:4411947\|PMID:19752193
Biological Process	GO:0071300	cellular response to retinoic acid	Abca1	IDA		Mouse	MGI:MGI:4411947\|PMID:19752193
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Abca1	IEP		Rat	PMID:21554872\|RGD:21408554
Biological Process	GO:0033344	cholesterol efflux	ABCA1	IDA		Human	PMID:10431236
Biological Process	GO:0033344	cholesterol efflux	ABCA1	IDA		Human	PMID:11162594
Biological Process	GO:0033344	cholesterol efflux	ABCA1	IMP		Human	PMID:16443932
Biological Process	GO:0033344	cholesterol efflux	ABCA1	IDA		Human	PMID:16702602
Biological Process	GO:0033344	cholesterol efflux	ABCA1	IMP		Human	PMID:19556522
Biological Process	GO:0033344	cholesterol efflux	ABCA1	IDA		Human	PMID:23931754
Biological Process	GO:0033344	cholesterol efflux	ABCA1	IMP		Human	PMID:25084135
Biological Process	GO:0033344	cholesterol efflux	ABCA1	IGI	UniProtKB:P02647\|UniProtKB:P02649	Human	PMID:28373057
Biological Process	GO:0033344	cholesterol efflux	ABCA1	IMP		Human	PMID:35974019
Biological Process	GO:0033344	cholesterol efflux	Abca1	IMP		Mouse	MGI:MGI:5427333\|PMID:22179027
Biological Process	GO:0033344	cholesterol efflux	Abca1	IMP	MGI:MGI:1935192	Mouse	PMID:15269218
Biological Process	GO:0033344	cholesterol efflux	Abca1	IDA		Mouse	PMID:15520449
Biological Process	GO:0033344	cholesterol efflux	Abca1	IMP		Mouse	PMID:15520449
Biological Process	GO:0033344	cholesterol efflux	Abca1	IDA		Mouse	PMID:12869555
Biological Process	GO:0033344	cholesterol efflux	Abca1	IMP	MGI:MGI:3613250	Mouse	PMID:17148552
Biological Process	GO:0042632	cholesterol homeostasis	ABCA1	IDA		Human	PMID:10431236
Biological Process	GO:0008203	cholesterol metabolic process	ABCA1	IDA		Human	PMID:14747463
Biological Process	GO:0008203	cholesterol metabolic process	Abca1	IDA		Mouse	PMID:11559713
Biological Process	GO:0030301	cholesterol transport	Abca1	IDA		Rat	PMID:12909583\|RGD:1304419
Biological Process	GO:0030301	cholesterol transport	Abca1	IMP		Rat	PMID:14993246\|RGD:1358264
Biological Process	GO:0016197	endosomal transport	ABCA1	IDA		Human	PMID:14747463
Biological Process	GO:0051649	establishment of localization in cell	Abca1	IMP	MGI:MGI:3613250	Mouse	PMID:17148552
Biological Process	GO:0051649	establishment of localization in cell	Abca1	IMP		Mouse	PMID:15520449
Biological Process	GO:0051649	establishment of localization in cell	Abca1	IMP	MGI:MGI:1935192	Mouse	PMID:10878804
Biological Process	GO:0140115	export across plasma membrane	Abca1	IMP		Mouse	MGI:MGI:6207500\|PMID:29937375
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ABCA1	IMP		Human	PMID:16443932
Biological Process	GO:0034380	high-density lipoprotein particle assembly	ABCA1	IMP		Human	PMID:10431236
Biological Process	GO:0034380	high-density lipoprotein particle assembly	ABCA1	IMP		Human	PMID:14754908
Biological Process	GO:0034380	high-density lipoprotein particle assembly	ABCA1	IMP		Human	PMID:17305370
Biological Process	GO:0032367	intracellular cholesterol transport	ABCA1	IMP		Human	PMID:10431236
Biological Process	GO:0042158	lipoprotein biosynthetic process	Abca1	IMP	MGI:MGI:1935192	Mouse	PMID:15520446
Biological Process	GO:0042158	lipoprotein biosynthetic process	Abca1	IMP	MGI:MGI:1935192	Mouse	PMID:12859204
Biological Process	GO:0042158	lipoprotein biosynthetic process	Abca1	IMP		Rat	PMID:14993246\|RGD:1358264
Biological Process	GO:0042158	lipoprotein biosynthetic process	Abca1	IEP		Rat	PMID:21554872\|RGD:21408554
Biological Process	GO:0042157	lipoprotein metabolic process	Abca1	IMP	MGI:MGI:1935192	Mouse	PMID:15269218
Biological Process	GO:0007040	lysosome organization	ABCA1	IDA		Human	PMID:15163665
Biological Process	GO:0002790	peptide secretion	Abca1	IMP	MGI:MGI:1935192	Mouse	PMID:15269218
Biological Process	GO:0006911	phagocytosis, engulfment	Abca1	IMP	MGI:MGI:1935192	Mouse	PMID:10878804
Biological Process	GO:0033700	phospholipid efflux	ABCA1	IDA		Human	PMID:10431236
Biological Process	GO:0033700	phospholipid efflux	ABCA1	IDA		Human	PMID:11162594
Biological Process	GO:0033700	phospholipid efflux	ABCA1	IMP		Human	PMID:16702602
Biological Process	GO:0033700	phospholipid efflux	ABCA1	IMP		Human	PMID:19556522
Biological Process	GO:0033700	phospholipid efflux	ABCA1	IGI	UniProtKB:P02647\|UniProtKB:P02649	Human	PMID:28373057
Biological Process	GO:0033700	phospholipid efflux	ABCA1	IMP		Human	PMID:35974019
Biological Process	GO:0033700	phospholipid efflux	Abca1	IMP		Mouse	PMID:15520449
Biological Process	GO:0033700	phospholipid efflux	Abca1	IDA		Mouse	PMID:15520449
Biological Process	GO:0055091	phospholipid homeostasis	ABCA1	IMP		Human	PMID:16702602
Biological Process	GO:0045332	phospholipid translocation	ABCA1	IDA		Human	PMID:24097981
Biological Process	GO:0045332	phospholipid translocation	Abca1	IMP	MGI:MGI:1935192	Mouse	PMID:10878804
Biological Process	GO:0015914	phospholipid transport	Abca1	IDA		Rat	PMID:12909583\|RGD:1304419
Biological Process	GO:0060155	platelet dense granule organization	ABCA1	IMP		Human	PMID:15163665
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Abca1	IMP		Mouse	MGI:MGI:3047008\|PMID:15210959
Biological Process	GO:0090108	positive regulation of high-density lipoprotein particle assembly	Abca1	IMP		Mouse	MGI:MGI:5427333\|PMID:22179027
Biological Process	GO:0006497	protein lipidation	Abca1	IMP	MGI:MGI:3577725	Mouse	PMID:16204232
Biological Process	GO:0009306	protein secretion	ABCA1	IMP		Human	PMID:11855831
Biological Process	GO:0009306	protein secretion	Abca1	IMP		Mouse	MGI:MGI:6207500\|PMID:29937375
Biological Process	GO:0071806	protein transmembrane transport	Abca1	IMP		Mouse	MGI:MGI:6207500\|PMID:29937375
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction	ABCA1	IMP		Human	PMID:16443932
Biological Process	GO:0010874	regulation of cholesterol efflux	abca1a	IGI	ZFIN:ZDB-MRPHLNO-130813-6,ZFIN:ZDB-MRPHLNO-130813-7	Zfish	PMID:23719382
Biological Process	GO:0034616	response to laminar fluid shear stress	ABCA1	IDA		Human	PMID:15358760
Biological Process	GO:0007584	response to nutrient	Abca1	IEP		Rat	PMID:15710224\|RGD:1598545
Biological Process	GO:0031667	response to nutrient levels	Abca1	IEP		Rat	PMID:25612518\|RGD:15045599
Biological Process	GO:0009410	response to xenobiotic stimulus	Abca1	IEP		Rat	PMID:14690017\|RGD:1598546
Biological Process	GO:0043691	reverse cholesterol transport	ABCA1	IMP		Human	PMID:10431236
Biological Process	GO:0043691	reverse cholesterol transport	Abca1	IMP		Mouse	MGI:MGI:3720273\|PMID:17657311
Biological Process	GO:0023061	signal release	ABCA1	IMP		Human	PMID:11855831
Biological Process	GO:0023061	signal release	Abca1	IMP		Mouse	MGI:MGI:6207500\|PMID:29937375
Biological Process	GO:0002040	sprouting angiogenesis	abca1a	IGI	ZFIN:ZDB-MRPHLNO-130813-6,ZFIN:ZDB-MRPHLNO-130813-7	Zfish	PMID:23719382

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.