Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Abcc2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes ABCC2
- Mouse genes Abcc2
- Rat genes Abcc2
- Zfish genes abcc2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abcc2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015431	ABC-type glutathione S-conjugate transporter activity	ABCC2	IMP		Human	PMID:10220572
Molecular Function	GO:0015431	ABC-type glutathione S-conjugate transporter activity	Abcc2	IMP		Rat	PMID:10220572\|RGD:42721988
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity	ABCC2	IMP		Human	PMID:10220572
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity	ABCC2	IMP		Human	PMID:18245269
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity	Abcc2	IMP		Rat	PMID:10220572\|RGD:42721988
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ABCC2	IDA		Human	PMID:11500505
Molecular Function	GO:0015127	bilirubin transmembrane transporter activity	ABCC2	IMP		Human	PMID:10421658
Molecular Function	GO:0015127	bilirubin transmembrane transporter activity	Abcc2	IMP		Rat	PMID:10421658\|RGD:42721987
Molecular Function	GO:0005515	protein binding	ABCC2	IPI	UniProtKB:P15311	Human	PMID:17825285
Molecular Function	GO:0005515	protein binding	ABCC2	IPI	UniProtKB:P35241	Human	PMID:17825285
Molecular Function	GO:0005515	protein binding	ABCC2	IPI	UniProtKB:P19838	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	Abcc2	IPI	PR:P26043	Mouse	PMID:12068294
Molecular Function	GO:0005515	protein binding	Abcc2	IPI	PR:P26040	Mouse	PMID:12068294
Molecular Function	GO:0005515	protein binding	Abcc2	IPI	UniProtKB:Q9JJ19	Rat	PMID:20404332\|RGD:8554090
Molecular Function	GO:0019904	protein domain specific binding	Abcc2	IPI	RGD:621161	Rat	PMID:19339379\|RGD:2312758
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	ABCC2	IDA		Human	PMID:11500505
Cellular Component	GO:0016324	apical plasma membrane	ABCC2	IDA		Human	PMID:10220572
Cellular Component	GO:0016324	apical plasma membrane	ABCC2	IDA		Human	PMID:11093739
Cellular Component	GO:0016324	apical plasma membrane	ABCC2	IDA		Human	PMID:17825285
Cellular Component	GO:0016324	apical plasma membrane	ABCC2	IDA		Human	PMID:28408210
Cellular Component	GO:0016324	apical plasma membrane	Abcc2	IDA		Mouse	PMID:12951053
Cellular Component	GO:0016324	apical plasma membrane	Abcc2	IDA		Rat	PMID:10220572\|RGD:42721988
Cellular Component	GO:0016324	apical plasma membrane	Abcc2	IDA		Rat	PMID:20404332\|RGD:8554090
Cellular Component	GO:0016324	apical plasma membrane	Abcc2	IDA		Rat	PMID:28842383\|RGD:13446404
Cellular Component	GO:0031526	brush border membrane	Abcc2	IDA		Rat	PMID:16899240\|RGD:1598605
Cellular Component	GO:0009986	cell surface	ABCC2	IDA		Human	PMID:17825285
Cellular Component	GO:0009986	cell surface	ABCC2	HDA		Human	PMID:19581412
Cellular Component	GO:0005737	cytoplasm	Abcc2	IDA		Rat	PMID:26665149\|RGD:152995433
Cellular Component	GO:0046581	intercellular canaliculus	Abcc2	IDA		Mouse	PMID:12068294
Cellular Component	GO:0046691	intracellular canaliculus	Abcc2	IDA		Rat	PMID:19027009\|RGD:39458026
Cellular Component	GO:0016020	membrane	Abcc2	IDA		Mouse	PMID:11279518
Cellular Component	GO:0016020	membrane	Abcc2	IDA		Rat	PMID:11557524\|RGD:70559
Cellular Component	GO:0005886	plasma membrane	Abcc2	IDA		Mouse	PMID:12951053
Biological Process	GO:0016999	antibiotic metabolic process	Abcc2	IMP		Rat	PMID:18638490\|RGD:11081006
Biological Process	GO:1901086	benzylpenicillin metabolic process	Abcc2	IMP		Rat	PMID:19255943\|RGD:11081014
Biological Process	GO:0015721	bile acid and bile salt transport	ABCC2	IMP		Human	PMID:16332456
Biological Process	GO:0015721	bile acid and bile salt transport	Abcc2	IEP		Rat	PMID:27090119\|RGD:15090804
Biological Process	GO:0038183	bile acid signaling pathway	Abcc2	IEP		Rat	PMID:27090119\|RGD:15090804
Biological Process	GO:0015723	bilirubin transport	ABCC2	IMP		Human	PMID:10421658
Biological Process	GO:0015723	bilirubin transport	Abcc2	IMP		Rat	PMID:10421658\|RGD:42721987
Biological Process	GO:0015722	canalicular bile acid transport	Abcc2	IMP		Rat	PMID:25547484\|RGD:11081070
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Abcc2	IEP		Rat	PMID:17683490\|RGD:11081015
Biological Process	GO:0071347	cellular response to interleukin-1	Abcc2	IEP		Rat	PMID:20702406\|RGD:11081005
Biological Process	GO:0071354	cellular response to interleukin-6	Abcc2	IEP		Rat	PMID:20702406\|RGD:11081005
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Abcc2	IEP		Rat	PMID:20702406\|RGD:11081005
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Abcc2	IEP		Rat	PMID:20702406\|RGD:11081005
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Abcc2	IEP		Rat	PMID:27090119\|RGD:15090804
Biological Process	GO:0050787	detoxification of mercury ion	Abcc2	IMP		Rat	PMID:23059061\|RGD:14700809
Biological Process	GO:0007565	female pregnancy	Abcc2	IEP		Rat	PMID:15917434\|RGD:11081008
Biological Process	GO:0006954	inflammatory response	Abcc2	IEP		Rat	PMID:19525466\|RGD:14985241
Biological Process	GO:0030644	intracellular chloride ion homeostasis	Abcc2	IDA		Rat	PMID:12085350\|RGD:1598603
Biological Process	GO:0071716	leukotriene transport	ABCC2	IMP		Human	PMID:10220572
Biological Process	GO:0071716	leukotriene transport	Abcc2	IMP		Rat	PMID:10220572\|RGD:42721988
Biological Process	GO:0071716	leukotriene transport	Abcc2	IMP		Rat	PMID:25539456\|RGD:11057932
Biological Process	GO:0015694	mercury ion transport	Abcc2	IMP		Rat	PMID:21134393\|RGD:11081013
Biological Process	GO:0010629	negative regulation of gene expression	Abcc2	IMP		Rat	PMID:17437408\|RGD:14929203
Biological Process	GO:0015711	organic anion transport	Abcc2	IMP		Rat	PMID:19525466\|RGD:14985241
Biological Process	GO:0015732	prostaglandin transport	Abcc2	IMP		Rat	PMID:16584400\|RGD:1598610
Biological Process	GO:0120188	regulation of bile acid secretion	Abcc2	IEP		Rat	PMID:27090119\|RGD:15090804
Biological Process	GO:0010468	regulation of gene expression	Abcc2	IEP		Rat	PMID:27090119\|RGD:15090804
Biological Process	GO:0097327	response to antineoplastic agent	Abcc2	IEP		Rat	PMID:21881227\|RGD:11081000
Biological Process	GO:0046685	response to arsenic-containing substance	Abcc2	IEP		Rat	PMID:16737587\|RGD:1598609
Biological Process	GO:0032355	response to estradiol	Abcc2	IEP		Rat	PMID:19299525\|RGD:14700813
Biological Process	GO:0043627	response to estrogen	Abcc2	IDA		Rat	PMID:12702498\|RGD:1598571
Biological Process	GO:0043627	response to estrogen	Abcc2	IEP		Rat	PMID:27090119\|RGD:15090804
Biological Process	GO:0033762	response to glucagon	Abcc2	IEP		Rat	PMID:28842383\|RGD:13446404
Biological Process	GO:0009408	response to heat	Abcc2	IEP		Rat	PMID:16572733\|RGD:1598611
Biological Process	GO:0032496	response to lipopolysaccharide	Abcc2	IEP		Rat	PMID:28842383\|RGD:13446404
Biological Process	GO:0014070	response to organic cyclic compound	Abcc2	IEP		Rat	PMID:16925582\|RGD:1598604
Biological Process	GO:0006979	response to oxidative stress	Abcc2	IEP		Rat	PMID:16785030\|RGD:1598601
Biological Process	GO:0048545	response to steroid hormone	Abcc2	IEP		Rat	PMID:16483613\|RGD:8693732
Biological Process	GO:0009410	response to xenobiotic stimulus	Abcc2	IDA		Rat	PMID:16757538\|RGD:1598607
Biological Process	GO:0070327	thyroid hormone transport	Abcc2	IMP		Rat	PMID:19211616\|RGD:2312759
Biological Process	GO:0070633	transepithelial transport	Abcc2	IMP		Rat	PMID:12663688\|RGD:704399
Biological Process	GO:0070633	transepithelial transport	Abcc2	IGI	UniProtKB:P43245	Rat	PMID:17437408\|RGD:14929203
Biological Process	GO:0042178	xenobiotic catabolic process	Abcc2	IMP		Rat	PMID:18088505\|RGD:14700808
Biological Process	GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	Abcc2	IMP		Rat	PMID:16857726\|RGD:1598606
Biological Process	GO:0046618	xenobiotic export from cell	ABCC2	IMP		Human	PMID:18245269
Biological Process	GO:0006855	xenobiotic transmembrane transport	ABCC2	IMP		Human	PMID:18245269
Biological Process	GO:0006855	xenobiotic transmembrane transport	Abcc2	IMP		Rat	PMID:10220572\|RGD:42721988
Biological Process	GO:1990962	xenobiotic transport across blood-brain barrier	Abcc2	IMP		Rat	PMID:12663688\|RGD:704399
Biological Process	GO:1990962	xenobiotic transport across blood-brain barrier	Abcc2	IGI	UniProtKB:P43245	Rat	PMID:17437408\|RGD:14929203

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.