Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCA5
  • Mouse genes Abca5
  • Rat genes Abca5
  • Zfish genes abca5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abca5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Cellular Component	GO:0005794	Golgi apparatus	Abca5	IDA		Rat	PMID:16162093|RGD:1549860
Cellular Component	GO:0005770	late endosome	Abca5	IDA		Mouse	MGI:MGI:3581349|PMID:15870284
Cellular Component	GO:0005764	lysosome	Abca5	IDA		Mouse	MGI:MGI:3581349|PMID:15870284
Biological Process	GO:0033344	cholesterol efflux	Abca5	IMP		Mouse	MGI:MGI:4454250|PMID:20382126
Biological Process	GO:0042632	cholesterol homeostasis	ABCA5	IMP		Human	PMID:25125465
Biological Process	GO:0008203	cholesterol metabolic process	ABCA5	IMP		Human	PMID:25125465
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	Abca5	IMP		Mouse	MGI:MGI:4454250|PMID:20382126
Biological Process	GO:0010745	negative regulation of macrophage derived foam cell differentiation	Abca5	IMP		Mouse	MGI:MGI:4454250|PMID:20382126
Biological Process	GO:1903064	positive regulation of reverse cholesterol transport	Abca5	IMP		Mouse	MGI:MGI:6508518|PMID:32687853
Biological Process	GO:0010874	regulation of cholesterol efflux	ABCA5	IMP		Human	PMID:25125465
Biological Process	GO:0010874	regulation of cholesterol efflux	Abca5	IMP		Mouse	MGI:MGI:6508518|PMID:32687853

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern