Comparative GO Graph (mouse, human, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCB1
  • Mouse genes Abcb1a
  • Rat genes
  • Zfish genes abcb4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abcb1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015462	ABC-type protein transporter activity	abcb4	IDA		Zfish	PMID:25193616
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity	ABCB1	IGI	RNAcentral:URS000021202F_9606	Human	PMID:23893241
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity	ABCB1	IDA		Human	PMID:26850595
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity	ABCB1	IGI	RNAcentral:URS00003496BE_9606	Human	PMID:28260112
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity	ABCB1	IMP		Human	PMID:28411377
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity	ABCB1	IDA		Human	PMID:28757552
Molecular Function	GO:0005524	ATP binding	ABCB1	IDA		Human	PMID:28757552
Molecular Function	GO:0005524	ATP binding	ABCB1	IDA		Human	PMID:29371429
Molecular Function	GO:0016887	ATP hydrolysis activity	Abcb1a	IDA		Mouse	PMID:11741934
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ABCB1	IDA		Human	PMID:28757552
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	Abcb1a	EXP		Mouse	MGI:MGI:5770073|PMID:17709369
Molecular Function	GO:0046943	carboxylic acid transmembrane transporter activity	ABCB1	IMP		Human	PMID:25986174
Molecular Function	GO:0099038	ceramide floppase activity	ABCB1	IDA		Human	PMID:8898203
Molecular Function	GO:0099038	ceramide floppase activity	Abcb1a	IDA		Mouse	MGI:MGI:5795830|PMID:8898203
Molecular Function	GO:0015562	efflux transmembrane transporter activity	ABCB1	IGI	RNAcentral:URS000021202F_9606	Human	PMID:23893241
Molecular Function	GO:0015562	efflux transmembrane transporter activity	ABCB1	IMP		Human	PMID:25986174
Molecular Function	GO:0015562	efflux transmembrane transporter activity	ABCB1	IDA		Human	PMID:26850595
Molecular Function	GO:0015562	efflux transmembrane transporter activity	ABCB1	IGI	RNAcentral:URS00003496BE_9606	Human	PMID:28260112
Molecular Function	GO:0015562	efflux transmembrane transporter activity	ABCB1	IMP		Human	PMID:28411377
Molecular Function	GO:0015562	efflux transmembrane transporter activity	ABCB1	IDA		Human	PMID:28587984
Molecular Function	GO:0015562	efflux transmembrane transporter activity	ABCB1	IDA		Human	PMID:28757552
Molecular Function	GO:0015562	efflux transmembrane transporter activity	Abcb1a	IMP		Mouse	MGI:MGI:6369882|PMID:28587984
Molecular Function	GO:0015562	efflux transmembrane transporter activity	abcb4	IMP	ZFIN:ZDB-MRPHLNO-140501-3	Zfish	PMID:23773777
Molecular Function	GO:0015562	efflux transmembrane transporter activity	abcb4	IMP	ZFIN:ZDB-MRPHLNO-140501-2	Zfish	PMID:23773777
Molecular Function	GO:0140328	floppase activity	ABCB1	IMP		Human	PMID:8898203
Molecular Function	GO:0140328	floppase activity	Abcb1a	IMP		Mouse	MGI:MGI:5795830|PMID:8898203
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	ABCB1	IDA		Human	PMID:8898203
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	Abcb1a	IDA		Mouse	MGI:MGI:5795830|PMID:8898203
Molecular Function	GO:0090555	phosphatidylethanolamine flippase activity	ABCB1	IDA		Human	PMID:8898203
Molecular Function	GO:0090555	phosphatidylethanolamine flippase activity	Abcb1a	IDA		Mouse	MGI:MGI:5795830|PMID:8898203
Molecular Function	GO:0005515	protein binding	ABCB1	IPI	UniProtKB:Q99496	Human	PMID:17088979
Molecular Function	GO:0005515	protein binding	ABCB1	IPI	UniProtKB:Q86VI4	Human	PMID:20711237
Molecular Function	GO:0019534	toxin transmembrane transporter activity	abcb4	IDA		Zfish	PMID:25193616
Molecular Function	GO:0022857	transmembrane transporter activity	Abcb1a	IMP		Mouse	MGI:MGI:6369882|PMID:28587984
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ABCB1	IPI	UniProtKB:P46934	Human	PMID:26006083
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	ABCB1	IMP		Human	PMID:25986174
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	ABCB1	IDA		Human	PMID:28587984
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	ABCB1	IDA		Human	PMID:28757552
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	Abcb1a	IMP		Mouse	MGI:MGI:6369882|PMID:28587984
Cellular Component	GO:0016324	apical plasma membrane	ABCB1	IDA		Human	PMID:16361082
Cellular Component	GO:0016324	apical plasma membrane	ABCB1	IDA		Human	PMID:28408210
Cellular Component	GO:0016324	apical plasma membrane	ABCB1	IDA		Human	PMID:8898203
Cellular Component	GO:0016324	apical plasma membrane	ABCB1	IDA		Human	PMID:31791063
Cellular Component	GO:0016324	apical plasma membrane	Abcb1a	IDA		Mouse	MGI:MGI:5795830|PMID:8898203
Cellular Component	GO:0009986	cell surface	ABCB1	IDA		Human	PMID:19384922
Cellular Component	GO:0005737	cytoplasm	ABCB1	IDA		Human	PMID:35970996
Cellular Component	GO:0070062	extracellular exosome	ABCB1	HDA		Human	PMID:19056867
Cellular Component	GO:0070062	extracellular exosome	ABCB1	HDA		Human	PMID:23533145
Cellular Component	GO:0046581	intercellular canaliculus	Abcb1a	IDA		Mouse	PMID:12068294
Cellular Component	GO:0016020	membrane	ABCB1	IDA		Human	PMID:26006083
Cellular Component	GO:0005886	plasma membrane	ABCB1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ABCB1	IDA		Human	PMID:18619525
Cellular Component	GO:0005886	plasma membrane	ABCB1	IDA		Human	PMID:35970996
Cellular Component	GO:0005886	plasma membrane	ABCB1	IDA		Human	PMID:23137377
Biological Process	GO:1905039	carboxylic acid transmembrane transport	ABCB1	IMP		Human	PMID:25986174
Biological Process	GO:0099040	ceramide translocation	ABCB1	IDA		Human	PMID:8898203
Biological Process	GO:0099040	ceramide translocation	Abcb1a	IDA		Mouse	MGI:MGI:5795830|PMID:8898203
Biological Process	GO:0140115	export across plasma membrane	ABCB1	IMP		Human	PMID:25986174
Biological Process	GO:0140115	export across plasma membrane	ABCB1	IDA		Human	PMID:28587984
Biological Process	GO:0140115	export across plasma membrane	Abcb1a	IMP		Mouse	MGI:MGI:6369882|PMID:28587984
Biological Process	GO:0000086	G2/M transition of mitotic cell cycle	ABCB1	IDA		Human	PMID:19384922
Biological Process	GO:0045332	phospholipid translocation	ABCB1	IDA		Human	PMID:8898203
Biological Process	GO:0045332	phospholipid translocation	Abcb1a	IDA		Mouse	MGI:MGI:5795830|PMID:8898203
Biological Process	GO:1901529	positive regulation of anion channel activity	ABCB1	IMP		Human	PMID:7828597
Biological Process	GO:2001225	regulation of chloride transport	ABCB1	IMP		Human	PMID:7828597
Biological Process	GO:0047484	regulation of response to osmotic stress	ABCB1	IMP		Human	PMID:7828597
Biological Process	GO:0009636	response to toxic substance	abcb4	IDA		Zfish	PMID:25193616
Biological Process	GO:0072089	stem cell proliferation	ABCB1	IMP		Human	PMID:19384922
Biological Process	GO:0046865	terpenoid transport	Abcb1a	IMP		Mouse	MGI:MGI:6369882|PMID:28587984
Biological Process	GO:0070633	transepithelial transport	ABCB1	IMP		Human	PMID:25986174
Biological Process	GO:0070633	transepithelial transport	ABCB1	IDA		Human	PMID:28757552
Biological Process	GO:0055085	transmembrane transport	abcb4	IMP	ZFIN:ZDB-MRPHLNO-140501-3	Zfish	PMID:23773777|ZFIN:ZDB-PUB-130710-16
Biological Process	GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	ABCB1	IGI	RNAcentral:URS000021202F_9606	Human	PMID:23893241
Biological Process	GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	ABCB1	IDA		Human	PMID:26850595
Biological Process	GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	ABCB1	IMP		Human	PMID:28260112
Biological Process	GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	ABCB1	IMP		Human	PMID:28411377
Biological Process	GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	Abcb1a	IDA		Mouse	PMID:11741934
Biological Process	GO:1990962	xenobiotic transport across blood-brain barrier	ABCB1	IMP		Human	PMID:25986174
Biological Process	GO:1990962	xenobiotic transport across blood-brain barrier	Abcb1a	IMP		Mouse	MGI:MGI:6369882|PMID:28587984

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern