Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCC4
  • Mouse genes Abcc4
  • Rat genes Abcc4
  • Zfish genes abcc4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abcc4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015432	ABC-type bile acid transporter activity	ABCC4	IMP		Human	PMID:16282361
Molecular Function	GO:0015431	ABC-type glutathione S-conjugate transporter activity	ABCC4	IDA		Human	PMID:17959747
Molecular Function	GO:0140359	ABC-type transporter activity	abcc4	IMP	ZFIN:ZDB-GENO-220112-18	Zfish	PMID:33669601
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ABCC4	IDA		Human	PMID:15364914
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ABCC4	IDA		Human	PMID:15454390
Molecular Function	GO:0015562	efflux transmembrane transporter activity	ABCC4	IMP		Human	PMID:25986174
Molecular Function	GO:0015562	efflux transmembrane transporter activity	abcc4	IDA		Zfish	PMID:25478949
Molecular Function	GO:0034634	glutathione transmembrane transporter activity	ABCC4	IMP		Human	PMID:11856762
Molecular Function	GO:0001409	guanine nucleotide transmembrane transporter activity	ABCC4	IDA		Human	PMID:15454390
Molecular Function	GO:0015132	prostaglandin transmembrane transporter activity	ABCC4	IMP		Human	PMID:15364914
Molecular Function	GO:0005515	protein binding	ABCC4	IPI	UniProtKB:Q96L92	Human	PMID:22411990
Molecular Function	GO:0005515	protein binding	ABCC4	IPI	UniProtKB:Q00013	Human	PMID:29146910
Molecular Function	GO:0015216	purine nucleotide transmembrane transporter activity	ABCC4	IMP		Human	PMID:25986174
Molecular Function	GO:0015143	urate transmembrane transporter activity	ABCC4	IMP		Human	PMID:15454390
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	ABCC4	IDA		Human	PMID:11856762
Molecular Function	GO:0042910	xenobiotic transmembrane transporter activity	ABCC4	IMP		Human	PMID:25986174
Cellular Component	GO:0016324	apical plasma membrane	ABCC4	IDA		Human	PMID:11856762
Cellular Component	GO:0016324	apical plasma membrane	ABCC4	IDA		Human	PMID:25986174
Cellular Component	GO:0016324	apical plasma membrane	ABCC4	IDA		Human	PMID:31791063
Cellular Component	GO:0016324	apical plasma membrane	Abcc4	IDA		Mouse	MGI:MGI:3054507|PMID:15314169
Cellular Component	GO:0016323	basolateral plasma membrane	ABCC4	IDA		Human	PMID:25986174
Cellular Component	GO:0016323	basolateral plasma membrane	ABCC4	IDA		Human	PMID:24130369
Cellular Component	GO:0016323	basolateral plasma membrane	ABCC4	IDA		Human	PMID:31791063
Cellular Component	GO:0016323	basolateral plasma membrane	Abcc4	IDA		Mouse	MGI:MGI:3054507|PMID:15314169
Cellular Component	GO:0016323	basolateral plasma membrane	Abcc4	IDA		Rat	PMID:18619525|RGD:2301072
Cellular Component	GO:0098591	external side of apical plasma membrane	Abcc4	IDA		Rat	PMID:18619525|RGD:2301072
Cellular Component	GO:0005794	Golgi apparatus	ABCC4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	ABCC4	IDA		Human	PMID:15297306
Cellular Component	GO:0016020	membrane	ABCC4	HDA		Human	PMID:19946888
Cellular Component	GO:0005730	nucleolus	ABCC4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ABCC4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ABCC4	IDA		Human	PMID:15297306
Cellular Component	GO:0005886	plasma membrane	ABCC4	IDA		Human	PMID:18619525
Cellular Component	GO:0005886	plasma membrane	ABCC4	IDA		Human	PMID:25173977
Cellular Component	GO:0005886	plasma membrane	ABCC4	IDA		Human	PMID:23137377
Cellular Component	GO:0005886	plasma membrane	ABCC4	IDA		Human	PMID:28112518
Cellular Component	GO:0005886	plasma membrane	Abcc4	IDA		Mouse	PMID:25173977
Cellular Component	GO:0005886	plasma membrane	abcc4	IDA		Zfish	PMID:23766510
Cellular Component	GO:0031088	platelet dense granule membrane	ABCC4	IDA		Human	PMID:15297306
Biological Process	GO:0015721	bile acid and bile salt transport	ABCC4	IMP		Human	PMID:16282361
Biological Process	GO:0038183	bile acid signaling pathway	Abcc4	IEP		Rat	PMID:30223280|RGD:15045612
Biological Process	GO:0070730	cAMP transport	ABCC4	IDA		Human	PMID:11856762
Biological Process	GO:0070730	cAMP transport	ABCC4	IMP		Human	PMID:25986174
Biological Process	GO:0060271	cilium assembly	ABCC4	IMP		Human	PMID:25173977
Biological Process	GO:0098754	detoxification	abcc4	IDA		Zfish	PMID:25478949
Biological Process	GO:0098754	detoxification	abcc4	IMP	ZFIN:ZDB-MRPHLNO-150402-9	Zfish	PMID:25478949
Biological Process	GO:0061687	detoxification of inorganic compound	abcc4	IMP	ZFIN:ZDB-GENO-220112-18	Zfish	PMID:33669601
Biological Process	GO:0140115	export across plasma membrane	ABCC4	IMP		Human	PMID:25986174
Biological Process	GO:0071716	leukotriene transport	ABCC4	IDA		Human	PMID:17959747
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Abcc4	IMP		Rat	PMID:18636120|RGD:2301071
Biological Process	GO:0032310	prostaglandin secretion	ABCC4	IDA		Human	PMID:25173977
Biological Process	GO:0015732	prostaglandin transport	ABCC4	IMP		Human	PMID:15364914
Biological Process	GO:1902017	regulation of cilium assembly	abcc4	IMP	ZFIN:ZDB-GENO-151015-27	Zfish	PMID:25173977
Biological Process	GO:0014070	response to organic cyclic compound	Abcc4	IEP		Rat	PMID:15047146|RGD:2301083
Biological Process	GO:0010033	response to organic substance	Abcc4	IEP		Rat	PMID:17544377|RGD:2301066
Biological Process	GO:0010243	response to organonitrogen compound	Abcc4	IEP		Rat	PMID:18418891|RGD:2301059
Biological Process	GO:0009410	response to xenobiotic stimulus	Abcc4	IEP		Rat	PMID:15047146|RGD:2301083
Biological Process	GO:0015747	urate transport	ABCC4	IMP		Human	PMID:15454390

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern