Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCA7
  • Mouse genes Abca7
  • Rat genes Abca7
  • Zfish genes abca7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abca7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034188	apolipoprotein A-I receptor activity	ABCA7	IDA		Human	PMID:14570867
Molecular Function	GO:0034188	apolipoprotein A-I receptor activity	Abca7	IDA		Mouse	MGI:MGI:5559672|PMID:12917409
Molecular Function	GO:0140328	floppase activity	ABCA7	IDA		Human	PMID:24097981
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	ABCA7	IDA		Human	PMID:24097981
Molecular Function	GO:0090556	phosphatidylserine floppase activity	ABCA7	IDA		Human	PMID:24097981
Molecular Function	GO:0005548	phospholipid transporter activity	ABCA7	IGI	UniProtKB:P02647|UniProtKB:P02649	Human	PMID:28373057
Molecular Function	GO:0005548	phospholipid transporter activity	Abca7	IDA		Mouse	PMID:15520449
Molecular Function	GO:0005515	protein binding	Abca7	IPI	UniProtKB:P02647	Mouse	MGI:MGI:5559672|PMID:12917409
Cellular Component	GO:0016324	apical plasma membrane	Abca7	IDA		Mouse	PMID:15520449
Cellular Component	GO:0030054	cell junction	ABCA7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0009986	cell surface	Abca7	IDA		Mouse	MGI:MGI:5553241|PMID:20495215
Cellular Component	GO:0009986	cell surface	Abca7	IDA		Mouse	MGI:MGI:5559672|PMID:12917409
Cellular Component	GO:0005737	cytoplasm	Abca7	IDA		Mouse	MGI:MGI:6271506|PMID:27472885
Cellular Component	GO:0097386	glial cell projection	Abca7	IDA		Mouse	MGI:MGI:6271506|PMID:27472885
Cellular Component	GO:0005794	Golgi apparatus	ABCA7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005622	intracellular anatomical structure	Abca7	IDA		Mouse	PMID:15520449
Cellular Component	GO:0016020	membrane	Abca7	IDA		Rat	PMID:12727224|RGD:1303958
Cellular Component	GO:0001891	phagocytic cup	Abca7	IDA		Mouse	MGI:MGI:3662940|PMID:16908670
Cellular Component	GO:0005886	plasma membrane	ABCA7	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ABCA7	IDA		Human	PMID:14570867
Cellular Component	GO:0005886	plasma membrane	ABCA7	IDA		Human	PMID:28373057
Cellular Component	GO:0005886	plasma membrane	Abca7	IDA		Rat	PMID:12727224|RGD:1303958
Cellular Component	GO:0032587	ruffle membrane	Abca7	IDA		Mouse	MGI:MGI:3662940|PMID:16908670
Biological Process	GO:0150094	amyloid-beta clearance by cellular catabolic process	Abca7	IMP		Mouse	MGI:MGI:6271506|PMID:27472885
Biological Process	GO:0034205	amyloid-beta formation	ABCA7	IMP		Human	PMID:26260791
Biological Process	GO:0034205	amyloid-beta formation	Abca7	IMP		Mouse	MGI:MGI:5694857|PMID:26260791
Biological Process	GO:0038027	apolipoprotein A-I-mediated signaling pathway	ABCA7	IDA		Human	PMID:14570867
Biological Process	GO:0038027	apolipoprotein A-I-mediated signaling pathway	Abca7	IMP		Mouse	MGI:MGI:5553241|PMID:20495215
Biological Process	GO:0038027	apolipoprotein A-I-mediated signaling pathway	Abca7	IDA		Mouse	MGI:MGI:5559672|PMID:12917409
Biological Process	GO:0033344	cholesterol efflux	ABCA7	IDA		Human	PMID:14570867
Biological Process	GO:0033344	cholesterol efflux	Abca7	IMP		Mouse	MGI:MGI:6271506|PMID:27472885
Biological Process	GO:0034380	high-density lipoprotein particle assembly	ABCA7	IDA		Human	PMID:14570867
Biological Process	GO:0007613	memory	Abca7	IMP		Mouse	MGI:MGI:5487687|PMID:23467355
Biological Process	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process	Abca7	IDA		Mouse	MGI:MGI:5553242|PMID:18429932
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	Abca7	IDA		Mouse	MGI:MGI:5553242|PMID:18429932
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	Abca7	IMP		Mouse	MGI:MGI:5487687|PMID:23467355
Biological Process	GO:1902430	negative regulation of amyloid-beta formation	Abca7	IMP		Mouse	MGI:MGI:5774886|PMID:27030769
Biological Process	GO:0045806	negative regulation of endocytosis	Abca7	IMP		Mouse	MGI:MGI:5694857|PMID:26260791
Biological Process	GO:0043409	negative regulation of MAPK cascade	Abca7	IMP		Mouse	MGI:MGI:5774886|PMID:27030769
Biological Process	GO:1903898	negative regulation of PERK-mediated unfolded protein response	Abca7	IMP		Mouse	MGI:MGI:5774886|PMID:27030769
Biological Process	GO:0018149	peptide cross-linking	Abca7	IDA		Mouse	MGI:MGI:5559672|PMID:12917409
Biological Process	GO:0033700	phospholipid efflux	ABCA7	IDA		Human	PMID:14570867
Biological Process	GO:0033700	phospholipid efflux	ABCA7	IGI	UniProtKB:P02647|UniProtKB:P02649	Human	PMID:28373057
Biological Process	GO:0033700	phospholipid efflux	Abca7	IMP		Mouse	MGI:MGI:6271506|PMID:27472885
Biological Process	GO:0033700	phospholipid efflux	Abca7	IDA		Mouse	PMID:15520449
Biological Process	GO:0045332	phospholipid translocation	ABCA7	IDA		Human	PMID:24097981
Biological Process	GO:0044857	plasma membrane raft organization	Abca7	IMP		Mouse	MGI:MGI:6274964|PMID:28091533
Biological Process	GO:1900223	positive regulation of amyloid-beta clearance	Abca7	IMP		Mouse	MGI:MGI:5487687|PMID:23467355
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Abca7	IDA		Mouse	MGI:MGI:5553242|PMID:18429932
Biological Process	GO:1901076	positive regulation of engulfment of apoptotic cell	Abca7	IMP		Mouse	MGI:MGI:3662940|PMID:16908670
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Abca7	IMP		Mouse	MGI:MGI:3662940|PMID:16908670
Biological Process	GO:0050766	positive regulation of phagocytosis	Abca7	IMP		Mouse	MGI:MGI:6271506|PMID:27472885
Biological Process	GO:0050766	positive regulation of phagocytosis	Abca7	IMP		Mouse	MGI:MGI:5553241|PMID:20495215
Biological Process	GO:1902995	positive regulation of phospholipid efflux	Abca7	IDA		Mouse	MGI:MGI:5559672|PMID:12917409
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	Abca7	IMP		Mouse	MGI:MGI:6274964|PMID:28091533
Biological Process	GO:0034504	protein localization to nucleus	Abca7	IDA		Mouse	MGI:MGI:5553242|PMID:18429932
Biological Process	GO:1902991	regulation of amyloid precursor protein catabolic process	ABCA7	IMP		Human	PMID:26260791
Biological Process	GO:0019216	regulation of lipid metabolic process	Abca7	IMP		Mouse	MGI:MGI:5774886|PMID:27030769
Biological Process	GO:0008542	visual learning	Abca7	IMP		Mouse	MGI:MGI:5774886|PMID:27030769

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern