Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCB4
  • Mouse genes Abcb4
  • Rat genes Abcb4
  • Zfish genes abcb4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abcb4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015462	ABC-type protein transporter activity	abcb4	IDA		Zfish	PMID:25193616
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ABCB4	IDA		Human	PMID:17523162
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ABCB4	IMP		Human	PMID:8898203
Molecular Function	GO:0015562	efflux transmembrane transporter activity	abcb4	IMP	ZFIN:ZDB-MRPHLNO-140501-3	Zfish	PMID:23773777
Molecular Function	GO:0015562	efflux transmembrane transporter activity	abcb4	IMP	ZFIN:ZDB-MRPHLNO-140501-2	Zfish	PMID:23773777
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	ABCB4	IDA		Human	PMID:17523162
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	ABCB4	IMP		Human	PMID:24045840
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	ABCB4	IMP		Human	PMID:24806754
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	ABCB4	IDA		Human	PMID:31873305
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	ABCB4	IDA		Human	PMID:8898203
Molecular Function	GO:0005515	protein binding	ABCB4	IPI	UniProtKB:P63244	Human	PMID:19674157
Molecular Function	GO:0005515	protein binding	Abcb4	IPI	RGD:727960	Rat	PMID:15159385|RGD:1302732
Molecular Function	GO:0005515	protein binding	Abcb4	IPI	UniProtKB:Q7TSE9	Rat	PMID:15159385|RGD:1302732
Molecular Function	GO:0019534	toxin transmembrane transporter activity	abcb4	IDA		Zfish	PMID:25193616
Cellular Component	GO:0016324	apical plasma membrane	ABCB4	IDA		Human	PMID:15258199
Cellular Component	GO:0016324	apical plasma membrane	ABCB4	IDA		Human	PMID:19674157
Cellular Component	GO:0016324	apical plasma membrane	ABCB4	IDA		Human	PMID:24122873
Cellular Component	GO:0016324	apical plasma membrane	ABCB4	IDA		Human	PMID:8898203
Cellular Component	GO:0016324	apical plasma membrane	Abcb4	IDA		Rat	PMID:10748167|RGD:1598590
Cellular Component	GO:0005737	cytoplasm	ABCB4	IDA		Human	PMID:24045840
Cellular Component	GO:0005829	cytosol	ABCB4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	ABCB4	HDA		Human	PMID:23533145
Cellular Component	GO:0005925	focal adhesion	ABCB4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000139	Golgi membrane	Abcb4	IDA		Rat	PMID:10748167|RGD:1598590
Cellular Component	GO:0046581	intercellular canaliculus	Abcb4	IDA		Mouse	PMID:12068294
Cellular Component	GO:0016020	membrane	Abcb4	IDA		Mouse	PMID:11279518
Cellular Component	GO:0005654	nucleoplasm	ABCB4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ABCB4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ABCB4	IDA		Human	PMID:24045840
Cellular Component	GO:0005886	plasma membrane	ABCB4	IDA		Human	PMID:24806754
Cellular Component	GO:0005886	plasma membrane	Abcb4	IDA		Mouse	MGI:MGI:79581|PMID:8615769
Biological Process	GO:0032782	bile acid secretion	Abcb4	IMP		Mouse	MGI:MGI:63651|PMID:8106172
Biological Process	GO:1903413	cellular response to bile acid	ABCB4	IDA		Human	PMID:17523162
Biological Process	GO:0055088	lipid homeostasis	ABCB4	IDA		Human	PMID:17523162
Biological Process	GO:0045332	phospholipid translocation	ABCB4	IMP		Human	PMID:24806754
Biological Process	GO:0045332	phospholipid translocation	ABCB4	IDA		Human	PMID:8898203
Biological Process	GO:0032376	positive regulation of cholesterol transport	ABCB4	IDA		Human	PMID:17523162
Biological Process	GO:0032376	positive regulation of cholesterol transport	ABCB4	IMP		Human	PMID:24045840
Biological Process	GO:0061092	positive regulation of phospholipid translocation	ABCB4	IDA		Human	PMID:17523162
Biological Process	GO:2001140	positive regulation of phospholipid transport	ABCB4	IMP		Human	PMID:24045840
Biological Process	GO:2001140	positive regulation of phospholipid transport	ABCB4	IDA		Human	PMID:8898203
Biological Process	GO:1901557	response to fenofibrate	Abcb4	IDA		Mouse	MGI:MGI:79581|PMID:8615769
Biological Process	GO:0051384	response to glucocorticoid	Abcb4	IEP		Rat	PMID:12429353|RGD:1598587
Biological Process	GO:0009636	response to toxic substance	abcb4	IDA		Zfish	PMID:25193616
Biological Process	GO:0009410	response to xenobiotic stimulus	Abcb4	IEP		Rat	PMID:10464145|RGD:1598595
Biological Process	GO:0055085	transmembrane transport	abcb4	IMP	ZFIN:ZDB-MRPHLNO-140501-3	Zfish	PMID:23773777|ZFIN:ZDB-PUB-130710-16

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern