Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCC6
  • Mouse genes Abcc6
  • Rat genes Abcc6
  • Zfish genes abcc6a,abcc6b.1,abcc6b.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abcc6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0015431	ABC-type glutathione S-conjugate transporter activity	ABCC6	IDA		Human	PMID:11880368
Molecular Function	GO:0008559	ABC-type xenobiotic transporter activity	Abcc6	IDA		Rat	PMID:10692506|RGD:1549867
Molecular Function	GO:0005524	ATP binding	ABCC6	IDA		Human	PMID:11880368
Molecular Function	GO:0005524	ATP binding	Abcc6	IDA		Rat	PMID:12069597|RGD:1549866
Molecular Function	GO:0016887	ATP hydrolysis activity	Abcc6	IDA		Rat	PMID:12069597|RGD:1549866
Molecular Function	GO:0042626	ATPase-coupled transmembrane transporter activity	ABCC6	IDA		Human	PMID:11880368
Molecular Function	GO:0030504	inorganic diphosphate transmembrane transporter activity	Abcc6	IDA		Rat	PMID:28111129|RGD:13792593
Cellular Component	GO:0016324	apical plasma membrane	Abcc6	IDA		Rat	PMID:10692506|RGD:1549867
Cellular Component	GO:0009925	basal plasma membrane	ABCC6	IDA		Human	PMID:35307651
Cellular Component	GO:0016323	basolateral plasma membrane	ABCC6	IDA		Human	PMID:12901863
Cellular Component	GO:0016323	basolateral plasma membrane	Abcc6	IDA		Mouse	MGI:MGI:3613353|PMID:15888484
Cellular Component	GO:0016323	basolateral plasma membrane	Abcc6	IDA		Rat	PMID:28111129|RGD:13792593
Cellular Component	GO:0005576	extracellular region	ABCC6	IDA		Human	PMID:28592560
Cellular Component	GO:0016328	lateral plasma membrane	Abcc6	IDA		Rat	PMID:10692506|RGD:1549867
Cellular Component	GO:0016020	membrane	Abcc6	IDA		Rat	PMID:12069597|RGD:1549866
Cellular Component	GO:0005654	nucleoplasm	ABCC6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	ABCC6	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	Abcc6	IDA		Rat	PMID:33058196|RGD:40902970
Biological Process	GO:0046034	ATP metabolic process	ABCC6	IDA		Human	PMID:28592560
Biological Process	GO:0015867	ATP transport	ABCC6	IDA		Human	PMID:24277820
Biological Process	GO:0015867	ATP transport	ABCC6	IDA		Human	PMID:24969777
Biological Process	GO:0015867	ATP transport	Abcc6	IDA		Rat	PMID:33058196|RGD:40902970
Biological Process	GO:0055074	calcium ion homeostasis	ABCC6	IDA		Human	PMID:28592560
Biological Process	GO:0055074	calcium ion homeostasis	Abcc6	IMP	MGI:MGI:3785162	Mouse	PMID:24732453
Biological Process	GO:0055074	calcium ion homeostasis	Abcc6	IMP	MGI:MGI:3045236	Mouse	PMID:24732453
Biological Process	GO:0055074	calcium ion homeostasis	Abcc6	IGI	MGI:MGI:1351634	Mouse	PMID:24732453
Biological Process	GO:0055074	calcium ion homeostasis	Abcc6	IGI	MGI:MGI:97370	Mouse	PMID:28592560
Biological Process	GO:0055074	calcium ion homeostasis	Abcc6	IGI	MGI:MGI:97370	Mouse	PMID:24732453
Biological Process	GO:0055074	calcium ion homeostasis	Abcc6	IGI	MGI:MGI:99782	Mouse	PMID:28592560
Biological Process	GO:0055074	calcium ion homeostasis	Abcc6	IMP	MGI:MGI:3614409	Mouse	PMID:28701330
Biological Process	GO:0043009	chordate embryonic development	abcc6a	IMP	ZFIN:ZDB-MRPHLNO-101228-3	Zfish	PMID:23702584
Biological Process	GO:0043009	chordate embryonic development	abcc6a	IMP	ZFIN:ZDB-MRPHLNO-101228-2	Zfish	PMID:24352041
Biological Process	GO:0010467	gene expression	ABCC6	IDA		Human	PMID:28592560
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Abcc6	IGI	MGI:MGI:1351634	Mouse	PMID:24732453
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Abcc6	IGI	MGI:MGI:97370	Mouse	PMID:24732453
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Abcc6	IMP	MGI:MGI:3785162	Mouse	PMID:24732453
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Abcc6	IMP	MGI:MGI:3045236	Mouse	PMID:24732453
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	Abcc6	IMP	MGI:MGI:3045236	Mouse	PMID:28652107
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	abcc6a	IMP	ZFIN:ZDB-MRPHLNO-200416-1	Zfish	PMID:30030150
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	abcc6a	IMP	ZFIN:ZDB-GENO-201210-2	Zfish	PMID:30030150
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	abcc6a	IMP	ZFIN:ZDB-GENO-201210-1	Zfish	PMID:30030150
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	abcc6a	IMP	ZFIN:ZDB-GENO-220919-2	Zfish	PMID:33383974
Biological Process	GO:0140928	inhibition of non-skeletal tissue mineralization	abcc6a	IMP	ZFIN:ZDB-GENO-220919-1	Zfish	PMID:33383974
Biological Process	GO:0030505	inorganic diphosphate transport	Abcc6	IMP	MGI:MGI:1857079	Mouse	PMID:28701330
Biological Process	GO:0030505	inorganic diphosphate transport	Abcc6	IMP	MGI:MGI:3614409	Mouse	PMID:28701330
Biological Process	GO:0030505	inorganic diphosphate transport	Abcc6	IDA		Mouse	PMID:28701330
Biological Process	GO:0030505	inorganic diphosphate transport	Abcc6	IDA		Rat	PMID:28111129|RGD:13792593
Biological Process	GO:0030643	intracellular phosphate ion homeostasis	Abcc6	IMP		Mouse	MGI:MGI:5544348|PMID:24277820
Biological Process	GO:0030643	intracellular phosphate ion homeostasis	Abcc6	IMP		Rat	PMID:28111129|RGD:13792593
Biological Process	GO:0071716	leukotriene transport	ABCC6	IDA		Human	PMID:11880368
Biological Process	GO:0055062	phosphate ion homeostasis	ABCC6	IDA		Human	PMID:28592560
Biological Process	GO:0055062	phosphate ion homeostasis	Abcc6	IMP	MGI:MGI:3045236	Mouse	PMID:28652107
Biological Process	GO:0055062	phosphate ion homeostasis	Abcc6	IDA		Mouse	PMID:28701330
Biological Process	GO:0055062	phosphate ion homeostasis	Abcc6	IMP	MGI:MGI:3614409	Mouse	PMID:28701330
Biological Process	GO:0055062	phosphate ion homeostasis	Abcc6	IMP	MGI:MGI:1857079	Mouse	PMID:28701330
Biological Process	GO:0030500	regulation of bone mineralization	abcc6a	IMP	ZFIN:ZDB-GENO-150601-5	Zfish	PMID:25758222
Biological Process	GO:1903053	regulation of extracellular matrix organization	abcc6a	IMP	ZFIN:ZDB-GENO-220919-1	Zfish	PMID:33383974
Biological Process	GO:0032026	response to magnesium ion	Abcc6	IGI	MGI:MGI:1351634	Mouse	PMID:24732453
Biological Process	GO:0032026	response to magnesium ion	Abcc6	IMP	MGI:MGI:3045236	Mouse	PMID:24732453
Biological Process	GO:0032026	response to magnesium ion	Abcc6	IGI	MGI:MGI:97370	Mouse	PMID:24732453
Biological Process	GO:0032026	response to magnesium ion	Abcc6	IMP	MGI:MGI:3785162	Mouse	PMID:24732453
Biological Process	GO:1904383	response to sodium phosphate	Abcc6	IMP	MGI:MGI:3785162	Mouse	PMID:24732453
Biological Process	GO:1904383	response to sodium phosphate	Abcc6	IGI	MGI:MGI:1351634	Mouse	PMID:24732453
Biological Process	GO:1904383	response to sodium phosphate	Abcc6	IGI	MGI:MGI:97370	Mouse	PMID:24732453
Biological Process	GO:1904383	response to sodium phosphate	Abcc6	IMP	MGI:MGI:3045236	Mouse	PMID:24732453
Biological Process	GO:0006855	xenobiotic transmembrane transport	Abcc6	IDA		Rat	PMID:10692506|RGD:1549867

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern