Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCA12
  • Mouse genes Abca12
  • Rat genes Abca12
  • Zfish genes abca12
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abca12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034191	apolipoprotein A-I receptor binding	ABCA12	IPI	UniProtKB:O95477	Human	PMID:23931754
Molecular Function	GO:0005319	lipid transporter activity	ABCA12	IDA		Human	PMID:16007253
Molecular Function	GO:0005515	protein binding	ABCA12	IPI	UniProtKB:O95477	Human	PMID:23931754
Molecular Function	GO:0005515	protein binding	Abca12	IPI	PR:P41233	Mouse	PMID:23931754
Molecular Function	GO:0005515	protein binding	Abca12	IPI	PR:Q60644	Mouse	PMID:23931754
Molecular Function	GO:0005102	signaling receptor binding	ABCA12	IPI	UniProtKB:P55055	Human	PMID:23931754
Cellular Component	GO:0005737	cytoplasm	ABCA12	IDA		Human	PMID:23931754
Cellular Component	GO:0005829	cytosol	Abca12	IDA		Mouse	PMID:18632686
Cellular Component	GO:0097209	epidermal lamellar body	ABCA12	IDA		Human	PMID:16007253
Cellular Component	GO:0097234	epidermal lamellar body membrane	ABCA12	IDA		Human	PMID:17927575
Cellular Component	GO:0000139	Golgi membrane	ABCA12	IDA		Human	PMID:17927575
Cellular Component	GO:0005743	mitochondrial inner membrane	Abca12	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005886	plasma membrane	ABCA12	IDA		Human	PMID:23931754
Biological Process	GO:0006672	ceramide metabolic process	ABCA12	IDA		Human	PMID:17927575
Biological Process	GO:0006672	ceramide metabolic process	Abca12	IMP		Mouse	MGI:MGI:4462766|PMID:20489143
Biological Process	GO:0035627	ceramide transport	ABCA12	IDA		Human	PMID:17927575
Biological Process	GO:0035627	ceramide transport	ABCA12	IMP		Human	PMID:20869849
Biological Process	GO:0035627	ceramide transport	Abca12	IMP		Mouse	MGI:MGI:5562607|PMID:24293640
Biological Process	GO:0035627	ceramide transport	Abca12	IMP		Mouse	MGI:MGI:6161848|PMID:27551807
Biological Process	GO:0035627	ceramide transport	Abca12	IMP		Mouse	MGI:MGI:4462766|PMID:20489143
Biological Process	GO:0035627	ceramide transport	Abca12	IMP	MGI:MGI:3528440	Mouse	PMID:18957418
Biological Process	GO:0033344	cholesterol efflux	Abca12	IMP	MGI:MGI:4461044	Mouse	PMID:23931754
Biological Process	GO:0003336	corneocyte desquamation	ABCA12	IMP		Human	PMID:19179616
Biological Process	GO:0003336	corneocyte desquamation	Abca12	IMP		Mouse	MGI:MGI:6161848|PMID:27551807
Biological Process	GO:0048730	epidermis morphogenesis	abca12	IMP	ZFIN:ZDB-MRPHLNO-120110-3	Zfish	PMID:21816950
Biological Process	GO:0051649	establishment of localization in cell	Abca12	IMP	MGI:MGI:4461044	Mouse	PMID:23931754
Biological Process	GO:0061436	establishment of skin barrier	Abca12	IMP		Mouse	MGI:MGI:4462766|PMID:20489143
Biological Process	GO:0061436	establishment of skin barrier	Abca12	IMP		Mouse	MGI:MGI:6161848|PMID:27551807
Biological Process	GO:0061436	establishment of skin barrier	Abca12	IMP	MGI:MGI:3528440	Mouse	PMID:18957418
Biological Process	GO:0061436	establishment of skin barrier	Abca12	IMP	MGI:MGI:3809668	Mouse	PMID:18632686
Biological Process	GO:0061436	establishment of skin barrier	Abca12	IMP	MGI:MGI:4461044	Mouse	PMID:18802465
Biological Process	GO:0006886	intracellular protein transport	ABCA12	IMP		Human	PMID:19179616
Biological Process	GO:0031424	keratinization	Abca12	IMP	MGI:MGI:4461044	Mouse	PMID:18802465
Biological Process	GO:0031424	keratinization	Abca12	IMP	MGI:MGI:3809668	Mouse	PMID:18632686
Biological Process	GO:0031424	keratinization	Abca12	IMP	MGI:MGI:3528440	Mouse	PMID:18957418
Biological Process	GO:0030216	keratinocyte differentiation	Abca12	IMP	MGI:MGI:4461044	Mouse	PMID:18802465
Biological Process	GO:0055088	lipid homeostasis	Abca12	IMP	MGI:MGI:4461044	Mouse	PMID:18802465
Biological Process	GO:0006869	lipid transport	ABCA12	IDA		Human	PMID:16007253
Biological Process	GO:0048286	lung alveolus development	Abca12	IMP	MGI:MGI:3809668	Mouse	PMID:18632686
Biological Process	GO:0033700	phospholipid efflux	ABCA12	IMP		Human	PMID:23931754
Biological Process	GO:0010875	positive regulation of cholesterol efflux	ABCA12	IDA		Human	PMID:23931754
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Abca12	IMP	MGI:MGI:4461044	Mouse	PMID:23931754
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Abca12	IGI	MGI:MGI:1352463	Mouse	PMID:23931754
Biological Process	GO:0032379	positive regulation of intracellular lipid transport	Abca12	IMP		Mouse	MGI:MGI:6161848|PMID:27551807
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	Abca12	IMP		Mouse	PMID:23931754
Biological Process	GO:0072659	protein localization to plasma membrane	ABCA12	IDA		Human	PMID:23931754
Biological Process	GO:0072659	protein localization to plasma membrane	ABCA12	IMP		Human	PMID:23931754
Biological Process	GO:0045055	regulated exocytosis	ABCA12	IMP		Human	PMID:16007253
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	Abca12	IMP		Mouse	MGI:MGI:6394227|PMID:32072744
Biological Process	GO:0045616	regulation of keratinocyte differentiation	ABCA12	IMP		Human	PMID:19179616
Biological Process	GO:0045616	regulation of keratinocyte differentiation	ABCA12	IMP		Human	PMID:20869849
Biological Process	GO:0045616	regulation of keratinocyte differentiation	Abca12	IMP		Mouse	MGI:MGI:4462766|PMID:20489143
Biological Process	GO:0032940	secretion by cell	ABCA12	IMP		Human	PMID:16007253
Biological Process	GO:0043129	surfactant homeostasis	Abca12	IMP	MGI:MGI:3809668	Mouse	PMID:18632686

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern