Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCA4
  • Mouse genes Abca4
  • Rat genes Abca4
  • Zfish genes abca4a,abca4b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abca4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005502	11-cis retinal binding	ABCA4	IDA		Human	PMID:23144455
Molecular Function	GO:0005503	all-trans retinal binding	ABCA4	IDA		Human	PMID:20404325
Molecular Function	GO:0005503	all-trans retinal binding	ABCA4	IDA		Human	PMID:29847635
Molecular Function	GO:0005503	all-trans retinal binding	ABCA4	IDA		Human	PMID:33375396
Molecular Function	GO:0016887	ATP hydrolysis activity	ABCA4	IDA		Human	PMID:29847635
Molecular Function	GO:0016887	ATP hydrolysis activity	ABCA4	IDA		Human	PMID:33375396
Molecular Function	GO:0140326	ATPase-coupled intramembrane lipid transporter activity	Abca4	IMP	MGI:MGI:1857860	Mouse	PMID:10412977
Molecular Function	GO:0140327	flippase activity	ABCA4	IDA		Human	PMID:24097981
Molecular Function	GO:0140347	N-retinylidene-phosphatidylethanolamine flippase activity	Abca4	IMP		Mouse	MGI:MGI:5691507|PMID:22735453
Molecular Function	GO:0140347	N-retinylidene-phosphatidylethanolamine flippase activity	Abca4	IMP		Mouse	MGI:MGI:1860041|PMID:10852960
Molecular Function	GO:0140347	N-retinylidene-phosphatidylethanolamine flippase activity	Abca4	IMP	MGI:MGI:1857860	Mouse	PMID:10412977
Molecular Function	GO:0090555	phosphatidylethanolamine flippase activity	ABCA4	IDA		Human	PMID:24097981
Cellular Component	GO:0031410	cytoplasmic vesicle	ABCA4	IDA		Human	PMID:29847635
Cellular Component	GO:0031410	cytoplasmic vesicle	ABCA4	IDA		Human	PMID:33375396
Cellular Component	GO:0005783	endoplasmic reticulum	ABCA4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005783	endoplasmic reticulum	ABCA4	IDA		Human	PMID:24097981
Cellular Component	GO:0001750	photoreceptor outer segment	Abca4	IDA		Mouse	MGI:MGI:1274766|PMID:9202155
Cellular Component	GO:0001750	photoreceptor outer segment	Abca4	IDA		Mouse	PMID:23943788
Biological Process	GO:0034204	lipid translocation	Abca4	IMP	MGI:MGI:1857860	Mouse	MGI:MGI:1340797|PMID:10412977
Biological Process	GO:0006649	phospholipid transfer to membrane	Abca4	IMP	MGI:MGI:1857860	Mouse	PMID:10412977
Biological Process	GO:0045332	phospholipid translocation	ABCA4	IDA		Human	PMID:24097981
Biological Process	GO:0045494	photoreceptor cell maintenance	Abca4	IMP	MGI:MGI:1857860	Mouse	PMID:11431429
Biological Process	GO:0042574	retinal metabolic process	ABCA4	IDA		Human	PMID:29847635
Biological Process	GO:0042574	retinal metabolic process	ABCA4	IDA		Human	PMID:33375396
Biological Process	GO:0007601	visual perception	Abca4	IMP	MGI:MGI:1857860	Mouse	PMID:10412977

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern