Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ABCG1
  • Mouse genes Abcg1
  • Rat genes Abcg1
  • Zfish genes abcg1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Abcg1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0034041	ABC-type sterol transporter activity	ABCG1	IDA		Human	PMID:17408620
Molecular Function	GO:0043531	ADP binding	ABCG1	IDA		Human	PMID:16702602
Molecular Function	GO:0005524	ATP binding	ABCG1	IDA		Human	PMID:16702602
Molecular Function	GO:0120020	cholesterol transfer activity	ABCG1	IDA		Human	PMID:15994327
Molecular Function	GO:0140328	floppase activity	ABCG1	IDA		Human	PMID:16702602
Molecular Function	GO:0140328	floppase activity	ABCG1	IDA		Human	PMID:24576892
Molecular Function	GO:0090554	phosphatidylcholine floppase activity	ABCG1	IDA		Human	PMID:16702602
Molecular Function	GO:0005515	protein binding	ABCG1	IPI	UniProtKB:Q03135	Human	PMID:24576892
Molecular Function	GO:0005515	protein binding	ABCG1	IPI	UniProtKB:Q9H172	Human	PMID:27228027
Molecular Function	GO:0046982	protein heterodimerization activity	ABCG1	IPI	UniProtKB:Q9H172	Human	PMID:16870176
Molecular Function	GO:0042803	protein homodimerization activity	ABCG1	IDA		Human	PMID:16702602
Molecular Function	GO:0042803	protein homodimerization activity	ABCG1	IDA		Human	PMID:16870176
Molecular Function	GO:0019534	toxin transmembrane transporter activity	ABCG1	IDA		Human	PMID:17408620
Cellular Component	GO:0005768	endosome	Abcg1	IDA		Mouse	MGI:MGI:3768186|PMID:17916878
Cellular Component	GO:0009897	external side of plasma membrane	ABCG1	IDA		Human	PMID:16556852
Cellular Component	GO:0009897	external side of plasma membrane	Abcg1	IDA		Mouse	MGI:MGI:3852307|PMID:16556852
Cellular Component	GO:0005794	Golgi apparatus	ABCG1	HDA		Human	PMID:16780588
Cellular Component	GO:0005739	mitochondrion	ABCG1	IDA		Human	PMID:22042635
Cellular Component	GO:0005886	plasma membrane	ABCG1	IDA		Human	PMID:16702602
Cellular Component	GO:0005886	plasma membrane	ABCG1	HDA		Human	PMID:16780588
Cellular Component	GO:0005886	plasma membrane	ABCG1	IDA		Human	PMID:24576892
Cellular Component	GO:0055037	recycling endosome	Abcg1	IDA		Mouse	MGI:MGI:3852307|PMID:16556852
Biological Process	GO:0042987	amyloid precursor protein catabolic process	ABCG1	IDA		Human	PMID:17293612
Biological Process	GO:0071403	cellular response to high density lipoprotein particle stimulus	Abcg1	IDA		Mouse	MGI:MGI:3047008|PMID:15210959
Biological Process	GO:0033344	cholesterol efflux	ABCG1	IDA		Human	PMID:15994327
Biological Process	GO:0033344	cholesterol efflux	ABCG1	IMP		Human	PMID:16702602
Biological Process	GO:0033344	cholesterol efflux	ABCG1	IMP		Human	PMID:24576892
Biological Process	GO:0033344	cholesterol efflux	Abcg1	IMP		Mouse	MGI:MGI:5634884|PMID:21481393
Biological Process	GO:0033344	cholesterol efflux	Abcg1	IMP		Mouse	MGI:MGI:3852307|PMID:16556852
Biological Process	GO:0042632	cholesterol homeostasis	ABCG1	IDA		Human	PMID:15994327
Biological Process	GO:0008203	cholesterol metabolic process	ABCG1	IDA		Human	PMID:15994327
Biological Process	GO:0030301	cholesterol transport	Abcg1	IDA		Mouse	PMID:15319426
Biological Process	GO:0034436	glycoprotein transport	ABCG1	IDA		Human	PMID:17293612
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	Abcg1	IMP		Mouse	MGI:MGI:5634884|PMID:21481393
Biological Process	GO:0034375	high-density lipoprotein particle remodeling	Abcg1	IMP		Mouse	MGI:MGI:3852307|PMID:16556852
Biological Process	GO:0032367	intracellular cholesterol transport	ABCG1	IMP		Human	PMID:15994327
Biological Process	GO:0034374	low-density lipoprotein particle remodeling	Abcg1	IMP		Mouse	MGI:MGI:3852307|PMID:16556852
Biological Process	GO:0010888	negative regulation of lipid storage	Abcg1	IMP		Mouse	MGI:MGI:3852307|PMID:16556852
Biological Process	GO:0033700	phospholipid efflux	ABCG1	IMP		Human	PMID:16702602
Biological Process	GO:0055091	phospholipid homeostasis	ABCG1	IMP		Human	PMID:16702602
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	ABCG1	IDA		Human	PMID:17293612
Biological Process	GO:0045542	positive regulation of cholesterol biosynthetic process	Abcg1	IMP		Mouse	MGI:MGI:3768186|PMID:17916878
Biological Process	GO:0010875	positive regulation of cholesterol efflux	Abcg1	IDA		Mouse	MGI:MGI:3047008|PMID:15210959
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	Abcg1	IMP		Rat	PMID:29540530|RGD:41404656
Biological Process	GO:0050714	positive regulation of protein secretion	ABCG1	IDA		Human	PMID:17293612
Biological Process	GO:1904411	positive regulation of secretory granule organization	Abcg1	IMP		Rat	PMID:29540530|RGD:41404656
Biological Process	GO:0010874	regulation of cholesterol efflux	abcg1	IGI	ZFIN:ZDB-MRPHLNO-130813-6,ZFIN:ZDB-MRPHLNO-130813-7	Zfish	PMID:23719382
Biological Process	GO:0090181	regulation of cholesterol metabolic process	Abcg1	IMP		Mouse	MGI:MGI:3852307|PMID:16556852
Biological Process	GO:0033993	response to lipid	ABCG1	IDA		Human	PMID:16556852
Biological Process	GO:0010033	response to organic substance	ABCG1	IEP		Human	PMID:11500512
Biological Process	GO:0043691	reverse cholesterol transport	Abcg1	IMP		Mouse	MGI:MGI:3720273|PMID:17657311
Biological Process	GO:0002040	sprouting angiogenesis	abcg1	IGI	ZFIN:ZDB-MRPHLNO-130813-6,ZFIN:ZDB-MRPHLNO-130813-7	Zfish	PMID:23719382

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern