Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCB7
  • Mouse genes Abcb7
  • Rat genes Abcb7
  • Zfish genes abcb7
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abcb7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0140481	ABC-type iron-sulfur cluster transporter activity	ABCB7	IMP		Human	PMID:33157103
Molecular Function	GO:0005515	protein binding	ABCB7	IPI	UniProtKB:Q9H8K7	Human	PMID:25063848
Molecular Function	GO:0005515	protein binding	ABCB7	IPI	UniProtKB:P22830,UniProtKB:Q9JI39	Human	PMID:30765471
Molecular Function	GO:0005515	protein binding	Abcb7	IPI	UniProtKB:P22315,UniProtKB:Q9JI39	Mouse	MGI:MGI:6695684|PMID:30765471
Molecular Function	GO:0005515	protein binding	Abcb7	IPI	UniProtKB:P10888	Rat	PMID:31511561|RGD:126781736
Molecular Function	GO:0005515	protein binding	Abcb7	IPI	UniProtKB:P15999	Rat	PMID:31511561|RGD:126781736
Molecular Function	GO:0042803	protein homodimerization activity	ABCB7	IDA		Human	PMID:30765471
Cellular Component	GO:0005743	mitochondrial inner membrane	ABCB7	IDA		Human	PMID:17006453
Cellular Component	GO:0005743	mitochondrial inner membrane	Abcb7	HDA		Mouse	PMID:12865426
Cellular Component	GO:0005739	mitochondrion	ABCB7	IDA		Human	PMID:22655043
Cellular Component	GO:0005739	mitochondrion	Abcb7	HDA		Mouse	PMID:14651853
Biological Process	GO:1990748	cellular detoxification	abcb7	IMP		Zfish	PMID:27734548|ZFIN:ZDB-PUB-161014-2
Biological Process	GO:0010312	detoxification of zinc ion	abcb7	IMP		Zfish	PMID:27734548|ZFIN:ZDB-PUB-161014-2
Biological Process	GO:0006879	intracellular iron ion homeostasis	ABCB7	IMP		Human	PMID:30765471
Biological Process	GO:0006879	intracellular iron ion homeostasis	Abcb7	IMP		Mouse	MGI:MGI:6695684|PMID:30765471
Biological Process	GO:0006879	intracellular iron ion homeostasis	Abcb7	IMP	MGI:MGI:3628654	Mouse	PMID:16424901
Biological Process	GO:0006879	intracellular iron ion homeostasis	Abcb7	IDA		Rat	PMID:31511561|RGD:126781736
Biological Process	GO:0034755	iron ion transmembrane transport	ABCB7	IDA		Human	PMID:17192393
Biological Process	GO:0016226	iron-sulfur cluster assembly	Abcb7	IMP		Mouse	MGI:MGI:6695684|PMID:30765471
Biological Process	GO:0140466	iron-sulfur cluster export from the mitochondrion	ABCB7	IMP		Human	PMID:33157103
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	Abcb7	IMP		Rat	PMID:31511561|RGD:126781736
Biological Process	GO:0070455	positive regulation of heme biosynthetic process	ABCB7	IMP		Human	PMID:30765471
Biological Process	GO:0070455	positive regulation of heme biosynthetic process	Abcb7	IMP		Mouse	MGI:MGI:6695684|PMID:30765471
Biological Process	GO:1903331	positive regulation of iron-sulfur cluster assembly	ABCB7	IMP		Human	PMID:17192393
Biological Process	GO:1903331	positive regulation of iron-sulfur cluster assembly	Abcb7	IMP		Mouse	MGI:MGI:3619656|PMID:16467350

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern