Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCA2
  • Mouse genes Abca2
  • Rat genes Abca2
  • Zfish genes abca2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abca2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	ABCA2	IDA		Human	PMID:15999530
Molecular Function	GO:0005524	ATP binding	Abca2	IDA		Rat	PMID:10970803|RGD:631993
Molecular Function	GO:0099038	ceramide floppase activity	ABCA2	IDA		Human	PMID:24201375
Molecular Function	GO:0061135	endopeptidase regulator activity	ABCA2	IMP		Human	PMID:22086926
Cellular Component	GO:0031410	cytoplasmic vesicle	Abca2	IDA		Rat	PMID:16539677|RGD:8554132
Cellular Component	GO:0005768	endosome	ABCA2	IDA		Human	PMID:11309290
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ABCA2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005765	lysosomal membrane	Abca2	IDA		Mouse	MGI:MGI:6478857|PMID:11157071
Cellular Component	GO:0005765	lysosomal membrane	Abca2	IDA		Rat	PMID:11157071|RGD:40902967
Cellular Component	GO:0005765	lysosomal membrane	Abca2	IDA		Rat	PMID:12210128|RGD:631995
Cellular Component	GO:0005764	lysosome	ABCA2	IDA		Human	PMID:11309290
Cellular Component	GO:0016020	membrane	ABCA2	IDA		Human	PMID:15999530
Cellular Component	GO:0016020	membrane	ABCA2	HDA		Human	PMID:19946888
Cellular Component	GO:0005815	microtubule organizing center	Abca2	IDA		Rat	PMID:16539677|RGD:8554132
Cellular Component	GO:0005886	plasma membrane	ABCA2	IDA		Human	PMID:24201375
Cellular Component	GO:0005886	plasma membrane	ABCA2	IDA		Human	PMID:23137377
Biological Process	GO:0032289	central nervous system myelin formation	Abca2	IMP		Mouse	MGI:MGI:3697245|PMID:17060448
Biological Process	GO:0032289	central nervous system myelin formation	Abca2	IDA		Rat	PMID:12210128|RGD:631995
Biological Process	GO:0099040	ceramide translocation	ABCA2	IDA		Human	PMID:24201375
Biological Process	GO:0042632	cholesterol homeostasis	ABCA2	IEP		Human	PMID:15238223
Biological Process	GO:0001573	ganglioside metabolic process	Abca2	IMP		Mouse	MGI:MGI:3718765|PMID:17488728
Biological Process	GO:0006687	glycosphingolipid metabolic process	Abca2	IMP		Mouse	MGI:MGI:3718765|PMID:17488728
Biological Process	GO:0090156	intracellular sphingolipid homeostasis	ABCA2	IDA		Human	PMID:26510981
Biological Process	GO:0007626	locomotory behavior	Abca2	IMP		Mouse	MGI:MGI:3697245|PMID:17060448
Biological Process	GO:0090370	negative regulation of cholesterol efflux	ABCA2	IDA		Human	PMID:21810484
Biological Process	GO:0032384	negative regulation of intracellular cholesterol transport	ABCA2	IDA		Human	PMID:21810484
Biological Process	GO:1905598	negative regulation of low-density lipoprotein receptor activity	ABCA2	IDA		Human	PMID:21810484
Biological Process	GO:1905598	negative regulation of low-density lipoprotein receptor activity	Abca2	IDA		Mouse	MGI:MGI:5306885|PMID:21810484
Biological Process	GO:1905598	negative regulation of low-density lipoprotein receptor activity	Abca2	IDA		Rat	PMID:21810484|RGD:14697730
Biological Process	GO:0071072	negative regulation of phospholipid biosynthetic process	ABCA2	IDA		Human	PMID:24201375
Biological Process	GO:0071072	negative regulation of phospholipid biosynthetic process	Abca2	IMP		Rat	PMID:24201375|RGD:14697729
Biological Process	GO:1905601	negative regulation of receptor-mediated endocytosis involved in cholesterol transport	ABCA2	IDA		Human	PMID:21810484
Biological Process	GO:0090155	negative regulation of sphingolipid biosynthetic process	ABCA2	IDA		Human	PMID:24201375
Biological Process	GO:0090155	negative regulation of sphingolipid biosynthetic process	Abca2	IMP		Rat	PMID:24201375|RGD:14697729
Biological Process	GO:0045939	negative regulation of steroid metabolic process	Abca2	IMP		Rat	PMID:24201375|RGD:14697729
Biological Process	GO:0042986	positive regulation of amyloid precursor protein biosynthetic process	ABCA2	IDA		Human	PMID:20704561
Biological Process	GO:1902993	positive regulation of amyloid precursor protein catabolic process	ABCA2	IGI	UniProtKB:P56818	Human	PMID:20704561
Biological Process	GO:1902993	positive regulation of amyloid precursor protein catabolic process	ABCA2	IMP		Human	PMID:22086926
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ABCA2	IMP		Human	PMID:22086926
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	Abca2	IMP		Rat	PMID:22086926|RGD:14697726
Biological Process	GO:0032805	positive regulation of low-density lipoprotein particle receptor catabolic process	ABCA2	IDA		Human	PMID:21810484
Biological Process	GO:0032383	regulation of intracellular cholesterol transport	ABCA2	IMP		Human	PMID:15238223
Biological Process	GO:0032383	regulation of intracellular cholesterol transport	Abca2	IMP		Mouse	MGI:MGI:6478054|PMID:22748276
Biological Process	GO:1901873	regulation of post-translational protein modification	ABCA2	IMP		Human	PMID:22086926
Biological Process	GO:0060049	regulation of protein glycosylation	Abca2	IMP		Mouse	MGI:MGI:6355606|PMID:22086926
Biological Process	GO:1904375	regulation of protein localization to cell periphery	Abca2	IMP		Mouse	MGI:MGI:6355606|PMID:22086926
Biological Process	GO:2000008	regulation of protein localization to cell surface	Abca2	IMP		Mouse	MGI:MGI:6355606|PMID:22086926
Biological Process	GO:0019218	regulation of steroid metabolic process	ABCA2	IDA		Human	PMID:24201375
Biological Process	GO:0070723	response to cholesterol	ABCA2	IEP		Human	PMID:11178988
Biological Process	GO:0048545	response to steroid hormone	ABCA2	IEP		Human	PMID:15238223
Biological Process	GO:0006684	sphingomyelin metabolic process	Abca2	IMP		Mouse	MGI:MGI:3718765|PMID:17488728
Biological Process	GO:0046512	sphingosine biosynthetic process	ABCA2	IDA		Human	PMID:26510981

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern